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Circulating levels of IGF-1 directly regulate bone growth and density

Shoshana Yakar, … , Yves R. Boisclair, Derek LeRoith

Shoshana Yakar, … , Yves R. Boisclair, Derek LeRoith

Published September 15, 2002
Citation Information: J Clin Invest. 2002;110(6):771-781. https://doi.org/10.1172/JCI15463.

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Circulating amino acids are associated with bone mineral density decline and ten-year major osteoporotic fracture risk in older community-dwelling adults Y Su, A Elshorbagy, C Turner, H Refsum, R Chan, T Kwok	Bone	2019
Predicting the vulnerability of birds to trophic threat posed by phenological mismatch based on nutritional and physiological status of nestlings S Zhang, L Zhao, X Zhang, W Liang, A Newman	Conservation Physiology	2019
Associations between serum levels of insulin-like growth factor-I and bone mineral acquisition in pubertal children: a 3-year follow-up study in Hamamatsu, Japan K Kouda, M Iki, K Ohara, H Nakamura, Y Fujita, T Nishiyama	Journal of PHYSIOLOGICAL ANTHROPOLOGY	2019
Insulin-like growth factor I of Yellow catfish (Pelteobagrus fulvidraco): cDNA characterization, tissue distribution, and expressions in response to starvation and refeeding Q Qin, X Chen, X Zhu, X Li, Y Zhao, Z Xu, W Liu	Fish Physiology and Biochemistry	2019
Genetic Diversity and Signatures of Selection in 15 Chinese Indigenous Dog Breeds Revealed by Genome-Wide SNPs Q Yang, H Chen, J Ye, C Liu, R Wei, C Chen, L Huang	Frontiers in Genetics	2019
Deficits in Bone Geometry in Growth Hormone-Deficient Prepubertal Boys Revealed by High-Resolution Peripheral Quantitative Computed Tomography TG Baer, S Agarwal, S Chen, C Chiuzan, AB Sopher, R Tao, A Hassoun, E Shane, I Fennoy, SE Oberfield, PM Vuguin	Hormone Research in Pædiatrics	2019
40 YEARS OF IGF1: Role of IGF1 and EFN–EPH signaling in skeletal metabolism RC Lindsey, CH Rundle, S Mohan	Journal of Molecular Endocrinology	2018
Actions of pituitary hormones beyond traditional targets M Zaidi, M New, HC Blair, A Zallone, R Baliram, TF Davies, C Cardozo, J Iqbal, L Sun, C Rosen, T Yuen	Journal of Endocrinology	2018
The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects F Dehkhoda, CM Lee, J Medina, AJ Brooks	Frontiers in Endocrinology	2018
40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton S Yakar, H Werner, CJ Rosen	Journal of Molecular Endocrinology	2018
Diabetes Mellitus-induced Bone Fragility I Kanazawa, T Sugimoto	Internal Medicine	2018
Gut Microbiota and IGF-1 J Yan, JF Charles	Calcified Tissue International	2018
Epicardial Fat Thickness and Bone Mineral Content: The Healthy Twin Study in Korea D Lee, MS Cho, EY Choe, SW Park, YM Song, SC Lee, J Sung	Journal of Epidemiology	2018
A meat- or dairy-based complementary diet leads to distinct growth patterns in formula-fed infants: a randomized controlled trial M Tang, AE Hendricks, NF Krebs	The American journal of clinical nutrition	2018
Protein Intake during the First Two Years of Life and Its Association with Growth and Risk of Overweight M Tang	International journal of environmental research and public health	2018
Deoxynivalenol- and zearalenone-contaminated feeds alter gene expression profiles in the livers of piglets KE Reddy, J young Jeong, Y Lee, HJ Lee, MS Kim, DW Kim, HJ Jung, C Choe, YK Oh, SD Lee	Asian-Australasian Journal of Animal Sciences	2018
A Translational Model of Incomplete Catch-Up Growth: Early-Life Hypoxia and the Effect of Physical Activity: A Translational Model of Incomplete Catch-Up Growth S Radom-Aizik, FP Zaldivar, DM Nance, F Haddad, DM Cooper, GR Adams	Clinical and Translational Science	2018
Assessment using serum insulin-like growth factor-I and bone mineral density is useful for detecting prevalent vertebral fractures in patients with type 2 diabetes mellitus I Kanazawa, M Notsu, H Miyake, K Tanaka, T Sugimoto	Osteoporosis International	2018
Effects of Moxibustion on the Levels of Insulin-Like Growth Factor 1: A Pilot Study JG Lin, SZ Lin, LH Lin, CC Wu, WT Tsai, HJ Harn, LH Su, WY Ho, CJ Hsieh, TJ Ho	Cell Transplantation	2018
Adult height and all-cause and cause-specific mortality in the Japan Public Health Center-based Prospective Study (JPHC) H Ihira, N Sawada, M Iwasaki, T Yamaji, A Goto, M Noda, H Iso, S Tsugane, C Steensma	PloS one	2018
Soy protein improves tibial whole-bone and tissue-level biomechanical properties in ovariectomized and ovary-intact, low-fit female rats PS Hinton, LC Ortinau, RK Dirkes, EL Shaw, MW Richard, TZ Zidon, SL Britton, LG Koch, VJ Vieira-Potter	Bone Reports	2018
Effect of cardiometabolic risk factors on the relationship between adiposity and bone mass in girls M Hetherington-Rauth, JW Bea, RM Blew, JL Funk, VR Lee, TC Varadi, DJ Roe, MD Wheeler, SB Going	International Journal of Obesity	2018
Abnormal Growth and Feeding Behavior in Upper Airway Obstruction in Rats A Tarasiuk, Y Segev	Frontiers in Endocrinology	2018
Systemic IGF-1 gene delivery by rAAV9 improves spontaneous autoimmune peripheral polyneuropathy (SAPP) T Gao, N Bogdanova, S Ghauri, G Zhang, J Lin, K Sheikh	Scientific Reports	2018
The growth hormone–insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders WF Blum, A Alherbish, A Alsagheir, AE Awwa, W Kaplan, E Koledova, MO Savage	Endocrine Connections	2018
A Novel Loss-of-Function Variant in Transmembrane Protein 263 (TMEM263) of Autosomal Dwarfism in Chicken Z Wu, MF Derks, B Dibbits, HJ Megens, MA Groenen, RP Crooijmans	Frontiers in Genetics	2018
CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis C Becker, A Kukat, K Szczepanowska, S Hermans, K Senft, CP Brandscheid, P Maiti, A Trifunovic	EMBO reports	2018
Inhibition of microRNA-19b promotes ovarian granulosa cell proliferation by targeting IGF-1 in polycystic ovary syndrome Z Zhong, F Li, Y Li, S Qin, C Wen, Y Fu, Q Xiao	Molecular medicine reports	2018
Fat and Lean Mass Predict Bone Mass During Energy Restriction in Sedentary and Exercising Rodents CE Metzger, SN Swift, K Baek, MJ Souza, SA Bloomfield	Frontiers in physiology	2018
Regulation of Skeletal Homeostasis M Zaidi, T Yuen, L Sun, CJ Rosen	Endocrine reviews	2018
Safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy: a randomised, placebo-controlled trial C Grunseich, R Miller, T Swan, DJ Glass, ME Mouelhi, M Fornaro, O Petricoul, I Vostiar, R Roubenoff, MN Meriggioli, A Kokkinis, RD Guber, MS Budron, J Vissing, G Soraru, T Mozaffar, A Ludolph, JT Kissel, KH Fischbeck, C Grunseich, R Miller, T Swan, DJ Glass, ME Mouelhi, M Fornaro, O Petricoul, I Vostiar, R Roubenoff, MN Meriggioli, J Dahlqvist, N Witting, J Vissing, I Martinelli, G Querin, G Soraru, NA Goyal, TM Cash, B Minton, T Mozaffar, A Rosenbohm, U Weiland, P Weydt, A Ludolph, S Chelnick, S Iyadurai, W King, JT Kissel, MS Budron, RD Guber, A Kokkinis, KH Fischbeck	Lancet neurology	2018
Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels A Nath, MA Molnár, A Csighy, K Kőszegi, I Galambos, KP Huszár, A Koris, G Vatai	MED LITH	2018
Tendon Healing in the Context of Complex Fractures E Ganji, ML Killian	Clinical Reviews in Bone and Mineral Metabolism	2018
Pharmacokinetics of IGF-1 in PAPP-A2-Deficient Patients, Growth Response, and Effects on Glucose and Bone Density C Cabrera-Salcedo, T Mizuno, L Tyzinski, M Andrew, AA Vinks, J Frystyk, H Wasserman, CM Gordon, V Hwa, P Backeljauw, A Dauber	The Journal of clinical endocrinology and metabolism	2017
Decreased Serum Insulin-like Growth Factor-I is a Risk Factor for Non-vertebral Fractures in Diabetic Postmenopausal Women H Miyake, I Kanazawa, T Sugimoto	Internal Medicine	2017
Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue TM Filion, JD Skelly, H Huang, DL Greiner, DC Ayers, J Song	Stem Cell Research & Therapy	2017
The Korean herbal formulation Yukmijihwangtang stimulates longitudinal bone growth in animal models SM Cho, SH Lee, D Lee, JH Lee, GT Chang, H Kim, JY Lee	BMC complementary and alternative medicine	2017
Exploring genetic susceptibility to obesity through genome functional pathway analysis: Exploring Genetic Susceptibility to Obesity AP Gabrielli, AM Manzardo, MG Butler	Obesity	2017
Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression A Kaklamanos, J Rozman, M Roulis, N Karagianni, M Armaka, M Wu, L Brachthäuser, J Calzada-Wack, M Horsch, J Beckers, B Rathkolb, T Adler, F Neff, E Wolf, V Gailus-Durner, H Fuchs, MH de Angelis, G Kollias	Scientific Reports	2017
Diet-Induced Low-Grade Metabolic Acidosis and Clinical Outcomes: A Review R Carnauba, A Baptistella, V Paschoal, G Hübscher	Nutrients	2017
Effect of Dietary sugar beet pulp supplementation on growth performance, nutrient digestibility, fecal Microflora, blood profiles and Diarrhea incidence in weaning pigs CL Yan, HS Kim, JS Hong, JH Lee, YG Han, YH Jin, SW Son, SH Ha, YY Kim	Journal of Animal Science and Technology	2017
Insights into the Development of the Adult Leydig Cell Lineage from Stem Leydig Cells L Ye, X Li, L Li, H Chen, RS Ge	Frontiers in physiology	2017
Vitamin D, a modulator of musculoskeletal health in chronic kidney disease: Vitamin D, a modulator of musculoskeletal health P Molina, JJ Carrero, J Bover, P Chauveau, S Mazzaferro, PU Torres	Journal of Cachexia, Sarcopenia and Muscle	2017
The Role of Growth Hormone and Insulin-Like Growth Factor-I in the Liver Y Takahashi	International journal of molecular sciences	2017
Delayed Puberty and Gonadal Failure in Patients with HAX1 Mutation S Cekic, H Saglam, O Gorukmez, T Yakut, O Tarim, SS Kilic	Journal of Clinical Immunology	2017
Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth Z Liu, T Han, S Fishman, J Butler, T Zimmermann, F Tremblay, C Harbison, N Agrawal, JJ Kopchick, MB Schaffler, S Yakar	Endocrinology	2017
Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass: MARROW FAT AND BMD AFTER GASTRIC BYPASS SURGERY TY Kim, AV Schwartz, X Li, K Xu, DM Black, DM Petrenko, L Stewart, SJ Rogers, AM Posselt, JT Carter, DM Shoback, AL Schafer	Journal of Bone and Mineral Research	2017
Bone Status in a Patient with Insulin-Like Growth Factor-1 Receptor Deletion Syndrome: Bone Quality and Structure Evaluation Using Dual-Energy X-Ray Absorptiometry, Peripheral Quantitative Computed Tomography, and Quantitative Ultrasonography P Pelosi, E Lapi, L Cavalli, A Verrotti, M Pantaleo, M Martino, S Stagi	Frontiers in Endocrinology	2017
Astragalus Extract Mixture HT042 Increases Longitudinal Bone Growth Rate by Upregulating Circulatory IGF-1 in Rats D Lee, SH Lee, YH Lee, J Song, H Kim	Evidence-Based Complementary and Alternative Medicine	2017
One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology J Argente, JA Chowen, LA PérezJurado, J Frystyk, C Oxvig	EMBO Molecular Medicine	2017
Osseointegration of layer-by-layer polyelectrolyte multilayers loaded with IGF1 and coated on titanium implant under osteoporotic condition H Xing, X Wang, S Xiao, G Zhang, M Li, P Wang, Q Shi, P Qiao, L E, H Liu	International Journal of Nanomedicine	2017
ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass R Barreto, Y Kitase, T Matsumoto, F Pin, KC Colston, KE Couch, TM OConnell, ME Couch, LF Bonewald, A Bonetto	Scientific Reports	2017
Bone Pain and Muscle Weakness in Cancer Patients DP Milgrom, NL Lad, LG Koniaris, TA Zimmers	Current Osteoporosis Reports	2017
Association of a Cac8I polymorphism in the IGF1 gene with growth traits in Indian goats T Naicy, RT Venkatachalapathy, TV Aravindakshan, E Kurian	Journal of Genetic Engineering and Biotechnology	2017
Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability A Dauber, MT Munoz-Calvo, V Barrios, HM Domene, S Kloverpris, C Serra-Juhe, V Desikan, J Pozo, R Muzumdar, GA Martos-Moreno, F Hawkins, HG Jasper, CA Conover, J Frystyk, S Yakar, V Hwa, JA Chowen, C Oxvig, RG Rosenfeld, LA Perez-Jurado, J Argente	EMBO Molecular Medicine	2016
A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production M Marzec, CP Hawkes, D Eletto, S Boyle, R Rosenfeld, V Hwa, JM Wit, HA van Duyvenvoorde, W Oostdijk, M Losekoot, O Pedersen, BB Yeap, L Flicker, N Barzilai, G Atzmon, A Grimberg, Y Argon	Endocrinology	2016
Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement JA Siddiqui, NC Partridge	Physiology (Bethesda, Md.)	2016
Multigenic Delineation of Lower Jaw Deformity in Triploid Atlantic Salmon (Salmo salar L.) G Amoroso, T Ventura, JM Cobcroft, MB Adams, A Elizur, CG Carter, P Xu	PloS one	2016
IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain V Nieto-Estévez, Ç Defterali, C Vicario-Abejón	Frontiers in neuroscience	2016
