Go to
JCI Insight
Citations to this article
Kristin Synnestvedt, … , Linda F. Thompson, Sean P. Colgan
Published October 1, 2002
Citation Information: J Clin Invest. 2002;110(7):993-1002. https://doi.org/10.1172/JCI15337.
Citation Information: J Clin Invest. 2002;110(7):993-1002. https://doi.org/10.1172/JCI15337.
Abstract
Research Article
Authors
Kristin Synnestvedt, Glenn T. Furuta, Katrina M. Comerford, Nancy Louis, Jorn Karhausen, Holger K. Eltzschig, Karl R. Hansen, Linda F. Thompson, Sean P. Colgan
Total citations by year
Citation information
Citations to this article (433)
| Title and authors | Publication | Year |
|---|---|---|
|
Oxygen carrying nanoemulsions and respiratory hyperoxia eliminate tumor hypoxia-induced suppression and improve cancer immunotherapy
Katarina Halpin-Veszeleiova, Michael Mallouh, Ashley Apro, Nuria Romero, Camille Bahr, Maureen Shin, Kelly Ward, Laura Rosenberg, Michail Sitkovsky, Bruce Spiess, Stephen M. Hatfield |
JCI Insight | 2025 |
|
Novel gene manipulation approaches to unlock the existing bottlenecks of CAR-NK cell therapy
Dehghan F, Metanat Y, Askarizadeh M, Ahmadi E, Moradi V |
Frontiers in Cell and Developmental Biology | 2025 |
|
Adaptation of Natural Killer Cells to Hypoxia: A Review of the Transcriptional, Translational, and Metabolic Processes
Chang TD, Chen YJ, Luo JL, Zhang C, Chen SY, Lin ZQ, Zhang PD, Shen YX, Tang TX, Li H, Dong LM, Tang ZH, Chen D, Wang YM |
ImmunoTargets and Therapy | 2025 |
|
Impact of Estrogen on Purinergic Signaling in Microvascular Disease
Cassavaugh J, Longhi MS, Robson SC |
International Journal of Molecular Sciences | 2025 |
|
CD73: a new immune checkpoint for leukemia treatment
Gao H, Zhang T, Li K, Li X |
Frontiers in Immunology | 2025 |
|
Unraveling the triad of hypoxia, cancer cell stemness, and drug resistance
Shang T, Jia Z, Li J, Cao H, Xu H, Cong L, Ma D, Wang X, Liu J |
Journal of Hematology & Oncology | 2025 |
|
Quantifying CD73 expression after chemotherapy or chemoradiotherapy in esophageal squamous cell carcinoma
Cooper ZA, Wang Y, Martin PL, Murayama K, Kumar R, Kato K, Yamamoto S, Sekine S |
Discover Oncology | 2025 |
|
Leveraging adenosine triphosphate for cancer theranostics
Li Y, Zhang X, Wang J, Wang K, Li B, Qiao X, He W, Cai J, Liu D, Yang LL |
Theranostics | 2025 |
|
MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer
Chi JJ, Xie P, Cheng MH, Zhu Y, Cui X, Watson J, Zeng L, Uddin A, Nguyen H, Li L, Moremen K, Reedy A, Wyatt M, Marcus A, Dai M, Paulos CM, Cristofanilli M, Gradishar WJ, Zhao S, Kalinsky K, Hung MC, Bahar I, Zhang B, Wan Y |
Nature Communications | 2025 |
|
Cross-priming in cancer immunology and immunotherapy.
Luri-Rey C, Teijeira Á, Wculek SK, de Andrea C, Herrero C, Lopez-Janeiro A, Rodríguez-Ruiz ME, Heras I, Aggelakopoulou M, Berraondo P, Sancho D, Melero I |
Nature reviews. Cancer | 2025 |
|
Pharmacological suppression of the OTUD4-CD73 proteolytic axis revives antitumor immunity against immune-cold breast cancers
Yueming Zhu, Anupam Banerjee, Ping Xie, Andrey A Ivanov, Amad Uddin, Qiao Jiao, Junlong Chi, Lidan Zeng, Ji Young Lee, Yifan Xue, Xinghua Lu, Massimo Cristofanilli, William Gradishar, Curtis Henry, Theresa Gillespie, Manali Ajay Bhave, Kevin Kalinsky, Haian Fu, Ivet Bahar, Bin Zhang, Yong Wan |
Journal of Clinical Investigation | 2024 |
|
Breakthrough of solid tumor treatment: CAR-NK immunotherapy.
Wang W, Liu Y, He Z, Li L, Liu S, Jiang M, Zhao B, Deng M, Wang W, Mi X, Sun Z, Ge X |
Cell Death Discovery | 2024 |
|
Purinergic pathways and their clinical use in the treatment of acute myeloid leukemia.
Wang H, Wei Y, Wang N |
Purinergic Signalling | 2024 |
|
Adenosine in Intestinal Epithelial Barrier Function
Stepanova M, Aherne CM |
Cells | 2024 |
|
CD73/adenosine axis exerts cardioprotection against hypobaric hypoxia-induced metabolic shift and myocarditis in a sex-dependent manner
Ndzie Noah ML, Mprah R, Wowui PI, Adekunle AO, Adu-Amankwaah J, Tan R, Gong Z, Li T, Fu L, Machuki JO, Zhang S, Sun H |
Cell communication and signaling : CCS | 2024 |
|
Optimizing Oxygen-Production Kinetics of Manganese Dioxide Nanoparticles Improves Hypoxia Reversal and Survival in Mice with Bone Metastases.
Murphy DA, Osteicochea D, Atkins A, Sannes C, McClarnon Z, Adjei IM |
Molecular Pharmaceutics | 2024 |
|
Reprogramming of tumor-associated macrophages by metabolites generated from tumor microenvironment
Kim SW, Kim CW, Moon YA, Kim HS |
Animal Cells and Systems | 2024 |
|
Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment
Kadariya Y, Sementino E, Ruan M, Cheung M, Hadikhani P, Osmanbeyoglu HU, Klein-Szanto AJ, Cai K, Testa JR |
2024 | |
|
GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment
Coban B, Wang Z, Liao CY, Beslmüller K, Timmermans MA, Martens JW, Hundscheid JH, Slutter B, Zweemer AJ, Neubert E, Danen EH |
iScience | 2024 |
|
Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma
Sun BY, Zhang D, Gan W, Wu JF, Wang ZT, Sun GQ, Zhou J, Fan J, Yi Y, Hu B, Zhang BH, Qiu SJ |
Journal of Cancer Research and Clinical Oncology | 2024 |
|
Regulation of CD73 on NAD metabolism: Unravelling the interplay between tumour immunity and tumour metabolism
Zhan J, Huang L, Niu L, Lu W, Sun C, Liu S, Ding Z, Li E |
Cell communication and signaling : CCS | 2024 |
|
Hypoxia-Induced Long Noncoding RNA HIF1A-AS2 Regulates Stability of MHC Class I Protein in Head and Neck Cancer
Liao TT, Chen YH, Li ZY, Hsiao AC, Huang YL, Hao RX, Tai SK, Chu PY, Shih JW, Kung HJ, Yang MH |
Cancer Immunology Research | 2024 |
|
The Adenosinergic Pathway in Non-Small Cell Lung Cancer
Van Kerkhove O, Verfaillie S, Maes B, Cuppens K |
Cancers | 2024 |
|
Ectonucleotidase inhibitors: targeting signaling pathways for therapeutic advancement-an in-depth review.
Sharafat RH, Saeed A |
Purinergic signalling | 2024 |
|
Hypoxia-adenosinergic regulation of B cell responses
Pruitt L, Abbott RK |
Frontiers in Immunology | 2024 |
|
Hypoxia-Inducible Factor-1α Modulates the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in Experimental Necrotizing Enterocolitis
Zhang Y, Yan M, Yue Y, Cheng Y |
Mediators of Inflammation | 2024 |
|
Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity
Ortmann BM |
BMJ Oncology | 2024 |
|
Co‐Delivery of aPD‐L1 and CD73 Inhibitor Using Calcium Phosphate Nanoparticles for Enhanced Melanoma Immunotherapy with Reduced Toxicity
Liu P, Guo J, Xie Z, Pan Y, Wei B, Peng Y, Hu S, Ding J, Chen X, Su J, Liu H, Zhou W |
Advanced Science | 2024 |
|
Hypoxia-inducible factor (HIF-1) orchestrates adenosine metabolism to promote liver cancer development
Jacinth Cheu, David Chiu, Kenneth Kwan, Chunxue Yang, Vincent Yuen, Chi Goh, Noreen Chui, Wei Shen, Cheuk-Ting Law, Misty Zhang, Macus Bao, Bowie Wong, Cerise Chan, Cindy Liu, Aki Tse, Irene Ng, Carmen Wong |
Science Advances | 2023 |
|
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity
Fu Z, Chen S, Zhu Y, Zhang D, Xie P, Jiao Q, Chi J, Xu S, Xue Y, Lu X, Song X, Cristofanilli M, Gradishar WJ, Kalinsky K, Yin Y, Zhang B, Wan Y |
Science Advances | 2023 |
|
The hypoxic tissue microenvironment as a driver of mucosal inflammatory resolution
Cartwright IM, Colgan SP |
Frontiers in immunology | 2023 |
|
Purinergic signaling: Diverse effects and therapeutic potential in cancer
Kaur J, Dora S |
Frontiers in Oncology | 2023 |
|
Tumor hypoxia: From basic knowledge to therapeutic implications
Liao C, Liu X, Zhang C, Zhang Q |
Seminars in Cancer Biology | 2023 |
|
The adenosinergic machinery in cancer: In-tandem insights from basic mechanisms to therapy
Kang C, Liu L, Wu C, Li L, Jia X, Xie W, Chen S, Wu X, Zheng H, Liu J, Li R, Zeng B |
Frontiers in immunology | 2023 |
|
Hypoxia signaling in the equine small intestine: Expression and distribution of hypoxia inducible factors during experimental ischemia
Verhaar N, de Buhr N, von Köckritz-Blickwede M, Dümmer K, Hewicker-Trautwein M, Pfarrer C, Dengler F, Kästner S |
Frontiers in Veterinary Science | 2023 |
|
Targeting CD73 increases therapeutic response to immunogenic chemotherapy by promoting dendritic cell maturation.
Lin YS, Chiang SF, Chen CY, Hong WZ, Chen TW, Chen WT, Ke TW, Yang PC, Liang JA, Shiau AC, Chao KSC, Huang KC |
Cancer Immunology, Immunotherapy | 2023 |
|
CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.
Faraoni EY, Singh K, Chandra V, Le Roux O, Dai Y, Sahin I, O'Brien BJ, Strickland LN, Li L, Vucic E, Warner AN, Pruski M, Clark T, Van Buren G, Thosani NC, Bynon JS, Wray CJ, Bar-Sagi D, Poulsen KL, Vornik LA, Savage MI, Sei S, Mohammed A, Zhao Z, Brown PH, Mills T, Eltzschig HK, McAllister F, Bailey-Lundberg JM |
Cancer research | 2023 |
|
Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion.
Tomas Bort E, Joseph MD, Wang Q, Carter EP, Roth NJ, Gibson J, Samadi A, Kocher HM, Simoncelli S, McCormick PJ, Grose RP |
eLife | 2023 |
|
Prognostic effect of CD73 in pancreatic ductal adenocarcinoma for disease-free survival after radical surgery.
Qin D, Wei R, Huang K, Wang R, Ding H, Yao Z, Xi P, Li S |
Journal of Cancer Research and Clinical Oncology | 2023 |
|
Tumor intrinsic and extrinsic functions of CD73 and the adenosine pathway in lung cancer
Kowash RR, Akbay EA |
Frontiers in immunology | 2023 |
|
Identification of Signature Genes of Dilated Cardiomyopathy Using Integrated Bioinformatics Analysis
Wu Z, Wang X, Liang H, Liu F, Li Y, Zhang H, Wang C, Wang Q |
International journal of molecular sciences | 2023 |
|
CD73 mediated host purinergic metabolism in intestine contributes to the therapeutic efficacy of a novel mesenchymal-like endometrial regenerative cells against experimental colitis
Shao B, Ren SH, Wang ZB, Wang HD, Zhang JY, Qin H, Zhu YL, Sun CL, Xu YN, Li X, Wang H |
Frontiers in immunology | 2023 |
|
The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer
Strickland LN, Faraoni EY, Ruan W, Yuan X, Eltzschig HK, Bailey-Lundberg JM |
Frontiers in immunology | 2023 |
|
Hypoxia inducible factor prolyl hydroxylases in inflammatory bowel disease
Lun J, Zhang H, Guo J, Yu M, Fang J |
Frontiers in pharmacology | 2023 |
|
Design, Synthesis and Biological Evaluation of Novel MDH Inhibitors Targeting Tumor Microenvironment.
