Junichi Sadoshima, Olivier Montagne, Qian Wang, Guiping Yang, Jill Warden, Jing Liu, Gen Takagi, Vijaya Karoor, Chull Hong, Gary L. Johnson, Dorothy E. Vatner, Stephen F. Vatner
Pressure overload causes more apoptosis in the inflammatory lesions of MEKK1–/– mice than in those of MEKK1+/+ mice. MEKK1+/+ (control) and MEKK1–/– mice were subjected to aortic banding for 7 days. DAPI staining (a and b) and TUNEL staining (c and d) in LV myocardium 7 days after aortic banding. White arrows indicate TUNEL-positive myocyte nuclei in a control mouse (a and c) and in a MEKK1–/– mouse (b and d). Bar = 100 μm. (e) TUNEL-positive cells in the inflammatory lesions in LV myocardium. More TUNEL-positive cells were observed in the inflammatory lesions of MEKK1–/– mice than in those of control mice. *P < 0.05.