Parallel mechanisms suppress cochlear bone remodeling to protect hearing EJ Jáuregui, O Akil, C Acevedo, F Hall-Glenn, BS Tsai, HA Bale, E Liebenberg, MB Humphrey, RO Ritchie, LR Lustig, T Alliston	Bone	2016
Characterization and comparison of osteoblasts derived from mouse embryonic stem cells and induced pluripotent stem cells MS Ma, V Kannan, AE de Vries, M Czepiel, EM Wesseling, V Balasubramaniyan, R Kuijer, A Vissink, SC Copray, GM Raghoebar	Journal of Bone and Mineral Metabolism	2016
Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development A Hellström, D Ley, I Hansen-Pupp, B Hallberg, C Löfqvist, L Marter, M Weissenbruch, LA Ramenghi, K Beardsall, D Dunger, AL Hård, LE Smith	Acta Pdiatrica	2016
Exercise during energy restriction mitigates bone loss but not alterations in estrogen status or metabolic hormones CE Metzger, K Baek, SN Swift, MJ de Souza, SA Bloomfield	Osteoporosis International	2016
Orexin Plays a Role in Growth Impediment Induced by Obstructive Sleep Breathing in Rats A Tarasiuk, A Levi, MH Assadi, A Troib, Y Segev	Sleep	2016
Nonproliferative and Proliferative Lesions of the Rat and Mouse Skeletal Tissues (Bones, Joints, and Teeth) S Fossey, J Vahle, P Long, S Schelling, H Ernst, RW Boyce, J Jolette, B Bolon, A Bendele, M Rinke, L Healy, W High, DR Roth, M Boyle, J Leininger	Journal of Toxicologic Pathology	2016
Cell non-autonomous regulation of hepatic IGF-1 and neonatal growth by Kinase Suppressor of Ras 2 (KSR2) L Guo, DL Costanzo-Garvey, DR Smith, ME Zavorka, M Venable-Kang, RG MacDonald, RE Lewis	Scientific Reports	2016
Receptor-mediated selective impairment of insulin-like growth factor-1 activity in congenital disorders of glycosylation patients GS Dhaunsi	Pediatric Research	2016
Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses NK Khankari, XO Shu, W Wen, P Kraft, S Lindström, U Peters, J Schildkraut, F Schumacher, P Bofetta, A Risch, H Bickeböller, CI Amos, D Easton, RA Eeles, SB Gruber, CA Haiman, DJ Hunter, SJ Chanock, BL Pierce, W Zheng, EL Franco	PLoS Medicine	2016
Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth? J Devesa, C Almenglo, P Devesa	Clinical Medicine Insights. Endocrinology and Diabetes	2016
Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation CZ Han, IJ Juncadella, JM Kinchen, MW Buckley, AL Klibanov, K Dryden, S Onengut-Gumuscu, U Erdbrügger, SD Turner, YM Shim, KS Tung, KS Ravichandran	Nature	2016
Gut microbiota induce IGF-1 and promote bone formation and growth J Yan, JW Herzog, K Tsang, CA Brennan, MA Bower, WS Garrett, BR Sartor, AO Aliprantis, JF Charles	Proceedings of the National Academy of Sciences	2016
Growth in patients with type 1 diabetes: DM Mitchell	Current opinion in endocrinology, diabetes, and obesity	2016
Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 (HP1BP3) Is Associated With Alterations in the Endocrine IGF-1 Pathway BP Garfinkel, S Arad, PT Le, M Bustin, CJ Rosen, Y Gabet, J Orly	Endocrinology	2015
Skeletal effects of growth hormone and insulin-like growth factor-I therapy RC Lindsey, S Mohan	Molecular and Cellular Endocrinology	2015
Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1: SOCS2 REGULATION OF GH INDUCED GROWTH R Dobie, SF Ahmed, KA Staines, C Pass, S Jasim, VE MacRae, C Farquharson	Journal of Cellular Physiology	2015
Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models S Yakar, O Isaksson	Growth Hormone & IGF Research	2015
Role of IGF-I signaling in muscle bone interactions DD Bikle, C Tahimic, W Chang, Y Wang, A Philippou, ER Barton	Bone	2015
DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH Z Liu, OD Kennedy, L Cardoso, J Basta-Pljakic, NC Partridge, MB Schaffler, CJ Rosen, S Yakar	The FASEB Journal	2015
The effects of dietary protein and amino acids on skeletal metabolism JD Bihuniak, KL Insogna	Molecular and Cellular Endocrinology	2015
Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development Y Chan, RM Salem, YH Hsu, G McMahon, TH Pers, S Vedantam, T Esko, MH Guo, ET Lim, L Franke, GD Smith, DP Strachan, JN Hirschhorn	The American Journal of Human Genetics	2015
Cancer-associated muscle weakness: What's bone got to do with it? DL Waning, TA Guise	BoneKEy Reports	2015
Predicting changes in mandibular length and total anterior facial height using IGF-1, cervical stage, skeletal classification, and gender MI Masoud, HY Marghalani, M Bamashmous, NM Alamoudi, DE Derwi, IM Masoud, V Allareddy, NF Gowharji	Progress in Orthodontics	2015
Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance A Galimov, A Hartung, R Trepp, A Mader, M Flück, A Linke, M Blüher, E Christ, J Krützfeldt	Journal of Molecular Medicine	2015
Longitudinal relationship between insulin-like growth factor-1 levels and vertical facial growth MI Masoud, HY Marghalani, NM Alamoudi, DE Derw, IM Masoud, NF Gowharji	Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie	2015
Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway H Saeed, W Qiu, C Li, A Flyvbjerg, BM Abdallah, M Kassem	Biogerontology	2015
Transcriptional Profiling Identifies the Signaling Axes of IGF and Transforming Growth Factor-β as Involved in the Pathogenesis of Osteosarcoma R Yang, S Piperdi, Y Zhang, W Zhu, N Neophytou, BH Hoang, G Mason, D Geller, H Dorfman, PA Meyers, JH Healey, DG Phinney, R Gorlick	Clinical Orthopaedics and Related Research®	2015
Caspases and osteogenic markers—in vitro screening of inhibition impact E Adamova, E Janeckova, K Kleparnik, E Matalova	In vitro cellular & developmental biology. Animal	2015
Effect of serum from postmenopausal women with osteoporosis exhibiting the Kidney‑Yang deficiency pattern on bone formation in an hFOBï¿½1.19 human osteoblastic cell line Y Li, W Liang, X Li, B Gao, H Gan, L Yin, J Shen, J Kang, S Ding, X Lin, L Liao, C Li	Experimental and therapeutic medicine	2015
Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis V Locatelli, VE Bianchi	International Journal of Endocrinology	2014
Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2-/- mice R Dobie, VE MacRae, C Huesa, R Hof, SF Ahmed, C Farquharson	Journal of Endocrinology	2014
Minireview: Mechanisms of Growth Hormone-Mediated Gene Regulation DJ Chia	Molecular Endocrinology	2014