Godesi S, Han JR, Kim JK, Kwak DI, Lee J, Nada H, Kim M, Yang HA, Im JY, Ban HS, Lee CH, Choi Y, Won M, Lee K |
Pharmaceuticals (Basel, Switzerland) | 2023 |
|
Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering A2BR signaling
Kelestemur T, Németh ZH, Pacher P, Beesley J, Robson SC, Eltzschig HK, Haskó G |
Respiratory Research | 2023 |
|
The Clinical Significance of CD73 in Cancer
Bach N, Winzer R, Tolosa E, Fiedler W, Brauneck F |
International journal of molecular sciences | 2023 |
|
Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.
Graziano V, Dannhorn A, Hulme H, Williamson K, Buckley H, Karim SA, Wilson M, Lee SY, Kaistha BP, Islam S, Thaventhiran JED, Richards FM, Goodwin R, Brais R, Morton JP, Dovedi SJ, Schuller AG, Eyles J, Jodrell DI |
Journal for ImmunoTherapy of Cancer | 2023 |
|
Regadenoson for the treatment of COVID-19: A five case clinical series and mouse studies
Rabin J, Zhao Y, Mostafa E, Al-Suqi M, Fleischmann E, Conaway MR, Mann BJ, Chhabra P, Brayman KL, Krupnick A, Linden J, Lau CL |
PloS one | 2023 |
|
Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma.
Fiorilla I, Martinotti S, Todesco AM, Bonsignore G, Cavaletto M, Patrone M, Ranzato E, Audrito V |
Cells | 2023 |
|
Purine and purinergic receptors in health and disease
Ai Y, Wang H, Liu L, Qi Y, Tang S, Tang J, Chen N |
2023 | |
|
The immune checkpoint adenosine 2A receptor is associated with aggressive clinical outcomes and reflects an immunosuppressive tumor microenvironment in human breast cancer
Zohair B, Chraa D, Rezouki I, Benthami H, Razzouki I, Elkarroumi M, Olive D, Karkouri M, Badou A |
Frontiers in immunology | 2023 |
|
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies.
Liao L, Xu H, Zhao Y, Zheng X |
Frontiers of Medicine | 2023 |
|
Adenosine, bridging chronic inflammation and tumor growth
Chen L, Alabdullah M, Mahnke K |
Frontiers in immunology | 2023 |
|
Immunomodulatory properties of CD38 antibodies and their effect on anticancer efficacy in multiple myeloma
Bisht K, Fukao T, Chiron M, Richardson P, Atanackovic D, Chini E, Chng WJ, Van De Velde H, Malavasi F |
Cancer Medicine | 2023 |
|
Tumor Microenvironment Responsive CD8+ T Cells and Myeloid‐Derived Suppressor Cells to Trigger CD73 Inhibitor AB680‐Based Synergistic Therapy for Pancreatic Cancer
Chen Q, Yin H, He J, Xie Y, Wang W, Xu H, Zhang L, Shi C, Yu J, Wu W, Liu L, Pu N, Lou W |
Advanced Science | 2023 |
|
Targeting hypoxia-inducible factors: therapeutic opportunities and challenges.
Yuan X, Ruan W, Bobrow B, Carmeliet P, Eltzschig HK |
Nature reviews. Drug discovery | 2023 |
|
Faecalibacterium prausnitzii promotes intestinal epithelial IL-18 production through activation of the HIF1α pathway
Fagundes RR, Bravo-Ruiseco G, Hu S, Kierans SJ, Weersma RK, Taylor CT, Dijkstra G, Harmsen HJ, Faber KN |
Frontiers in microbiology | 2023 |
|
Hypoxia in the Pathophysiology of Inflammatory Bowel Disease
Morales M, Xue X |
Comprehensive Physiology | 2023 |
|
The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency
Sperber HS, Raymond KA, Bouzidi MS, Ma T, Valdebenito S, Eugenin EA, Roan NR, Deeks SG, Winning S, Fandrey J, Schwarzer R, Pillai SK |
Cell Reports | 2023 |
|
Immune consequences of exercise in hypoxia: A narrative review
Burtscher J, Pasha Q, Chanana N, Millet GP, Burtscher M, Strasser B |
Journal of Sport and Health Science | 2023 |
|
Disruption of hypoxia-inducible factor-2α in neutrophils decreases colitis-associated colon cancer
Singhal R, Kotla NK, Solanki S, Huang W, Bell HN, El-Derany MO, Castillo C, Shah YM |
AJP Gastrointestinal and Liver Physiology | 2023 |
|
MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression
Fu Y, Mackowiak B, Feng D, Lu H, Guan Y, Lehner T, Pan H, Wang X, He Y, Gao B |
Gut | 2023 |
|
Fighting in a wasteland: deleterious metabolites and antitumor immunity
McLane Watson, Greg Delgoffe |
Journal of Clinical Investigation | 2022 |
|
Multifaceted Interplay between Hormones, Growth Factors and Hypoxia in the Tumor Microenvironment
R Lappano, L Todd, M Stanic, Q Cai, M Maggiolini, F Marincola, V Pietrobon |
Cancers | 2022 |
|
Tumor Infiltration with CD20+CD73+ B Cells Correlates with Better Outcome in Colorectal Cancer
F Hansen, Z Wu, P David, A Mittelstädt, A Jacobsen, M Podolska, K Ubieta, M Brunner, D Kouhestani, I Swierzy, L Roßdeutsch, B Klösch, I Kutschick, S Merkel, A Denz, K Weber, C Geppert, R Grützmann, A Bénard, G Weber |
International journal of molecular sciences | 2022 |
|
Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-Cells
R Mooli, D Mukhi, A Pasupulati, S Evers, I Sipula, M Jurczak, R Seeley, Y Shah, S Ramakrishnan |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2022 |
|
Microbial Metabolite Regulation of Epithelial Cell-Cell Interactions and Barrier Function
A Ornelas, A Dowdell, J Lee, S Colgan |
Cells | 2022 |
|
Role of Hypoxia in the Interferon Response
E Arnaiz, A Harris |
Frontiers in immunology | 2022 |
|
Hypoxia and Hypoxia-Inducible Factors in Lymphedema
X Jiang, W Tian, D Kim, A McQuiston, R Vinh, S Rockson, G Semenza, M Nicolls |
Frontiers in pharmacology | 2022 |
|
Inflammation and Myeloid Cells in Cancer Progression and Metastasis
J Deng, J Fleming |
Frontiers in Cell and Developmental Biology | 2022 |
|
Purinergic and Adenosinergic Signaling in Pancreatobiliary Diseases
E Faraoni, C Ju, S Robson, H Eltzschig, J Bailey-Lundberg |
Frontiers in physiology | 2022 |
|
Hypoxia as a Modulator of Inflammation and Immune Response in Cancer
R Castillo-Rodríguez, C Trejo-Solís, A Cabrera-Cano, S Gómez-Manzo, V Dávila-Borja |
Cancers | 2022 |
|
Appraisal of novel azomethine–thioxoimidazolidinone conjugates as ecto-5′-nucleotidase inhibitors: synthesis and molecular docking studies
Channar PA, Bano S, Hassan S, Perveen F, Saeed A, Mahesar PA, Khan IA, Iqbal J |
RSC Advances | 2022 |
|
The Multifaceted Actions of CD73 During Development and Suppressive Actions of Regulatory T Cells
Da M, Chen L, Enk A, Ring S, Mahnke K |
Frontiers in immunology | 2022 |
|
NK Cells Under Hypoxia: The Two Faces of Vascularization in Tumor and Pregnancy
Garcés-Lázaro I, Kotzur R, Cerwenka A, Mandelboim O |
Frontiers in immunology | 2022 |
|
CD73 Induces GM-CSF/MDSC-mediated Suppression of T cells to Accelerate Pancreatic Cancer Pathogenesis
King RJ, Shukla SK, He C, Vernucci E, Thakur R, Attri KS, Dasgupta A, Chaika NV, Mulder SE, Abrego J, Murthy D, Gunda V, Pacheco CG, Grandgenett PM, Lazenby AJ, Hollingsworth MA, Yu F, Mehla K, Singh PK |
Oncogene | 2022 |
|
Immunogenic cell death and its therapeutic or prognostic potential in high-grade glioma
Decraene B, Yang Y, De Smet F, Garg AD, Agostinis P, De Vleeschouwer S |
Genes and Immunity | 2022 |
|
Combination of Anti-Angiogenics and Checkpoint Inhibitors for Renal Cell Carcinoma: Is the Whole Greater Than the Sum of Its Parts?
Jonasch E, Atkins MB, Chowdhury S, Mainwaring P |
Cancers | 2022 |
|
Elevated ATP via enhanced miRNA-30b, 30c, and 30e downregulates the expression of CD73 in CD8+ T cells of HIV-infected individuals
Shahbaz S, Okoye I, Blevins G, Elahi S |
PLoS pathogens | 2022 |
|
The Effects of CD73 on Gastrointestinal Cancer Progression and Treatment
Sun P, Zheng X, Li X |
Journal of Oncology | 2022 |
|
The Dynamic Role of NK Cells in Liver Cancers: Role in HCC and HBV Associated HCC and Its Therapeutic Implications
Sajid M, Liu L, Sun C |
Frontiers in immunology | 2022 |
|
Implications of Hyperoxia over the Tumor Microenvironment: An Overview Highlighting the Importance of the Immune System
Herrera-Campos AB, Zamudio-Martinez E, Delgado-Bellido D, Fernández-Cortés M, Montuenga LM, Oliver FJ, Garcia-Diaz A |
Cancers | 2022 |
|
Nt5e deficiency does not affect post-stroke inflammation and lesion size in a murine ischemia/reperfusion stroke model
Schädlich IS, Schnapauff O, Pöls L, Schrader J, Tolosa E, Rissiek B, Magnus T |
iScience | 2022 |
|
Alternative adenosine Receptor activation: The netrin-Adora2b link.
Yuan X, Mills T, Doursout MF, Evans SE, Vidal Melo MF, Eltzschig HK |
Frontiers in pharmacology | 2022 |
|
Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression.
Watanabe Y, Fukuda T, Hayashi C, Nakao Y, Toyoda M, Kawakami K, Shinjo T, Iwashita M, Yamato H, Yotsumoto K, Taketomi T, Uchiumi T, Sanui T, Nishimura F |
Scientific Reports | 2022 |
|
CoCl2-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors.
Kutryb-Zajac B, Kawecka A, Braczko A, Franczak M, Slominska EM, Giovannoni R, Smolenski RT |
Biomedicines | 2022 |
|
Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma.
Coy S, Wang S, Stopka SA, Lin JR, Yapp C, Ritch CC, Salhi L, Baker GJ, Rashid R, Baquer G, Regan M, Khadka P, Cole KA, Hwang J, Wen PY, Bandopadhayay P, Santi M, De Raedt T, Ligon KL, Agar NYR, Sorger PK, Touat M, Santagata S |
Nature Communications | 2022 |
|
Overcoming tumor resistance mechanisms in CAR-NK cell therapy
Valeri A, García-Ortiz A, Castellano E, Córdoba L, Maroto-Martín E, Encinas J, Leivas A, Río P, Martínez-López J |
Frontiers in immunology | 2022 |
|
The Hypoxia-Adenosine Link during Myocardial Ischemia—Reperfusion Injury
Ruan W, Ma X, Bang IH, Liang Y, Muehlschlegel JD, Tsai KL, Mills TW, Yuan X, Eltzschig HK |
Biomedicines | 2022 |
|
Hypoxia-inducible factor as a bridge between healthy barrier function, wound healing, and fibrosis.
Steiner CA, Cartwright IM, Taylor CT, Colgan SP |
American journal of physiology. Cell physiology | 2022 |
|
CD73-Adenosinergic Axis Mediates the Protective Effect of Extracellular Vesicles Derived from Mesenchymal Stromal Cells on Ischemic Renal Damage in a Rat Model of Donation after Circulatory Death
Grignano MA, Bruno S, Viglio S, Avanzini MA, Tapparo M, Ramus M, Croce S, Valsecchi C, Pattonieri EF, Ceccarelli G, Manzoni F, Asti A, Libetta C, Sepe V, Iadarola P, Gregorini M, Rampino T |
International journal of molecular sciences | 2022 |
|
SNAI1-dependent upregulation of CD73 increases extracellular adenosine release to mediate immune suppression in TNBC
Hasmim M, Xiao M, Van Moer K, Kumar A, Oniga A, Mittelbronn M, Duhem C, Chammout A, Berchem G, Thiery JP, Volpert M, Hollier B, Noman MZ, Janji B |
Frontiers in immunology | 2022 |
|
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain
Yegutkin GG, Boison D |
Pharmacological reviews | 2022 |
|
Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function.
