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Ji Hoon Ahn, … , Chang-Seop Lee, Gou Young Koh
Published May 18, 2021
Citation Information: J Clin Invest. 2021;131(13):e148517. https://doi.org/10.1172/JCI148517.
Citation Information: J Clin Invest. 2021;131(13):e148517. https://doi.org/10.1172/JCI148517.
Abstract
The upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-2 tropism at the cellular level is not fully defined. Unlike recent single-cell RNA-Seq analyses indicating uniformly low mRNA expression of SARS-CoV-2 entry–related host molecules in all nasal epithelial cells, we show that the protein levels are relatively high and that their localizations are restricted to the apical side of multiciliated epithelial cells. In addition, we provide evidence in patients with COVID-19 that SARS-CoV-2 is massively detected and replicated within the multiciliated cells. We observed these findings during the early stage of COVID-19, when infected ciliated cells were rapidly replaced by differentiating precursor cells. Moreover, our analyses revealed that SARS-CoV-2 cellular tropism was restricted to the nasal ciliated versus oral squamous epithelium. These results imply that targeting ciliated cells of the nasal epithelium during the early stage of COVID-19 could be an ideal strategy to prevent SARS-CoV-2 propagation.
Authors
Ji Hoon Ahn, JungMo Kim, Seon Pyo Hong, Sung Yong Choi, Myung Jin Yang, Young Seok Ju, Young Tae Kim, Ho Min Kim, MD Tazikur Rahman, Man Ki Chung, Sang Duk Hong, Hosung Bae, Chang-Seop Lee, Gou Young Koh
Citation information
Citations to this article (150)
| Title and authors | Publication | Year |
|---|---|---|
|
Mucosal immune response in biology, disease prevention and treatment
Zhou X, Wu Y, Zhu Z, Lu C, Zhang C, Zeng L, Xie F, Zhang L, Zhou F |
Signal Transduction and Targeted Therapy | 2025 |
|
Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge
Coates ML, Richoz N, Tuong ZK, Bowyer GS, Lee CY, Ferdinand JR, Gillman E, McClure M, Dratva L, Teichmann SA, Jayne DR, Di Marco Barros R, Stewart BJ, Clatworthy MR |
Nature Immunology | 2025 |
|
Selective Control by Pistacia vera L. and Its Carotenoid Zeaxanthin on SARS-CoV-2 Virus
Pennisi R, Gentile D, Trischitta P, Barreca D, Rescifina A, Mandalari G, Sciortino MT |
International Journal of Molecular Sciences | 2025 |
|
A risk-risk tradeoff approach for incorporating the public’s risk perceptions into quantitative microbial risk assessment
Wilson AM, Mussio I, Verhougstraete MP, Jung Y, Ashraf A, Chilton S, Hamilton KA |
Journal of occupational and environmental hygiene | 2025 |
|
Simian Immunodeficiency Virus-Based Virus-like Particles Are an Efficient Tool to Induce Persistent Anti-SARS-CoV-2 Spike Neutralizing Antibodies and Specific T Cells in Mice
Gallinaro A, Falce C, Pirillo MF, Borghi M, Grasso F, Canitano A, Cecchetti S, Baratella M, Michelini Z, Mariotti S, Chiantore MV, Farina I, Di Virgilio A, Tinari A, Scarlatti G, Negri D, Cara A |
Vaccines | 2025 |
|
Processing of genomic RNAs by Dicer in bat cells limits SARS-CoV-2 replication
Owolabi IJ, Karim SU, Khanal S, Valdivia S, Frenzel C, Bai F, Flynt AS |
Virology Journal | 2025 |
|
Variable DPP4 expression in multiciliated cells of the human nasal epithelium as a determinant for MERS-CoV tropism.
Breugem TI, Riesebosch S, Zhang J, Mykytyn AZ, Krabbendam L, Groen N, Baptista Varela S, Schipper D, van den Doel PB, van Acker R, Stadhouders R, Lamers MM, Haagmans BL, Breugem TI, Riesebosch S, Zhang J, Mykytyn AZ, Krabbendam L, Groen N, Baptista Varela S, Schipper D, van den Doel PB, van Acker R, Stadhouders R, Lamers MM, Haagmans BL |
Proceedings of the National Academy of Sciences of the United States of America | 2025 |
|
DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients' airway epithelial cells.
