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Citations to this article

Mucus clearance as a primary innate defense mechanism for mammalian airways
Michael R. Knowles, Richard C. Boucher
Michael R. Knowles, Richard C. Boucher
Published March 1, 2002
Citation Information: J Clin Invest. 2002;109(5):571-577. https://doi.org/10.1172/JCI15217.
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Mucus clearance as a primary innate defense mechanism for mammalian airways

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Authors

Michael R. Knowles, Richard C. Boucher

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Total
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Pharmaceutics 2021
The role of Psl in the failure to eradicate Pseudomonas aeruginosa biofilms in children with cystic fibrosis
AJ Morris, L Jackson, YC Yau, C Reichhardt, T Beaudoin, S Uwumarenogie, KM Guttman, PL Howell, MR Parsek, LR Hoffman, D Nguyen, A DiGiandomenico, DS Guttman, DJ Wozniak, VJ Waters
npj Biofilms and Microbiomes 2021
Mukoziliäre Clearance bei COVID-19-Erkrankungen: Ein unterschätztes Gefahrengebiet in der Frühphase?
T Wittig
MMW - Fortschritte der Medizin 2021
Hyperinflammation and airway surface liquid dehydration in cystic fibrosis: purinergic system as therapeutic target
TI do Carmo, VE Soares, J Wruck, F dos Anjos, DT de Resende e Silva, SF de Oliveira Maciel, MD Bagatini
Inflammation Research 2021
Airway Basal Cells, Protectors of Epithelial Walls in Health and Respiratory Diseases
E Ruysseveldt, K Martens, B Steelant
2021
Proteases, Mucus, and Mucosal Immunity in Chronic Lung Disease
MC McKelvey, R Brown, S Ryan, MA Mall, S Weldon, CC Taggart
International journal of molecular sciences 2021
Molecular dynamics simulations to explore the structure and rheological properties of normal and hyperconcentrated airway mucus
A Ford, X Cao, M Papanikolas, T Kato, R Boucher, M Markovetz, D Hill, R Freeman, M Forest
Studies in Applied Mathematics 2021
Major Determinants of Airway Epithelial Cell Sensitivity to S. aureus Alpha-Toxin: Disposal of Toxin Heptamers by Extracellular Vesicle Formation and Lysosomal Degradation
N Möller, S Ziesemer, C Hentschker, U Völker, JP Hildebrandt
Toxins 2021
An Adverse Outcome Pathway for Decreased Lung Function Focusing on Mechanisms of Impaired Mucociliary Clearance Following Inhalation Exposure
K Luettich, M Sharma, H Yepiskoposyan, D Breheny, F Lowe
2021
The MUC5B Promoter Polymorphism Associates With Severe COVID-19 in the European Population
CH van Moorsel, JJ van der Vis, A Duckworth, CJ Scotton, C Benschop, D Ellinghaus, HJ Ruven, MJ Quanjel, JC Grutters
Frontiers in Medicine 2021
Entropy Production in Electroosmotic Cilia Facilitated Stream of Thermally Radiated Nanofluid with Ohmic Heating.
Saleem N, Munawar S, Mehmood A, Daqqa I
Micromachines 2021
Airway Epithelial Innate Immunity.
Johnston SL, Goldblatt DL, Evans SE, Tuvim MJ, Dickey BF
Frontiers in physiology 2021
Defining the Clinical Utility of the Lung Clearance Index. Are We There Yet?
Spano J, Milla CE
American journal of respiratory and critical care medicine 2021
Lung Microbiome in Cystic Fibrosis.
Scialo F, Amato F, Cernera G, Gelzo M, Zarrilli F, Comegna M, Pastore L, Bianco A, Castaldo G
2021
Potential of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapy.
Bandara RA, Chen ZR, Hu J
Cell & Bioscience 2021
The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λ.
Nelli RK, Mora-Díaz JC, Giménez-Lirola LG
mSphere 2021
OCT particle tracking velocimetry of biofluids in a microparallel plate strain induction chamber
Oeler KJ, Hill DB, Oldenburg AL
Journal of Biomedical Optics 2021
Entropy generation in thermally radiated hybrid nanofluid through an electroosmotic pump with ohmic heating: Case of synthetic cilia regulated stream
Munawar S, Saleem N
Science Progress 2021
Lack of airway submucosal glands impairs respiratory host defenses
LS Ostedgaard, MP Price, KM Whitworth, MH Alaiwa, AJ Fischer, A Warrier, M Samuel, LD Spate, PD Allen, BM Hilkin, GS Ibarra, ME Bezara, BJ Goodell, SE Mather, LS Powers, MR Stroik, ND Gansemer, CE Hippee, K Zarei, JA Goeken, TR Businga, EA Hoffman, DK Meyerholz, RS Prather, DA Stoltz, MJ Welsh
eLife 2020
Ionocytes and CFTR Chloride Channel Expression in Normal and Cystic Fibrosis Nasal and Bronchial Epithelial Cells
P Scudieri, I Musante, A Venturini, D Guidone, M Genovese, F Cresta, E Caci, A Palleschi, M Poeta, F Santamaria, F Ciciriello, V Lucidi, LJ Galietta
Cells 2020
Acid exposure disrupts mucus secretion and impairs mucociliary transport in neonatal piglet airways
YS Liao, SP Kuan, MV Guevara, EN Collins, KR Atanasova, JS Dadural, K Vogt, V Schurmann, L Bravo, E Eken, M Sponchiado, LR Reznikov
American journal of physiology. Lung cellular and molecular physiology 2020
Epithelial cell function and remodeling in nasal polyposis
LG Bankova, NA Barrett
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2020
The Innate Lymphoid System Is a Critical Player in the Manifestation of Mucoinflammatory Airway Disease in Mice
BW Lewis, I Choudhary, K Paudel, Y Mao, R Sharma, Y Wang, JS Deshane, RC Boucher, S Patial, Y Saini
Journal of immunology (Baltimore, Md. : 1950) 2020
S. aureus alpha-toxin monomer binding and heptamer formation in host cell membranes – Do they determine sensitivity of airway epithelial cells toward the toxin?
N Möller, S Ziesemer, P Hildebrandt, N Assenheimer, U Völker, JP Hildebrandt, L Bulla
PloS one 2020
Airway mechanical compression: its role in asthma pathogenesis and progression
PC Veerati, JA Mitchel, AT Reid, DA Knight, NW Bartlett, JA Park, CL Grainge
European Respiratory Review 2020
The Role of Specialized Pro-Resolving Mediators in Cystic Fibrosis Airways Disease
M Briottet, M Shum, V Urbach
Frontiers in pharmacology 2020
ENaC inhibition in cystic fibrosis: potential role in the new era of CFTR modulator therapies
MA Mall
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2020
Ablation of IL-33 Suppresses Th2 Responses but Is Accompanied by Sustained Mucus Obstruction in the Scnn1b Transgenic Mouse Model
BW Lewis, T Vo, I Choudhary, A Kidder, C Bathula, C Ehre, N Wakamatsu, S Patial, Y Saini
Journal of immunology (Baltimore, Md. : 1950) 2020
Preclinical evaluation of the epithelial sodium channel inhibitor BI 1265162 for treatment of cystic fibrosis
P Nickolaus, B Jung, J Sabater, S Constant, A Gupta
ERJ Open Research 2020
A mathematical model describing the localization and spread of influenza A virus infection within the human respiratory tract
C Quirouette, NP Younis, MB Reddy, CA Beauchemin, R Antia
PLoS computational biology 2020
TRPV4: A Physio and Pathophysiologically Significant Ion Channel
T Rosenbaum, M Benítez-Angeles, R Sánchez-Hernández, SL Morales-Lázaro, M Hiriart, LE Morales-Buenrostro, F Torres-Quiroz
International journal of molecular sciences 2020
Mechanisms of Epithelial Immunity Evasion by Respiratory Bacterial Pathogens
L Sharma, J Feng, CJ Britto, CS Cruz
Frontiers in immunology 2020
Apolipoprotein E and Periostin Are Potential Biomarkers of Nasal Mucosal Inflammation. A Parallel Approach of In Vitro and In Vivo Secretomes
YW Chung, J Cha, S Han, Y Chen, M Gucek, HJ Cho, K Nakahira, AM Choi, JH Ryu, JH Yoon
American journal of respiratory cell and molecular biology 2020
Rhinovirus and Innate Immune Function of Airway Epithelium
H Ganjian, C Rajput, M Elzoheiry, U Sajjan
Frontiers in Cellular and Infection Microbiology 2020
Intravital microscopic optical coherence tomography imaging to assess mucus-mobilizing interventions for muco-obstructive lung disease in mice
M Pieper, H Schulz-Hildebrandt, MA Mall, G Hüttmann, P König
American journal of physiology. Lung cellular and molecular physiology 2020
Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors
P Kumar, P Scholze, M Fronius, G KrastevaChrist, MI Hollenhorst
British Journal of Pharmacology 2020
Zwitterionic micelles efficiently deliver oral insulin without opening tight junctions
X Han, Y Lu, J Xie, E Zhang, H Zhu, H Du, K Wang, B Song, C Yang, Y Shi, Z Cao
Nature Nanotechnology 2020
Airway cholinergic history modifies mucus secretion properties to subsequent cholinergic challenge in diminished chloride and bicarbonate conditions
YS Liao, EN Collins, MV Guevara, V Schurmann, KR Atanasova, L Bravo, M Sponchiado, MJ Hoegger, LR Reznikov
Experimental Physiology 2020
Mucins and the Microbiome
GC Hansson
Annual Review of Biochemistry 2020
Ammonia Exposure Induced Cilia Dysfunction of Nasal Mucosa in the Piglets.
Wang Q, Wang M, Liu C, Huang L, Gao Y, Yu M, Zhao S, Li X
BioMed Research International 2020
S-allylmercaptocysteine inhibits mucin overexpression and inflammation via MAPKs and PI3K-Akt signaling pathways in acute respiratory distress syndrome.
An L, Zhao J, Sun X, Zhou Y, Zhao Z
Pharmacological Research 2020
Bioinspired cilia arrays with programmable nonreciprocal motion and metachronal coordination.
Dong X, Lum GZ, Hu W, Zhang R, Ren Z, Onck PR, Sitti M
Science Advances 2020
The versatile X-ray beamline of the Munich Compact Light Source: design, instrumentation and applications.
Günther B, Gradl R, Jud C, Eggl E, Huang J, Kulpe S, Achterhold K, Gleich B, Dierolf M, Pfeiffer F
Journal of Synchrotron Radiation 2020
A comparative study of the turnover of multiciliated cells in the mouse trachea, oviduct, and brain.
Roberson EC, Tran NK, Konjikusic MJ, Fitch RD, Gray RS, Wallingford JB
Developmental dynamics : an official publication of the American Association of Anatomists 2020
Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives.
Cao X, Coyle JP, Xiong R, Wang Y, Heflich RH, Ren B, Gwinn WM, Hayden P, Rojanasakul L
In vitro cellular & developmental biology. Animal 2020
In Vitro and In Vivo Assessment of PEGylated PEI for Anti-IL-8/CxCL-1 siRNA Delivery to the Lungs
Hibbitts AJ, Ramsey JM, Barlow J, MacLoughlin R, Cryan SA
Nanomaterials 2020
Treatment of Cystic Fibrosis Patients Homozygous for F508del with Lumacaftor-Ivacaftor (Orkambi®) Restores Defective CFTR Channel Function in Circulating Mononuclear Cells.