Seifert M, Benmebarek MR, Briukhovetska D, Märkl F, Dörr J, Cadilha BL, Jobst J, Stock S, Andreu-Sanz D, Lorenzini T, Grünmeier R, Oner A, Obeck H, Majed L, Dhoqina D, Feinendegen M, Gottschlich A, Zhang J, Schindler U, Endres S, Kobold S |
British Journal of Cancer | 2022 |
|
Identification of CD73 as a Novel Biomarker Encompassing the Tumor Microenvironment, Prognosis, and Therapeutic Responses in Various Cancers
Tang K, Zhang J, Cao H, Xiao G, Wang Z, Zhang X, Zhang N, Wu W, Zhang H, Wang Q, Xu H, Cheng Q |
Cancers | 2022 |
|
Immune checkpoint blockade in pancreatic cancer: Trudging through the immune desert.
Li X, Gulati M, Larson AC, Solheim JC, Jain M, Kumar S, Batra SK |
Seminars in Cancer Biology | 2022 |
|
Mitochondria Drive Immune Responses in Critical Disease
Tiwari-Heckler S, Robson SC, Longhi MS |
Cells | 2022 |
|
Evidence that cervical cancer cells cultured as tumorspheres maintain high CD73 expression and increase their protumor characteristics through TGF-β production.
García-Rocha R, Monroy-García A, Carrera-Martínez M, Hernández-Montes J, Don-López CA, Weiss-Steider B, Monroy-Mora KA, Ponce-Chavero MLÁ, Montesinos-Montesinos JJ, Escobar-Sánchez ML, Castillo GM, Chacón-Salinas R, Vallejo-Castillo L, Pérez-Tapia SM, Mora-García ML |
Cell Biochemistry and Function | 2022 |
|
Functional expression of CD73 on human natural killer cells.
Chambers AM, Wang J, Dao TN, Lupo KB, Veenhuis P, Ayers MG, Slivova V, Cohen-Gadol AA, Matosevic S |
Cancer Immunology, Immunotherapy | 2022 |
|
Adenosine at the Interphase of Hypoxia and Inflammation in Lung Injury
X Li, NK Berg, T Mills, K Zhang, HK Eltzschig, X Yuan |
Frontiers in immunology | 2021 |
|
Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages
D Chen, X Zhang, Z Li, B Zhu |
Theranostics | 2021 |
|
Role of Purinergic Signalling in Endothelial Dysfunction and Thrombo-Inflammation in Ischaemic Stroke and Cerebral Small Vessel Disease
NT Lee, LK Ong, P Gyawali, CM Nassir, M Mustapha, HH Nandurkar, M Sashindranath |
Biomolecules | 2021 |
|
Enhancing Extracellular Adenosine Levels Restores Barrier Function in Acute Lung Injury Through Expression of Focal Adhesion Proteins
W Wang, N Chen, D Ren, J Davies, K Philip, HK Eltzschig, MR Blackburn, B Akkanti, H Karmouty-Quintana, T Weng |
Frontiers in Molecular Biosciences | 2021 |
|
Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers
R King, C Hayes, CL Donohoe, MR Dunne, M Davern, NE Donlon |
World journal of gastrointestinal oncology | 2021 |
|
Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy
M Krishnamoorthy, L Gerhardt, SM Vareki |
Cells | 2021 |
|
Sustained compensatory p38 MAPK signaling following treatment with MAPK inhibitors induces the immunosuppressive protein CD73 in cancer: combined targeting could improve outcomes
MG Terp, OL Gammelgaard, H Vever, MF Gjerstorff, HJ Ditzel |
Molecular Oncology | 2021 |
|
ATP and cancer immunosurveillance
O Kepp, L Bezu, T Yamazaki, FD Virgilio, MJ Smyth, G Kroemer, L Galluzzi |
The EMBO Journal | 2021 |
|
The therapeutic implications of immunosuppressive tumor aerobic glycolysis
BI Reinfeld, WK Rathmell, TK Kim, JC Rathmell |
Cellular and Molecular Immunology | 2021 |
|
Tumor-Derived Exosomes: Hidden Players in PD-1/PD-L1 Resistance
V Vautrot, H Bentayeb, S Causse, C Garrido, J Gobbo |
Cancers | 2021 |
|
Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue
JL Simões, HF Basso, GC Kosvoski, J Gavioli, F Marafon, CE Assmann, FB Carvalho, MD Bagatini |
International Immunopharmacology | 2021 |
|
Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?
V Collado-Díaz, MÁ Martinez-Cuesta, MA Blanch-Ruiz, A Sánchez-López, P García-Martínez, JE Peris, I Usach, MD Ivorra, A Lacetera, S Martín-Santamaría, JV Esplugues, A Alvarez |
Frontiers in pharmacology | 2021 |
|
The elegant complexity of mammalian ecto-5′-nucleotidase (CD73)
KP Alcedo, JL Bowser, NT Snider |
Trends in Cell Biology | 2021 |
|
Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73
LB Jarvis, DB Rainbow, V Coppard, SK Howlett, Z Georgieva, JL Davies, HK Mullay, J Hester, T Ashmore, AV Bosch, JT Grist, AJ Coles, HS Mousa, S Pluchino, KT Mahbubani, JL Griffin, K Saeb-Parsy, F Issa, L Peruzzotti-Jametti, LS Wicker, JL Jones |
2021 | |
|
How Cells Communicate with Each Other in the Tumor Microenvironment: Suggestions to Design Novel Therapeutic Strategies in Cancer Disease
R Zefferino, C Piccoli, SD Gioia, N Capitanio, M Conese |
International journal of molecular sciences | 2021 |
|
Interfering with Tumor Hypoxia for Radiotherapy Optimization
I Telarovic, RH Wenger, M Pruschy |
Journal of Experimental & Clinical Cancer Research | 2021 |
|
CD73 Maintains Hepatocyte Metabolic Integrity and Mouse Liver Homeostasis in a Sex-Dependent Manner
KP Alcedo, MA Rouse, GS Jung, D Fu, M Minor, HH Willcockson, KG Greene, NT Snider |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2021 |
|
Anti-Inflammatory Effects of Endogenously Released Adenosine in Synovial Cells of Osteoarthritis and Rheumatoid Arthritis Patients
R Sohn, M Junker, A Meurer, F Zaucke, RH Straub, Z Jenei-Lanzl |
International journal of molecular sciences | 2021 |
|
Hyperoxia and modulation of pulmonary vascular and immune responses in COVID-19
D Hanidziar, SC Robson |
American journal of physiology. Lung cellular and molecular physiology | 2021 |
|
Overexpression of CD73 in pancreatic ductal adenocarcinoma is associated with immunosuppressive tumor microenvironment and poor survival
J Zhao, L Soto, H Wang, M Katz, L Prakash, M Kim, C Tzeng, J Lee, R Wolff, Y Huang, I Wistuba, A Maitra, H Wang |
Pancreatology | 2021 |
|
HIF2 Regulates Intestinal Wnt5a Expression
CJ García, AC Diaz, N Kumari, S Govindaraju, M de la Cruz Bonilla, FA Lucas, ND Nguyen, IJ Sacarello, H Piwnica-Worms, A Maitra, CM Taniguchi |
Frontiers in Oncology | 2021 |
|
Purinergic Signaling in the Regulation of Gout Flare and Resolution
Li X, Gao J, Tao J |
Frontiers in immunology | 2021 |
|
Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity
Hesse J, Rosse MK, Steckel B, Blank-Landeshammer B, Idel S, Reinders Y, Sickmann A, Sträter N, Schrader J |
Purinergic Signalling | 2021 |
|
Role of mesenteric component in Crohn’s disease: A friend or foe?
Yin Y, Zhu ZX, Li Z, Chen YS, Zhu WM |
World journal of gastrointestinal surgery | 2021 |
|
An overview of current therapeutic strategies for glioblastoma and the role of CD73 as an alternative curative approach.
Arab S, Hasannejad F |
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico | 2021 |
|
Modulatory activity of adenosine on the immune response in cord and adult blood.
Ďurčo F, Köstlin-Gille N, Poets CF, Gille C |
Pediatric Research | 2021 |
|
HIFs and innate immunity in liver cancer
Vincent Wai-Hin Yuen, Carmen Chak-Lui Wong |
Journal of Clinical Investigation | 2020 |
|
Anti-hypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy
Stephen M. Hatfield, Michail V. Sitkovsky |
Journal of Clinical Investigation | 2020 |
|
Purinergic Signaling in the Hallmarks of Cancer
A del Rocío Campos-Contreras, M Díaz-Muñoz, FG Vázquez-Cuevas |
Cells | 2020 |
|
Hypoxia and Innate Immunity: Keeping Up with the HIFsters
SP Colgan, GT Furuta, CT Taylor |
Annual Review of Immunology | 2020 |
|
CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint
M Yu, G Guo, L Huang, L Deng, CS Chang, BR Achyut, M Canning, N Xu, AS Arbab, RJ Bollag, PC Rodriguez, AL Mellor, H Shi, DH Munn, Y Cui |
Nature Communications | 2020 |
|
Role of hyperoxic treatment in cancer
SW Kim, IK Kim, SH Lee |
Experimental biology and medicine (Maywood, N.J.) | 2020 |
|
CD73's Potential as an Immunotherapy Target in Gastrointestinal Cancers
JB Harvey, LH Phan, OE Villarreal, JL Bowser |
Frontiers in immunology | 2020 |
|
The adenosine pathway in immuno-oncology
B Allard, D Allard, L Buisseret, J Stagg |
Nature Reviews Clinical Oncology | 2020 |
|
Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine
R Singhal, YM Shah |
The Journal of biological chemistry | 2020 |
|
Inflammatory Bowel Diseases: It's Time for the Adenosine System
L Antonioli, M Fornai, C Pellegrini, L Bertani, ZH Nemeth, C Blandizzi |
Frontiers in immunology | 2020 |
|
Bacteria elevate extracellular adenosine to exploit host signaling for blood-brain barrier disruption
Z Zhao, X Shang, Y Chen, Y Zheng, W Huang, H Jiang, Q Lv, D Kong, Y Jiang, P Liu |
Virulence | 2020 |
|
Interleukin 13 (IL‐13) alters hypoxia‐associated genes and upregulates CD73
SM Khalil, I Bernstein, H Kulaga, N Gour, N Rowan, S Lajoie, AP Lane |
International Forum of Allergy & Rhinology | 2020 |
|
CD73 acts as a prognostic biomarker and promotes progression and immune escape in pancreatic cancer
Q Chen, N Pu, H Yin, J Zhang, G Zhao, W Lou, W Wu |
Journal of Cellular and Molecular Medicine | 2020 |
|
Prognostic significance and immune correlates of CD73 expression in renal cell carcinoma
A Tripathi, E Lin, W Xie, A Flaifel, JA Steinharter, EN Gatof, G Bouchard, JH Fleischer, N Martinez-Chanza, C Gray, C Mantia, L Thompson, XX Wei, M Giannakis, BA McGregor, TK Choueiri, N Agarwal, DF McDermott, S Signoretti, LC Harshman |
Journal for ImmunoTherapy of Cancer | 2020 |
|
Cathelicidin-Related Antimicrobial Peptide Regulates CD73 Expression in Mouse Th17 Cells via p38
J Lee, KO Shin, Y Kim, J Cho, HW Lim, SI Yoon, GS Lee, HJ Ko, PH Kim, Y Uchida, K Park, SG Kang |
Cells | 2020 |
|
Current Progresses and Challenges of Immunotherapy in Triple-Negative Breast Cancer
K Mediratta, S El-Sahli, V DCosta, L Wang |
Cancers | 2020 |
|
Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia
K Losenkova, M Zuccarini, M Karikoski, J Laurila, D Boison, S Jalkanen, GG Yegutkin |
Journal of cell science | 2020 |
|
CD73 alleviates GSDMD‐mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling
S Xu, J Wang, J Zhong, M Shao, J Jiang, J Song, W Zhu, F Zhang, H Xu, G Xu, Y Zhang, X Ma, F Lyu |
Clinical and Translational Medicine | 2020 |
|
Extracellular ATP: A Feasible Target for Cancer Therapy
V Vultaggio-Poma, AC Sarti, FD Virgilio |
Cells | 2020 |
|
Role of Hypoxia and the Adenosine System in Immune Evasion and Prognosis of Patients with Brain Metastases of Melanoma: A Multiplex Whole Slide Immunofluorescence Study
A Mayer, M Haist, C Loquai, S Grabbe, M Rapp, W Roth, P Vaupel, H Schmidberger |
Cancers | 2020 |
|
Adenosinergic System Involvement in Ischemic Stroke Patients’ Lymphocytes
S Pasquini, F Vincenzi, I Casetta, M Laudisi, S Merighi, S Gessi, PA Borea, K Varani |
Cells | 2020 |
|
Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathway
N Li, N Tang, C Cheng, T Hu, X Wei, W Han, H Wang |
OncoImmunology | 2020 |
|
Mir-370-3p Impairs Glioblastoma Stem-Like Cell Malignancy Regulating a Complex Interplay between HMGA2/HIF1A and the Oncogenic Long Non-Coding RNA (lncRNA) NEAT1
V Lulli, M Buccarelli, R Ilari, G Castellani, CD Dominicis, AD Giamberardino, QG DAlessandris, S Giannetti, M Martini, V Stumpo, A Boe, GD Luca, M Biffoni, G Marziali, R Pallini, L Ricci-Vitiani |
International journal of molecular sciences | 2020 |
|
Hypoxic tumor microenvironment: Implications for cancer therapy
S Roy, S Kumaravel, A Sharma, CL Duran, KJ Bayless, S Chakraborty |
Experimental biology and medicine (Maywood, N.J.) | 2020 |
|
Hypoxia Inducible Factor-1α: The Curator of Gut Homeostasis
T Kumar, R Pandey, NS Chauhan |
Frontiers in Cellular and Infection Microbiology | 2020 |