Messingschlager M, Mackowiak SD, Voelker MT, Bieg M, Loske J, Chua RL, Liebig J, Lukassen S, Thürmann L, Seegebarth A, Twardziok S, Doncevic D, Herrmann C, Lorenz S, Klages S, Steinbeis F, Witzenrath M, Kurth F, Conrad C, Sander LE, Ishaque N, Eils R, Lehmann I, Laudi S, Trump S |
EMBO molecular medicine | 2025 |
|
Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2.
Walsh JML, Miao VN, Owings AH, Tang Y, Bromley JD, Kazer SW, Kimler K, Asare C, Ziegler CGK, Ibrahim S, Jivanjee T, George M, Navia AW, Drake RS, Parker A, Billingsley BC, Dotherow P, Tarugu S, Kota SK, Laird H, Wichman TG, Davis YT, Dhaliwal NS, Pride Y, Guo Y, Senitko M, Harvey J, Bates JT, Diamond G, Garrett MR, Robinson DA, Frame IJ, Lyons JJ, Robinson TO, Shalek AK, Horwitz BH, Glover SC, Ordovas-Montanes J |
Nature immunology | 2025 |
|
IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques
Christine Nelson, Taylor Foreman, Keith Kauffman, Shunsuke Sakai, Sydnee Gould, Joel Fleegle, Felipe Gomez, Cyril Nouen, Xueqiao Liu, Tracey Burdette, Nicole Garza, Bernard Lafont, Kelsie Brooks, Cecilia Arlehamn, Daniela Weiskopf, Alessandro Sette, Heather Hickman, Ursula Buchholz, Reed Johnson, Jason Brenchley, Laura Via, Daniel Barber |
PLoS pathogens | 2024 |
|
Differences Between Patients With Chronic Epipharyngitis With and Without Previous COVID-19 Infection
Mogitate M |
Cureus | 2024 |
|
SUB-Immunogold-SEM reveals nanoscale distribution of submembranous epitopes
Miller KK, Wang P, Grillet N |
Research square | 2024 |
|
Pathogenesis and virulence of coronavirus disease: Comparative pathology of animal models for COVID-19.
Kirk NM, Liang Y, Ly H |
Virulence | 2024 |
|
Apoptosis and pyroptosis in the nasal mucosa of Syrian hamster during SARS-CoV-2 infection and reinfection.
Li H, Zhao X, Zhang X, Zheng H, Wang Y, Hou J, Li J, Zhao Y, Peng S, Li Y, Zhang X, Zhang Y, Yang J, Zhang Z, Shi H, Liu L |
Apoptosis : an international journal on programmed cell death | 2024 |
|
Mucosal Immunity against SARS-CoV-2 in the Respiratory Tract.
Noh HE, Rha MS |
2024 | |
|
HIV and COVID-19: two pandemics with significant (but different) central nervous system complications.
Magaki S, Zhang T, Han K, Hilda M, Yong WH, Achim C, Fishbein G, Fishbein MC, Garner O, Salamon N, Williams CK, Valdes-Sueiras MA, Hsu JJ, Kelesidis T, Mathisen GE, Lavretsky H, Singer EJ, Vinters HV |
Free neuropathology | 2024 |
|
Lipid Nanoparticle-Based Inhibitors for SARS-CoV-2 Host Cell Infection.
Yathindranath V, Safa N, Tomczyk MM, Dolinsky V, Miller DW |
International Journal of Nanomedicine | 2024 |
|
Temperature impacts SARS-CoV-2 spike fusogenicity and evolution
Dufloo J, Sanjuán R |
mBio | 2024 |
|
Age-specific nasal epithelial responses to SARS-CoV-2 infection.