Favia M, Gallo C, Guerra L, De Venuto D, Diana A, Polizzi AM, Montemurro P, Mariggiò MA, Leonetti G, Manca A, Casavola V, Conese M
International journal of molecular sciences 2020
Engineered mutant α-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis-based cell and mice models.
Mukherjee A, MacDonald KD, Kim J, Henderson MI, Eygeris Y, Sahay G
Science Advances 2020
Modified Sialic Acids on Mucus and Erythrocytes Inhibit Influenza A Virus Hemagglutinin and Neuraminidase Functions
Barnard KN, Alford-Lawrence BK, Buchholz DW, Wasik BR, LaClair JR, Yu H, Honce R, Ruhl S, Pajic P, Daugherity EK, Chen X, Schultz-Cherry SL, Aguilar HC, Varki A, Parrish CR
Journal of virology 2020
Paracellular Pathway-Mediated Mycoplasma hyopneumoniae Migration across Porcine Airway Epithelial Barrier under Air-Liquid Interface Conditions
Wang H, Zhang Z, Xie X, Liu B, Wei Y, Gan Y, Yuan T, Ni B, Wang J, Zhang L, Xiong Q, Shao G, Feng Z
Infection and immunity 2020
Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency
FA Akcan, Y Dündar, HB Akcan, A Uluat, D Cebeci, İ Ünlü
European Archives of Oto-Rhino-Laryngology 2019
TMEM16A in Cystic Fibrosis: Activating or Inhibiting?
K Kunzelmann, J Ousingsawat, I Cabrita, T Doušová, A Bähr, M Janda, R Schreiber, R Benedetto
Frontiers in pharmacology 2019
Upregulation of the WNK4 Signaling Pathway Inhibits Epithelial Sodium Channels of Mouse Tracheal Epithelial Cells After Influenza A Infection
Y Hou, Y Cui, Z Zhou, H Liu, H Zhang, Y Ding, H Nie, HL Ji
Frontiers in pharmacology 2019
Targeted Gene Delivery through the Respiratory System: Rationale for Intratracheal Gene Transfer
M Katz, A Fargnoli, S Gubara, K Fish, T Weber, C Bridges, R Hajjar, K Ishikawa
Journal of Cardiovascular Development and Disease 2019
Sphingomyelin Depletion from Plasma Membranes of Human Airway Epithelial Cells Completely Abrogates the Deleterious Actions of S. aureus Alpha-Toxin
S Ziesemer, N Möller, A Nitsch, C Müller, A Beule, JP Hildebrandt
Toxins 2019
Roles of Cyclic AMP Response Element Binding Activation in the ERK1/2 and p38 MAPK Signalling Pathway in Central Nervous System, Cardiovascular System, Osteoclast Differentiation and Mucin and Cytokine Production
Y Koga, H Tsurumaki, H Aoki-Saito, M Sato, M Yatomi, K Takehara, T Hisada
International journal of molecular sciences 2019
Inflammation and Endotyping in Chronic Rhinosinusitis—A Paradigm Shift
S Ahern, A Cervin
MED LITH 2019
Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity
IT Myszor, Z Parveen, H Ottosson, P Bergman, B Agerberth, R Strömberg, GH Gudmundsson
Scientific Reports 2019
Immunopathology of Airway Surface Liquid Dehydration Disease
BW Lewis, S Patial, Y Saini
Journal of Immunology Research 2019
Airway regeneration using iPS cell-derived airway epithelial cells with Cl - channel function
S Yoshie, K Omori, A Hazama
Channels (Austin, Tex.) 2019
Mechanical shear controls bacterial penetration in mucus
N Figueroa-Morales, L Dominguez-Rubio, TL Ott, IS Aranson
Scientific Reports 2019
Particle coating alters mucociliary transit in excised rat trachea: A synchrotron X-ray imaging study
M Gardner, A McCarron, K Morgan, D Parsons, M Donnelley
Scientific Reports 2019
Stenotrophomonas maltophilia Differential Gene Expression in Synthetic Cystic Fibrosis Sputum Reveals Shared and Cystic Fibrosis Strain-Specific Responses to the Sputum Environment
GG Willsey, K Eckstrom, AE LaBauve, LA Hinkel, K Schutz, RJ Meagher, JJ LiPuma, MJ Wargo, MY Galperin
Journal of bacteriology 2019
Nebulized hypertonic saline in noncystic fibrosis bronchiectasis: a comprehensive review
LM Carro, MA Martínez-García
Therapeutic advances in respiratory disease 2019
Mathematical Modeling of Mucociliary Clearance: A Mini-Review
L Xu, Y Jiang
Cells 2019
Mucin Thin Layers: A Model for Mucus-Covered Tissues
Rondelli, Cola, Koutsioubas, Alongi, Ferruti, Ranucci, Brocca
International journal of molecular sciences 2019
Inhaled Biologicals for the Treatment of Cystic Fibrosis
V Sala, A Murabito, A Ghigo
Recent Patents on Inflammation & Allergy Drug Discovery 2019
The Cancer Microbiota: EMT and Inflammation as Shared Molecular Mechanisms Associated with Plasticity and Progression
D Vergara, P Simeone, M Damato, M Maffia, P Lanuti, M Trerotola
Journal of Oncology 2019
Nanoparticle diffusion in spontaneously expectorated sputum as a biophysical tool to probe disease severity in COPD
JF Chisholm, SK Shenoy, JK Shade, V Kim, N Putcha, KA Carson, R Wise, NN Hansel, JS Hanes, JS Suk, E Neptune
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2019
Spatial Mapping of Tracheal Ciliary Beat Frequency Using Real Time Phase-Resolved Doppler Spectrally Encoded Interferometric Microscopy
Y He, JC Jing, Y Qu, BJ Wong, Z Chen
ACS Photonics 2019
Engineering Polymer-Binding Bispecific Antibodies for Enhanced Pretargeted Delivery of Nanoparticles to Mucus-Covered Epithelium.
Huckaby JT, Parker CL, Jacobs TM, Schaefer A, Wadsworth D, Nguyen A, Wang A, Newby J, Lai SK
Angewandte Chemie (International ed. in English) 2019
Comparing the Performance Characteristics of Different Positive Expiratory Pressure Devices.
Franks LJ, Walsh JR, Hall K, Jacuinde G, Yerkovich S, Morris NR
Respiratory Care 2019
Cystic Fibrosis Lung Disease: An Overview.
Turcios NL
Respiratory Care 2019
ATP12A promotes mucus dysfunction during Type 2 airway inflammation
AT Lennox, SL Coburn, JA Leech, EM Heidrich, TR Kleyman, SE Wenzel, JM Pilewski, TE Corcoran, MM Myerburg
Scientific Reports 2018
Fatty Acid Metabolism is Associated With Disease Severity After H7N9 Infection
X Sun, L Song, S Feng, L Li, H Yu, Q Wang, X Wang, Z Hou, X Li, Y Li, Q Zhang, K Li, C Cui, J Wu, Z Qin, Q Wu, H Chen
EBioMedicine 2018
Buffer drains and mucus is transported upward in a tilted mucus clearance assay
J Carpenter, SE Lynch, JA Cribb, S Kylstra, DB Hill, R Superfine
American journal of physiology. Lung cellular and molecular physiology 2018
Mucus models to evaluate the diffusion of drugs and particles
JY Lock, TL Carlson, RL Carrier
Advanced Drug Delivery Reviews 2018
Seeing cilia: imaging modalities for ciliary motion and clinical connections
JE Peabody, RJ Shei, BM Bermingham, SE Phillips, B Turner, SM Rowe, GM Solomon
American journal of physiology. Lung cellular and molecular physiology 2018
Mucin Production and Hydration Responses to Mucopurulent Materials in Normal versus Cystic Fibrosis Airway Epithelia
LH Abdullah, R Coakley, MJ Webster, Y Zhu, R Tarran, G Radicioni, M Kesimer, RC Boucher, CW Davis, CM Ribeiro
American journal of respiratory and critical care medicine 2018
New insights into the mechanisms controlling the bronchial mucus balance
C Karamaoun, B Sobac, B Mauroy, AV Muylem, B Haut, N Palaniyar
PloS one 2018
Airway disease phenotypes in animal models of cystic fibrosis
A McCarron, M Donnelley, D Parsons
Respiratory Research 2018
Taste receptors in the upper airway
JR Freund, RJ Lee
World Journal of Otorhinolaryngology-Head and Neck Surgery 2018
Role of mucins in lung homeostasis: regulated expression and biosynthesis in health and disease
BA Symmes, AL Stefanski, CM Magin, CM Evans
Biochemical Society Transactions 2018
Secondhand Smoke Induces Inflammation and Impairs Immunity to Respiratory Infections
TA Bhat, SG Kalathil, PN Bogner, A Miller, PV Lehmann, TH Thatcher, RP Phipps, PJ Sime, Y Thanavala
Journal of immunology (Baltimore, Md. : 1950) 2018
Recent advances in developing therapeutics for cystic fibrosis
LJ Strug, AL Stephenson, N Panjwani, A Harris
Human Molecular Genetics 2018
An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy
GA Duncan, N Kim, Y Colon-Cortes, J Rodriguez, M Mazur, SE Birket, SM Rowe, NE West, A Livraghi-Butrico, RC Boucher, J Hanes, G Aslanidi, JS Suk
Molecular Therapy — Methods & Clinical Development 2018
ZMapp Reinforces the Airway Mucosal Barrier Against Ebola Virus
B Yang, A Schaefer, YY Wang, J McCallen, P Lee, JM Newby, H Arora, PA Kumar, L Zeitlin, KJ Whaley, SA McKinley, WA Fischer, D Harit, SK Lai
The Journal of Infectious Diseases 2018
Transport and Mixing Induced by Beating Cilia in Human Airways
S Chateau, U D'Ortona, S Poncet, J Favier
Frontiers in physiology 2018
Rhinosectan® spray (containing xyloglucan) on the ciliary function of the nasal respiratory epithelium; results of an in vitro study
N Piqué, BD Servi
Allergy Asthma & Clinical Immunology 2018
In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source
R Gradl, M Dierolf, B Günther, L Hehn, W Möller, D Kutschke, L Yang, M Donnelley, R Murrie, A Erl, T Stoeger, B Gleich, K Achterhold, O Schmid, F Pfeiffer, KS Morgan
Scientific Reports 2018
Spatiotemporal organization of cilia drives multiscale mucus swirls in model human bronchial epithelium
MK Khelloufi, E Loiseau, M Jaeger, N Molinari, P Chanez, D Gras, A Viallat
Scientific Reports 2018
Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice
A Perniss, N Schmidt, C Gurtner, K Dietert, O Schwengers, M Weigel, J Hempe, C Ewers, U Pfeil, U Gärtner, AD Gruber, T Hain, W Kummer
Scientific Reports 2018
Pathophysiology and Genetics of Bronchiectasis Unrelated to Cystic Fibrosis
A Nikolic
Lung 2018
Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease
GD Amatngalim, PS Hiemstra
Chinese Medical Journal 2018
Technological strategies to estimate and control diffusive passage times through the mucus barrier in mucosal drug delivery
JM Newby, I Seim, M Lysy, Y Ling, J Huckaby, SK Lai, MG Forest
Advanced Drug Delivery Reviews 2018
Predictors of pneumonia on routine chest radiographs in patients with COPD: a post hoc analysis of two 1-year randomized controlled trials
DB Rubin, HA Ahmad, M O'Neal, S Bennett, S Lettis, DV Galkin, C Crim
International journal of chronic obstructive pulmonary disease 2018
Molecular strategy for blocking isopeptide bond formation in nascent pilin proteins
JA Rivas-Pardo, CL Badilla, R Tapia-Rojo, Á Alonso-Caballero, JM Fernández
Proceedings of the National Academy of Sciences 2018
Mucociliary Clearance in Mice Measured by Tracking Trans-tracheal Fluorescence of Nasally Aerosolized Beads
TD Rogers, LE Ostrowski, A Livraghi-Butrico, B Button, BR Grubb
Scientific Reports 2018