|
MiR-155 contributes to intestinal barrier dysfunction in DSS-induced mice colitis via targeting HIF-1α/TFF-3 axis
Y Liu, F Zhu, H Li, H Fan, H Wu, Y Dong, S Chu, C Tan, Q Wang, H He, F Gao, X Leng, Q Zhou, X Zhu |
Aging | 2020 |
|
Characterization of the N6-etheno-bridge method to assess extracellular metabolism of adenine nucleotides: detection of a possible role for purine nucleoside phosphorylase in adenosine metabolism
EK Jackson, DG Gillespie, D Cheng, Z Mi, EV Menshikova |
Purinergic Signalling | 2020 |
|
CD73+ Dendritic Cells in Cascading Th17 Responses of Experimental Autoimmune Uveitis-Induced Mice
MH Ko, H Shao, HJ Kaplan, D Sun |
Frontiers in immunology | 2020 |
|
CD73 blockade enhances the local and abscopal effects of radiotherapy in a murine rectal cancer model
Tsukui H, Horie H, Koinuma K, Ohzawa H, Sakuma Y, Hosoya Y, Yamaguchi H, Yoshimura K, Lefor AK, Sata N, Kitayama J |
BMC Cancer | 2020 |
|
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
Yang R, Elsaadi S, Misund K, Abdollahi P, Vandsemb EN, Moen SH, Kusnierczyk A, Slupphaug G, Standal T, Waage A, Slørdahl TS, Rø TB, Rustad E, Sundan A, Hay C, Cooper Z, Schuller AG, Woessner R, Borodovsky A, Menu E, Børset M, Sponaas AM |
Journal for ImmunoTherapy of Cancer | 2020 |
|
Hypoxia signaling in human diseases and therapeutic targets
JW Lee, J Ko, C Ju, HK Eltzschig |
Experimental & molecular medicine | 2019 |
|
Inhibition of the adenosinergic pathway: the indispensable part of oncological therapy in the future
Y Huang, Z Gu, Y Fan, G Zhai, X Zhao, Q Sun, Y Shi, G Lin |
Purinergic Signalling | 2019 |
|
The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases
L Antonioli, C Blandizzi, P Pacher, G Haskó, C Page |
Pharmacological reviews | 2019 |
|
CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy
S Chen, J Fan, M Zhang, L Qin, D Dominguez, A Long, G Wang, R Ma, H Li, Y Zhang, D Fang, J Sosman, B Zhang |
Nature Communications | 2019 |
|
Innate Immune Cells: A Potential and Promising Cell Population for Treating Osteosarcoma
Z Wang, Z Wang, B Li, S Wang, T Chen, Z Ye |
Frontiers in immunology | 2019 |
|
HPV-16 Infection Is Associated with a High Content of CD39 and CD73 Ectonucleotidases in Cervical Samples from Patients with CIN-1
M de Lourdes Mora-García, S López-Cisneros, V Gutiérrez-Serrano, R García-Rocha, B Weiss-Steider, J Hernández-Montes, HI Sánchez-Peña, LR Ávila-Ibarra, CA Don-López, R Muñóz-Godínez, DB Pineda, R Chacón-Salinas, L Vallejo-Castillo, SM Pérez-Tapia, A Monroy-García |
Mediators of Inflammation | 2019 |
|
Purinergic Signaling in Pulmonary Inflammation
TT Le, NK Berg, MT Harting, X Li, HK Eltzschig, X Yuan |
Frontiers in immunology | 2019 |
|
Immunometabolic Dysfunction of Natural Killer Cells Mediated by the Hypoxia-CD73 Axis in Solid Tumors
AM Chambers, S Matosevic |
Frontiers in Molecular Biosciences | 2019 |
|
Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
S Vigano, D Alatzoglou, M Irving, C Ménétrier-Caux, C Caux, P Romero, G Coukos |
Frontiers in immunology | 2019 |
|
CD73: an emerging checkpoint for cancer immunotherapy
S Chen, DA Wainwright, JD Wu, Y Wan, DE Matei, Y Zhang, B Zhang |
Immunotherapy | 2019 |
|
The Ecto-5’-Nucleotidase/CD73 Inhibitor, α,β-Methylene Adenosine 5’-Diphosphate, Exacerbates Carrageenan-Induced Pleurisy in Rat
E Caiazzo, S Morello, R Carnuccio, A Ialenti, C Cicala |
Frontiers in pharmacology | 2019 |
|
Special issue on hypoxia
EJ Yeo |
Experimental & molecular medicine | 2019 |
|
Generation and Function of Non-cell-bound CD73 in Inflammation
E Schneider, A Rissiek, R Winzer, B Puig, B Rissiek, F Haag, HW Mittrücker, T Magnus, E Tolosa |
Frontiers in immunology | 2019 |
|
Circadian-Hypoxia Link and its Potential for Treatment of Cardiovascular Disease
CM Bartman, T Eckle |
Current pharmaceutical design | 2019 |
|
Tumor‐Selective Altered Glycosylation and Functional Attenuation of CD73 in Human Hepatocellular Carcinoma
KP Alcedo, A Guerrero, V Basrur, D Fu, ML Richardson, JS McLane, CC Tsou, AI Nesvizhskii, TH Welling, CB Lebrilla, CA Otey, HJ Kim, MB Omary, NT Snider |
Hepatology Communications | 2019 |
|
Ectonucleotidases in Blood Malignancies: A Tale of Surface Markers and Therapeutic Targets
T Vaisitti, F Arruga, G Guerra, S Deaglio |
Frontiers in immunology | 2019 |
|
The CD73/Ado System—A New Player in RT Induced Adverse Late Effects
S de Leve, F Wirsdörfer, V Jendrossek |
Cancers | 2019 |
|
Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response
S Cassim, J Pouyssegur |
International journal of molecular sciences | 2019 |
|
Metabolic Regulation of Macrophage Polarization in Cancer
K Mehla, PK Singh |
Trends in Cancer | 2019 |
|
DMOG, a Prolyl Hydroxylase Inhibitor, Increases Hemoglobin Levels without Exacerbating Hypertension and Renal Injury in Salt-Sensitive Hypertensive Rats
S Kato, T Takahashi, N Miyata, RJ Roman |
The Journal of pharmacology and experimental therapeutics | 2019 |
|
Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer
L Fong, A Hotson, JD Powderly, M Sznol, RS Heist, TK Choueiri, S George, BG Hughes, MD Hellmann, DR Shepard, BI Rini, S Kummar, AM Weise, MJ Riese, B Markman, LA Emens, D Mahadevan, JJ Luke, G Laport, JD Brody, L Hernandez-Aya, P Bonomi, JW Goldman, L Berim, DJ Renouf, RA Goodwin, B Munneke, PY Ho, J Hsieh, I McCaffery, L Kwei, SB Willingham, RA Miller |
Cancer Discovery | 2019 |
|
Inorganic Nanozyme with Combined Self-Oxygenation/Degradable Capabilities for Sensitized Cancer Immunochemotherapy
J Wang, L Fang, P Li, L Ma, W Na, C Cheng, Y Gu, D Deng |
Nano-Micro Letters | 2019 |
|
CD73 expression in normal and pathological human hepatobiliopancreatic tissues.
Sciarra A, Monteiro I, Ménétrier-Caux C, Caux C, Gilbert B, Halkic N, La Rosa S, Romero P, Sempoux C, de Leval L |
Cancer Immunology, Immunotherapy | 2019 |
|
Immunometabolism in cancer at a glance
K Singer, WC Cheng, M Kreutz, PC Ho, PJ Siska |
Disease models & mechanisms | 2018 |
|
Targeting Hypoxia Signaling for Perioperative Organ Injury:
X Yuan, JW Lee, JL Bowser, V Neudecker, S Sridhar, HK Eltzschig |
Anesthesia & Analgesia | 2018 |
|
Hypoxia-induced intestinal barrier changes in balloon-assisted enteroscopy: Fortified gut barrier by short-term hypoxia
TC Lee, YC Huang, YZ Lu, YC Yeh, LC Yu |
The Journal of Physiology | 2018 |
|
Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function
JS Lee, RX Wang, EE Alexeev, JM Lanis, KD Battista, LE Glover, SP Colgan |
The Journal of biological chemistry | 2018 |
|
Intestinal HIF-1α Deletion Exacerbates Alcoholic Liver Disease through Inducing Intestinal Dysbiosis and Barrier Dysfunction
T Shao, C Zhao, F Li, Z Gu, L Liu, L Zhang, Y Wang, L He, Y Liu, Q Liu, Y Chen, H Donde, R Wang, VR Jala, S Barve, SY Chen, X Zhang, Y Chen, CJ McClain, W Feng |
Journal of Hepatology | 2018 |
|
The hypoxic tumour microenvironment
V Petrova, M Annicchiarico-Petruzzelli, G Melino, I Amelio |
Oncogenesis | 2018 |
|
Targeting the Adenosinergic Axis in Chronic Lymphocytic Leukemia: A Way to Disrupt the Tumor Niche?
T Vaisitti, F Arruga, S Deaglio |
International journal of molecular sciences | 2018 |
|
Adenosinergic signaling as a target for natural killer cell immunotherapy
J Wang, S Matosevic |
Journal of Molecular Medicine | 2018 |
|
The Hypoxia–Adenosine Link during Intestinal Inflammation
JL Bowser, LH Phan, HK Eltzschig |
Journal of immunology (Baltimore, Md. : 1950) | 2018 |
|
Adenosine metabolism, immunity and joint health
G Haskó, L Antonioli, BN Cronstein |
Biochemical Pharmacology | 2018 |
|
Controlling the Immune Suppressor: Transcription Factors and MicroRNAs Regulating CD73/NT5E
T Kordaß, W Osen, SB Eichmüller |
Frontiers in immunology | 2018 |
|
Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension
TC Mertens, A Hanmandlu, L Tu, C Phan, SD Collum, NY Chen, T Weng, J Davies, C Liu, HK Eltzschig, SS Jyothula, K Rajagopal, Y Xia, A Guha, BA Bruckner, MR Blackburn, C Guignabert, H Karmouty-Quintana |
Frontiers in physiology | 2018 |
|
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
D Samanta, Y Park, X Ni, H Li, CA Zahnow, E Gabrielson, F Pan, GL Semenza |
Proceedings of the National Academy of Sciences | 2018 |
|
Cellular Stress Responses and Gut Microbiota in Inflammatory Bowel Disease
SS Cao |
Gastroenterology Research and Practice | 2018 |
|
Ecto-5′-nucleotidase/CD73 contributes to the radiosensitivity of T24 human bladder cancer cell line
F Dietrich, F Figueiró, EC Filippi-Chiela, AR Cappellari, L Rockenbach, A Tremblay, PB de Paula, R Roesler, AB Filho, J Sévigny, FB Morrone, AM Battastini |
Journal of Cancer Research and Clinical Oncology | 2018 |
|
Infant cardiopulmonary bypass: CD73 kinetics, association with clinical outcomes, and influence on serum adenosine production capacity
JN Persson, CH Baird, S Tong, TT Urban, J Klawitter, PE Wischmeyer, JA Davidson |
Pediatric Research | 2018 |
|
Hypoxia enhances indoleamine 2,3-dioxygenase production in dendritic cells
X Song, Y Zhang, L Zhang, W Song, L Shi |
Oncotarget | 2018 |
|
Unveiling the Role of Ecto-5′-Nucleotidase/CD73 in Astrocyte Migration by Using Pharmacological Tools
M Adzic, N Nedeljkovic |
Frontiers in pharmacology | 2018 |
|
Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy
Y Li, SP Patel, J Roszik, Y Qin |
Frontiers in immunology | 2018 |
|
The ecto-enzymes CD73 and adenosine deaminase modulate 5′-AMP-derived adenosine in myofibroblasts of the rat small intestine
A Bin, V Caputi, M Bistoletti, M Montopoli, R Colucci, L Antonioli, SD Martin, I Castagliuolo, G Orso, C Giaroni, P Debetto, MC Giron |
Purinergic Signalling | 2018 |
|
The Role of Hydrogen Peroxide in Redox-Dependent Signaling: Homeostatic and Pathological Responses in Mammalian Cells
ND Marzo, E Chisci, R Giovannoni |
Cells | 2018 |
|
Neutrophils as sources of dinucleotide polyphosphates and metabolism by epithelial ENPP1 to influence barrier function via adenosine signaling
VF Curtis, IM Cartwright, JS Lee, RX Wang, DJ Kao, JM Lanis, KM Burney, N Welch, CH Hall, MS Goldberg, EL Campbell, SP Colgan, A Nusrat |
Molecular biology of the cell | 2018 |
|
Tumor Microenvironment-Induced Immunometabolic Reprogramming of Natural Killer Cells
AM Chambers, KB Lupo, S Matosevic |
Frontiers in immunology | 2018 |
|
Control and dysregulation of redox signalling in the gastrointestinal tract
EL Campbell, SP Colgan |
Nature Reviews Gastroenterology & Hepatology | 2018 |
|
The Adaptive Complexity of Cancer
Y Derbal |
BioMed Research International | 2018 |
|
Purinergic targeting enhances immunotherapy of CD73+ solid tumors with piggyBac-engineered chimeric antigen receptor natural killer cells
J Wang, KB Lupo, AM Chambers, S Matosevic |
Journal for ImmunoTherapy of Cancer | 2018 |
|
Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer
L Li, L Wang, J Li, Z Fan, L Yang, Z Zhang, C Zhang, D Yue, G Qin, T Zhang, F Li, X Chen, Y Ping, D Wang, Q Gao, Q He, L Huang, H Li, J Huang, X Zhao, W Xue, Z Sun, J Lu, JJ Yu, J Zhao, B Zhang, Y Zhang |
Cancer research | 2018 |
|
Synthesis of novel (E)-1-(2-(2-(4(dimethylamino) benzylidene) hydrazinyl)-4-methylthiazol-5-yl)ethanone derivatives as ecto-5′-nucleotidase inhibitors
Hassan S, Channar PA, Larik FA, Saeed A, Shah HS, Lecka J, Sévigny J, Iqbal J |
Royal Society Open Science | 2018 |
|
Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy.
