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The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

Jennifer M. McCoy, … , Joan R. Wicks, Laurent P. Audoly

Jennifer M. McCoy, … , Joan R. Wicks, Laurent P. Audoly

Published September 1, 2002
Citation Information: J Clin Invest. 2002;110(5):651-658. https://doi.org/10.1172/JCI15528.

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Prostaglandin E 2 Inhibition of IL-27 Production in Murine Dendritic Cells: A Novel Mechanism That Involves IRF1 KM Hooper, JH Yen, W Kong, KM Rahbari, PC Kuo, AM Gamero, D Ganea	Journal of immunology (Baltimore, Md. : 1950)	2017
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Therapeutic Effect of Emodin on Collagen-Induced Arthritis in Mice X Zhu, K Zeng, Y Qiu, F Yan, C Lin	Inflammation	2013
Cytosolic Phospholipase A2 Regulates TNF-Induced Production of Joint Destructive Effectors in Synoviocytes RM Sommerfelt, AJ Feuerherm, K Jones, B Johansen, CM Yang	PloS one	2013
Prostaglandins and rheumatoid arthritis MJ Fattahi, A Mirshafiey	Arthritis	2012
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Matrix metalloproteinase-dependent microsomal prostaglandin E synthase-1 expression in macrophages: role of TNF-α and the EP4 prostanoid receptor KM Khan, P Kothari, B Du, AJ Dannenberg, DJ Falcone	Journal of immunology (Baltimore, Md. : 1950)	2012
Prostaglandins and Inflammation E Ricciotti, GA FitzGerald	Arteriosclerosis, thrombosis, and vascular biology	2011
Effects of testosterone, estrogen and progesterone on TNF-α mediated cellular damage in rat arthritic synovial fibroblasts K Ganesan, C Balachandran, BM Manohar, R Puvanakrishnan	Rheumatology International	2011
Interleukin-6 Synthesis in Human Chondrocytes Is Regulated via the Antagonistic Actions of Prostaglandin (PG)E2 and 15-deoxy-Δ12,14-PGJ2 P Wang, F Zhu, K Konstantopoulos	PloS one	2011
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Prostaglandin (PG)E2 exhibits antifibrotic activity in vocal fold fibroblasts H Zhou, D Felsen, VC Sandulache, MR Amin, DH Kraus, RC Branski	The Laryngoscope	2011
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Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation P Wang, F Zhu, K Konstantopoulos	American journal of physiology. Cell physiology	2010
Hydrodynamic delivery of chitosan-folate-DNA nanoparticles in rats with adjuvant-induced arthritis Q Shi, H Wang, C Tran, X Qiu, FM Winnik, X Zhang, K Dai, M Benderdour, JC Fernandes	Journal of biomedicine & biotechnology	2010
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Complement - a key system for immune surveillance and homeostasis D Ricklin, G Hajishengallis, K Yang, JD Lambris	Nature Immunology	2010
A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models: EP4 receptor antagonist for inflammatory arthritis Q Chen, K Muramoto, N Masaaki, Y Ding, H Yang, M Mackey, W Li, Y Inoue, K Ackermann, H Shirota, I Matsumoto, M Spyvee, S Schiller, T Sumida, F Gusovsky, M Lamphier	British Journal of Pharmacology	2010
Design of Group IIA Secreted/Synovial Phospholipase A2 Inhibitors: An Oxadiazolone Derivative Suppresses Chondrocyte Prostaglandin E2 Secretion JE Ombetta, N Thelier, CZ Dong, S Plocki, L Tsagris, F Rannou, F Massicot, A Djimdé, E El-Hayek, Y Shi, F Heymans, N Gresh, C Chauvet, S Agarwal	PloS one	2010
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Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy SA Maher, MA Birrell, MG Belvisi	American journal of respiratory and critical care medicine	2009
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA F Kojima, M Kapoor, S Kawai, L Yang, DM Aronoff, LJ Crofford	Prostaglandins & Other Lipid Mediators	2009
PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis R Tsutsumi, C Xie, X Wei, M Zhang, X Zhang, LM Flick, EM Schwarz, RJ O'Keefe	Journal of Bone and Mineral Research	2009
Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production HP Lemos, R Grespan, SM Vieira, TM Cunha, WA Verri, KS Fernandes, FO Souto, IB McInnes, SH Ferreira, FY Liew, FQ Cunha	Proceedings of the National Academy of Sciences	2009
Sperm and oocyte communication mechanisms controlling C. elegans fertility SM Han, PA Cottee, MA Miller	Developmental Dynamics	2009