Temporal differentiation of bovine airway epithelial cells grown at an air-liquid interface
D Cozens, E Sutherland, F Marchesi, G Taylor, CC Berry, RL Davies
Scientific Reports 2018
Functional Anatomic Imaging of the Airway Surface
RJ Shei, JE Peabody, SM Rowe
Annals of the American Thoracic Society 2018
Chair’s Summary: Secreted Mucins in Lung Diseases
BF Dickey
Annals of the American Thoracic Society 2018
Ivacaftor improves rhinologic, psychologic, and sleep-related quality of life in G551D cystic fibrosis patients: Improved quality of life in G551D CF patients
J McCormick, DY Cho, B Lampkin, J Richman, H Hathorne, SM Rowe, BA Woodworth
International Forum of Allergy & Rhinology 2018
Tissue-dependent expression of bitter receptor TAS2R38 mRNA
JE Douglas, C Lin, CJ Mansfield, CJ Arayata, BJ Cowart, AI Spielman, ND Adappa, JN Palmer, NA Cohen, DR Reed
Chemical Senses 2018
The development and functions of multiciliated epithelia
N Spassky, A Meunier
Nature Reviews Molecular Cell Biology 2017
Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography: EX VIVO VISUALIZATION OF HUMAN CILIATED EPITHELIUM
Y Ling, X Yao, UA Gamm, E Arteaga-Solis, CW Emala, MA Choma, CP Hendon
Lasers in Surgery and Medicine 2017
Taste Receptors Mediate Sinonasal Immunity and Respiratory Disease
J Douglas, N Cohen
International journal of molecular sciences 2017
Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation
X Wang, Y Li, D Luo, X Wang, Y Zhang, Z Liu, N Zhong, M Wu, G Li
Scientific Reports 2017
Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants
K Reinmuth-Selzle, CJ Kampf, K Lucas, N Lang-Yona, J Fröhlich-Nowoisky, M Shiraiwa, PS Lakey, S Lai, F Liu, AT Kunert, K Ziegler, F Shen, R Sgarbanti, B Weber, I Bellinghausen, J Saloga, MG Weller, A Duschl, D Schuppan, U Pöschl
Environmental science & technology 2017
Quantitative Proteomic Analysis of Human Airway Cilia Identifies Previously Uncharacterized Proteins of High Abundance
K Blackburn, X Bustamante-Marin, W Yin, MB Goshe, LE Ostrowski
Journal of Proteome Research 2017
Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1
AS Konduru, S Matsuyama, BC Lee, K Komatsu, JD Li
International Journal of Inflammation 2017
Lung structure and function similarities between primary ciliary dyskinesia and mild cystic fibrosis: a pilot study
M Maglione, S Montella, C Mollica, V Carnovale, P Iacotucci, FD Gregorio, A Tosco, M Cervasio, V Raia, F Santamaria
Italian Journal of Pediatrics 2017
Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor
BM Hariri, DB McMahon, B Chen, JR Freund, CJ Mansfield, LJ Doghramji, ND Adappa, JN Palmer, DW Kennedy, DR Reed, P Jiang, RJ Lee
The Journal of biological chemistry 2017
Active microrheology determines scale-dependent material properties of Chaetopterus mucus
WJ Weigand, A Messmore, J Tu, A Morales-Sanz, DL Blair, DD Deheyn, JS Urbach, RM Robertson-Anderson, K Garikipati
PloS one 2017
The particle in the spider's web: transport through biological hydrogels
J Witten, K Ribbeck
Nanoscale 2017
Small Airway Absorption and Microdosimetry of Inhaled Corticosteroid Particles after Deposition
PW Longest, M Hindle
Pharmaceutical Research 2017
Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease
SL Fossum, MJ Mutolo, A Tugores, S Ghosh, SH Randell, LC Jones, SH Leir, A Harris
The Journal of biological chemistry 2017
A new index for characterizing micro-bead motion in a flow induced by ciliary beating: Part II, modeling
M Bottier, MP Fernández, G Pelle, D Isabey, B Louis, JB Grotberg, M Filoche, M Alber
PLoS computational biology 2017
A new index for characterizing micro-bead motion in a flow induced by ciliary beating: Part I, experimental analysis
M Bottier, S Blanchon, G Pelle, E Bequignon, D Isabey, A Coste, E Escudier, JB Grotberg, JF Papon, M Filoche, B Louis, M Alber
PLoS computational biology 2017
Overnight delivery of hypertonic saline by nasal cannula aerosol for cystic fibrosis
TE Corcoran, JE Godovchik, KH Donn, DR Busick, J Goralski, LW Locke, MR Markovetz, MM Myerburg, A Muthukrishnan, L Weber, RT Lacy, JM Pilewski
Pediatric Pulmonology 2017
Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens
X Luan, G Belev, JS Tam, S Jagadeeshan, N Hassan, P Gioino, N Grishchenko, Y Huang, JL Carmalt, T Duke, T Jones, B Monson, M Burmester, T Simovich, O Yilmaz, VA Campanucci, TE Machen, LD Chapman, JP Ianowski
Nature Communications 2017
Physicochemical properties of mucus and their impact on transmucosal drug delivery
J Leal, HD Smyth, D Ghosh
International Journal of Pharmaceutics 2017
Mitochondrial toxicity of tobacco smoke and air pollution
JL Fetterman, MJ Sammy, SW Ballinger
Toxicology 2017
SPX-101 Is a Promising and Novel Nebulized ENaC Inhibitor
A Lennox, MM Myerburg
American journal of respiratory and critical care medicine 2017
Role of Smad3 and p38 Signalling in Cigarette Smoke-induced CFTR and BK dysfunction in Primary Human Bronchial Airway Epithelial Cells
J Sailland, A Grosche, N Baumlin, JS Dennis, A Schmid, S Krick, M Salathe
Scientific Reports 2017
Motile cilia create fluid-mechanical microhabitats for the active recruitment of the host microbiome
JC Nawroth, H Guo, E Koch, EA Heath-Heckman, JC Hermanson, EG Ruby, JO Dabiri, E Kanso, M McFall-Ngai
Proceedings of the National Academy of Sciences 2017
Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation
TJ Bensman, JG Jayne, M Sun, E Kimura, J Meinert, JC Wang, JB Schaal, D Tran, AP Rao, O Akbari, ME Selsted, PM Beringer
Antimicrobial agents and chemotherapy 2017
Enhancement of lung gene delivery after aerosol: a new strategy using non-viral complexes with antibacterial properties
A Mottais, T Le Gall, Y Sibiril, J Ravel, V Laurent, F dArbonneau, T Montier
Bioscience Reports 2017
Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease
ZM Sellers, B Illek, MF Figueira, G Hari, NS Joo, E Sibley, J Souza-Menezes, MM Morales, H Fischer, JJ Wine, S Ahmad
PloS one 2017
In Vitro Models to Study Human Lung Development, Disease and Homeostasis
AJ Miller, JR Spence
Physiology (Bethesda, Md.) 2017
Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma
Luke Bonser, Lorna Zlock, Walter Finkbeiner, David J. Erle
Journal of Clinical Investigation 2016
Repurposing Tromethamine as Inhaled Therapy to Treat CF Airway Disease
Mahmoud Abou Alaiwa, Janice Launspach, Kelsey Sheets, Jade Rivera, Nicholas Gansemer, Peter Taft, Peter Thorne, Michael Welsh, David Stoltz, Joseph Zabner
JCI Insight 2016
Microstructural Alterations of Sputum in Cystic Fibrosis Lung Disease
Gregg Duncan, James Jung, Andrea Joseph, Abigail Thaxton, Natalie West, Michael Boyle, Justin Hanes, Jung Soo Suk
JCI Insight 2016
Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder
S Kikuta, Y Matsumoto, A Kuboki, T Nakayama, D Asaka, N Otori, H Kojima, T Sakamoto, K Akinori, K Kanaya, R Ueha, R Kagoya, H Nishijima, M Toma-Hirano, Y Kikkawa, K Kondo, K Tsunoda, T Miyaji, T Yamaguchi, K Kataoka, K Mori, T Yamasoba
Scientific Reports 2016
Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release
G Gorrieri, P Scudieri, E Caci, M Schiavon, V Tomati, F Sirci, F Napolitano, D Carrella, A Gianotti, I Musante, M Favia, V Casavola, L Guerra, F Rea, R Ravazzolo, DD Bernardo, LJ Galietta
Scientific Reports 2016
Effect of TH2 cytokines and interferon gamma on beat frequency of human respiratory cilia
J Grosse-Onnebrink, C Werner, NT Loges, K Hörmann, A Blum, R Schmidt, H Olbrich, H Omran
Pediatric Research 2016
Non-diluted seawater enhances nasal ciliary beat frequency and wound repair speed compared to diluted seawater and normal saline: Seawater superior to saline on CBF and WRS
A Bonnomet, E Luczka, C Coraux, L Gabory
International Forum of Allergy & Rhinology 2016
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Uses its C-Terminus to Regulate the A2B Adenosine Receptor
MJ Watson, SL Lee, AJ Marklew, RC Gilmore, M Gentzsch, MF Sassano, MA Gray, R Tarran
Scientific Reports 2016
Inhibition of airway surface fluid absorption by cholinergic stimulation
NS Joo, ME Krouse, JY Choi, HJ Cho, JJ Wine
Scientific Reports 2016
The evolving spectrum of ciliopathies and respiratory disease:
CE Milla
Current Opinion in Pediatrics 2016
Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency
BW Richmond, RM Brucker, W Han, RH Du, Y Zhang, DS Cheng, L Gleaves, R Abdolrasulnia, D Polosukhina, PE Clark, SR Bordenstein, TS Blackwell, VV Polosukhin
Nature Communications 2016
Aerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery Systems
SR Youngren-Ortiz, NS Gandhi, L España-Serrano, MB Chougule
KONA POWDER PART J 2016
Taste Receptors: Regulators of Sinonasal Innate Immunity: Taste Receptors
RM Carey, ND Adappa, JN Palmer, RJ Lee, NA Cohen
Laryngoscope Investigative Otolaryngology 2016
The genetics of the bitter taste receptor T2R38 in upper airway innate immunity and implications for chronic rhinosinusitis: T2R38 Genetics and Chronic Rhinosinusitis
NA Cohen
The Laryngoscope 2016
A Macroscopic Model for Simulating the Mucociliary Clearance in a Bronchial Bifurcation: The Role of Surface Tension
M Manolidis, D Isabey, B Louis, JB Grotberg, M Filoche
Journal of Biomechanical Engineering 2016
Cilia and Mucociliary Clearance
XM Bustamante-Marin, LE Ostrowski
Cold Spring Harbor perspectives in biology 2016
ATS Core Curriculum 2016: Part III. Pediatric Pulmonary Medicine
D Boyer, CC Thomson, R Cohen, D Rao, S Dell, J Rayment, R Wang, FJ Dy, J Wambach, J Tam-Williams, D Simon, E Price, CM Oermann, A Singh, JS Rettig, ED Duncan, CD Baker, DR Liptzin, PE Moore
Annals of the American Thoracic Society 2016
Pneumonia
Popper H
Pathology of Lung Disease 2016
Cilia Dysfunction in Lung Disease
AE Tilley, MS Walters, R Shaykhiev, RG Crystal
Annual Review of Physiology 2015
Cystic fibrosis
F Ratjen, SC Bell, SM Rowe, CH Goss, AL Quittner, A Bush
Nature Reviews Disease Primers 2015
Airway hydration and COPD
A Ghosh, RC Boucher, R Tarran
Cellular and Molecular Life Sciences 2015
Pediatric Cystic Fibrosis Sputum Can Be Chemically Dynamic, Anoxic, and Extremely Reduced Due to Hydrogen Sulfide Formation
ES Cowley, SH Kopf, A LaRiviere, W Ziebis, DK Newman
mBio 2015