Tokunaga R, Cao S, Naseem M, Lo JH, Battaglin F, Puccini A, Berger MD, Soni S, Millstein J, Zhang W, Stintzing S, Loupakis F, Cremolini C, Heinemann V, Falcone A, Lenz HJ |
Clinical Colorectal Cancer | 2018 |
|
WDR4-driven PML destruction fosters immunosuppressive and pro-metastatic lung tumor microenvironment
Ya-Ting Wang, Jocelyn Chen, Chou-Wei Chang, Jayu Jen, Tzu-Yu Huang, Chun-Ming Chen, Roger Shen, Suh-Yuen Liang, I-Cheng Cheng, Shuenn-Chen Yang, Wu-Wei Lai, Kuang-Hung Cheng, Tao-Shih Hsieh, Ming-Zong Lai, Hung-Chi Cheng, Yi-Ching Wang, Ruey-Hwa Chen |
Journal of Clinical Investigation | 2017 |
|
The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets
B Allard, MS Longhi, SC Robson, J Stagg |
Immunological Reviews | 2017 |
|
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
A Song, Y Zhang, L Han, GG Yegutkin, H Liu, K Sun, A DAlessandro, J Li, H Karmouty-Quintana, T Iriyama, T Weng, S Zhao, W Wang, H Wu, T Nemkov, AW Subudhi, SJ Houten, CG Julian, AT Lovering, KC Hansen, H Zhang, M Bogdanov, W Dowhan, J Jin, RE Kellems, HK Eltzschig, M Blackburn, RC Roach, Y Xia |
Nature Communications | 2017 |
|
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis
C Xie, T Yagai, Y Luo, X Liang, T Chen, Q Wang, D Sun, J Zhao, SK Ramakrishnan, L Sun, C Jiang, X Xue, Y Tian, KW Krausz, AD Patterson, YM Shah, Y Wu, C Jiang, FJ Gonzalez |
Nature Medicine | 2017 |
|
Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury
J McClendon, NL Jansing, EF Redente, A Gandjeva, Y Ito, SP Colgan, A Ahmad, DW Riches, HA Chapman, RJ Mason, RM Tuder, RL Zemans |
The American Journal of Pathology | 2017 |
|
An Elf2-like transcription factor acts as repressor of the mouse ecto-5′-nucleotidase gene expression in hepatic myofibroblasts
M Fausther, EG Lavoie, JR Goree, JA Dranoff |
Purinergic Signalling | 2017 |
|
Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over
L Kling, U Benck, A Breedijk, L Leikeim, M Heitzmann, S Porubsky, BK Krämer, BA Yard, AI Kälsch |
Scientific Reports | 2017 |
|
Neutrophils as Components of Mucosal Homeostasis
CH Hall, EL Campbell, SP Colgan |
Cellular and Molecular Gastroenterology and Hepatology | 2017 |
|
Hypoxia induces cancer-associated cAMP/PKA signalling through HIF-mediated transcriptional control of adenylyl cyclases VI and VII
V Simko, F Iuliano, A Sevcikova, M Labudova, M Barathova, P Radvak, S Pastorekova, J Pastorek, L Csaderova |
Scientific Reports | 2017 |
|
Immune recognition of irradiated cancer cells
E Wennerberg, C Vanpouille-Box, S Bornstein, T Yamazaki, S Demaria, L Galluzzi |
Immunological Reviews | 2017 |
|
Intestinal Epithelial Ecto-5′-Nucleotidase (CD73) Regulates Intestinal Colonization and Infection by Nontyphoidal Salmonella
DJ Kao, BJ Saeedi, D Kitzenberg, KM Burney, E Dobrinskikh, KD Battista, A Vázquez-Torres, SP Colgan, DJ Kominsky, B McCormick |
Infection and immunity | 2017 |
|
Characterization of ectonucleotidase expression in the rat carotid body: regulation by chronic hypoxia
S Salman, C Vollmer, GB McClelland, CA Nurse |
American journal of physiology. Cell physiology | 2017 |
|
Ecto-5′-nucleotidase (CD73) is a biomarker for clear cell renal carcinoma stem-like cells
L Song, W Ye, Y Cui, J Lu, Y Zhang, N Ding, W Hu, H Pei, Z Yue, G Zhou |
Oncotarget | 2017 |
|
Prognostic impact of CD73 and A2A adenosine receptor expression in non-small-cell lung cancer
Y Inoue, K Yoshimura, N Kurabe, T Kahyo, A Kawase, M Tanahashi, H Ogawa, N Inui, K Funai, K Shinmura, H Niwa, T Suda, H Sugimura |
Oncotarget | 2017 |
|
MicroRNA in gastrointestinal cell signalling
P Mishra, D Singh, L Ganju, B Kumar |
Inflammopharmacology | 2017 |
|
The hypoxia-adenosine link during inflammation
JL Bowser, JW Lee, X Yuan, HK Eltzschig |
Journal of applied physiology | 2017 |
|
Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?
Y Huang, D Lin, CM Taniguchi |
Science China Life Sciences | 2017 |
|
Targeting immunosuppressive adenosine in cancer
D Vijayan, A Young, MW Teng, MJ Smyth |
Nature Reviews Cancer | 2017 |
|
Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD
SV Welden, AC Selfridge, P Hindryckx |
Nature Reviews Gastroenterology & Hepatology | 2017 |
|
Loss of CD73-mediated extracellular adenosine production exacerbates inflammation and abnormal alveolar development in newborn mice exposed to prolonged hyperoxia.
Li H, Karmouty-Quintana H, Chen NY, Mills T, Molina J, Blackburn MR, Davies J |
Pediatric Research | 2017 |
|
The impact of hypoxia on tumor-associated macrophages (TAMs)
Anne-Theres Henze, Massimiliano Mazzone |
Journal of Clinical Investigation | 2016 |
|
Reducing Radiation-induced Gastrointestinal Toxicity – Role of the PHD/HIF axis
Monica Olcina, Amato Giaccia |
Journal of Clinical Investigation | 2016 |
|
The role of hypoxia in intestinal inflammation
YM Shah |
Molecular and Cellular Pediatrics | 2016 |
|
Hypoxia and Mucosal Inflammation
SP Colgan, EL Campbell, DJ Kominsky |
Annual review of pathology | 2016 |
|
Altered Hypoxic–Adenosine Axis and Metabolism in Group III Pulmonary Hypertension
LJ Garcia-Morales, NY Chen, T Weng, F Luo, J Davies, K Philip, KA Volcik, E Melicoff, J Amione-Guerra, RR Bunge, BA Bruckner, M Loebe, HK Eltzschig, LM Pandit, MR Blackburn, H Karmouty-Quintana |
American journal of respiratory cell and molecular biology | 2016 |
|
Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities
L Antonioli, GG Yegutkin, P Pacher, C Blandizzi, G Haskó |
Trends in Cancer | 2016 |
|
Neutrophils and the inflammatory tissue microenvironment in the mucosa
EL Campbell, DJ Kao, SP Colgan |
Immunological Reviews | 2016 |
|
Extracellular purines, purinergic receptors and tumor growth
FD Virgilio, E Adinolfi |
Oncogene | 2016 |
|
A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment
A Ohta |
Frontiers in immunology | 2016 |
|
The ever-expanding role of HIF in tumour and stromal biology
EL LaGory, AJ Giaccia |
Nature Cell Biology | 2016 |
|
Purinergic Signaling to Terminate TLR Responses in Macrophages
K Hamidzadeh, DM Mosser |
Frontiers in immunology | 2016 |
|
Tissue Metabolism and Host-Microbial Interactions in the Intestinal Mucosa
C Chun, L Zheng, SP Colgan |
Free radical biology & medicine | 2016 |
|
Hypoxia inducible factor-1α-induced interleukin-33 expression in intestinal epithelia contributes to mucosal homeostasis in inflammatory bowel disease: HIF-1α-dependent IL-33 in mucosal homeostasis
M Sun, C He, W Wu, G Zhou, F Liu, Y Cong, Z Liu |
Clinical & Experimental Immunology | 2016 |
|
SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73
D Pan, S Roy, P Gascard, J Zhao, C Chen-Tanyolac, TD Tlsty |
Cellular Signalling | 2016 |
|
Production of heterozygous alpha 1,3-galactosyltransferase (GGTA1) knock-out transgenic miniature pigs expressing human CD39
K Choi, J Shim, N Ko, H Eom, J Kim, JW Lee, DI Jin, H Kim |
Transgenic Research | 2016 |
|
The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome
L Pyfferoen, E Brabants, C Everaert, ND Cabooter, K Heyns, K Deswarte, M Vanheerswynghels, SD Prijck, G Waegemans, M Dullaers, H Hammad, OD Wever, P Mestdagh, J Vandesompele, BN Lambrecht, KY Vermaelen |
OncoImmunology | 2016 |
|
Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment
S Serra, T Vaisitti, V Audrito, C Bologna, R Buonincontri, SS Chen, F Arruga, D Brusa, M Coscia, O Jaksic, G Inghirami, D Rossi, RR Furman, SC Robson, G Gaidano, N Chiorazzi, S Deaglio |
Blood Advances | 2016 |
|
Prostaglandin E 2 -mediated adenosinergic effects on CD14 + cells: Self-amplifying immunosuppression in cancer
S Al-Taei, J Salimu, LK Spary, A Clayton, JF Lester, Z Tabi |
OncoImmunology | 2016 |
|
The G S Protein-coupled A2a Adenosine Receptor Controls T Cell Help in the Germinal Center
RK Abbott, M Silva, J Labuda, M Thayer, DW Cain, P Philbrook, S Sethumadhavan, S Hatfield, A Ohta, M Sitkovsky |
The Journal of biological chemistry | 2016 |
|
Loss of CD73-mediated actin polymerization promotes endometrial tumor progression
Jessica L. Bowser, Michael R. Blackburn, Gregory L. Shipley, Jose G. Molina, Kenneth Dunner Jr., Russell R. Broaddus |
Journal of Clinical Investigation | 2015 |
|
The role of hypoxia in inflammatory disease (Review)
J Biddlestone, D Bandarra, S Rocha |
International journal of molecular medicine | 2015 |
|
Hypoxia-Inducible Factor-2 Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury
J Zhang, C Han, H Dai, J Hou, Y Dong, X Cui, L Xu, M Zhang, Q Xia |
Journal of the American Society of Nephrology : JASN | 2015 |
|
Immunological mechanisms of the antitumor effects of supplemental oxygenation
SM Hatfield, J Kjaergaard, D Lukashev, TH Schreiber, B Belikoff, R Abbott, S Sethumadhavan, P Philbrook, K Ko, R Cannici, M Thayer, S Rodig, JL Kutok, EK Jackson, B Karger, ER Podack, A Ohta, MV Sitkovsky |
Science Translational Medicine | 2015 |
|
Variations in genes involved in immune response checkpoints and association with outcomes in patients with resected colorectal liver metastases
S Stremitzer, Y Sunakawa, W Zhang, D Yang, Y Ning, S Stintzing, A Sebio, S Yamauchi, S Matsusaka, R El-Khoueiry, J Stift, F Wrba, T Gruenberger, HJ Lenz |
The Pharmacogenomics Journal | 2015 |
|
Opiorphin-dependent upregulation of CD73 (a key enzyme in the adenosine signaling pathway) in corporal smooth muscle cells exposed to hypoxic conditions and in corporal tissue in pre-priapic sickle cell mice
S Fu, KP Davies |
International Journal of Impotence Research | 2015 |
|
Pathophysiological Role of Extracellular Purinergic Mediators in the Control of Intestinal Inflammation
Y Kurashima, H Kiyono, J Kunisawa |
Mediators of Inflammation | 2015 |
|
Neutrophils and inflammatory resolution in the mucosa
SP Colgan |
Seminars in Immunology | 2015 |
|
Oxygen sensing in intestinal mucosal inflammation
K Flück, J Fandrey |
Pflügers Archiv - European Journal of Physiology | 2015 |
|
Big opportunities for small molecules in immuno-oncology
JL Adams, J Smothers, R Srinivasan, A Hoos |
Nature Reviews Drug Discovery | 2015 |
|
Phenotypic switch of CD8 + T cells reactivated under hypoxia toward IL-10 secreting, poorly proliferative effector cells: Cellular immune response
R Vuillefroy de Silly, L Ducimetière, C Yacoub Maroun, PY Dietrich, M Derouazi, PR Walker |
European Journal of Immunology | 2015 |
|
Extracellular ATP Selectively Upregulates Ecto-Nucleoside Triphosphate Diphosphohydrolase 2 and Ecto-5′-Nucleotidase by Rat Cortical Astrocytes In Vitro
D Brisevac, M Adzic, D Laketa, A Parabucki, M Milosevic, I Lavrnja, I Bjelobaba, J Sévigny, M Kipp, N Nedeljkovic |
Journal of Molecular Neuroscience | 2015 |
|
Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma
Y Yu, W Wang, L Song, W Hu, C Dong, H Pei, G Zhou, Z Yue |
Oncology Letters | 2015 |
|
Pathogenesis of Crohn's disease
R Boyapati, J Satsangi, GT Ho |
F1000prime reports | 2015 |
|
Extracellular Adenosine Generation in the Regulation of Pro-Inflammatory Responses and Pathogen Colonization
M Alam, M Costales, C Cavanaugh, K Williams |
Biomolecules | 2015 |
|
HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity
BJ Saeedi, DJ Kao, DA Kitzenberg, E Dobrinskikh, KD Schwisow, JC Masterson, AA Kendrick, CJ Kelly, AJ Bayless, DJ Kominsky, EL Campbell, KA Kuhn, GT Furuta, SP Colgan, LE Glover |
