Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis
Masashi Nishida, … , Hiroaki Yoshida, Iekuni Ichikawa
Masashi Nishida, … , Hiroaki Yoshida, Iekuni Ichikawa
Published December 15, 2002
Citation Information: J Clin Invest. 2002;110(12):1859-1868. https://doi.org/10.1172/JCI15045.
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Article

Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis

Abstract

Research Article

Authors

Masashi Nishida, Hidehiko Fujinaka, Taiji Matsusaka, James Price, Valentina Kon, Agnes B. Fogo, Jeffrey M. Davidson, MacRae F. Linton, Sergio Fazio, Toshio Homma, Hiroaki Yoshida, Iekuni Ichikawa

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Macrophage infiltration after UUO in wild-type mice with either Agtr1–/–...
Macrophage infiltration after UUO in wild-type mice with either Agtr1–/– marrow or Agtr1+/+ marrow. (a) Immunohistochemical demonstration of macrophages with anti-F4/80 antibody in mice with Agtr1–/– marrow (left) and mice with Agtr1+/+ marrow (right) at day 14 after UUO. Magnification, ×400. (b) Macrophages (F4/80-positive cells) infiltrating to the interstitium at day 5 (left) and day 14 (right) after UUO. Black bars represent mice with Agtr1–/– marrow; white bars represent mice with Agtr1+/+ marrow. Data are expressed as means ± SEM. *P < 0.001 for mice with Agtr1–/– marrow versus mice with Agtr1+/+ marrow. NS, not significant.