Ferret and Pig Models of Cystic Fibrosis: Prospects and Promise for Gene Therapy
Z Yan, ZA Stewart, PL Sinn, JC Olsen, J Hu, PB McCray, JF Engelhardt
Human Gene Therapy Clinical Development 2015
Genetics, diagnosis and future treatment strategies for primary ciliary dyskinesia
ML Daniels, PG Noone
Expert Opinion on Orphan Drugs 2015
Proteomic Analysis of Pure Human Airway Gland Mucus Reveals a Large Component of Protective Proteins
NS Joo, IA Evans, HJ Cho, IH Park, JF Engelhardt, JJ Wine, JM Jacobs
PloS one 2015
Successful Treatment Of Chronic Lower Respiratory Tract Infection By Macrolide Administration In A Patient With Intralobar Pulmonary Sequestration And Primary Ciliary Dyskinesia
H Tsubouchi, N Matsumoto, S Yanagi, J Ashitani, M Nakazato
Respiratory Medicine Case Reports 2015
The lung communication network
D Losa, M Chanson
Cellular and Molecular Life Sciences 2015
Evaluation of nasal mucociliary activity in patients with chronic renal failure
C Kucur, I Ozbay, E Gulcan, S Kulekci, S Aksoy, F Oghan
European Archives of Oto-Rhino-Laryngology 2015
1,8-Cineol Reduces Mucus-Production in a Novel Human Ex Vivo Model of Late Rhinosinusitis
H Sudhoff, C Klenke, JF Greiner, J Müller, V Brotzmann, J Ebmeyer, B Kaltschmidt, C Kaltschmidt, YP Di
PloS one 2015
Airway Surface Dehydration Aggravates Cigarette Smoke-Induced Hallmarks of COPD in Mice
LJ Seys, FM Verhamme, LL Dupont, E Desauter, J Duerr, AS Agircan, G Conickx, GF Joos, GG Brusselle, MA Mall, KR Bracke, M Idzko
PloS one 2015
Continuous mucociliary transport by primary human airway epithelial cells in vitro
PR Sears, WN Yin, LE Ostrowski
American journal of physiology. Lung cellular and molecular physiology 2015
Vinpocetine Inhibits Streptococcus pneumoniae-Induced Upregulation of Mucin MUC5AC Expression via Induction of MKP-1 Phosphatase in the Pathogenesis of Otitis Media
JY Lee, K Komatsu, BC Lee, M Miyata, AO Bohn, H Xu, C Yan, JD Li
Journal of immunology (Baltimore, Md. : 1950) 2015
The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines
P Mazzi, E Caveggion, JA Lapinet-Vera, CA Lowell, G Berton
Journal of immunology (Baltimore, Md. : 1950) 2015
Salt, chloride, bleach, and innate host defense
G Wang, WM Nauseef
Journal of leukocyte biology 2015
The Evolution of Cystic Fibrosis Care
JE Pittman, TW Ferkol
Chest 2015
Impact of Cardiopulmonary Bypass on Respiratory Mucociliary Function in an Experimental Porcine Model
R Sánchez-Véliz, MJ Carmona, DA Otsuki, C Freitas, A Benício, EM Negri, LM Malbouisson, F Staffieri
PloS one 2015
The expansion of autologous adipose-derived stem cells in vitro for the functional reconstruction of nasal mucosal tissue
X Xu, L Li, C Wang, Y Liu, C Chen, J Yan, H Ding, S Tang
Cell & Bioscience 2015
Cryptococcus neoformans Infection in Mice Lacking Type I Interferon Signaling Leads to Increased Fungal Clearance and IL-4-Dependent Mucin Production in the Lungs
K Sato, H Yamamoto, T Nomura, I Matsumoto, T Miyasaka, T Zong, E Kanno, K Uno, K Ishii, K Kawakami, EA Eugenin
PloS one 2015
The Role of Bitter and Sweet Taste Receptors in Upper Airway Immunity
AD Workman, JN Palmer, ND Adappa, NA Cohen
Current Allergy and Asthma Reports 2015
Chronic rhinosinusitis pathogenesis
WW Stevens, RJ Lee, RP Schleimer, NA Cohen
Journal of Allergy and Clinical Immunology 2015
Nanoparticle based insulin delivery system: the next generation efficient therapy for Type 1 diabetes
G Sharma, AR Sharma, JS Nam, GP Doss, SS Lee, C Chakraborty
Journal of nanobiotechnology 2015
Nasal Mucociliary Clearance in Adenoid Hypertrophy and Otitis Media with Effusion
H Yazıcı
Current Allergy and Asthma Reports 2015
A role for airway taste receptor modulation in the treatment of upper respiratory infections
JE Douglas, CJ Saunders, DR Reed, NA Cohen
Expert Review of Respiratory Medicine 2015
Putting the Squeeze on Airway Epithelia
JA Park, JJ Fredberg, JM Drazen
Physiology (Bethesda, Md.) 2015
Defective Innate Immunity and Hyperinflammation in Newborn Cystic Fibrosis Transmembrane Conductance Regulator–Knockout Ferret Lungs
NW Keiser, SE Birket, IA Evans, SR Tyler, AK Crooke, X Sun, W Zhou, JR Nellis, EK Stroebele, KK Chu, GJ Tearney, MJ Stevens, JK Harris, SM Rowe, JF Engelhardt
American journal of respiratory cell and molecular biology 2014
Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration
R Tarran, MR Redinbo
The International Journal of Biochemistry & Cell Biology 2014
Nitrous Oxide Production in Sputum from Cystic Fibrosis Patients with Chronic Pseudomonas aeruginosa Lung Infection
M Kolpen, M Kühl, T Bjarnsholt, C Moser, CR Hansen, L Liengaard, A Kharazmi, T Pressler, N Høiby, PØ Jensen, E Gulbins
PloS one 2014
Vocal Fold Ion Transport and Mucin Expression Following Acrolein Exposure
EE Levendoski, MP Sivasankar
The Journal of Membrane Biology 2014
Cystic fibrosis: An inherited disease affecting mucin-producing organs
C Ehre, C Ridley, DJ Thornton
The International Journal of Biochemistry & Cell Biology 2014
Cystic Fibrosis: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases
JE Pittman, G Cutting, SD Davis, T Ferkol, R Boucher
Annals of the American Thoracic Society 2014
dsRNA-induced changes in gene expression profiles of primary nasal and bronchial epithelial cells from patients with asthma, rhinitis and controls
AH Wagener, AH Zwinderman, S Luiten, WJ Fokkens, EH Bel, PJ Sterk, CM van Drunen
Respiratory Research 2014
Proteome of the porosome complex in human airway epithelia: Interaction with the cystic fibrosis transmembrane conductance regulator (CFTR)
X Hou, KT Lewis, Q Wu, S Wang, X Chen, A Flack, G Mao, DJ Taatjes, F Sun, BP Jena
Journal of Proteomics 2014
A pilot study of an in-vitro bovine trachea model of the effect of continuous positive airway pressure breathing on airway surface liquid
DE White, RJ Nates, J Bartley
BioMedical Engineering OnLine 2014
Effect of cigarette smoking on nasal mucociliary clearance: A comparative analysis using saccharin test
MK Baby, PK Muthu, P Johnson, S Kannan
Lung India : official organ of Indian Chest Society 2014
Pseudomonas aeruginosa triggers CFTR-mediated airway surface liquid secretion in swine trachea
X Luan, VA Campanucci, M Nair, O Yilmaz, G Belev, TE Machen, D Chapman, JP Ianowski
Proceedings of the National Academy of Sciences 2014
Nanoparticle penetration of human cervicovaginal mucus: The effect of polyvinyl alcohol
M Yang, SK Lai, T Yu, YY Wang, C Happe, W Zhong, M Zhang, A Anonuevo, C Fridley, A Hung, J Fu, J Hanes
Journal of Controlled Release 2014
Gaining the Upper Hand on Pulmonary Drug Delivery
J Tyrrell, R Tarran
2014
Basal foot MTOC organizes pillar MTs required for coordination of beating cilia
DK Clare, J Magescas, T Piolot, M Dumoux, C Vesque, E Pichard, T Dang, B Duvauchelle, F Poirier, D Delacour
Nature Communications 2014
Taste receptors in innate immunity
RJ Lee, NA Cohen
Cellular and Molecular Life Sciences 2014
Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells
SL Fossum, MJ Mutolo, R Yang, H Dang, WK O'Neal, MR Knowles, SH Leir, A Harris
Nucleic Acids Research 2014
Endogenous lung surfactant inspired pH responsive nanovesicle aerosols: Pulmonary compatible and site-specific drug delivery in lung metastases
N Joshi, N Shirsath, A Singh, KS Joshi, R Banerjee
Scientific Reports 2014
Allergic Airway Inflammation Decreases Lung Bacterial Burden following Acute Klebsiella pneumoniae Infection in a Neutrophil- and CCL8-Dependent Manner
DE Dulek, DC Newcomb, K Goleniewska, J Cephus, W Zhou, S Reiss, S Toki, F Ye, R Zaynagetdinov, TP Sherrill, TS Blackwell, ML Moore, KL Boyd, JK Kolls, RS Peebles
Infection and immunity 2014
Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition
AB Astrand, M Hemmerling, J Root, C Wingren, J Pesic, E Johansson, AL Garland, A Ghosh, R Tarran
American journal of physiology. Lung cellular and molecular physiology 2014
Mycoplasma pneumoniae Modulates STAT3-STAT6/EGFR-FOXA2 Signaling To Induce Overexpression of Airway Mucins
Y Hao, Z Kuang, J Jing, J Miao, LY Mei, RJ Lee, S Kim, S Choe, DC Krause, GW Lau
Infection and immunity 2014
IL-1  induction of MUC5AC gene expression is mediated by CREB and NF- B and repressed by dexamethasone
Y Chen, LM Garvin, TJ Nickola, AM Watson, AM Colberg-Poley, MC Rose
American journal of physiology. Lung cellular and molecular physiology 2014
Vocal Fold Epithelial Barrier in Health and Injury: A Research Review
EE Levendoski, C Leydon, SL Thibeault
Journal of speech, language, and hearing research : JSLHR 2014
Porosome in Cystic Fibrosis
BP Jena
Discoveries 2014
Tumor Necrosis Factor Alpha Induces a Serotonin Dependent Early Increase in Ciliary Beat Frequency and Epithelial Transport Velocity in Murine Tracheae
S Weiterer, D Schulte, S Müller, T Kohlen, F Uhle, MA Weigand, M Henrich, H Fehrenbach
PloS one 2014
Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects
Barua S, Mitragotri S
Nano Today 2014
Quantifying the effects of altering ambient humidity on ionic composition of vocal fold surface fluid
MP Sivasankar, TL Carroll, AM Kosinski, CA Rosen
The Laryngoscope 2013
Liquid hyper-absorption as a cause of increased DTPA clearance in the cystic fibrosis airway
TE Corcoran, KM Thomas, S Brown, MM Myerburg, LW Locke, JM Pilewski
EJNMMI Research 2013
Intrapulmonary Versus Nasal Transduction of Murine Airways With GP64-pseudotyped Viral Vectors
M Oakland, W Maury, PB McCray, PL Sinn
Molecular Therapy — Nucleic Acids 2013
Repression of the Equilibrative Nucleoside Transporters Dampens Inflammatory Lung Injury
JC Morote-Garcia, D Köhler, JM Roth, V Mirakaj, T Eldh, HK Eltzschig, P Rosenberger
American journal of respiratory cell and molecular biology 2013
Comprehensive Physiology
A Tsuda, FS Henry, JP Butler
Comprehensive Physiology 2013
Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways
AL Garland, WG Walton, RD Coakley, CD Tan, RC Gilmore, CA Hobbs, A Tripathy, LA Clunes, S Bencharit, MJ Stutts, L Betts, MR Redinbo, R Tarran
Proceedings of the National Academy of Sciences 2013
Barrier function of airway tract epithelium
S Ganesan, AT Comstock, US Sajjan
Tissue Barriers 2013
Primary Ciliary Dyskinesia. Recent Advances in Diagnostics, Genetics, and Characterization of Clinical Disease