Woodall MNJ, Cujba AM, Worlock KB, Case KM, Masonou T, Yoshida M, Polanski K, Huang N, Lindeboom RGH, Mamanova L, Bolt L, Richardson L, Cakir B, Ellis S, Palor M, Burgoyne T, Pinto A, Moulding D, McHugh TD, Saleh A, Kilich E, Mehta P, O'Callaghan C, Zhou J, Barclay W, DeCoppi P, Butler CR, Cortina-Borja M, Vinette H, Roy S, Breuer J, Chambers RC, Heywood WE, Mills K, Hynds RE, Teichmann SA, Meyer KB, Nikolić MZ, Smith CM |
Nature Microbiology | 2024 |
|
Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1.
Li X, Xu M, Yang J, Zhou L, Liu L, Li M, Wang S, Liu MQ, Huang Z, Zhang Z, Liu S, Hu Y, Lin H, Liu B, Sun Y, Wu Q, Shi ZL, Lan K, Chen Y, Yan H, Chen YQ |
Signal Transduction and Targeted Therapy | 2024 |
|
Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury
Cao JB, Zhu ST, Huang XS, Wang XY, Wu ML, Li X, Liu FL, Chen L, Zheng YT, Wang JH |
Virologica Sinica | 2024 |
|
Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses.
Hartmann JA, Cardoso MR, Talarico MCR, Kenney DJ, Leone MR, Reese DC, Turcinovic J, O'Connell AK, Gertje HP, Marino C, Ojeda PE, De Paula EV, Orsi FA, Velloso LA, Cafiero TR, Connor JH, Ploss A, Hoelzemer A, Carrington M, Barczak AK, Crossland NA, Douam F, Boucau J, Garcia-Beltran WF |
Cell | 2024 |
|
Genes involved in the limited spread of SARS-CoV-2 in the lower respiratory airways of hamsters may be associated with adaptive evolution.
Takada K, Orba Y, Kida Y, Wu J, Ono C, Matsuura Y, Nakagawa S, Sawa H, Watanabe T |
Journal of virology | 2024 |
|
Effects of Nozzle Retraction Elimination on Spray Distribution in Middle-Posterior Turbinate Regions: A Comparative Study
Seifelnasr A, Si X, Xi J |
Pharmaceutics | 2024 |
|
SARS-CoV-2-Induced Type I Interferon Signaling Dysregulation in Olfactory Networks Implications for Alzheimer’s Disease
Vavougios GD, Mavridis T, Doskas T, Papaggeli O, Foka P, Hadjigeorgiou G |
Current issues in molecular biology | 2024 |
|
Uncovering strain- and age-dependent innate immune responses to SARS-CoV-2 infection in air-liquid-interface cultured nasal epithelia
Chang JJ, Grimley SL, Tran BM, Deliyannis G, Tumpach C, Nguyen AN, Steinig E, Zhang J, Schröder J, Caly L, McAuley J, Wong SL, Waters SA, Stinear TP, Pitt ME, Purcell D, Vincan E, Coin LJ |
iScience | 2024 |
|
TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication
Gonzalez-Orozco M, Tseng HC, Hage A, Xia H, Behera P, Afreen K, Peñaflor-Tellez Y, Giraldo MI, Huante M, Puebla-Clark L, van Tol S, Odle A, Crown M, Teruel N, Shelite TR, Menachery V, Endsley M, Endsley JJ, Najmanovich RJ, Bashton M, Stephens R, Shi PY, Xie X, Freiberg AN, Rajsbaum R |
2024 | |
|
Building a human lung from pluripotent stem cells to model respiratory viral infections
Turner DL, Amoozadeh S, Baric H, Stanley E, Werder RB |
Respiratory Research | 2024 |
|
Cytokine Storm in COVID-19: Insight into Pathological Mechanisms and Therapeutic Benefits of Chinese Herbal Medicines
Yu Q, Zhou X, Kapini R, Arsecularatne A, Song W, Li C, Liu Y, Ren J, Münch G, Liu J, Chang D |
Medicines | 2024 |
|
CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment
Kar M, Johnson KE, Vanderheiden A, Elrod EJ, Floyd K, Geerling E, Stone ET, Salinas E, Banakis S, Wang W, Sathish S, Shrihari S, Davis-Gardner ME, Kohlmeier J, Pinto A, Klein R, Grakoui A, Ghedin E, Suthar MS |
Science Advances | 2024 |
|
The Interplay between Airway Cilia and Coronavirus Infection, Implications for Prevention and Control of Airway Viral Infections
Dai X, Xu R, Li N |
Cells | 2024 |
|
SUB-immunogold-SEM reveals nanoscale distribution of submembranous epitopes
Miller KK, Wang P, Grillet N |
Nature Communications | 2024 |
|
Uncovering the Contrasts and Connections in PASC: Viral Load and Cytokine Signatures in Acute COVID-19 versus Post-Acute Sequelae of SARS-CoV-2 (PASC)
Compeer B, Neijzen TR, van Lelyveld SF, Martina BE, Russell CA, Goeijenbier M |
Biomedicines | 2024 |
|
Interactions of SARS-CoV-2 with Human Target Cells—A Metabolic View
Eisenreich W, Leberfing J, Rudel T, Heesemann J, Goebel W |
International Journal of Molecular Sciences | 2024 |
|
SARS-CoV-2 spike-specific nasal-resident CD49a+CD8+ memory T cells exert immediate effector functions with enhanced IFN-γ production
Rha MS, Kim G, Lee S, Kim J, Jeong Y, Jung CM, Noh HE, Noh JY, Kim YM, Cho HJ, Kim CH, Shin EC |
Nature Communications | 2024 |
|
A complex remodeling of cellular homeostasis distinguishes RSV/SARS-CoV-2 co-infected A549-hACE2 expressing cell lines
Vanetti C, Saulle I, Artusa V, Moscheni C, Cappelletti G, Zecchini S, Strizzi S, Garziano M, Fenizia C, Tosoni A, Broggiato M, Ogno P, Nebuloni M, Clerici M, Trabattoni D, Limanaqi F, Biasin M |
Microbial Cell | 2024 |
|
Durability of immune responses to SARS-CoV-2 infection and vaccination
Suthar MS |
Seminars in immunology | 2024 |
|
Effectiveness of an Infection Control Program Among the Ysleta del Sur Pueblo in Preventing COVID-19-Related Hospitalizations and Deaths.
Torres CM, Aparicio V, Calzada G, Mena A, Spencer CT |
Pathogens (Basel, Switzerland) | 2024 |
|
Single-cell analysis of nasal epithelial cell development in domestic pigs
Wang W, Liu R, Zhong Q, Cao Y, Qi J, Li Y, Yang Q |
Veterinary Research | 2024 |
|
COVID-19: a multi-organ perspective.
Guarienti FA, Gonçalves JIB, Gonçalves JB, Antônio Costa Xavier F, Marinowic D, Machado DC |
Frontiers in cellular and infection microbiology | 2024 |
|
Using Zebrafish to Study Multiciliated Cell Development and Disease States
Nguyen TK, Baker S, Rodriguez JM, Arceri L, Wingert RA |
Cells | 2024 |
|
TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication
Gonzalez-Orozco M, Tseng HC, Hage A, Xia H, Behera P, Afreen K, Peñaflor-Tellez Y, Giraldo MI, Huante M, Puebla-Clark L, van Tol S, Odle A, Crown M, Teruel N, Shelite TR, Moreno-Contreras J, Terasaki K, Makino S, Menachery V, Endsley M, Endsley JJ, Najmanovich RJ, Bashton M, Stephens R, Shi PY, Xie X, Freiberg AN, Rajsbaum R |
Nature Communications | 2024 |
|
Identification of virus-rich intermediate cells as crucial players in SARS-CoV-2 infection and differentiation dynamics of human airway epithelium
Kim MI, Lee C |
Frontiers in Microbiology | 2024 |
