Circulating levels of IGF-1 directly regulate bone growth and density
Shoshana Yakar, … , Yves R. Boisclair, Derek LeRoith
Shoshana Yakar, … , Yves R. Boisclair, Derek LeRoith
Published September 15, 2002
Citation Information: J Clin Invest. 2002;110(6):771-781. https://doi.org/10.1172/JCI15463.
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Article Endocrinology

Circulating levels of IGF-1 directly regulate bone growth and density

Abstract

Research Article

Authors

Shoshana Yakar, Clifford J. Rosen, Wesley G. Beamer, Cheryl L. Ackert-Bicknell, Yiping Wu, Jun-Li Liu, Guck T. Ooi, Jennifer Setser, Jan Frystyk, Yves R. Boisclair, Derek LeRoith

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Figure 4

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LID+ALSKO mice exhibit alterations in growth plate height. Representativ...
LID+ALSKO mice exhibit alterations in growth plate height. Representative proximal tibia sections from control (a), LID (b), ALSKO (c), and LID+ALSKO (d) mice at postnatal day 28. Sections were visualized with the Masson trichrome technique, which stains nuclei black, stains collagen blue, and stains calcified matrix red. In LID+ALSKO mice, the total height of the growth plate is significantly reduced (bar, 200 μm). Inserts (bar = 50 μm) show the germinal zone (GZ), proliferating zone (PZ), and hypertrophic zone (HZ) of chondrocytes.