MR Knowles, LA Daniels, SD Davis, MA Zariwala, MW Leigh
American journal of respiratory and critical care medicine 2013
Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase
M Cohen, XQ Zhang, HP Senaati, HW Chen, NM Varki, RT Schooley, P Gagneux
Virology Journal 2013
The impact of topically applied preservation solutions on the respiratory epithelium of tracheal grafts submitted to cold ischemia: functional and morphological analysis
AE de Azevedo-Pereira, JA Saka, KA de Oliveira-Braga, R Pazetti, M Canzian, PM Pêgo-Fernandes, FB Jatene
Clinics (São Paulo, Brazil) 2013
Abnormal nasal nitric oxide production, ciliary beat frequency, and Toll-like receptor response in pulmonary nontuberculous mycobacterial disease epithelium
CJ Fowler, KN Olivier, JM Leung, CC Smith, AG Huth, H Root, DB Kuhns, C Logun, A Zelazny, CA Frein, J Daub, C Haney, JH Shelhamer, CE Bryant, SM Holland
American journal of respiratory and critical care medicine 2013
Control of Airway Tube Diameter and Integrity by Secreted Chitin-Binding Proteins in Drosophila
K Tiklová, V Tsarouhas, C Samakovlis, EM Skoulakis
PloS one 2013
Postentry Processing of Recombinant Adeno-Associated Virus Type 1 and Transduction of the Ferret Lung Are Altered by a Factor in Airway Secretions
Z Yan, X Sun, IA Evans, SR Tyler, Y Song, X Liu, H Sui, JF Engelhardt
Human Gene Therapy 2013
Continuum-kinetic-microscopic model of lung clearance due to core-annular fluid entrainment
S Mitran
Journal of Computational Physics 2013
Mucociliary Clearance Defects in a Murine In Vitro Model of Pneumococcal Airway Infection
M Fliegauf, AF Sonnen, B Kremer, P Henneke, S Jeyaseelan
PloS one 2013
Primary ciliary dyskinesia-causing mutations in Amish and Mennonite communities
TW Ferkol, EG Puffenberger, H Lie, C Helms, KA Strauss, A Bowcock, JL Carson, M Hazucha, DH Morton, AC Patel, MW Leigh, MR Knowles, MA Zariwala
The Journal of Pediatrics 2013
Status of Fluid and Electrolyte Absorption in Cystic Fibrosis
MM Reddy, MJ Stutts
Cold Spring Harbor Perspectives in Medicine 2013
A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface
S Jonas, E Zhou, E Deniz, B Huang, K Chandrasekera, D Bhattacharya, Y Wu, R Fan, TM Deserno, MK Khokha, MA Choma
Lab on a Chip 2013
Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures
CA Hobbs, MG Blanchard, O Alijevic, CD Tan, S Kellenberger, S Bencharit, R Cao, M Kesimer, WG Walton, AG Henderson, MR Redinbo, MJ Stutts, R Tarran
American journal of physiology. Lung cellular and molecular physiology 2013
Increased Susceptibility to Pulmonary Pseudomonas Infection in Splunc1 Knockout Mice
Y Liu, ME Di, HW Chu, X Liu, L Wang, S Wenzel, YP Di
Journal of immunology (Baltimore, Md. : 1950) 2013
Use of Single-Site-Functionalized PEG Dendrons To Prepare Gene Vectors that Penetrate Human Mucus Barriers
AJ Kim, NJ Boylan, JS Suk, M Hwangbo, T Yu, BS Schuster, L Cebotaru, WG Lesniak, JS Oh, P Adstamongkonkul, AY Choi, RM Kannan, J Hanes
Angewandte Chemie 2013
Cystic Fibrosis Chronic Rhinosinusitis: A Comprehensive Review
MR Chaaban, A Kejner, SM Rowe, BA Woodworth
American journal of rhinology & allergy 2013
In Vitro Spatial and Temporal Analysis of Mycoplasma pneumoniae Colonization of Human Airway Epithelium
OA Prince, TM Krunkosky, DC Krause, BA McCormick
Infection and immunity 2013
Enhanced response to pulmonary Streptococcus pneumoniae infection is associated with primary ciliary dyskinesia in mice lacking Pcdp1 and Spef2
CW McKenzie, JM Klonoski, T Maier, G Trujillo, PF Vitiello, VC Huber, L Lee
Cilia 2013
Myb promotes centriole amplification and later steps of the multiciliogenesis program
FE Tan, EK Vladar, L Ma, LC Fuentealba, R Hoh, FH Espinoza, JD Axelrod, A Alvarez-Buylla, T Stearns, C Kintner, MA Krasnow
Development (Cambridge, England) 2013
Cellular and Molecular Biology of Airway Mucins
Lillehoj EP, Kato K, Lu W, Kim KC
International review of cell and molecular biology 2013
Infectious Mechanisms Regulating Susceptibility to Acute Exacerbations of COPD
Provost K, Desai H, Sethi S
2013
Role of Epithelial Cells in Chronic Inflammatory Lung Disease
Kim V, Kato K, Kim KC, Lillehoj EP
2013
Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury
M Koeppen, EN McNamee, KS Brodsky, CM Aherne, M Faigle, GP Downey, SP Colgan, CM Evans, DA Schwartz, HK Eltzschig
Mucosal Immunology 2012
Acquired Cilia Dysfunction in Chronic Rhinosinusitis
D Gudis, KQ Zhao, NA Cohen
American journal of rhinology & allergy 2012
An advanced stochastic model for mucociliary particle clearance in cystic fibrosis lungs
R Sturm
Journal of Thoracic Disease 2012
A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia
B Button, LH Cai, C Ehre, M Kesimer, DB Hill, JK Sheehan, RC Boucher, M Rubinstein
Science 2012
Bead-size directed distribution of Pseudomonas aeruginosa results in distinct inflammatory response in a mouse model of chronic lung infection: Distribution of pulmonary inflammation
LJ Christophersen, H Trøstrup, DS Damlund, T Bjarnsholt, K Thomsen, PØ Jensen, HP Hougen, N Høiby, C Moser
Clinical & Experimental Immunology 2012
Advances in Cell and Gene-based Therapies for Cystic Fibrosis Lung Disease
M Oakland, PL Sinn, PB McCray
Molecular Therapy 2012
Triiodothyronine Represses MUC5AC Expression by Antagonizing Sp1 Binding to Its Promoter in Human Bronchial Epithelial HBE16 Cells
X Wang, Q Li, X Zhou, VP Kolosov, JM Perelman
Journal of Biomedicine and Biotechnology 2012
CFTR Regulates Early Pathogenesis of Chronic Obstructive Lung Disease in βENaC-Overexpressing Mice
B Johannesson, S Hirtz, J Schatterny, C Schultz, MA Mall
PloS one 2012
PmrB Mutations Promote Polymyxin Resistance of Pseudomonas aeruginosa Isolated from Colistin-Treated Cystic Fibrosis Patients
SM Moskowitz, MK Brannon, N Dasgupta, M Pier, N Sgambati, AK Miller, SE Selgrade, SI Miller, M Denton, SP Conway, HK Johansen, N Høiby
Antimicrobial agents and chemotherapy 2012
Host Evasion by Burkholderia cenocepacia
S Ganesan, US Sajjan
Frontiers in Cellular and Infection Microbiology 2012
Effects of second hand smoke on airway secretion and mucociliary clearance
Y Liu, YP Di
Frontiers in physiology 2012
Clinical translation of RNAi-based treatments for respiratory diseases
B Ballarín-González, TB Thomsen, KA Howard
Drug Delivery and Translational Research 2012
Monitoring airway mucus flow and ciliary activity with optical coherence tomography
AL Oldenburg, RK Chhetri, DB Hill, B Button
Biomedical Optics Express 2012
Near-Universal Prevalence of Pneumocystis and Associated Increase in Mucus in the Lungs of Infants With Sudden Unexpected Death
SL Vargas, CA Ponce, M Gallo, F Perez, JF Astorga, R Bustamante, M Chabe, I Durand-Joly, P Iturra, RF Miller, EM Aliouat, E Dei-Cas
Clinical Infectious Diseases 2012
Pharmaceutical nanoparticles and the mucin biopolymer barrier
G Aljayyoussi, M Abdulkarim, P Griffiths, M Gumbleton
BioImpacts : BI 2012
The susceptibility of T5-TG12 of the CFTR gene in chronic bronchitis occurrence in a Chinese population in Jiangsu province, China
P Wang, S Naruse, H Yin, Z Yu, T Zhuang, W Ding, Y Wu, M Wei
Journal of Biomedical Research 2012
Ciliated cells of pseudostratified airway epithelium do not become mucous cells after ovalbumin challenge
A Pardo-Saganta, BM Law, M Gonzalez-Celeiro, V Vinarsky, J Rajagopal
American journal of respiratory cell and molecular biology 2012
Using unfixed, frozen tissues to study natural mucin distribution
M Cohen, NM Varki, MD Jankowski, P Gagneux
Journal of visualized experiments : JoVE 2012
Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways
M Kesimer, C Ehre, KA Burns, CW Davis, JK Sheehan, RJ Pickles
Mucosal Immunology 2012
Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways
CA Hobbs, MG Blanchard, S Kellenberger, S Bencharit, R Cao, M Kesimer, WG Walton, MR Redinbo, MJ Stutts, R Tarran
The FASEB Journal 2012
MUC2 protein expression status is useful in assessing the effects of hyperthermic intraperitoneal chemotherapy for peritoneal dissemination of colon cancer
Y Fujishima, T Goi, Y Kimura, Y Hirono, K Katayama, A Yamaguchi
International journal of oncology 2012
Epithelial Na⁺ channel activity in human airway epithelial cells: the role of serum and glucocorticoid-inducible kinase 1
GB Watt, NA Ismail, AG Caballero, SC Land, SM Wilson
British Journal of Pharmacology 2012
Allergic Host Defenses
NW Palm, RK Rosenstein, R Medzhitov
Nature 2012
CFTR, mucins, and mucus obstruction in cystic fibrosis
SM Kreda, CW Davis, MC Rose
Cold Spring Harbor Perspectives in Medicine 2012
Glucose transporter/T1R3-expressing cells in rat tracheal epithelium
F Merigo, D Benati, M Cristofoletti, F Amarù, F Osculati, A Sbarbati
Journal of Anatomy 2012
Pulmonary delivery of therapeutic siRNA
JK Lam, W Liang, HK Chan
Advanced Drug Delivery Reviews 2012
A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles
O Mert, SK Lai, L Ensign, M Yang, YY Wang, J Wood, J Hanes
Journal of Controlled Release 2012
Expression of dual oxidases and secreted cytokines in chronic rhinosinusitis: DUOX1/DUOX2 and secreted cytokines in CRS
DY Cho, JV Nayak, DT Bravo, W Le, A Nguyen, JA Edward, PH Hwang, B Illek, H Fischer
International Forum of Allergy & Rhinology 2012
Glucocorticoid Receptor and Histone Deacetylase–2 Mediate Dexamethasone-Induced Repression of MUC5AC Gene Expression
Y Chen, AM Watson, CD Williamson, M Rahimi, C Liang, AM Colberg-Poley, MC Rose
American journal of respiratory cell and molecular biology 2012
Hemagglutinin from the H5N1 Virus Activates Janus Kinase 3 to Dysregulate Innate Immunity
W Xu, M Chen, N Ge, J Xu, SG Zheng
PloS one 2012
Methods in Molecular Biology
LH Abdullah, C Wolber, M Kesimer, JK Sheehan, CW Davis
Methods in molecular biology (Clifton, N.J.) 2012
Phosphodiesterase 4B Mediates Extracellular Signal-regulated Kinase-dependent Up-regulation of Mucin MUC5AC Protein by Streptococcus pneumoniae by Inhibiting cAMP-protein Kinase A-dependent MKP-1 Phosphatase Pathway
J Lee, K Komatsu, BC Lee, JH Lim, H Jono, H Xu, H Kai, ZJ Zhang, C Yan, JD Li
The Journal of biological chemistry 2012
Structure and function of the Type III secretion system of Pseudomonas aeruginosa.