Effects of nutrition level of concentrate-based diets on growth performance and carcass characteristics of Hainan black goats D Wang, L Zhou, H Zhou, G Hou, M Li, L Shi, X Huang, S Guan	Tropical Animal Health and Production	2014
Design, Synthesis, and Osteogenic Activity of Daidzein Analogs on Human Mesenchymal Stem Cells AL Strong, Q Jiang, Q Zhang, S Zheng, SM Boue, S Elliott, ME Burow, BA Bunnell, G Wang	ACS Medicinal Chemistry Letters	2014
Choline kinase beta is required for normal endochondral bone formation Z Li, G Wu, RB Sher, Z Khavandgar, M Hermansson, GA Cox, MR Doschak, M Murshed, F Beier, DE Vance	Biochimica et Biophysica Acta (BBA) - General Subjects	2014
The polymorphism of Insulin-like growth factor-I (IGF-I) is related to osteoporosis and bone mineral density in postmenopausal population L Yun-Kai, W Hui, Z Xin-Wei, G Liang, Z Jin-Liang	PAK J MED SCI	2014
Osteoporosis and fractures in liver disease: Relevance, pathogenesis and therapeutic implications IA Nakchbandi	World journal of gastroenterology : WJG	2014
In vivo evidence of IGF-I–estrogen crosstalk in mediating the cortical bone response to mechanical strain S Mohan, CG Bhat, JE Wergedal, C Kesavan	Bone Research	2014
RECENT RESEARCH ON THE GROWTH PLATE: Recent insights into the regulation of the growth plate JC Lui, O Nilsson, J Baron	Journal of Molecular Endocrinology	2014
High Dietary Cholesterol Masks Type 2 Diabetes-Induced Osteopenia and Changes in Bone Microstructure in Rats S Lapmanee, N Charoenphandhu, R Aeimlapa, P Suntornsaratoon, K Wongdee, W Tiyasatkulkovit, K Kengkoom, K Chaimongkolnukul, D Seriwatanachai, N Krishnamra	Lipids	2014
Abdominal Fat and Sarcopenia in Women Significantly Alter Osteoblasts Homeostasis In Vitro by a WNT/β-Catenin Dependent Mechanism F Wannenes, V Papa, EA Greco, R Fornari, C Marocco, C Baldari, LD Luigi, GP Emerenziani, E Poggiogalle, L Guidetti, LM Donini, A Lenzi, S Migliaccio	International Journal of Endocrinology	2014
Skeletal Response of Male Mice to Anabolic Hormone Therapy in the Absence of the Igfals Gene OD Kennedy, H Sun, YJ Wu, HW Courtland, GA Williams, L Cardoso, J Basta-Pljakic, MB Schaffler, S Yakar	Endocrinology	2014
Human amnion mesenchymal stem cells promote proliferation and osteogenic differentiation in human bone marrow mesenchymal stem cells Y Wang, Y Yin, F Jiang, N Chen	Journal Of Molecular Histology	2014
Osteoprotective effect of extract from <i>Achyranthes</i> japonica in ovariectomized rats J Kim, SW Lee, SK Kim, SW Na, YO Kim	Journal of Exercise Rehabilitation	2014
PTEN Deficiency Mediates a Reciprocal Response to IGFI and mTOR Inhibition M Patel, NC Gomez, AW McFadden, BM Moats-Staats, S Wu, A Rojas, T Sapp, JM Simon, SV Smith, K Kaiser-Rogers, IJ Davis	Molecular cancer research : MCR	2014
Acute Illness is Associated with Suppression of the Growth Hormone Axis in Zimbabwean Infants AD Jones, S Rukobo, B Chasekwa, K Mutasa, R Ntozini, MN Mbuya, RJ Stoltzfus, JH Humphrey, AJ Prendergast	The American journal of tropical medicine and hygiene	2014
Pleiotropic effects of extended blockade of CSF1R signaling in adult mice KA Sauter, C Pridans, A Sehgal, YT Tsai, BM Bradford, S Raza, L Moffat, DJ Gow, PM Beard, NA Mabbott, LB Smith, DA Hume	Journal of leukocyte biology	2014
Liver-Specific GH Receptor Gene-Disrupted (LiGHRKO) Mice Have Decreased Endocrine IGF-I, Increased Local IGF-I, and Altered Body Size, Body Composition, and Adipokine Profiles EO List, DE Berryman, K Funk, A Jara, B Kelder, F Wang, MB Stout, X Zhi, L Sun, TA White, NK LeBrasseur, T Pirtskhalava, T Tchkonia, EA Jensen, W Zhang, MM Masternak, JL Kirkland, RA Miller, A Bartke, JJ Kopchick	Endocrinology	2014
Skeletal Development of Mice Lacking Bone Sialoprotein (BSP) - Impairment of Long Bone Growth and Progressive Establishment of High Trabecular Bone Mass W Bouleftour, M Boudiffa, NM Wade-Gueye, G Bouët, M Cardelli, N Laroche, A Vanden-Bossche, M Thomas, E Bonnelye, JE Aubin, L Vico, MH Lafage-Proust, L Malaval, JM Vanacker	PloS one	2014
Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons. Maggio M, Lauretani F, De Vita F, Basaria S, Lippi G, Butto V, Luci M, Cattabiani C, Ceresini G, Verzicco I, Ferrucci L, Ceda GP	Current pharmaceutical design	2014
Potential of Human Fetal Chorionic Stem Cells for the Treatment of Osteogenesis Imperfecta GN Jones, D Moschidou, H Abdulrazzak, BS Kalirai, M Vanleene, S Osatis, SJ Shefelbine, NJ Horwood, M Marenzana, PD Coppi, JH Bassett, GR Williams, NM Fisk, PV Guillot	Stem Cells and Development	2013
Diabetes, Biochemical Markers of Bone Turnover, Diabetes Control, and Bone J Starup-Linde	Frontiers in Endocrinology	2013
Controlled release strategies for bone, cartilage, and osteochondral engineering--Part I: recapitulation of native tissue healing and variables for the design of delivery systems VE Santo, ME Gomes, JF Mano, RL Reis	Tissue Engineering Part B Reviews	2013
PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins M Schlapschy, U Binder, C Borger, I Theobald, K Wachinger, S Kisling, D Haller, A Skerra	Protein Engineering Design and Selection	2013
Function of matrix IGF-1 in coupling bone resorption and formation JL Crane, X Cao	Journal of Molecular Medicine	2013
Active-resisted stance modulates regional bone mineral density in humans with spinal cord injury S Dudley-Javoroski, RK Shields	The journal of spinal cord medicine	2013
Effects of growth hormone replacement therapy on bone mineral density in growth hormone deficient adults: a meta-analysis P Xue, Y Wang, J Yang, Y Li	International Journal of Endocrinology	2013
Negative association between trunk fat, insulin resistance and skeleton in obese women EA Greco, D Francomano, R Fornari, C Marocco, C Lubrano, V Papa, F Wannenes, LD Luigi, LM Donini, A Lenzi, A Aversa, S Migliaccio	World journal of diabetes	2013
Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor Y Wu, H Sun, J Basta-Pljakic, L Cardoso, OD Kennedy, H Jasper, H Domené, L Karabatas, C Guida, MB Schaffler, CJ Rosen, S Yakar	Journal of Bone and Mineral Research	2013
Role of recombinant plasmid pEGFP-N1-IGF-1 transfection in alleviating osteoporosis in ovariectomized rats HC Liu, H Zhao, J Chen, WL Wu, HL Wang, GJ Jiao, YZ Chen	Journal Of Molecular Histology	2013
Osteocytes: Master Orchestrators of Bone MB Schaffler, WY Cheung, R Majeska, O Kennedy	Calcified Tissue International	2013