Molecular biology of the cell | 2015 |
|
Physiologic Hypoxia and Oxygen Homeostasis in the Healthy Intestine
L Zheng, CJ Kelly, SP Colgan |
American journal of physiology. Cell physiology | 2015 |
|
Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa
EL Campbell, SP Colgan |
Journal of leukocyte biology | 2015 |
|
Isolation, selection and culture methods to enhance clonogenicity of mouse bone marrow derived mesenchymal stromal cell precursors
C Baustian, S Hanley, R Ceredig |
Stem Cell Research & Therapy | 2015 |
|
Ecto-5′-Nucleotidase (CD73) Deficiency in Mycobacterium tuberculosis-Infected Mice Enhances Neutrophil Recruitment
L Petit-Jentreau, G Jouvion, P Charles, L Majlessi, B Gicquel, L Tailleux, S Ehrt |
Infection and immunity | 2015 |
|
Gene expression and pathway analysis of human hepatocellular carcinoma cells treated with cadmium
L Cartularo, F Laulicht, H Sun, T Kluz, JH Freedman, M Costa |
Toxicology and Applied Pharmacology | 2015 |
|
CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer
MS Wettstein, L Buser, T Hermanns, F Roudnicky, D Eberli, P Baumeister, T Sulser, P Wild, C Poyet |
Disease Markers | 2015 |
|
Extracellular adenosine levels are associated with the progression and exacerbation of pulmonary fibrosis
F Luo, NB Le, T Mills, NY Chen, H Karmouty-Quintana, JG Molina, J Davies, K Philip, KA Volcik, H Liu, Y Xia, HK Eltzschig, MR Blackburn |
The FASEB Journal | 2015 |
|
Ecto-5'-nucleotidase CD73 modulates the innate immune response to influenza infection but is not required for development of influenza-induced acute lung injury
F Aeffner, PS Woods, IC Davis |
American journal of physiology. Lung cellular and molecular physiology | 2015 |
|
Beneficial and detrimental role of adenosine signaling in diseases and therapy
H Liu, Y Xia |
Journal of applied physiology | 2015 |
|
Molecular Mechanisms of Ischemic Preconditioning in the Kidney
PP Kapitsinou, VH Haase |
American journal of physiology. Renal physiology | 2015 |
|
Hypoxia signaling during acute lung injury
CU Vohwinkel, S Hoegl, HK Eltzschig |
Journal of applied physiology | 2015 |
|
Targeting Hypoxia in Inflammatory Bowel Disease:
SP Colgan |
Journal of Investigative Medicine | 2015 |
|
Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
M Schneider, JM Harnoss, MJ Strowitzki, P Radhakrishnan, L Platzer, JC Harnoss, T Hank, J Cai, A Ulrich |
Hypoxia | 2015 |
|
Interrelated Roles for the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor-1α in the Immune Response to Infection
Wagage S, Hunter CA |
Current medicinal chemistry | 2015 |
|
Extracellular nucleotide and nucleoside signaling in vascular and blood disease
M Idzko, D Ferrari, AK Riegel, HK Eltzschig |
Blood | 2014 |
|
Potential for Developing Purinergic Drugs for Gastrointestinal Diseases:
F Ochoa-Cortes, A Liñán-Rico, KA Jacobson, FL Christofi |
Inflammatory Bowel Diseases | 2014 |
|
Extracellular adenosine controls NKT-cell-dependent hepatitis induction: Immunomodulation
M Subramanian, R Kini, M Madasu, A Ohta, M Nowak, M Exley, M Sitkovsky, A Ohta |
European Journal of Immunology | 2014 |
|
Treatment with a Rho Kinase Inhibitor Improves Survival from Graft-Versus-Host Disease in Mice after MHC-Haploidentical Hematopoietic Cell Transplantation
S Iyengar, C Zhan, J Lu, R Korngold, DH Schwartz |
Biology of Blood and Marrow Transplantation | 2014 |
|
Ecto-5'-nucleotidase (CD73) regulates host inflammatory responses and exacerbates murine salmonellosis
MS Alam, JL Kuo, PB Ernst, V Derr-Castillo, M Pereira, D Gaines, M Costales, E Bigley, K Williams |
Scientific Reports | 2014 |
|
Extracellular adenosine-mediated modulation of regulatory T cells
A Ohta, M Sitkovsky |
Frontiers in immunology | 2014 |
|
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection
SM Hatfield, J Kjaergaard, D Lukashev, B Belikoff, TH Schreiber, S Sethumadhavan, R Abbott, P Philbrook, M Thayer, D Shujia, S Rodig, JL Kutok, J Ren, A Ohta, ER Podack, B Karger, EK Jackson, M Sitkovsky |
Journal of Molecular Medicine | 2014 |
|
Metabolic regulation of intestinal epithelial barrier during inflammation
SP Colgan, VF Curtis, JM Lanis, LE Glover |
Tissue Barriers | 2014 |
|
Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases
HK Eltzschig, DL Bratton, SP Colgan |
Nature Reviews Drug Discovery | 2014 |
|
Adenosine promotes vascular barrier function in hyperoxic lung injury
J Davies, H Karmouty-Quintana, TT Le, NY Chen, T Weng, F Luo, J Molina, B Moorthy, MR Blackburn |
Physiological Reports | 2014 |
|
CD117 Expression in Fibroblasts-Like Stromal Cells Indicates Unfavorable Clinical Outcomes in Ovarian Carcinoma Patients
R Huang, D Wu, Y Yuan, X Li, R Holm, CG Trope, JM Nesland, Z Suo, JW Lee |
PloS one | 2014 |
|
Hypoxia-Inducible Factor/MAZ-Dependent Induction of Caveolin-1 Regulates Colon Permeability through Suppression of Occludin, Leading to Hypoxia-Induced Inflammation
L Xie, X Xue, M Taylor, SK Ramakrishnan, K Nagaoka, C Hao, FJ Gonzalez, YM Shah |
Molecular and cellular biology | 2014 |
|
Reducing CD73 Expression by IL1 -Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors
S Chatterjee, K Thyagarajan, P Kesarwani, JH Song, M Soloshchenko, J Fu, SR Bailey, C Vasu, AS Kraft, CM Paulos, XZ Yu, S Mehrotra |
Cancer research | 2014 |
|
Hostile, Hypoxia-A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists
MV Sitkovsky, S Hatfield, R Abbott, B Belikoff, D Lukashev, A Ohta |
Cancer immunology research | 2014 |
|
Activation of HIF-1 does not increase intestinal tumorigenesis
X Xue, SK Ramakrishnan, YM Shah |
AJP Gastrointestinal and Liver Physiology | 2014 |
|
Gene Expression Markers of Efficacy and Resistance to Cetuximab Treatment in Metastatic Colorectal Cancer: Results from CALGB 80203 (Alliance)
SM Cushman, C Jiang, AJ Hatch, I Shterev, AB Sibley, D Niedzwiecki, AP Venook, K Owzar, HI Hurwitz, AB Nixon |
Clinical cancer research | 2014 |
|
CD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence
LJ Conter, E Song, MJ Shlomchik, MM Tomayko, Y Richard |
PloS one | 2014 |
|
Purinergic Signaling on Leukocytes Infiltrating the LPS-Injured Lung
D Friebe, T Yang, T Schmidt, N Borg, B Steckel, Z Ding, J Schrader, T Eckle |
PloS one | 2014 |
|
IFN-γ-Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia
DJ Kominsky, EL Campbell, SF Ehrentraut, KE Wilson, CJ Kelly, LE Glover, CB Collins, AJ Bayless, B Saeedi, E Dobrinskikh, BE Bowers, CF Macmanus, W Müller, SP Colgan, D Bruder |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
|
Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liver
MA Zimmerman, A Grenz, E Tak, M Kaplan, D Ridyard, KS Brodsky, MS Mandell, I Kam, HK Eltzschig |
Proceedings of the National Academy of Sciences | 2013 |
|
Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease
T Weng, H Karmouty-Quintana, LJ Garcia-Morales, JG Molina, M Pedroza, RR Bunge, BA Bruckner, M Loebe, H Seethamraju, MR Blackburn |
The FASEB Journal | 2013 |
|
Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia
M Cui, X Bai, T Li, F Chen, Q Dong, Y Zhao, X Liu |
PloS one | 2013 |
|
Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation
BJ Goggins, C Chaney, GL Radford-Smith, JC Horvat, S Keely |
Frontiers in immunology | 2013 |
|
CD73-Dependent Generation of Adenosine and Endothelial Adora2b Signaling Attenuate Diabetic Nephropathy
E Tak, D Ridyard, JH Kim, M Zimmerman, T Werner, XX Wang, U Shabeka, SW Seo, U Christians, J Klawitter, R Moldovan, G Garcia, M Levi, V Haase, K Ravid, HK Eltzschig, A Grenz |
Journal of the American Society of Nephrology : JASN | 2013 |
|
Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states
MS Longhi, SC Robson, SH Bernstein, S Serra, S Deaglio |
Journal of Molecular Medicine | 2013 |
|
Adenosine signaling during acute and chronic disease states
H Karmouty-Quintana, Y Xia, MR Blackburn |
Journal of Molecular Medicine | 2013 |
|
Attenuating myocardial ischemia by targeting A2B adenosine receptors
HK Eltzschig, SK Bonney, T Eckle |
Trends in Molecular Medicine | 2013 |
|
Detecting adenosine triphosphate in the pericellular space
S Falzoni, G Donvito, FD Virgilio |
Interface Focus | 2013 |
|
Hypoxia inducible factor pathway inhibitors as anticancer therapeutics
SK Burroughs, S Kaluz, D Wang, K Wang, EG van Meir, B Wang |
Future Medicinal Chemistry | 2013 |
|
Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis
S Keely, EL Campbell, AW Baird, PM Hansbro, RA Shalwitz, A Kotsakis, EN McNamee, HK Eltzschig, DJ Kominsky, SP Colgan |
Mucosal Immunology | 2013 |
|
Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas
S Xu, QQ Shao, JT Sun, N Yang, Q Xie, DH Wang, QB Huang, B Huang, XY Wang, XG Li, X Qu |
Neuro-Oncology | 2013 |
|
Biological Implications of Extracellular Adenosine in Hepatic Ischemia and Reperfusion Injury: Extracellular Adenosine in Hepatic Ischemia
MA Zimmerman, I Kam, H Eltzschig, A Grenz |
American Journal of Transplantation | 2013 |
|
Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice
X Xue, S Ramakrishnan, E Anderson, M Taylor, EM Zimmermann, JR Spence, S Huang, JK Greenson, YM Shah |
Gastroenterology | 2013 |
|
The Inflammatory Tissue Microenvironment in IBD:
SP Colgan, VF Curtis, EL Campbell |
Inflammatory Bowel Diseases | 2013 |
|
Intestinal Mast Cells Mediate Gut Injury and Systemic Inflammation in a Rat Model of Deep Hypothermic Circulatory Arrest*:
J Karhausen, M Qing, A Gibson, AJ Moeser, H Griefingholt, LP Hale, SN Abraham, GB Mackensen |
Critical Care Medicine | 2013 |
|
Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance
M Perez-Aso, A Mediero, BN Cronstein |
Purinergic Signalling | 2013 |
|
Protective role for netrin-1 during diabetic nephropathy
E Tak, D Ridyard, A Badulak, A Giebler, U Shabeka, T Werner, E Clambey, R Moldovan, MA Zimmerman, HK Eltzschig, A Grenz |
Journal of Molecular Medicine | 2013 |
|
Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion: Hepatology, Vol. 00, No. X, 2013 Zimmerman, Tak, et al
MA Zimmerman, E Tak, SF Ehrentraut, M Kaplan, A Giebler, T Weng, DS Choi, MR Blackburn, I Kam, HK Eltzschig, A Grenz |
Hepatology | 2013 |
|
The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury
M Kim, A Ham, JY Kim, KM Brown, VD D'Agati, HT Lee |
Kidney international. Supplement | 2013 |
|
Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible
A Ohta, M Madasu, M Subramanian, R Kini, G Jones, A Chouker, A Ohta, M Sitkovsky |
International Immunology | 2013 |
|
Netrin-1 guides inflammatory cell migration to control mucosal immune responses during intestinal inflammation
CM Aherne, CB Collins, HK Eltzschig |
Tissue Barriers | 2013 |
|
The Critical Role of the Tumor Microenvironment in Shaping Natural Killer Cell-Mediated Anti-Tumor Immunity
J Baginska, E Viry, J Paggetti, S Medves, G Berchem, E Moussay, B Janji |
Frontiers in immunology | 2013 |
|
Role of extracellular ATP and P2 receptor signaling in regulating renal cyst growth and interstitial inflammation in polycystic kidney disease
G Rangan |
Frontiers in physiology | 2013 |
|
Expression and clinical significance of CD73 and hypoxia-inducible factor-1α in gastric carcinoma
XX Lu, YT Chen, B Feng, XB Mao, B Yu, XY Chu |
World journal of gastroenterology : WJG | 2013 |
|
Adenosine receptors as drug targets--what are the challenges?
