Thirteen days after immunization with MBPp87–99/CFA to induce active EAE, cervical lymph node cells and spleen cells (not shown) of EAE rats were determined for their ability to mount a proliferative response to MBPp87–88, MBPp68–86, whole Guinea-pig MBP, and MT. (a) The proliferative responses to each antigen. (b) The proliferative responses to each antigen in the presence of rabbit anti-rat neutralizing Ab’s (10 μg/ml) to IL-4. (c) The proliferative responses to each antigen in the presence of rabbit anti-rat neutralizing Ab’s (10 μg/ml) to IL-10. Results are shown as mean of triplicates ± SE.