IGF-1 and Survival in ESRD T Jia, TG Axelsson, O Heimburger, P Barany, B Lindholm, P Stenvinkel, AR Qureshi	Clinical journal of the American Society of Nephrology : CJASN	2013
Nutrition, insulin-like growth factor-1 and retinopathy of prematurity AL Hård, LE Smith, A Hellström	Seminars in Fetal and Neonatal Medicine	2013
Serum IGF-1 levels as a clinical tool for optimizing orthodontic treatment timing S Jain, S Jain, A Deoskar, VS Prasad	Progress in Orthodontics	2013
Bromocriptine modulates the expression of PTHrP receptor, Indian hedgehog, and Runx2 proteins in the growth plate of lactating rats K Wongdee, N Thonapan, W Saengamnart, N Krishnamra, N Charoenphandhu	Molecular and Cellular Biochemistry	2013
The Effects of Delayed Puberty on the Growth Plate: TA Butler, VR Yingling	Journal of Pediatric Orthopedics	2013
Body size regulation and insulin-like growth factor signaling S Hyun	Cellular and Molecular Life Sciences	2013
Teriparatide for Idiopathic Osteoporosis in Premenopausal Women: A Pilot Study A Cohen, EM Stein, RR Recker, JM Lappe, DW Dempster, H Zhou, S Cremers, DJ McMahon, TL Nickolas, R Müller, A Zwahlen, P Young, J Stubby, E Shane	The Journal of clinical endocrinology and metabolism	2013
Role of Insulin-like Growth Factor-1 in the Regulation of Skeletal Growth S Mohan, C Kesavan	Current Osteoporosis Reports	2012
Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production ER Barton, SH Park, JK James, CA Makarewich, A Philippou, D Eletto, H Lei, B Brisson, O Ostrovsky, Z Li, Y Argon	The FASEB Journal	2012
Systemically delivered insulin-like growth factor-I enhances mesenchymal stem cell-dependent fracture healing TJ Myers, Y Yan, F Granero-Molto, JA Weis, L Longobardi, T Li, Y Li, C Contaldo, H Ozkhan, A Spagnoli	Growth Factors	2012
Insulin-Like Growth Factor Binding Proteins: A Structural Perspective BE Forbes, P McCarthy, RS Norton	Frontiers in Endocrinology	2012
The Role of IGF-1 for Fracture Risk in Men L Vandenput, K Sjögren, J Svensson, C Ohlsson	Frontiers in Endocrinology	2012
Skeletal muscle mass is associated with bone geometry and microstructure and serum insulin-like growth factor binding protein-2 levels in adult women and men NK LeBrasseur, SJ Achenbach, LJ Melton, S Amin, S Khosla	Journal of Bone and Mineral Research	2012
Serum response factor regulates bone formation via IGF-1 and Runx2 signals J Chen, K Yuan, X Mao, JM Miano, H Wu, Y Chen	Journal of Bone and Mineral Research	2012
The insulin-like growth factor system in bone: basic and clinical implications M Kawai, CJ Rosen	Endocrinology and metabolism clinics of North America	2012
Silk constructs for delivery of musculoskeletal therapeutics L Meinel, DL Kaplan	Advanced Drug Delivery Reviews	2012
Determinants of bone microarchitecture and mechanical properties in obese men MA Bredella, E Lin, AV Gerweck, MG Landa, BJ Thomas, M Torriani, ML Bouxsein, KK Miller	The Journal of clinical endocrinology and metabolism	2012
Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers G Güllü, S Karabulut, M Akkiprik	Chinese journal of cancer	2012
Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging HW Courtland, OD Kennedy, Y Wu, Y Gao, H Sun, MB Schaffler, S Yakar	AGE	2012
The Heparin-binding Domain of IGFBP-2 Has Insulin-like Growth Factor Binding-independent Biologic Activity in the Growing Skeleton* M Kawai, AC Breggia, VE DeMambro, X Shen, E Canalis, ML Bouxsein, WG Beamer, DR Clemmons, CJ Rosen	The Journal of biological chemistry	2011
Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels K Blumbach, A Niehoff, BF Belgardt, HW Ehlen, M Schmitz, R Hallinger, JN Schulz, JC Brüning, T Krieg, M Schubert, D Gullberg, B Eckes	The Journal of biological chemistry	2011
A marked deficiency in circulating and renal IGF-I peptide does not inhibit compensatory renal enlargement in uninephrectomized mice D Landau, J Biada, Y Chen, S Sood, S Yakar, D LeRoith, Y Segev, R Rabkin	Growth Hormone & IGF Research	2011
Emerging Therapeutic Opportunities for Skeletal Restoration M Kawai, UI Mödder, S Khosla, CJ Rosen	Nature reviews. Drug discovery	2011
Proteoglycan 4: A dynamic regulator of skeletogenesis and parathyroid hormone skeletal anabolism CM Novince, MN Michalski, AJ Koh, BP Sinder, P Entezami, MR Eber, GJ Pettway, TJ Rosol, TJ Wronski, KM Kozloff, LK McCauley	Journal of Bone and Mineral Research	2011
Metabolic control and bone health in adolescents with type 1 diabetes JH Simmons, M Raines, KD Ness, R Hall, T Gebretsadik, S Mohan, A Spagnoli	International Journal of Pediatric Endocrinology	2011
Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer LP Jones, S Stefansson, MS Kim, SN Ahn	Journal of nanobiotechnology	2011
Areal and Volumetric Bone Mineral Density and Geometry at Two Levels of Protein Intake During Caloric Restriction: A Randomized, Controlled Trial D Sukumar, H Ambia-Sobhan, R Zurfluh, Y Schlussel, TJ Stahl, CL Gordon, SA Shapses	Journal of Bone and Mineral Research	2011
Foxo1 Mediates Insulin-like Growth Factor 1 (IGF1)/Insulin Regulation of Osteocalcin Expression by Antagonizing Runx2 in Osteoblasts* S Yang, H Xu, S Yu, H Cao, J Fan, C Ge, RT Fransceschi, HH Dong, G Xiao	The Journal of biological chemistry	2011
Mechanisms Limiting Body Growth in Mammals JC Lui, J Baron	Endocrine reviews	2011
Determinants of bone mineral density in obese premenopausal women MA Bredella, M Torriani, RH Ghomi, BJ Thomas, DJ Brick, AV Gerweck, LM Harrington, A Breggia, CJ Rosen, KK Miller	Bone	2011
Insulin-like growth factor-1 increases bone calcium accumulation only during rapid growth in female rats Q Zhang, ME Wastney, CJ Rosen, WG Beamer, CM Weaver	The Journal of nutrition	2011
Altered plasma membrane dynamics of bone morphogenetic protein receptor type Ia in a low bone mass mouse model B Bragdon, A D'Angelo, L Gurski, J Bonor, KL Schultz, WG Beamer, CJ Rosen, A Nohe	Bone	2011
Human Periosteum Is a Source of Cells for Orthopaedic Tissue Engineering: A Pilot Study MD Ball, IC Bonzani, MJ Bovis, A Williams, MM Stevens	Clinical Orthopaedics and Related Research®	2011
A Role for Myokines in Muscle-Bone Interactions: MW Hamrick	Exercise and Sport Sciences Reviews	2011
Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production HW Courtland, H Sun, M Beth-On, Y Wu, S Elis, CJ Rosen, S Yakar	Journal of Bone and Mineral Research	2011
Serum IGF-1 Affects Skeletal Acquisition in a Temporal and Compartment-Specific Manner HW Courtland, S Elis, Y Wu, H Sun, CJ Rosen, KJ Jepsen, S Yakar, P Kapahi	PloS one	2011
Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator Wt1 YY Chau, D Brownstein, H Mjoseng, WC Lee, N Buza-Vidas, C Nerlov, SE Jacobsen, P Perry, R Berry, A Thornburn, D Sexton, N Morton, P Hohenstein, E Freyer, K Samuel, R Hof, N Hastie, AO Wilkie	PLoS genetics	2011
Liver-Derived IGF-I Contributes to GH-Dependent Increases in Lean Mass and Bone Mineral Density in Mice with Comparable Levels of Circulating GH SM Nordstrom, JL Tran, BC Sos, KU Wagner, EJ Weiss	Molecular Endocrinology	2011
Unbound (bioavailable) IGF1 enhances somatic growth S Elis, Y Wu, HW Courtland, D Cannata, H Sun, M Beth-On, C Liu, H Jasper, H Domené, L Karabatas, C Guida, J Basta-Pljakic, L Cardoso, CJ Rosen, J Frystyk, S Yakar	Disease models & mechanisms	2011
Endocrine Actions of Myostatin: Systemic Regulation of the IGF and IGF Binding Protein Axis NG Williams, JP Interlichia, MF Jackson, D Hwang, P Cohen, BD Rodgers	Endocrinology	2011
Association between circulating levels of adiponectin and indices of bone mass and bone metabolism in middle-aged post-menopausal women R Tenta, M D Kontogianni, N Yiannakouris	Journal of Endocrinological Investigation	2011
Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1 S Elis, HW Courtland, Y Wu, CJ Rosen, H Sun, KJ Jepsen, RJ Majeska, S Yakar	Journal of Bone and Mineral Research	2010
Deletion of IGF-I receptor (IGF-IR) in primary osteoblasts reduces GH-induced STAT5 signaling Y Gan, Y Zhang, DJ Digirolamo, J Jiang, X Wang, X Cao, KR Zinn, DP Carbone, TL Clemens, SJ Frank	Molecular Endocrinology	2010
IGF-1 and Bone: New Discoveries From Mouse Models S Yakar, HW Courtland, D Clemmons	Journal of Bone and Mineral Research	2010
The Skeletal Subsystem as an Integrative Physiology Paradigm AJ Weiss, J Iqbal, N Zaidi, JI Mechanick	Current Osteoporosis Reports	2010
Bone fragility in type 2 diabetes mellitus T Yamaguchi	World Journal of Orthopedics	2010
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice I Chimenti, RR Smith, TS Li, G Gerstenblith, E Messina, A Giacomello, E Marbán	Circulation research	2010
Skeletal Integrity and Visceral Transplantation J Resnick, N Gupta, J Wagner, G Costa, RJ Cruz, L Martin, DA Koritsky, S Perera, L Matarese, K Eid, B Schuster, M Roberts, S Greenspan, K Abu-Elmagd	American Journal of Transplantation	2010
Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact S Elis, HW Courtland, Y Wu, JC Fritton, H Sun, CJ Rosen, S Yakar	Journal of Bone and Mineral Research	2010
Nocturnin Suppresses Igf1 Expression in Bone by Targeting the 3′ Untranslated Region of Igf1 mRNA M Kawai, AM Delany, CB Green, ML Adamo, CJ Rosen	Endocrinology	2010
Effects of alcohol on skeletal response to growth hormone in hypophysectomized rats RT Turner, CJ Rosen, UT Iwaniec	Bone	2010
Skeletal aging and the adipocyte program: New insights from an "old" molecule B Lecka-Czernik, CJ Rosen, M Kawai	Cell cycle (Georgetown, Tex.)	2010
Possible chondroregulatory role of prolactin on the tibial growth plate of lactating rats P Suntornsaratoon, K Wongdee, N Krishnamra, N Charoenphandhu	Histochemistry and Cell Biology	2010
Serum insulin-like growth factor-I is a marker for assessing the severity of vertebral fractures in postmenopausal women with type 2 diabetes mellitus I Kanazawa, T Yamaguchi, T Sugimoto	Osteoporosis International	2010
Sex-specific regulation of body size and bone slenderness by the acid labile subunit HW Courtland, V DeMambro, J Maynard, H Sun, S Elis, C Rosen, S Yakar	Journal of Bone and Mineral Research	2010
Baseline atherosclerosis parameter could assess the risk of bone loss during pioglitazone treatment in type 2 diabetes mellitus I Kanazawa, T Yamaguchi, S Yano, M Yamamoto, M Yamauchi, S Kurioka, T Sugimoto	Osteoporosis International	2010
Caloric restriction leads to high marrow adiposity and low bone mass in growing mice MJ Devlin, AM Cloutier, NA Thomas, DA Panus, S Lotinun, I Pinz, R Baron, CJ Rosen, ML Bouxsein	Journal of Bone and Mineral Research	2010
Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosa EA Lawson, KK Miller, MA Bredella, C Phan, M Misra, E Meenaghan, L Rosenblum, D Donoho, R Gupta, A Klibanski	Bone	2010
Factors that affect postnatal bone growth retardation in the twitcher murine model of Krabbe disease MA Contreras, WL Ries, S Shanmugarajan, G Arboleda, I Singh, AK Singh	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease	2010
LEPROT and LEPROTL1 cooperatively decrease growth hormone action Thierry Touvier, Françoise Conté-Auriol, Olivier Briand, Céline Cudejko, Réjane Paumelle, Sandrine Caron, Eric Baugé, Yves Rouillé, Jean-Pierre Salles, Bart Staels, bernard bailleul	Journal of Clinical Investigation	2009
Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform O Escribano, C Guillén, C Nevado, A Gómez-Hernández, CR Kahn, M Benito	Diabetes	2009
Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1) JC Fritton, KB Emerton, H Sun, Y Kawashima, W Mejia, Y Wu, CJ Rosen, D Panus, M Bouxsein, RJ Majeska, MB Schaffler, S Yakar	Journal of Bone and Mineral Research	2009
Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth D Gautam, J Jeon, MF Starost, SJ Han, FF Hamdan, Y Cui, AF Parlow, O Gavrilova, I Szalayova, E Mezey, J Wess	Proceedings of the National Academy of Sciences	2009
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism Y Fan, RK Menon, P Cohen, D Hwang, T Clemens, DJ DiGirolamo, JJ Kopchick, DL Roith, M Trucco, MA Sperling	The Journal of biological chemistry	2009
Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice Y Wu, H Sun, S Yakar, D LeRoith	Endocrinology	2009
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
The IGF/IGFBP system in relation to macroscopic bone architecture in pediatric renal transplant patients D Kiepe, EM Rüth, WF Blum, S Mohan, LT Weber, B Tönshoff	Pediatric Nephrology	2009
The role of liver-derived insulin-like growth factor-I C Ohlsson, S Mohan, K Sjögren, A Tivesten, J Isgaard, O Isaksson, JO Jansson, J Svensson	Endocrine reviews	2009
