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Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome)
Martin Tristani-Firouzi, … , Louis J. Ptacek, Rabi Tawil
Martin Tristani-Firouzi, … , Louis J. Ptacek, Rabi Tawil
Published August 1, 2002
Citation Information: J Clin Invest. 2002;110(3):381-388. https://doi.org/10.1172/JCI15183.
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Article Genetics

Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome)

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Abstract

Research Article

Authors

Martin Tristani-Firouzi, Judy L. Jensen, Matthew R. Donaldson, Valeria Sansone, Giovanni Meola, Angelika Hahn, Said Bendahhou, Hubert Kwiecinski, Anna Fidzianska, Nikki Plaster, Ying-Hui Fu, Louis J. Ptacek, Rabi Tawil

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Figure 3

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Representative ECGs from AS subjects. (a) ECG demonstrating prolongation...
Representative ECGs from AS subjects. (a) ECG demonstrating prolongation of the QT interval. (b) ECG traces demonstrating a short run of nonsustained polymorphic VT followed by bigeminy (normal QRS complex alternating with a premature ventricular complex). Ventricular arrhythmias dominated the rhythm of this subject throughout the day. (c) Bidirectional VT (note alternating QRS axis polarity) degenerating into a brief run of polymorphic VT. (d) ECG trace demonstrating prominent U wave (indicated by arrows).

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