Galle M, Carpentier I, Beyaert R
Current protein & peptide science 2012
Inhaled innate immune ligands to prevent pneumonia
SE Evans, MJ Tuvim, CJ Fox, N Sachdev, L Gibiansky, BF Dickey
British Journal of Pharmacology 2011
The role of female hormones on lung function in chronic lung diseases
A Tam, D Morrish, S Wadsworth, D Dorscheid, SF Man, DD Sin
BMC Women's Health 2011
Improvement of adenoviral vector-mediated gene transfer to airway epithelia by folate-modified anionic liposomes
Z Zhong, Y Wan, J Han, S Shi, Z Zhang, X Sun
International Journal of Nanomedicine 2011
Impact of topically-applied ipd-giucose on tracheal mucociliary clearance after warm and cold ischemia: short communication
AE de Azevedo-Pereira, JA Saka, KA de Oliveira, R Pazetti, PM Pêgo-Fernandes, FB Jatene
Clinics (São Paulo, Brazil) 2011
Embryonic frog epidermis: a model for the study of cell-cell interactions in the development of mucociliary disease
E Dubaissi, N Papalopulu
Disease models & mechanisms 2011
Characterization of Virulence Factors of Staphylococcus aureus: Novel Function of Known Virulence Factors That Are Implicated in Activation of Airway Epithelial Proinflammatory Response
J Bien, O Sokolova, P Bozko
Journal of Pathogens 2011
Host Defense and the Airway Epithelium: Frontline Responses That Protect against Bacterial Invasion and Pneumonia
NA Eisele, DM Anderson
Journal of Pathogens 2011
Models for oral uptake of nanoparticles in consumer products
E Fröhlich, E Roblegg
Toxicology 2011
Ciliopathies: The Central Role of Cilia in a Spectrum of Pediatric Disorders
TW Ferkol, MW Leigh
The Journal of Pediatrics 2011
Measurement of the Airway Surface Liquid Volume with Simple Light Refraction Microscopy
PR Harvey, R Tarran, S Garoff, MM Myerburg
American journal of respiratory cell and molecular biology 2011
The Role of TLR2 and Bacterial Lipoprotein in Enhancing Airway Inflammation and Immunity
AA Lugade, PN Bogner, TF Murphy, Y Thanavala
Frontiers in immunology 2011
Effect of Polarized Release of CXC-Chemokines from Wild-Type and Cystic Fibrosis Murine Airway Epithelial Cells
MM Farberman, A Ibricevic, TD Joseph, KT Akers, R Garcia-Medina, S Crosby, LL Clarke, SL Brody, TW Ferkol
American journal of respiratory cell and molecular biology 2011
Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures
PR Sears, CW Davis, M Chua, JK Sheehan
AJP Lung Cellular and Molecular Physiology 2011
Biodegradable Nanoparticles Composed Entirely of Safe Materials that Rapidly Penetrate Human Mucus
M Yang, SK Lai, YY Wang, W Zhong, C Happe, M Zhang, J Fu, J Hanes
Angewandte Chemie (International ed. in English) 2011
Limited effects of Muc1 deficiency on mouse adenovirus type 1 respiratory infection
Y Nguyen, MC Procario, SL Ashley, WK O’Neal, RJ Pickles, JB Weinberg
Virus Research 2011
PhoQ Mutations Promote Lipid A Modification and Polymyxin Resistance of Pseudomonas aeruginosa Found in Colistin-Treated Cystic Fibrosis Patients
AK Miller, MK Brannon, L Stevens, HK Johansen, SE Selgrade, SI Miller, N Høiby, SM Moskowitz
Antimicrobial agents and chemotherapy 2011
NF-κB Mediates IL-1β– and IL-17A–Induced MUC5B Expression in Airway Epithelial Cells
T Fujisawa, MM Chang, S Velichko, P Thai, LY Hung, F Huang, N Phuong, Y Chen, R Wu
American journal of respiratory cell and molecular biology 2011
Gene therapy for cystic fibrosis lung disease
Sumner-Jones SG, Gill DR, Hyde SC
2011
Airway Surface Liquid Volume Regulation Determines Different Airway Phenotypes in Liddle Compared with βENaC-overexpressing Mice*
MA Mall, B Button, B Johannesson, Z Zhou, A Livraghi, RA Caldwell, SC Schubert, C Schultz, WK O'Neal, S Pradervand, E Hummler, BC Rossier, BR Grubb, RC Boucher
The Journal of biological chemistry 2010
Human Alveolar Type II Cells Secrete and Absorb Liquid in Response to Local Nucleotide Signaling*
PF Bove, BR Grubb, SF Okada, CM Ribeiro, TD Rogers, SH Randell, WK O'Neal, RC Boucher
The Journal of biological chemistry 2010
Inducible Innate Resistance of Lung Epithelium to Infection
SE Evans, Y Xu, MJ Tuvim, BF Dickey
Annual Review of Physiology 2010
Endotoxins: Structure, Function and Recognition
X Wang, PJ Quinn
2010
Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases
EA Gaillard, P Kota, M Gentzsch, NV Dokholyan, MJ Stutts, R Tarran
Pflügers Archiv - European Journal of Physiology 2010
Mucus secretion from individual submucosal glands of the ferret trachea
HJ Cho, NS Joo, JJ Wine
American journal of physiology. Lung cellular and molecular physiology 2010
Planar cell polarity signaling, cilia and polarized ciliary beating
JB Wallingford
Current Opinion in Cell Biology 2010
Transcriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGE
KM Lonergan, R Chari, BP Coe, IM Wilson, MS Tsao, RT Ng, C Macaulay, S Lam, WL Lam
PloS one 2010
Airway Mucus Function and Dysfunction
JV Fahy, BF Dickey
New England Journal of Medicine 2010
SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes
BM Rollins, A Garcia-Caballero, MJ Stutts, R Tarran
Channels (Austin, Tex.) 2010
Primary Ciliary Dyskinesia in Amish Communities
H Lie, MA Zariwala, C Helms, AM Bowcock, JL Carson, DE Brown, MJ Hazucha, J Forsen, D Molter, MR Knowles, MW Leigh, TW Ferkol
The Journal of Pediatrics 2010
Tissue Distribution of Murine Muc19/Smgc Gene Products
B Das, MN Cash, AR Hand, A Shivazad, SS Grieshaber, B Robinson, DJ Culp
Journal of Histochemistry & Cytochemistry 2010
Klebsiella pneumoniae Capsule Polysaccharide Impedes the Expression of β-Defensins by Airway Epithelial Cells
D Moranta, V Regueiro, C March, E Llobet, J Margareto, E Larrate, J Garmendia, JA Bengoechea
Infection and immunity 2010
Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process
1. Jae Young Choi 2. Monal Sonecha 3. Nam Soo Joo 4. Mauri E. Krouse 5. Robert C. Robbins 6. David Weill 7. Jeffrey J. Wine.