Gene regulation by growth hormone P Rotwein, DJ Chia	Pediatric Nephrology	2009
Inflammation and Cancer SV Kozlov	Inflammation and Cancer	2009
Effects of taurine supplementation on bone mineral density in ovariectomized rats fed calcium deficient diet MJ Choi	Nutrition Research and Practice	2009
Systems analysis of bone KJ Jepsen	Wiley Interdisciplinary Reviews: Systems Biology and Medicine	2009
Current understanding of osteoporosis associated with liver disease IA Nakchbandi, SW van der Merwe	Nature Reviews Gastroenterology & Hepatology	2009
Insulin-like growth factor and epidermal growth factor treatment: new approaches to protecting steatotic livers against ischemia-reperfusion injury A Casillas-Ramírez, A Zaouali, S Padrissa-Altés, IB Mosbah, A Pertosa, I Alfany-Fernández, M Bintanel-Morcillo, C Xaus, A Rimola, J Rodés, J Roselló-Catafau, C Peralta	Endocrinology	2009
The acid-labile subunit is required for full effects of exogenous growth hormone on growth and carbohydrate metabolism I Ueki, SL Giesy, KJ Harvatine, JW Kim, YR Boisclair	Endocrinology	2009
The insulin-like growth factor-1 binding protein acid-labile subunit alters mesenchymal stromal cell fate JC Fritton, Y Kawashima, W Mejia, HW Courtland, S Elis, H Sun, Y Wu, CJ Rosen, D Clemmons, S Yakar	The Journal of biological chemistry	2009
Growth hormone regulates the balance between bone formation and bone marrow adiposity PJ Menagh, RT Turner, DB Jump, CP Wong, MB Lowry, S Yakar, CJ Rosen, UT Iwaniec	Journal of Bone and Mineral Research	2009
Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases N Wang, L Fallavollita, L Nguyen, J Burnier, M Rafei, J Galipeau, S Yakar, P Brodt	Molecular Therapy	2009
Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions S Yakar, E Canalis, H Sun, W Mejia, Y Kawashima, P Nasser, HW Courtland, V Williams, M Bouxsein, C Rosen, KJ Jepsen	Journal of Bone and Mineral Research	2009
Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism S Yakar, CJ Rosen, ML Bouxsein, H Sun, W Mejia, Y Kawashima, Y Wu, K Emerton, V Williams, K Jepsen, MB Schaffler, RJ Majeska, O Gavrilova, M Gutierrez, D Hwang, P Pennisi, J Frystyk, Y Boisclair, J Pintar, H Jasper, H Domene, P Cohen, D Clemmons, D LeRoith	The FASEB Journal	2009
Biotin deficiency in mice is associated with decreased serum availability of insulin-like growth factor-I A Báez-Saldaña, G Gutiérrez-Ospina, J Chimal-Monroy, C Fernandez-Mejia, R Saavedra	European Journal of Nutrition	2009
Inflammatory bowel disease causes reversible suppression of osteoblast and chondrocyte function in mice L Harris, P Senagore, VB Young, LR McCabe	AJP Gastrointestinal and Liver Physiology	2009
Consequences of lifetime isolated growth hormone (GH) deficiency and effects of short-term GH treatment on bone in adults with a mutation in the GHRH-receptor gene FJ de Paula, MB Góis-Júnior, MH Aguiar-Oliveira, FA Pereira, CR Oliveira, RM Pereira, CT Farias, TA Vicente, R Salvatori	Clinical Endocrinology	2009
Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type 1 diabetes mellitus BJ van Sickle, J Simmons, R Hall, M Raines, K Ness, A Spagnoli	Cytokine	2009
Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse JA Williams, N Kondo, T Okabe, N Takeshita, DM Pilchak, E Koyama, T Ochiai, D Jensen, ML Chu, MA Kane, JL Napoli, M Enomoto-Iwamoto, N Ghyselinck, P Chambon, M Pacifici, M Iwamoto	Developmental Biology	2009
Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice K Sun, MA Battle, RP Misra, SA Duncan	Hepatology	2009
Dynamic in Vivo Binding of STAT5 to Growth Hormone-Regulated Genes in Intact Rat Liver. Sex-Specific Binding at Low- But Not High-Affinity STAT5 Sites EV Laz, A Sugathan, DJ Waxman	Molecular Endocrinology	2009
Insulin-like growth factor-I and bone: lessons from mice and men M Kawai, CJ Rosen	Pediatric Nephrology	2009
Variations of plasmatic concentrations of Insulin-like Growth Factor-I in post-pubescent horses affected with developmental osteochondral lesions DR Verwilghen, L Vanderheyden, T Franck, V Busoni, E Enzerink, M Gangl, JP Lejeune, G van Galen, S Grulke, D Serteyn	Veterinary Research Communications	2009
Steroid receptor coactivator 3 maintains circulating insulin-like growth factor I (IGF-I) by controlling IGF-binding protein 3 expression L Liao, X Chen, S Wang, AF Parlow, J Xu	Molecular and cellular biology	2008
Growth Hormone, Insulin-Like Growth Factors, and the Skeleton A Giustina, G Mazziotti, E Canalis	Endocrine reviews	2008
IGF Ligand and Receptor Regulation of Mammary Development AM Rowzee, DA Lazzarino, L Rota, Z Sun, TL Wood	Journal of Mammary Gland Biology and Neoplasia	2008
Cannabinoid receptors and the regulation of bone mass I Bab, A Zimmer	British Journal of Pharmacology	2008
Prepubertal OVX increases IGF-I expression and bone accretion in C57BL/6J mice KE Govoni, JE Wergedal, RB Chadwick, AK Srivastava, S Mohan	American journal of physiology. Endocrinology and metabolism	2008
Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice VE DeMambro, DR Clemmons, LG Horton, ML Bouxsein, TL Wood, WG Beamer, E Canalis, CJ Rosen	Endocrinology	2008
General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2 S Yu, Y Jiang, DL Galson, M Luo, Y Lai, Y Lu, HJ Ouyang, J Zhang, G Xiao	The Journal of biological chemistry	2008
The hormonal action of IGF1 in postnatal mouse growth E Stratikopoulos, M Szabolcs, I Dragatsis, A Klinakis, A Efstratiadis	Proceedings of the National Academy of Sciences	2008
Sugar and bone: a not-so sweet story CJ Rosen	Journal of Bone and Mineral Research	2008
Hepatocyte nuclear factor-1alpha regulates glucocorticoid receptor expression to control postnatal body growth WY Lin, YJ Hu, YH Lee	American journal of physiology. Gastrointestinal and liver physiology	2008
IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women J Liu, H Zhao, G Ning, Y Chen, L Zhang, L Sun, Y Zhao, M Xu, J Chen	Journal of Bone and Mineral Metabolism	2008
IGF-1 and IGF-Binding Proteins and Bone Mass, Geometry, and Strength: Relation to Metabolic Control in Adolescent Girls With Type 1 Diabetes LJ Moyer-Mileur, H Slater, KC Jordan, MA Murray	Journal of Bone and Mineral Research	2008