JF Chen, HK Eltzschig, BB Fredholm |
Nature Reviews Drug Discovery | 2013 |
|
Contributions of neutrophils to resolution of mucosal inflammation
SP Colgan, SF Ehrentraut, LE Glover, DJ Kominsky, EL Campbell |
Immunologic Research | 2013 |
|
Adenosine A(2A) receptors promote collagen production by a Fli1- and CTGF-mediated mechanism
ES Chan, H Liu, P Fernandez, A Luna, M Perez-Aso, AM Bujor, M Trojanowska, BN Cronstein |
Arthritis Research & Therapy | 2013 |
|
Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus
R Shechter, O Miller, G Yovel, N Rosenzweig, A London, J Ruckh, KW Kim, E Klein, V Kalchenko, P Bendel, SA Lira, S Jung, M Schwartz |
Immunity | 2013 |
|
TLR9 Deficiency Promotes CD73 Expression in T Cells and Diabetes Protection in Nonobese Diabetic Mice
N Tai, FS Wong, L Wen |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
|
Targeting Purinergic Signaling for Perioperative Organ Protection:
HK Eltzschig |
Anesthesiology | 2013 |
|
Isolation and Characterization of Novel, Highly Proliferative Human CD34/CD73-Double-Positive Testis-Derived Stem Cells for Cell Therapy
WY Choi, HG Jeon, Y Chung, JJ Lim, DH Shin, JM Kim, BS Ki, SH Song, SJ Choi, KH Park, SH Shim, J Moon, SJ Jung, HM Kang, S Park, HM Chung, JJ Ko, KY Cha, TK Yoon, H Kim, DR Lee |
Stem Cells and Development | 2013 |
|
CD39 and CD73 in immunity and inflammation
L Antonioli, P Pacher, ES Vizi, G Haskó |
Trends in Molecular Medicine | 2013 |
|
HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium
T Eckle, K Brodsky, M Bonney, T Packard, J Han, CH Borchers, TJ Mariani, DJ Kominsky, M Mittelbronn, HK Eltzschig, AJ Vidal-Puig |
PLoS Biology | 2013 |
|
The Stimulatory Adenosine Receptor ADORA2B Regulates Serotonin (5-HT) Synthesis and Release in Oxygen-Depleted EC Cells in Inflammatory Bowel Disease
R Damen, M Haugen, B Svejda, D Alaimo, O Brenna, R Pfragner, BI Gustafsson, M Kidd, J Karhausen |
PloS one | 2013 |
|
Ensemble of Gene Signatures Identifies Novel Biomarkers in Colorectal Cancer Activated through PPARγ and TNFα Signaling
SM Pagnotta, C Laudanna, M Pancione, L Sabatino, C Votino, A Remo, L Cerulo, P Zoppoli, E Manfrin, V Colantuoni, M Ceccarelli, AW Lo |
PloS one | 2013 |
|
CD73 + regulatory T cells contribute to adenosine-mediated resolution of acute lung injury
H Ehrentraut, ET Clambey, EN McNamee, KS Brodsky, SF Ehrentraut, JM Poth, AK Riegel, JA Westrich, SP Colgan, HK Eltzschig |
The FASEB Journal | 2013 |
|
Equilibrative nucleoside transporter ENT1 regulates post-ischemic blood-flow during acute kidney injury in mice
Almut Grenz, Jessica Bauerle, Julee Dalton, Douglas Ridyard, Alexander Badulak, Eunyoung Tak, Eoin Mcnamee, Eric Clambey, Radu Moldovan, German Reyes, Jost Klawitter, Kelly Ambler, Kristann Magee, Uwe Christians, Kelley Brodsky, Katya Ravid, Doo-Sup Choi, Jiaming Wen, Dimitriy Lukashev, Michael Blackburn, Hartmut Osswald, Imogen Coe, Bernd Nürnberg, Volker H. Haase, Yang Xia, Michail Sitkovsky, Holger Eltzschig |
Journal of Clinical Investigation | 2012 |
|
Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury
M Koeppen, EN McNamee, KS Brodsky, CM Aherne, M Faigle, GP Downey, SP Colgan, CM Evans, DA Schwartz, HK Eltzschig |
Mucosal Immunology | 2012 |
|
Regulation of Lymphocyte Function by Adenosine
J Linden, C Cekic |
Arteriosclerosis, thrombosis, and vascular biology | 2012 |
|
Purinergic Signaling during Inflammation
HK Eltzschig, MV Sitkovsky, SC Robson |
New England Journal of Medicine | 2012 |
|
Hypoxia signaling during intestinal ischemia and inflammation:
A Grenz, E Clambey, HK Eltzschig |
Current Opinion in Critical Care | 2012 |
|
Tissue-Resident Ecto-5′ Nucleotidase (CD73) Regulates Leukocyte Trafficking in the Ischemic Brain
D Petrovic-Djergovic, MC Hyman, JJ Ray, D Bouis, SH Visovatti, T Hayasaki, DJ Pinsky |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
|
The CD39-adenosinergic axis in the pathogenesis of renal ischemia-reperfusion injury
V Roberts, B Lu, S Rajakumar, PJ Cowan, KM Dwyer |
Purinergic Signalling | 2012 |
|
The CD39-adenosinergic axis in the pathogenesis of immune and nonimmune diabetes
JS Chia, JL McRae, PJ Cowan, KM Dwyer |
Journal of Biomedicine and Biotechnology | 2012 |
|
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
K Sarkar, Z Cai, R Gupta, N Parajuli, K Fox-Talbot, MS Darshan, FJ Gonzalez, GL Semenza |
Proceedings of the National Academy of Sciences | 2012 |
|
Hypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity
Y Badawi, P Ramamoorthy, H Shi |
ASN NEURO | 2012 |
|
Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease
JM Poth, K Brodsky, H Ehrentraut, A Grenz, HK Eltzschig |
Journal of Molecular Medicine | 2012 |
|
Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2
NR Prabhakar, GL Semenza |
Physiological reviews | 2012 |
|
Production of adenosine by ectonucleotidases: a key factor in tumor immunoescape
F Ghiringhelli, M Bruchard, F Chalmin, C Rébé |
Journal of Biomedicine and Biotechnology | 2012 |
|
CD73-generated adenosine promotes osteoblast differentiation
M Takedachi, H Oohara, BJ Smith, M Iyama, M Kobashi, K Maeda, CL Long, MB Humphrey, BJ Stoecker, S Toyosawa, LF Thompson, S Murakami |
Journal of Cellular Physiology | 2012 |
|
Sustained adenosine exposure causes lung endothelial barrier dysfunction via nucleoside transporter-mediated signaling
Q Lu, J Newton, V Hsiao, P Shamirian, MR Blackburn, M Pedroza |
American journal of respiratory cell and molecular biology | 2012 |
|
Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine
T Kusu, H Kayama, M Kinoshita, SG Jeon, Y Ueda, Y Goto, R Okumura, H Saiga, T Kurakawa, K Ikeda, Y Maeda, J Nishimura, Y Arima, K Atarashi, K Honda, M Murakami, J Kunisawa, H Kiyono, M Okumura, M Yamamoto, K Takeda |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
|
Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response
SF Ehrentraut, DJ Kominsky, LE Glover, EL Campbell, CJ Kelly, BE Bowers, AJ Bayless, SP Colgan |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
|
CD73-generated adenosine: orchestrating the tumor-stroma interplay to promote cancer growth
B Allard, M Turcotte, J Stagg |
Journal of Biomedicine and Biotechnology | 2012 |
|
CD73 is critical for the resolution of murine colonic inflammation
MS Bynoe, AT Waickman, DA Mahamed, C Mueller, JH Mills, A Czopik |
Journal of Biomedicine and Biotechnology | 2012 |
|
Adenosine-5'-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets
JA Rathmacher, JC Fuller, SM Baier, NN Abumrad, HF Angus, RL Sharp |
Journal of the International Society of Sports Nutrition | 2012 |
|
Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release
N Hatano, Y Itoh, H Suzuki, Y Muraki, H Hayashi, K Onozaki, IC Wood, DJ Beech, K Muraki |
The Journal of biological chemistry | 2012 |
|
Implications of protein post-translational modifications in IBD
SF Ehrentraut, SP Colgan |
Inflammatory Bowel Diseases | 2012 |
|
Targeting Hypoxia to Augment Mucosal Barrier Function
CJ Kelly |
Journal of Epithelial Biology and Pharmacology | 2012 |
|
Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration: Immunomodulation
T Köhler, B Reizis, RS Johnson, H Weighardt, I Förster |
European Journal of Immunology | 2012 |
|
An Endogenously Anti-Inflammatory Role for Methylation in Mucosal Inflammation Identified through Metabolite Profiling
DJ Kominsky, S Keely, CF MacManus, LE Glover, M Scully, CB Collins, BE Bowers, EL Campbell, SP Colgan |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
|
Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery
SP Colgan, HK Eltzschig |
Annual Review of Physiology | 2011 |
|
Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia
A Grenz, D Homann, HK Eltzschig |
Antioxidants & Redox Signaling | 2011 |
|
Ecto-5′-Nucleotidase (CD73) Decreases Mortality and Organ Injury in Sepsis
G Haskó, B Csóka, B Koscsó, R Chandra, P Pacher, LF Thompson, EA Deitch, Z Spolarics, L Virág, P Gergely, RH Rolandelli, ZH Németh |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
|
Purinergic Regulation of Respiratory Diseases
M Picher, RC Boucher |
2011 | |
|
Emerging role of extracellular nucleotides and adenosine in multiple sclerosis
M Cieślak, F Kukulski, M Komoszyński |
Purinergic Signalling | 2011 |
|
Interactions between Nitric Oxide and Hypoxia-Inducible Factor Signaling Pathways in Inflammatory Disease
N Olson, A der Vliet |
Nitric Oxide | 2011 |
|
The Hypoxia-Inflammation Link and Potential Drug Targets
M Koeppen, T Eckle, HK Eltzschig |
Current Opinion in Anaesthesiology | 2011 |
|
Use of a Hanging Weight System for Coronary Artery Occlusion in Mice
T Eckle, M Koeppen, H Eltzschig |
Journal of visualized experiments : JoVE | 2011 |
|
Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation
AK Riegel, M Faigle, S Zug, P Rosenberger, B Robaye, JM Boeynaems, M Idzko, HK Eltzschig |
Blood | 2011 |
|
Hypoxia and Metabolic Factors that Influence IBD Pathogenesis
LE Glover, SP Colgan |
Gastroenterology | 2011 |
|
Vasodilator Phosphostimulated Protein (VASP) Protects Endothelial Barrier Function During Hypoxia
MA Schmit, V Mirakaj, M Stangassinger, K König, D Köhler, P Rosenberger |
Inflammation | 2011 |
|
IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β
LE Glover, K Irizarry, M Scully, EL Campbell, BE Bowers, CM Aherne, DJ Kominsky, CF MacManus, SP Colgan |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
|
Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury
Y Wang, I Kirpich, Y Liu, Z Ma, S Barve, CJ McClain, W Feng |
The American Journal of Pathology | 2011 |
|
Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction
N Olson, M Hristova, NH Heintz, KM Lounsbury, A der Vliet |
American journal of physiology. Lung cellular and molecular physiology | 2011 |
|
Hypoxia-Inducible Factor-1α–Dependent Protection from Intestinal Ischemia/Reperfusion Injury Involves Ecto-5′-Nucleotidase (CD73) and the A2B Adenosine Receptor
ML Hart, A Grenz, IC Gorzolla, J Schittenhelm, JH Dalton, HK Eltzschig |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
|
Hypoxia and Inflammation
HK Eltzschig, P Carmeliet |
New England Journal of Medicine | 2011 |
|
Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning
GL Semenza |
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2011 |
|
Adenosine Negative Feedback on A2A Adenosine Receptors Mediates Hyporesponsiveness in Chronically Septic Mice:
B Belikoff, S Hatfield, M Sitkovsky, DG Remick |
Shock | 2011 |
|
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity
SF Häusler, IM Barrio, J Strohschein, PA Chandran, JB Engel, A Hönig, M Ossadnik, E Horn, B Fischer, M Krockenberger, S Heuer, AA Seida, M Junker, H Kneitz, D Kloor, KN Klotz, J Dietl, J Wischhusen |
Cancer Immunology, Immunotherapy | 2011 |
|
Hypoxia promotes growth of stem cells in dental follicle cell populations
Y Dai, H He, GE Wise, S Yao |
Journal of Biomedical Science and Engineering | 2011 |
|
Partial Netrin-1 Deficiency Aggravates Acute Kidney Injury
A Grenz, JH Dalton, JD Bauerle, A Badulak, D Ridyard, A Gandjeva, CM Aherne, KS Brodsky, JH Kim, RM Tuder, HK Eltzschig, L Tailleux |
PloS one | 2011 |
|
Induction of Glutathione Peroxidase 4 Expression during Enterocytic Cell Differentiation
B Speckmann, HJ Bidmon, A Pinto, M Anlauf, H Sies, H Steinbrenner |
The Journal of biological chemistry | 2011 |
|
Role of adenosine A2B receptors in inflammation
Feoktistov I, Biaggioni I |
Advances in pharmacology (San Diego, Calif.) | 2011 |
|
Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity.
