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Citations to this article

PTPN2 mutations cause epithelium-intrinsic barrier loss that synergizes with mucosal immune hyperactivation
Yan Y. Sweat, Jerrold R. Turner
Yan Y. Sweat, Jerrold R. Turner
Published September 1, 2021
Citation Information: J Clin Invest. 2021;131(17):e151414. https://doi.org/10.1172/JCI151414.
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Commentary Article has an altmetric score of 4

PTPN2 mutations cause epithelium-intrinsic barrier loss that synergizes with mucosal immune hyperactivation

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Abstract

It is clear that excessive mucosal immune activation and intestinal barrier dysfunction both contribute to inflammatory bowel disease (IBD) pathogenesis. T cell protein tyrosine phosphatase (TCPTP), which extinguishes signaling in immune cells, is linked to IBD and other immune-mediated diseases. In this issue of the JCI, Marchelletta and Krishnan et al. demonstrate that, in intestinal epithelial cells, TCPTP regulates tight junction permeability in vivo. Intestinal epithelial TCPTP loss potentiated cytokine-induced barrier loss, and this synergized with effects of TCPTP loss in immune cells. This work implicates a single mutation as the cause of distinct functional aberrations in diverse cell types and demonstrates how one genetic defect can drive multihit disease pathogenesis.

Authors

Yan Y. Sweat, Jerrold R. Turner

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Total citations by year

Year: 2023 Total
Citations: 1 1
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (1)

Title and authors Publication Year
Intestinal Barrier Dysfunction in Inflammatory Bowel Disease: Underpinning Pathogenesis and Therapeutics.
Dunleavy KA, Raffals LE, Camilleri M
Digestive Diseases and Sciences 2023

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