In vivo bradykinin B2 receptor activation reduces renal fibrosis
Joost P. Schanstra, Eric Neau, Pascale Drogoz, Miguel A. Arevalo Gomez, José Miguel Lopez Novoa, Denis Calise, Christiane Pecher, Michael Bader, Jean-Pierre Girolami, Jean-Loup Bascands
Joost P. Schanstra, Eric Neau, Pascale Drogoz, Miguel A. Arevalo Gomez, José Miguel Lopez Novoa, Denis Calise, Christiane Pecher, Michael Bader, Jean-Pierre Girolami, Jean-Loup Bascands
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Article Genetics

In vivo bradykinin B2 receptor activation reduces renal fibrosis

Abstract

Research Article

Authors

Joost P. Schanstra, Eric Neau, Pascale Drogoz, Miguel A. Arevalo Gomez, José Miguel Lopez Novoa, Denis Calise, Christiane Pecher, Michael Bader, Jean-Pierre Girolami, Jean-Loup Bascands

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(a–d) Upper panels: representative light micrographs of immunodetection ...
(a–d) Upper panels: representative light micrographs of immunodetection of collagen I, III, IV, and fibronectin expression within kidney sections from B2+/+ and B2–/– mice either sham-operated or UUO for 5 days. Lower panels, corresponding quantitative analysis of collagen I, III, IV, and fibronectin expression. Data are expressed as the mean ± SD percentage of the interstitial area stained; n = 10; *P < 0.05 compared with respective sham-operated mice. ‡P < 0.05 compared with obstructed B2+/+ mice. Original magnification ×400.