|
Neuropsychiatric Burden of SARS-CoV-2: A Review of Its Physiopathology, Underlying Mechanisms, and Management Strategies
Pacnejer AM, Butuca A, Dobrea CM, Arseniu AM, Frum A, Gligor FG, Arseniu R, Vonica RC, Vonica-Tincu AL, Oancea C, Mogosan C, Popa Ilie IR, Morgovan C, Dehelean CA |
Viruses | 2024 |
|
Resistance to SARS-CoV-2 infection in camelid nasal organoids is associated with lack of ACE2 expression
Breugem TI, Riesebosch S, Schipper D, Mykytyn AZ, van den Doel P, Segalés J, Lamers MM, Haagmans BL |
npj Viruses | 2024 |
|
Organoids in virology
Chu JT, Lamers MM |
npj Viruses | 2024 |
|
Protein Nanoparticles for Targeted SARS‐CoV‐2 Trapping and Neutralization
Fornt\u2010Suñé M, Puertas MC, Martinez\u2010Picado J, García\u2010Pardo J, Ventura S |
Advanced Healthcare Materials | 2024 |
|
Clinical Features of SARS-CoV-2 Infected Patients in a Large Population Cohort from the South-West Region of Romania
BUIBAȘ FI, CERCEL AR, ȘERBĂNESCU MS, TURCU A, DUMITRESCU F, PIRICI I, MOGOANTĂ L |
Current Health Sciences Journal | 2024 |
|
Cell-autonomous requirement for ACE2 across organs in lethal SARS-CoV-2 infection
Alan Tang, David Buchholz, Katherine Szigety, Brian Imbiakha, Siqi Gao, Maxwell Frankfurter, Min Wang, Jisheng Yang, Peter Hewins, Patricia Mericko-Ishizuka, N Leu, Stephanie Sterling, Isaac Monreal, Julie Sahler, Avery August, Xuming Zhu, Kellie Jurado, Mingang Xu, Edward Morrisey, Sarah Millar, Hector Aguilar, Mark Kahn |
PLoS Biology | 2023 |
|
COVID-19 and hepatic injury: cellular and molecular mechanisms in diverse liver cells
Ali FE, Abd El-Aziz MK, Ali MM, Ghogar OM, Bakr AG |
World Journal of Gastroenterology | 2023 |
|
Innate immune recognition against SARS-CoV-2
Yamada T, Takaoka A |
Ensho Saisei | 2023 |
|
In Silico and In Vitro Inhibition of SARS-CoV-2 PLpro with Gramicidin D
Protić S, Kaličanin N, Sencanski M, Prodanović O, Milicevic J, Perovic V, Paessler S, Prodanović R, Glisic S |
International journal of molecular sciences | 2023 |
|
Animal Models for the Study of SARS-CoV-2–induced Respiratory Disease and Pathology
Dillard JA, Martinez SA, Dearing JJ, Montgomery SA, Baxter VK |
Comparative medicine | 2023 |
|
Type 2 Immunity and Its Impact on COVID-19 Infection in the Airways
Pathinayake PS, Awatade NT, Wark PA |
Viruses | 2023 |
|
Protein Arginylation Is Regulated during SARS-CoV-2 Infection
Macedo-da-Silva J, Rosa-Fernandes L, Gomes VD, Santiago VF, Santos DM, Molnar CM, Barboza BR, de Souza EE, Marques RF, Boscardin SB, Durigon EL, Marinho CR, Wrenger C, Marie SK, Palmisano G |
Viruses | 2023 |
|
Fast model-free standardization and integration of single-cell transcriptomics data
Xu Y, Kramann R, McCord RP, Hayat S |
Research square | 2023 |
|
Binding and inactivation of human coronaviruses, including SARS-CoV-2, onto purified clinoptilolite-tuff
Nizet S, Rieger J, Sarabi A, Lajtai G, Zatloukal K, Tschegg C |
Scientific Reports | 2023 |
|
A low dose of RBD and TLR7/8 agonist displayed on influenza virosome particles protects rhesus macaque against SARS-CoV-2 challenge.
