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Semaphorins as signals for cell repulsion and invasion
Yoshio Goshima, … , Yukio Sasaki, Fumio Nakamura
Yoshio Goshima, … , Yukio Sasaki, Fumio Nakamura
Published April 15, 2002
Citation Information: J Clin Invest. 2002;109(8):993-998. https://doi.org/10.1172/JCI15467.
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Perspective

Semaphorins as signals for cell repulsion and invasion

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Abstract

Authors

Yoshio Goshima, Takaaki Ito, Yukio Sasaki, Fumio Nakamura

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Figure 2

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Schematic representation of possible signal transduction pathways trigge...
Schematic representation of possible signal transduction pathways triggered by Sema3A. This semaphorin binds a complex containing the receptor proteins Plex-A1 and NP-1, as well as other, still poorly characterized signal transducing molecules. In neurons, some of the downstream events, including reorganization of the actin cytoskeleton and the consequent collapse of the axonal growth cone, are also influenced by pertussis toxin–sensitive (PTX-sensitive) G proteins. The CRMP appears to be central to several of the cellular responses to Sema3A.

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