Journal of Clinical Investigation 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Innate Immunity to Aspergillus Species
SJ Park, B Mehrad
Clinical microbiology reviews 2009
Inhaled therapeutics for prevention and treatment of pneumonia
A Safdar, SA Shelburne, SE Evans, BF Dickey
Expert Opinion on Drug Safety 2009
Endogenous lung stem cells and contribution to disease
JC Snyder, RM Teisanu, BR Stripp
The Journal of Pathology 2009
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
SK Lai, YY Wang, J Hanes
Advanced Drug Delivery Reviews 2009
SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage
A Garcia-Caballero, JE Rasmussen, E Gaillard, MJ Watson, JC Olsen, SH Donaldson, MJ Stutts, R Tarran
Proceedings of the National Academy of Sciences 2009
Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures
DM Cholon, WK O'Neal, SH Randell, JR Riordan, M Gentzsch
American journal of physiology. Lung cellular and molecular physiology 2009
Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium
W Zheng, J Kuhlicke, K Jäckel, HK Eltzschig, A Singh, M Sjöblom, B Riederer, C Weinhold, U Seidler, SP Colgan, J Karhausen
The FASEB Journal 2009
The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases
Y Xu, S Szép, Z Lu
Proceedings of the National Academy of Sciences 2009
Conditional deletion of dnaic1 in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitis
LE Ostrowski, W Yin, TD Rogers, KB Busalacchi, M Chua, WK O'Neal, BR Grubb
American journal of respiratory cell and molecular biology 2009
Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses
SK Lai, YY Wang, K Hida, R Cone, J Hanes
Proceedings of the National Academy of Sciences 2009
Proton secretion in freshly excised sinonasal mucosa from asthma and sinusitis patients
DY Cho, M Hajighasemi, PH Hwang, B Illek, H Fischer
American journal of rhinology & allergy 2009
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier
BC Tang, M Dawson, SK Lai, YY Wang, JS Suk, M Yang, P Zeitlin, MP Boyle, J Fu, J Hanes
Proceedings of the National Academy of Sciences 2009
Absorptive clearance of DTPA as an aerosol-based biomarker in the cystic fibrosis airway
TE Corcoran, KM Thomas, MM Myerburg, A Muthukrishnan, L Weber, R Frizzell, JM Pilewski
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009
Purinergic receptors in airway epithelia
ER Lazarowski, RC Boucher
Current Opinion in Pharmacology 2009
Altering mucus rheology to "solidify" human mucus at the nanoscale
SK Lai, YY Wang, R Cone, D Wirtz, J Hanes
PloS one 2009
Chronic intermittent mechanical stress increases MUC5AC protein expression
JA Park, DJ Tschumperlin
American journal of respiratory cell and molecular biology 2009
Micro- and macrorheology of mucus
SK Lai, YY Wang, D Wirtz, J Hanes
Advanced Drug Delivery Reviews 2009
Mucus hypersecretion in asthma: causes and effects:
CM Evans, K Kim, MJ Tuvim, BF Dickey
Current Opinion in Pulmonary Medicine 2009
Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos
MK Brannon, JM Davis, JR Mathias, CJ Hall, JC Emerson, PS Crosier, A Huttenlocher, L Ramakrishnan, SM Moskowitz
Cellular Microbiology 2009
Clinical and genetic aspects of primary ciliary dyskinesia/Kartagener syndrome
MW Leigh, JE Pittman, JL Carson, TW Ferkol, SD Dell, SD Davis, MR Knowles, MA Zariwala
Genetics in Medicine 2009
Metagenomic Analysis of Respiratory Tract DNA Viral Communities in Cystic Fibrosis and Non-Cystic Fibrosis Individuals
D Willner, M Furlan, M Haynes, R Schmieder, FE Angly, J Silva, S Tammadoni, B Nosrat, D Conrad, F Rohwer, JA Gold
PloS one 2009
Klebsiella pneumoniae Increases the Levels of Toll-Like Receptors 2 and 4 in Human Airway Epithelial Cells
V Regueiro, D Moranta, MA Campos, J Margareto, J Garmendia, JA Bengoechea
Infection and immunity 2009
Synaptotagmin 2 Couples Mucin Granule Exocytosis to Ca2+ Signaling from Endoplasmic Reticulum
MJ Tuvim, AR Mospan, KA Burns, M Chua, PJ Mohler, E Melicoff, R Adachi, Z Ammar-Aouchiche, CW Davis, BF Dickey
The Journal of biological chemistry 2009
Histo-blood group gene polymorphisms as potential genetic modifiers of infection and cystic fibrosis lung disease severity.
Taylor-Cousar JL, Zariwala MA, Burch LH, Pace RG, Drumm ML, Calloway H, Fan H, Weston BW, Wright FA, Knowles MR
PloS one 2009
The Role of Innate Immunity in the Pathogenesis of Chronic Rhinosinusitis
Lane AP
Current Allergy and Asthma Reports 2009
17beta-Estradiol Inhibits Calcium-Dependent Airway Surface Liquid Volume Homeostasis in Cystic Fibrosis Airway Epithelia
Ray D. Coakley, Hengrui Sun, Julia E. Rasmussen, Lucy A. Chambers, James R. Stackhouse, Seiko F. Okada, Ingrid Fricks, Steven L. Young & Robert Tarran
Journal of Clinical Investigation 2008
Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice
CG Clement, SE Evans, CM Evans, D Hawke, R Kobayashi, PR Reynolds, SJ Moghaddam, BL Scott, E Melicoff, R Adachi, BF Dickey, MJ Tuvim
American journal of respiratory and critical care medicine 2008
Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype
A Fernandez-Gonzalez, S Kourembanas, TA Wyatt, SA Mitsialis
American journal of respiratory cell and molecular biology 2008
Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B
F Xu, Z Xu, R Zhang, Z Wu, JH Lim, T Koga, JD Li, H Shen
Respiratory Research 2008
Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells
M Ramanathan, WK Lee, EW Spannhake, AP Lane
American journal of rhinology 2008
Flagellin-stimulated Cl- secretion and innate immune responses in airway epithelia: role for p38
B Illek, Z Fu, C Schwarzer, T Banzon, S Jalickee, SS Miller, TE Machen
American journal of physiology. Lung cellular and molecular physiology 2008
Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis
MT Clunes, RC Boucher
Current Opinion in Pharmacology 2008
Clinical practice and genetic counseling for cystic fibrosis and CFTR-related disorders
SM Moskowitz, JF Chmiel, DL Sternen, E Cheng, RL Gibson, SG Marshall, GR Cutting
Genetics in Medicine 2008
Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium
CY Kao, C Kim, F Huang, R Wu
The Journal of biological chemistry 2008
Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier
YY Wang, SK Lai, JS Suk, A Pace, R Cone, J Hanes
Angewandte Chemie (International ed. in English) 2008
Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?
M Kesimer, S Kirkham, RJ Pickles, AG Henderson, NE Alexis, G Demaria, D Knight, DJ Thornton, JK Sheehan
American journal of physiology. Lung cellular and molecular physiology 2008
A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system
BM Rollins, M Burn, RD Coakley, LA Chambers, AJ Hirsh, MT Clunes, MI Lethem, SH Donaldson, R Tarran
American journal of respiratory cell and molecular biology 2008
Allergen-induced airway hyperresponsiveness is absent in ecto-5′-nucleotidase (CD73)-deficient mice
R Schreiber, H Castrop, K Kunzelmann
Pflügers Archiv - European Journal of Physiology 2008
Coupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling
CW Davis, E Lazarowski
Respiratory Physiology & Neurobiology 2008
Diminished Self-Chaperoning Activity of the ΔF508 Mutant of CFTR Results in Protein Misfolding
AW Serohijos, T Hegedűs, JR Riordan, NV Dokholyan, EI Shakhnovich
PLoS computational biology 2008
MKP1 Regulates the Induction of MUC5AC Mucin by Streptococcus pneumoniae Pneumolysin by Inhibiting the PAK4-JNK Signaling Pathway
UH Ha, JH Lim, HJ Kim, W Wu, S Jin, H Xu, JD Li
The Journal of biological chemistry 2008
Role of mechanical stress in regulating airway surface hydration and mucus clearance rates.
Button B, Boucher RC
Respiratory Physiology & Neurobiology 2008
Extracellular barriers in respiratory gene therapy.
Sanders N, Rudolph C, Braeckmans K, De Smedt SC, Demeester J
Advanced Drug Delivery Reviews 2008
Lung Defenses
Kobzik L
2008
VIP and carbachol cause synergistic airway gland secretion that is lost in cystic fibrosis
Jae Young Choi, Nam Soo Joo, Mauri E. Krouse, Jin V. Wu, Robert C. Robbins, Juan P. Ianowski, John W. Hanrahan Jeffrey J. Wine
Journal of Clinical Investigation 2007
IL-13 regulates cilia loss and foxj1 expression in human airway epithelium
BN Gomperts, LJ Kim, SA Flaherty, BP Hackett
American journal of respiratory cell and molecular biology 2007
Identification of novel ciliogenesis factors using a new in vivo model for mucociliary epithelial development
JM Hayes, SK Kim, PB Abitua, TJ Park, ER Herrington, A Kitayama, MW Grow, N Ueno, JB Wallingford
Developmental Biology 2007
Parasympathetic control of airway submucosal glands: central reflexes and the airway intrinsic nervous system
JJ Wine
Autonomic neuroscience : basic & clinical 2007
Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens
T Bjarnsholt, M Givskov
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2007
Liquid movement across the surface epithelium of large airways
LA Chambers, BM Rollins, R Tarran
Respiratory Physiology & Neurobiology 2007
The immunopathogenesis of chronic obstructive pulmonary disease: insights from recent research
JL Curtis, CM Freeman, JC Hogg
Proceedings of the American Thoracic Society 2007
Primary Ciliary Dyskinesia: Recent Advances in Pathogenesis, Diagnosis and Treatment
H Lie, T Ferkol
Drugs 2007
Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF
Y Huang, F Mikami, H Jono, W Zhang, X Weng, T Koga, H Xu, C Yan, H Kai, JD Li
Biochemical and Biophysical Research Communications 2007
Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis
Zahn A, Moehle C, Langmann T, Ehehalt R, Autschbach F, Stremmel W, Schmitz G
World journal of gastroenterology : WJG 2007
Identification of novel ciliogenesis factors using a new in vivo model for mucociliary epithelial development.
Hayes JM, Kim SK, Abitua PB, Park TJ, Herrington ER, Kitayama A, Grow MW, Ueno N, Wallingford JB
Developmental Biology 2007
Soluble Mediators, Not Cilia, Determine Airway Surface Liquid Volume in Normal and Cystic Fibrosis Superficial Airway Epithelia
R Tarran, L Trout, SH Donaldson, RC Boucher
The Journal of General Physiology 2006
Neutrophil elastase, an innate immunity effector molecule, represses flagellin transcription in Pseudomonas aeruginosa
A Sonawane, J Jyot, R During, R Ramphal
Infection and immunity 2006
State of the art. Bronchiolitis in chronic obstructive pulmonary disease
JC Hogg
Proceedings of the American Thoracic Society 2006
Cerebral microcirculation shear stress levels determine Neisseria meningitidis attachment sites along the blood-brain barrier
E Mairey, A Genovesio, E Donnadieu, C Bernard, F Jaubert, E Pinard, J Seylaz, JC Olivo-Marin, X Nassif, G Duménil
Journal of Experimental Medicine 2006
Mucociliary and long-term particle clearance in airways of patients with immotile cilia
W Möller, K Häussinger, L Ziegler-Heitbrock, J Heyder
Respiratory Research 2006
Should patients with acute exacerbation of chronic bronchitis be treated with antibiotics? Advantages of the use of fluoroquinolones
Mensa J, Trilla A
Clinical Microbiology and Infection 2006
Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections
R Tarran, B Button, M Picher, AM Paradiso, CM Ribeiro, ER Lazarowski, L Zhang, PL Collins, RJ Pickles, JJ Fredberg, RC Boucher
The Journal of biological chemistry 2005
Cystic fibrosis lung disease: genetic influences, microbial interactions, and radiological assessment
SM Moskowitz, RL Gibson, EL Effmann
Pediatric Radiology 2005
Pathogen-host interactions in Pseudomonas aeruginosa pneumonia
RT Sadikot, TS Blackwell, JW Christman, AS Prince
American journal of respiratory and critical care medicine 2005
Vasotocin and vasopressin stimulation of the chloride secretion in the human bronchial epithelial cell line, 16HBE14o-
K Bernard, S Bogliolo, J Ehrenfeld
British Journal of Pharmacology 2005
Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions
BL Schulz, AJ Sloane, LJ Robinson, LT Sebastian, AR Glanville, Y Song, AS Verkman, JL Harry, NH Packer, NG Karlsson
Biochemical Journal 2005
Inositol polyphosphate derivative inhibits Na+ transport and improves fluid dynamics in cystic fibrosis airway epithelia
M Moody, C Pennington, C Schultz, R Caldwell, C Dinkel, MW Rossi, S McNamara, J Widdicombe, S Gabriel, AE Traynor-Kaplan
American journal of physiology. Cell physiology 2005
TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity
YN Andrade, J Fernandes, E Vázquez, JM Fernández-Fernández, M Arniges, TM Sánchez, M Villalón, MA Valverde
The Journal of Cell Biology 2005
Effect of herpesvirus infection on pancreatic duct cell secretion.