Koopman G, Amacker M, Stegmann T, Verschoor EJ, Verstrepen BE, Bhoelan F, Bemelman D, Böszörményi KP, Fagrouch Z, Kiemenyi-Kayere G, Mortier D, Verel DE, Niphuis H, Acar RF, Kondova I, Kap YS, Bogers WMJM, Mooij P, Fleury S |
Scientific Reports | 2023 |
|
Synergistic Detrimental Effects of Cigarette Smoke, Alcohol, and SARS-CoV-2 in COPD Bronchial Epithelial Cells
Muralidharan A, Bauer CD, Katafiasz DM, Strah HM, Siddique A, Reid SP, Bailey KL, Wyatt TA |
Pathogens | 2023 |
|
Assessing the generation of tissue resident memory T cells by vaccines
Rotrosen E, Kupper TS |
Nature reviews. Immunology | 2023 |
|
Promises and challenges of mucosal COVID-19 vaccines
Rathore AP, St. John AL |
Vaccine | 2023 |
|
SARS-CoV-2 infection and immune responses
Harne R, Williams B, Abdelal HF, Baldwin SL, Coler RN |
AIMS Microbiology | 2023 |
|
Specific Activation of T Cells by an ACE2-Based CAR-Like Receptor upon Recognition of SARS-CoV-2 Spike Protein.
Gonzalez-Garcia P, Muñoz-Miranda JP, Fernandez-Cisnal R, Olvera L, Moares N, Gabucio A, Fernandez-Ponce C, Garcia-Cozar F |
International journal of molecular sciences | 2023 |
|
Type 2 inflammation reduces SARS-CoV-2 replication in the airway epithelium in allergic asthma through functional alteration of ciliated epithelial cells
Doni Jayavelu N, Altman MC, Benson B, Dufort MJ, Vanderwall ER, Rich LM, White MP, Becker PM, Togias A, Jackson DJ, Debley JS |
Journal of Allergy and Clinical Immunology | 2023 |
|
In-office Eustachian tube balloon dilation under local anesthesia as a response to operating room restrictions associated with the COVID-19 pandemic
Sheppard SC, Beckmann S, Caversaccio M, Anschuetz L |
Frontiers in Surgery | 2023 |
|
MASI enables fast model-free standardization and integration of single-cell transcriptomics data
Xu Y, Kramann R, McCord RP, Hayat S |
Communications biology | 2023 |
|
From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVID.
Gonzalez-Garcia P, Fiorillo Moreno O, Zarate Peñata E, Calderon-Villalba A, Pacheco Lugo L, Acosta Hoyos A, Villarreal Camacho JL, Navarro Quiroz R, Pacheco Londoño L, Aroca Martinez G, Moares N, Gabucio A, Fernandez-Ponce C, Garcia-Cozar F, Navarro Quiroz E |
International journal of molecular sciences | 2023 |
|
COVID-19—The Shift of Homeostasis into Oncopathology or Chronic Fibrosis in Terms of Female Reproductive System Involvement
Petersen E, Chudakova D, Erdyneeva D, Zorigt D, Shabalina E, Gudkov D, Karalkin P, Reshetov I, Mynbaev OA |
International journal of molecular sciences | 2023 |
|
Apical-Out Human Airway Organoids Modeling SARS-CoV-2 Infection.
Chiu MC, Zhang S, Li C, Liu X, Yu Y, Huang J, Wan Z, Zhu X, Zhou J |
Viruses | 2023 |
|
Crosslink between SARS-CoV-2 replication and cystic fibrosis hallmarks
Lotti V, Lagni A, Diani E, Sorio C, Gibellini D |
Frontiers in microbiology | 2023 |
|
COVID-19 Therapeutic Potential of Natural Products
Low Z, Lani R, Tiong V, Poh C, AbuBakar S, Hassandarvish P |
International journal of molecular sciences | 2023 |
|
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients.
Diray-Arce J, Fourati S, Doni Jayavelu N, Patel R, Maguire C, Chang AC, Dandekar R, Qi J, Lee BH, van Zalm P, Schroeder A, Chen E, Konstorum A, Brito A, Gygi JP, Kho A, Chen J, Pawar S, Gonzalez-Reiche AS, Hoch A, Milliren CE, Overton JA, Westendorf K, Cairns CB, Rouphael N, Bosinger SE, Kim-Schulze S, Krammer F, Rosen L, Grubaugh ND, van Bakel H, Wilson M, Rajan J, Steen H, Eckalbar W, Cotsapas C, Langelier CR, Levy O, Altman MC, Maecker H, Montgomery RR, Haddad EK, Sekaly RP, Esserman D, Ozonoff A, Becker PM, Augustine AD, Guan L, Peters B, Kleinstein SH |
Cell reports. Medicine | 2023 |
|
Saline nasal irrigation and gargling in COVID-19: a multidisciplinary review of effects on viral load, mucosal dynamics, and patient outcomes.