Deaglio S, Robson SC |
Advances in pharmacology (San Diego, Calif.) | 2011 |
|
Hypoxia: an alarm signal during intestinal inflammation
SP Colgan, CT Taylor |
Nature Reviews Gastroenterology & Hepatology | 2010 |
|
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
J Stagg, U Divisekera, N McLaughlin, J Sharkey, S Pommey, D Denoyer, KM Dwyer, MJ Smyth |
Proceedings of the National Academy of Sciences | 2010 |
|
Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3
M Fausther, J Pelletier, CM Ribeiro, J Sévigny, M Picher |
American journal of physiology. Lung cellular and molecular physiology | 2010 |
|
Hypoxia-driven immunosuppression: a new reason to use thermal therapy in the treatment of cancer?
CT Lee, T Mace, EA Repasky |
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group | 2010 |
|
SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning
ML Hart, IC Gorzolla, J Schittenhelm, SC Robson, HK Eltzschig |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
|
Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits
NA Sowa, B Taylor-Blake, MJ Zylka |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2010 |
|
The resurgence of A2B adenosine receptor signaling
CM Aherne, EM Kewley, HK Eltzschig |
Biochimica et Biophysica Acta | 2010 |
|
Deficiency or Inhibition of CD73 Protects in Mild Kidney Ischemia-Reperfusion Injury:
SV Rajakumar, B Lu, S Crikis, SC Robson, AJ dʼApice, PJ Cowan, KM Dwyer |
Transplantation | 2010 |
|
Hypoxia-inducible Factor-dependent Regulation of Platelet-activating Factor Receptor as a Route for Gram-Positive Bacterial Translocation across Epithelia
S Keely, LE Glover, T Weissmueller, CF MacManus, S Fillon, B Fennimore, SP Colgan, A Nusrat |
Molecular biology of the cell | 2010 |
|
CD73: A Novel Target for Cancer Immunotherapy: Figure 1
B Zhang |
Cancer research | 2010 |
|
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
|
The Janus-faced effects of hypoxia on astrocyte function
G Vangeison, DA Rempe |
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry | 2009 |
|
Adenosine: An Old Drug Newly Discovered
HK Eltzschig |
Anesthesiology | 2009 |
|
A2B adenosine receptors in immunity and inflammation
G Haskó, B Csóka, ZH Németh, ES Vizi, P Pacher |
Trends in Immunology | 2009 |
|
Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium
W Zheng, J Kuhlicke, K Jäckel, HK Eltzschig, A Singh, M Sjöblom, B Riederer, C Weinhold, U Seidler, SP Colgan, J Karhausen |
The FASEB Journal | 2009 |
|
Selective induction of integrin β1 by hypoxia-inducible factor: implications for wound healing
S Keely, LE Glover, CF MacManus, EL Campbell, MM Scully, GT Furuta, SP Colgan |
The FASEB Journal | 2009 |
|
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
P Fraisl, J Aragonés, P Carmeliet |
Nature Reviews Drug Discovery | 2009 |
|
Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia
P Rosenberger, JM Schwab, V Mirakaj, E Masekowsky, A Mager, JC Morote-Garcia, K Unertl, HK Eltzschig |
Nature Immunology | 2009 |
|
Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling
C Linnemann, FA Schildberg, A Schurich, L Diehl, SI Hegenbarth, E Endl, S Lacher, CE Müller, J Frey, L Simeoni, B Schraven, D Stabenow, PA Knolle |
Immunology | 2009 |
|
Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation
Q Liu, J Li, J Khoury, SP Colgan, JC Ibla |
The Journal of biological chemistry | 2009 |
|
Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development
M Katebi, M Soleimani, BN Cronstein |
Journal of leukocyte biology | 2009 |
|
Morphological and immunocytochemical characteristics indicate the yield of early progenitors and represent a quality control for human mesenchymal stem cell culturing
F Haasters, WC Prall, D Anz, C Bourquin, C Pautke, S Endres, W Mutschler, D Docheva, M Schieker |
Journal of Anatomy | 2009 |
|
Feedback effects of host-derived adenosine on enteropathogenic Escherichia coli
JK Crane, I Shulgina |
FEMS Immunology and Medical Microbiology | 2009 |
|
Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation
HK Eltzschig, J Rivera-Nieves, SP Colgan |
Expert Opinion on Therapeutic Targets | 2009 |
|
Contribution of Adenosine A2B Receptors to Inflammatory Parameters of Experimental Colitis
JS Frick, CF MacManus, M Scully, LE Glover, HK Eltzschig, SP Colgan |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
|
A2B adenosine receptor attenuates ventilator induced lung injury by enhancing alveolar fluid clearance
Tobias Eckle, Almut Grenz, Stefanie Laucher, and Holger K. Eltzschig |
Journal of Clinical Investigation | 2008 |
|
Neutrophil-facilitated platelet translocation identifies functional expression of epithelial ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) activity
Thomas Weissmuller, Peter Rosenberger, Eric L. Campbell, Melanie Scully, Paul L. Beck, Glenn T. Furuta and Sean P. Colgan |
Journal of Clinical Investigation | 2008 |
|
Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade
YM Shah, S Ito, K Morimura, C Chen, SH Yim, VH Haase, FJ Gonzalez |
Gastroenterology | 2008 |
|
Neutrophils as Sources of Extracellular Nucleotides: Functional Consequences at the Vascular Interface
HK Eltzschig, CF Macmanus, SP Colgan |
Trends in Cardiovascular Medicine | 2008 |
|
Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury
ML Hart, M Henn, D Köhler, D Kloor, M Mittelbronn, IC Gorzolla, GL Stahl, HK Eltzschig |
The FASEB Journal | 2008 |
|
Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection
HA Haeberle, C Dürrstein, P Rosenberger, YM Hosakote, J Kuhlicke, VA Kempf, RP Garofalo, HK Eltzschig |
PloS one | 2008 |
|
Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells
M Sitkovsky, D Lukashev, S Deaglio, K Dwyer, SC Robson, A Ohta |
British Journal of Pharmacology | 2008 |
|
Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition
A Robinson, S Keely, J Karhausen, ME Gerich, GT Furuta, SP Colgan |
Gastroenterology | 2008 |
|
Anti-Inflammatory Adaptation to Hypoxia through Adenosine-Mediated Cullin-1 Deneddylation
Joseph Khoury, and Juan C. Ibla, Andrew S. Neish, Sean P. Colgan |
Journal of Clinical Investigation | 2007 |
|
Ecto-5′-nucleotidase and intestinal ion secretion by enteropathogenic Escherichia coli
JK Crane, I Shulgina, TM Naeher |
Purinergic Signalling | 2007 |
|
Hypoxia and gastrointestinal disease
CT Taylor, SP Colgan |
Journal of Molecular Medicine | 2007 |
|
From ‘Hellstrom Paradox–to anti-adenosinergic cancer immunotherapy
D Lukashev, M Sitkovsky, A Ohta |
Purinergic Signalling | 2007 |
|
Identification of vasodilator-stimulated phosphoprotein (VASP) as an HIF-regulated tissue permeability factor during hypoxia
P Rosenberger, J Khoury, T Kong, T Weissmüller, AM Robinson, SP Colgan |
The FASEB Journal | 2007 |
|
Effect of Zinc in Enteropathogenic Escherichia coli Infection
JK Crane, TM Naeher, I Shulgina, C Zhu, EC Boedeker |
Infection and immunity | 2007 |
|
Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26
HK Eltzschig, M Faigle, S Knapp, J Karhausen, J Ibla, P Rosenberger, KC Odegard, PC Laussen, LF Thompson, SP Colgan |
Blood | 2006 |
|
Physiological roles for ecto-5'-nucleotidase (CD73)
SP Colgan, HK Eltzschig, T Eckle, LF Thompson |
Purinergic Signalling | 2006 |
|
Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa
NJ Patel, O Zaborina, L Wu, Y Wang, DJ Wolfgeher, V Valuckaite, MJ Ciancio, JE Kohler, O Shevchenko, SP Colgan, EB Chang, JR Turner, JC Alverdy |
American journal of physiology. Gastrointestinal and liver physiology | 2006 |
|
Modulation of purinergic signaling by NPP-type ectophosphodiesterases
C Stefan, S Jansen, M Bollen |
Purinergic Signalling | 2006 |
|
Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility
SP Hogan, L Seidu, C Blanchard, K Groschwitz, A Mishra, ML Karow, R Ahrens, D Artis, AJ Murphy, DM Valenzuela, GD Yancopoulos, ME Rothenberg |
Journal of Allergy and Clinical Immunology | 2006 |
|
Invited Lectures: Overviews Purinergic signalling: past, present and future
|
Purinergic Signalling | 2006 |
|
HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia
HK Eltzschig, P Abdulla, E Hoffman, KE Hamilton, D Daniels, C Schönfeld, M Löffler, G Reyes, M Duszenko, J Karhausen, A Robinson, KA Westerman, IR Coe, SP Colgan |
Journal of Experimental Medicine | 2005 |
|
Dynamic purine signaling and metabolism during neutrophil-endothelial interactions
T Weissmuller, HK Eltzschig, SP Colgan |
Purinergic Signalling | 2005 |
|
Epithelial hypoxia inducible factor-1 (HIF-1) is protective in murine experimental colitis
Jörn Karhausen, Glenn T. Furuta, John E. Tomaszewski, Randall S. Johnson, Sean P. Colgan and Volker H. Haase |
Journal of Clinical Investigation | 2004 |
|
Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia
LF Thompson, HK Eltzschig, JC Ibla, CJ van de Wiele, R Resta, JC Morote-Garcia, SP Colgan |
Journal of Experimental Medicine | 2004 |
|
Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression
T Kong, HK Eltzschig, J Karhausen, SP Colgan, CS Shelley |
Proceedings of the National Academy of Sciences | 2004 |
|
Coordinated Adenine Nucleotide Phosphohydrolysis and Nucleoside Signaling in Posthypoxic Endothelium: Role of Ectonucleotidases and Adenosine A 2B Receptors
HK Eltzschig, JC Ibla, GT Furuta, MO Leonard, KA Jacobson, K Enjyoji, SC Robson, SP Colgan |
Journal of Experimental Medicine | 2003 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)