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Citations to this article

All our knowledge begins with the antisenses
Ethan M. Goldberg
Ethan M. Goldberg
Published December 1, 2021
Citation Information: J Clin Invest. 2021;131(23):e155233. https://doi.org/10.1172/JCI155233.
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Commentary Article has an altmetric score of 7

All our knowledge begins with the antisenses

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Abstract

Epilepsy is the neurological disorder defined by spontaneous recurrent seizures, which are abnormal patterns of electrical discharge in the brain. A major advance in neurology over the last 20 years is the identification of genetic variation as an important cause of epilepsy, and in particular as a cause of the epileptic encephalopathies, defined by childhood-onset, treatment-resistant epilepsy accompanied by developmental delay leading to intellectual disability. Unfortunately, this progress in genetic diagnosis has yet to translate to effective precision or targeted therapeutics. However, in this issue of the JCI, Li and Jancovski et al. use antisense oligonucleotides (ASO) to treat or prevent epilepsy and epilepsy-associated cognitive and behavioral comorbidities in a mouse model of SCN2A encephalopathy, paralogous to the recurrent human variant SCN2A c.5645G>A (p.R1882Q) associated with epileptic encephalopathy. These findings may inform the development of targeted or personalized therapies for what is currently an incurable and largely untreatable disorder.

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Ethan M. Goldberg

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Total citations by year

Year: 2024 Total
Citations: 1 1
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This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (1)

Title and authors Publication Year
Antisense oligonucleotides as a precision therapy for developmental and epileptic encephalopathies.
Quilón PG, Volpedo G, Cappato S, Ferrera L, Zara F, Bocciardi R, Riva A, Striano P
CNS neuroscience & therapeutics 2024

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