Phenotypic integration of skeletal traits during growth buffers genetic variants affecting the slenderness of femora in inbred mouse strains KJ Jepsen, B Hu, SM Tommasini, HW Courtland, C Price, M Cordova, JH Nadeau	Mammalian Genome	2008
Microarray analysis of perichondral and reserve growth plate zones identifies differential gene expressions and signal pathways M Zhang, MR Pritchard, FA Middleton, JA Horton, TA Damron	Bone	2008
Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit DL Hwang, PD Lee, P Cohen	Growth Hormone & IGF Research	2008
IGF-I improved bone mineral density and body composition of weaver mutant mice W Yao, J Zhong, J Yu, T Warner, T Bozic, P Ye, AJ D’Ercole, JM Hock, WH Lee	Growth Hormone & IGF Research	2008
Disruption of insulin-like growth factor-I expression in type IIalphaI collagen-expressing cells reduces bone length and width in mice KE Govoni, SK Lee, YS Chung, RR Behringer, JE Wergedal, DJ Baylink, S Mohan	Physiological genomics	2007
Growth hormone axis in chronic kidney disease S Mahesh, F Kaskel	Pediatric nephrology (Berlin, Germany)	2007
Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression D Engblom, JW Kornfeld, L Schwake, F Tronche, A Reimann, H Beug, L Hennighausen, R Moriggl, G Schütz	Genes & development	2007
Serum insulin-like growth factor-I level is associated with the presence of vertebral fractures in postmenopausal women with type 2 diabetes mellitus I Kanazawa, T Yamaguchi, M Yamamoto, M Yamauchi, S Yano, T Sugimoto	Osteoporosis International	2007
Dietary protein intake and bone mineral content in adolescents—The Copenhagen Cohort Study AZ Budek, C Hoppe, H Ingstrup, KF Michaelsen, S Bügel, C Mølgaard	Osteoporosis International	2007
Intrauterine programming of bone. Part 1: Alteration of the osteogenic environment SA Lanham, C Roberts, C Cooper, RO Oreffo	Osteoporosis International	2007
Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial D Mühlen, GA Laughlin, D Kritz-Silverstein, J Bergstrom, R Bettencourt	Osteoporosis International	2007
Conditional Deletion of Insulin-Like Growth Factor-I in Collagen Type 1α2-Expressing Cells Results in Postnatal Lethality and a Dramatic Reduction in Bone Accretion KE Govoni, JE Wergedal, L Florin, P Angel, DJ Baylink, S Mohan	Endocrinology	2007
Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) by Rosiglitazone Suppresses Components of the Insulin-Like Growth Factor Regulatory System in Vitro and in Vivo B Lecka-Czernik, C Ackert-Bicknell, ML Adamo, V Marmolejos, GA Churchill, KR Shockley, IR Reid, A Grey, CJ Rosen	Endocrinology	2007
Effects of systemic and local administration of recombinant human IGF-I (rhIGF-I) on de novo bone formation in an aged mouse model JL Fowlkes, KM Thrailkill, L Liu, EC Wahl, RC Bunn, GE Cockrell, DS Perrien, J Aronson, CK Lumpkin	Journal of Bone and Mineral Research	2006
Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis CM Gordon, E Binello, MS LeBoff, ME Wohl, CJ Rosen, AA Colin	Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA	2006
Suppressor of cytokine signaling 2 negatively regulates growth hormone action in vitro and in vivo Christopher J Greenhalgh, Elizabeth Rico-Bautista, Mattias Lorentzon, Anne L Thaus, Phillip O Morgan, Tracy A Willson, Panagiota Zervoudakis, Donald Metcalf, Ian Street, Nicos A Nicola, Andrew D Nash, Louis J Fabri, Gunnar Norstedt, Claes Ohlsson, Amilcar Flores-Morales, Warren S Alexander, and Douglas J Hilton	Journal of Clinical Investigation	2005
Impaired skeletal growth in mice with haploinsufficiency of IGF-I: genetic evidence that differences in IGF-I expression could contribute to peak bone mineral density differences S Mohan, DJ Baylink	The Journal of endocrinology	2005
Recombinant insulin-like growth factor-1 as a therapy for IGF-1 deficiency in renal failure RG Clark	Pediatric Nephrology	2005
The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting S Yakar, H Kim, H Zhao, Y Toyoshima, P Pennisi, O Gavrilova, D LeRoith	Pediatric Nephrology	2005
Mosaic analysis of insulin receptor function Tadahiro Kitamura, Yukari Kitamura, Jun Nakae, Antonio Giordano, Saverio Cinti, C. Ronald Kahn, Argiris Efstratiadis, Domenico Accili	Journal of Clinical Investigation	2004
Insulin-like growth factor-binding protein-5 induces a gender-related decrease in bone mineral density in transgenic mice DA Salih, S Mohan, Y Kasukawa, G Tripathi, FA Lovett, NF Anderson, EJ Carter, JE Wergedal, DJ Baylink, JM Pell	Endocrinology	2004
Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice DA Salih, G Tripathi, C Holding, TA Szestak, MI Gonzalez, EJ Carter, LJ Cobb, JE Eisemann, JM Pell	Proceedings of the National Academy of Sciences	2004
The multi-functional role of insulin-like growth factor binding proteins in bone KE Govoni, DJ Baylink, S Mohan	Pediatric nephrology (Berlin, Germany)	2004
beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice ML Bouxsein, DD Pierroz, V Glatt, DS Goddard, F Cavat, R Rizzoli, SL Ferrari	Journal of Bone and Mineral Research	2004
Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth F Tronche, C Opherk, R Moriggl, C Kellendonk, A Reimann, L Schwake, HM Reichardt, K Stangl, D Gau, A Hoeflich, H Beug, W Schmid, G Schütz	Genes & development	2004
Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition CJ Rosen, C Ackert-Bicknell, WG Beamer, T Nelson, M Adamo, P Cohen, ML Bouxsein, MC Horowitz	Pediatric Nephrology	2004
Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice S Movérare, K Venken, AL Eriksson, N Andersson, S Skrtic, J Wergedal, S Mohan, P Salmon, R Bouillon, JA Gustafsson, D Vanderschueren, C Ohlsson	Proceedings of the National Academy of Sciences	2003
Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene PA Dawson, L Beck, D Markovich	Proceedings of the National Academy of Sciences	2003
Mapping quantitative trait loci that influence serum insulin-like growth factor binding protein-5 levels in F2 mice (MRL/MpJ X SJL/J). Mohan S, Masinde G, Li X, Baylink DJ	Endocrinology	2003
A Model for Tissue-Specific Inducible Insulin-like Growth Factor-I (IGF-I) Inactivation to Determine the Physiological Role of Liver-Derived IGF-I K Sjögren, JO Jansson, OG Isaksson, C Ohlsson	Endocrine	2002
The Role of Circulating IGF-I: Lessons from Human and Animal Models S Yakar, Y Wu, J Setser, CJ Rosen	Endocrine	2002

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