Prostaglandin E2 Differentially Modulates Proinflammatory/Prodestructive Effects of TNF- on Synovial Fibroblasts via Specific E Prostanoid Receptors/cAMP E Kunisch, A Jansen, F Kojima, I Loffler, M Kapoor, S Kawai, I Rubio, LJ Crofford, RW Kinne	Journal of immunology (Baltimore, Md. : 1950)	2009
Prostaglandin E 2 Exerts Homeostatic Regulation of Pulmonary Vascular Remodeling in Allergic Airway Inflammation A Lundequist, SN Nallamshetty, W Xing, C Feng, TM Laidlaw, S Uematsu, S Akira, JA Boyce	Journal of immunology (Baltimore, Md. : 1950)	2009
Pharmacological activation of the prostaglandin E2 receptor EP4 improves cardiac function after myocardial ischaemia/reperfusion injury K Hishikari, J Suzuki, M Ogawa, K Isobe, T Takahashi, M Onishi, K Takayama, M Isobe	Cardiovascular Research	2008
Pro-inflammatory prostaglandins and progression of colorectal cancer D Wang, RN DuBois	Cancer Letters	2008
Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B F Xu, Z Xu, R Zhang, Z Wu, JH Lim, T Koga, JD Li, H Shen	Respiratory Research	2008
Nickel and the microbial toxin, MALP-2, stimulate proangiogenic mediators from human lung fibroblasts via a HIF-1alpha and COX-2-mediated pathway KA Brant, JP Fabisiak	Toxicological sciences : an official journal of the Society of Toxicology	2008
Cyclooxygenase-2 Deficiency Enhances Th2 Immune Responses and Impairs Neutrophil Recruitment in Hepatic Ischemia/Reperfusion Injury Hamada T, Tsuchihashi S, Avanesyan A, Duarte S, Moore C, Busuttil RW, Coito AJ	Journal of immunology (Baltimore, Md. : 1950)	2008
Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice. Kojima F, Kapoor M, Yang L, Fleishaker EL, Ward MR, Monrad SU, Kottangada PC, Pace CQ, Clark JA, Woodward JG, Crofford LJ	Journal of immunology (Baltimore, Md. : 1950)	2008
In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells. Khayrullina T, Yen JH, Jing H, Ganea D	Journal of immunology (Baltimore, Md. : 1950)	2008
Night eating and obesity in the EP3R-deficient mouse M Sanchez-Alavez, I Klein, SE Brownell, IV Tabarean, CN Davis, B Conti, T Bartfai	Proceedings of the National Academy of Sciences	2007
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Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis KS Nandakumar, R Holmdahl	Arthritis Research & Therapy	2007
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy EV Tchetina, JA di Battista, DJ Zukor, J Antoniou, AR Poole	Arthritis Research & Therapy	2007
Gender differences and protective effects of testosterone in collagen induced arthritis in rats K Ganesan, R Selvam, R Abhirami, KV Raju, BM Manohar, R Puvanakrishnan	Rheumatology International	2007
Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation MN Ballinger, TR McMillan, BB Moore	Archivum Immunologiae et Therapiae Experimentalis	2007
Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells Jingsong Wang, John W. Fathman, Geanncarlo Lugo-Villarino, Lucila Scimone, Ulrich von Andrian, David M. Dorfman, and Laurie H. Glimcher	Journal of Clinical Investigation	2006
Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis T Honda, E Segi-Nishida, Y Miyachi, S Narumiya	Journal of Experimental Medicine	2006
IL-32, a proinflammatory cytokine in rheumatoid arthritis LA Joosten, MG Netea, SH Kim, DY Yoon, B Oppers-Walgreen, TR Radstake, P Barrera, FA van de Loo, CA Dinarello, WB van Berg	Proceedings of the National Academy of Sciences	2006
Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene M Gosset, F Berenbaum, A Levy, A Pigenet, S Thirion, JL Saffar, C Jacques	Arthritis Research & Therapy	2006
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase CE Trebino, JL Stock, CP Gibbons, BM Naiman, TS Wachtmann, JP Umland, K Pandher, JM Lapointe, S Saha, ML Roach, D Carter, NA Thomas, BA Durtschi, JD McNeish, JE Hambor, PJ Jakobsson, TJ Carty, JR Perez, LP Audoly	Proceedings of the National Academy of Sciences	2003
Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis M Hegen, L Sun, N Uozumi, K Kume, ME Goad, CL Nickerson-Nutter, T Shimizu, JD Clark	Journal of Experimental Medicine	2003
Targeting rheumatoid inflammation and joint destruction in the mouse Masaki Inada, Stephan Krane	Journal of Clinical Investigation	2002

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