Hegyi P, Ordog B, Rakonczai Z Jr, Takács T, Lonovics J, Szabolcs A, Sári R, Tóth A, Papp JG, Varró A, Kovács MK, Gray MA, Argent BE, Boldogköi Z
World Journal of Gastroenterology 2005
Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients
MC Wolfgang, J Jyot, AL Goodman, R Ramphal, S Lory
Proceedings of the National Academy of Sciences 2004
Expression Analysis of a Highly Adherent and Cytotoxic Small Colony Variant of Pseudomonas aeruginosa Isolated from a Lung of a Patient with Cystic Fibrosis
F von Götz, S Häussler, D Jordan, SS Saravanamuthu, D Wehmhöner, A Strüßmann, J Lauber, I Attree, J Buer, B Tümmler, I Steinmetz
Journal of bacteriology 2004
Lymphocytes in cystic fibrosis lung disease: a tale of two immunities
RB Moss
Clinical & Experimental Immunology 2004
Responses of well-differentiated airway epithelial cell cultures from healthy donors and patients with cystic fibrosis to Burkholderia cenocepacia infection
U Sajjan, S Keshavjee, J Forstner
Infection and immunity 2004
Nucleotide release provides a mechanism for airway surface liquid homeostasis
ER Lazarowski, R Tarran, BR Grubb, CA van Heusden, S Okada, RC Boucher
The Journal of biological chemistry 2004
Ca 2+ dependency of ‘Ca 2+ -independent’ exocytosis in SPOC1 airway goblet cells: Ca 2+ dependency of SPOC1 cell exocytosis
AH Rossi, PR Sears, CW Davis
The Journal of Physiology 2004
Airway hypersecretion in allergic rhinitis and asthma: New pharmacotherapy
DF Rogers
Current Allergy and Asthma Reports 2003
Disruptive effects of Anion Secretion Inhibitors on Airway Mucus Morphology in Isolated Perfused Pig Lung
L Trout, MI Townsley, AL Bowden, ST Ballard
The Journal of Physiology 2003
Antimicrobial polypeptides in host defense of the respiratory tract
Thomas Ganz
Journal of Clinical Investigation 2002
Cytokines in innate host defense in the lung
Robert Strieter, John A. Belpario, Michael Keane
Journal of Clinical Investigation 2002
Reduced oxygen concentrations in airway mucus contribute to the early and late pathogenesis of Pseudomonas aeruginosa cystic fibrosis airways infection
Dieter Worlitzsch, Robert Tarran, Martina Ulrich, Ute Schwab, Aynur Cekici, Keith C. Meyer, Peter Birrer, Gabriel Bellon, Jürgen Berger, Tilo Weiß, Konrad Botzenhart, James R. Yankaskas, Scott Randell, Richard C. Boucher, Gerd Döring
Journal of Clinical Investigation 2002
Regulation of Murine Airway Surface Liquid Volume by CFTR and Ca 2+ -activated Cl − Conductances
R Tarran, ME Loewen, AM Paradiso, JC Olsen, MA Gray, BE Argent, RC Boucher, SE Gabriel
The Journal of General Physiology 2002
Airway Hydration, Apical K+ Secretion, and the Large-Conductance, Ca2+-activated and Voltage-dependent Potassium (BK) Channel
Adrian Kis, Stefanie Krick, Nathalie Baumlin, Matthias Salathe
Annals of the American Thoracic Society
Probing mucin interaction behavior of magnetic nanoparticles
VN Boya, R Lovett, S Setua, V Gandhi, PK Nagesh, S Khan, M Jaggi, MM Yallapu, SC Chauhan
Journal of Colloid and Interface Science 2017
Bacterial Pathogens and the Microbiome
TW Vickery, VR Ramakrishnan
Otolaryngologic Clinics of North America 2017
Effects of Sialic Acid Modifications on Virus Binding and Infection
BR Wasik, KN Barnard, CR Parrish
Trends in Microbiology 2016
Incidence and risk factors for aspiration pneumonia after cardiovascular surgery in elderly patients
E Miyata, A Tanaka, H Emori, A Taruya, S Miyai, N Sakagoshi
General Thoracic and Cardiovascular Surgery 2016
Primary Ciliary Dyskinesia
MR Knowles, M Zariwala, M Leigh
Clinics in Chest Medicine 2016
Synthetic Mucus Nanobarriers for Identification of Glycan-Dependent Primary Influenza A Infection Inhibitors
M Cohen, HP Senaati, CJ Fisher, ML Huang, P Gagneux, K Godula
ACS Central Science 2016
Gefitinib, an EGFR Tyrosine Kinase inhibitor, Prevents Smoke-Mediated Ciliated Airway Epithelial Cell Loss and Promotes Their Recovery
M Valencia-Gattas, GE Conner, NL Fregien, S Ahmad
PloS one 2016
Effect of Shear Stress on Pseudomonas aeruginosa Isolated from the Cystic Fibrosis Lung
J Dingemans, P Monsieurs, SH Yu, A Crabbé, KU Förstner, A Malfroot, P Cornelis, RV Houdt
mBio 2016
The Mucus Barrier to Inhaled Gene Therapy
GA Duncan, J Jung, J Hanes, JS Suk
Molecular Therapy 2016
Role of CFTR in epithelial physiology
V Saint-Criq, MA Gray
Cellular and Molecular Life Sciences 2016
Marked increases in mucociliary clearance produced by synergistic secretory agonists or inhibition of the epithelial sodium channel
NS Joo, JH Jeong, HJ Cho, JJ Wine
Scientific Reports 2016
Ultrahigh-speed, phase-sensitive full-field interferometric confocal microscopy for quantitative microscale physiology
I Sencan, BK Huang, Y Bian, E Mis, MK Khokha, H Cao, M Choma
Biomedical Optics Express 2016
Staphylococcus aureus Infection Reduces Nutrition Uptake and Nucleotide Biosynthesis in a Human Airway Epithelial Cell Line
P Gierok, M Harms, K Methling, F Hochgräfe, M Lalk
Metabolites 2016
Identification of essential genes of Pseudomonas aeruginosa for its growth in airway mucus
MA Alrahman, SS Yoon
The Journal of Microbiology 2016
Validation of antibody reagents for mucin analysis in chronic inflammatory airway diseases
T Krause, N Röckendorf, KI Gaede, K Ramaker, H Sinnecker, A Frey
mAbs 2016
Allergic Aspergillus Rhinosinusitis
A Chakrabarti, H Kaur
Journal of Fungi 2016
Measuring Airway Surface Liquid Depth in Ex Vivo Mouse Airways by X-Ray Imaging for the Assessment of Cystic Fibrosis Airway Therapies
KS Morgan, M Donnelley, DM Paganin, A Fouras, N Yagi, Y Suzuki, A Takeuchi, K Uesugi, RC Boucher, DW Parsons, KK Siu, D Hartl
PloS one 2013
LRRC6 Mutation Causes Primary Ciliary Dyskinesia with Dynein Arm Defects
A Horani, TW Ferkol, D Shoseyov, MG Wasserman, YS Oren, B Kerem, I Amirav, M Cohen-Cymberknoh, SK Dutcher, SL Brody, O Elpeleg, E Kerem, SF Grant
PloS one 2013
PKCθ Synergizes with TLR-Dependent TRAF6 Signaling Pathway to Upregulate MUC5AC Mucin via CARMA1
H Jono, JH Lim, H Xu, JD Li, AJ Ratner
PloS one 2012
Suppression of Adenosine-Activated Chloride Transport by Ethanol in Airway Epithelia
SV Raju, G Wang, Z Zhang
PloS one 2012
Mucin Variable Number Tandem Repeat Polymorphisms and Severity of Cystic Fibrosis Lung Disease: Significant Association with MUC5AC
XL Guo, RG Pace, JR Stonebraker, CW Commander, AT Dang, ML Drumm, A Harris, F Zou, DM Swallow, FA Wright, WK O'Neal, MR Knowles, T Eckle
PloS one 2011
Defective Fluid Secretion from Submucosal Glands of Nasal Turbinates from CFTR-/- and CFTRΔF508/ΔF508 Pigs
HJ Cho, NS Joo, JJ Wine, N Vij
PloS one 2011
Serotonin Increases Cilia-Driven Particle Transport via an Acetylcholine-Independent Pathway in the Mouse Trachea
P König, B Krain, G Krasteva, W Kummer, M Rojas
PloS one 2009
Risk of high blood pressure in salt workers working near salt milling plants: A cross-sectional and interventional study
KR Haldiya, ML Mathur, R Sachdev, HN Saiyed
Environmental Health 2005
Cell Jamming in the Airway Epithelium
Jin-Ah Park, Jeffrey J. Fredberg
Annals of the American Thoracic Society
Reduced mucociliary clearance in old mice is associated with a decrease in Muc5b mucin
BR Grubb, A Livraghi-Butrico, TD Rogers, W Yin, B Button, LE Ostrowski
American journal of physiology. Lung cellular and molecular physiology 2016
Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide
E Pouokam, M Althaus
Oxidative medicine and cellular longevity 2016
CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks
DJ Echelman, J Alegre-Cebollada, CL Badilla, C Chang, H Ton-That, JM Fernández
Proceedings of the National Academy of Sciences 2016
Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium
S Weiterer, T Kohlen, F Veit, L Sachs, F Uhle, C Lichtenstern, MA Weigand, M Henrich, J Porter
PloS one 2015
SNAP23 Is Selectively Expressed in Airway Secretory Cells and Mediates Baseline and Stimulated Mucin Secretion
B Ren, Z Azzegagh, A Jaramillo, Y Zhu, A Pardo-saganta, R Bagirzadeh, J Flores, W Han, Y Tang, J Tu, D Alanis, C Evans, M Guindani, P Roche, J Rajagopal, J Chen, C Davis, M Tuvim, B Dickey
Bioscience Reports 2015
Airway Surface Dehydration by Transforming Growth Factor β (TGF-β) in Cystic Fibrosis Is Due to Decreased Function of a Voltage-dependent Potassium Channel and Can Be Rescued by the Drug Pirfenidone
D Manzanares, S Krick, N Baumlin, JS Dennis, J Tyrrell, R Tarran, M Salathe
The Journal of biological chemistry 2015
Regulation of Airway MUC5AC Expression by IL-1  and IL-17A; the NF- B Paradigm
T Fujisawa, S Velichko, P Thai, LY Hung, F Huang, R Wu
Journal of immunology (Baltimore, Md. : 1950) 2009

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