Huijghebaert S, Parviz S, Rabago D, Baxter A, Chatterjee U, Khan FR, Fabbris C, Poulas K, Hsu S |
Frontiers in public health | 2023 |
|
Factors affecting nasal drug delivery and design strategies for intranasal drug delivery.
Hu X, Yue X, Wu C, Zhang X |
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences | 2023 |
|
High-throughput bioprinting of the nasal epithelium using patient-derived nasal epithelial cells
Deniz Derman I, Yeo M, Castaneda DC, Callender M, Horvath M, Mo Z, Xiong R, Fleming E, Chen P, Peeples ME, Palucka K, Oh J, Ozbolat IT |
Biofabrication | 2023 |
|
SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters1
Zhou B, Zhou R, Chan JF, Zeng J, Zhang Q, Yuan S, Liu L, Robinot R, Shan S, Liu N, Ge J, Kwong HY, Zhou D, Xu H, Chan CC, Poon VK, Chu H, Yue M, Kwan KY, Chan CY, Chan CC, Chik KK, Du Z, Au KK, Huang H, Man HO, Cao J, Li C, Wang Z, Zhou J, Song Y, Yeung ML, To KK, Ho DD, Chakrabarti LA, Wang X, Zhang L, Yuen KY, Chen Z |
Emerging Microbes & Infections | 2023 |
|
ProtoCell4P: an explainable prototype-based neural network for patient classification using single-cell RNA-seq.
Xiong G, Bekiranov S, Zhang A |
Bioinformatics (Oxford, England) | 2023 |
|
Ultrastructure for the diagnosis of primary ciliary dyskinesia in South Africa, a resource-limited setting.
Birkhead M, Otido S, Mabaso T, Mopeli K, Tlhapi D, Verwey C, Dangor Z |
Frontiers in Pediatrics | 2023 |
|
MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity.
Cheng Z, Cai Y, Zhang K, Zhang J, Gui H, Luo YS, Zhou J, DeVeale B |
iScience | 2023 |
|
Organoids to Remodel SARS-CoV-2 Research: Updates, Limitations and Perspectives
An Y, He Y, Ge N, Guo J, Yang F, Sun S |
Aging and disease | 2023 |
|
Curbside particulate matter and susceptibility to SARS–CoV-2 infection
Miyashita L, Foley G, Semple S, Gibbons JM, Pade C, McKnight Á, Grigg J |
2023 | |
|
General classification of rhinopaties: the need for standardization according to etiology and nasal cytology
Gelardi M, Fiore V, Giancaspro R, Di Canio FM, Fiorentino C, Patruno S, Ruzza A, Cassano M |
European Archives of Oto-Rhino-Laryngology | 2023 |
|
The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection
Lécuyer D, Nardacci R, Tannous D, Gutierrez-Mateyron E, Deva Nathan A, Subra F, Di Primio C, Quaranta P, Petit V, Richetta C, Mostefa-Kara A, Del Nonno F, Falasca L, Marlin R, Maisonnasse P, Delahousse J, Pascaud J, Deprez E, Naigeon M, Chaput N, Paci A, Saada V, Ghez D, Mariette X, Costa M, Pistello M, Allouch A, Delelis O, Piacentini M, Le Grand R, Perfettini JL |
Frontiers in immunology | 2023 |
|
COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging
Vijaykumar K, Leung HM, Barrios A, Fernandez-Petty CM, Solomon GM, Hathorne HY, Wade JD, Monroe K, Slaten KB, Li Q, Leal SM Jr, Moates DB, Pierce HM, Olson KR, Currier P, Foster S, Marsden D, Tearney GJ, Rowe SM |
American journal of respiratory cell and molecular biology | 2023 |
|
Development trends of human organoid-based COVID-19 research based on bibliometric analysis.
Li M, Yuan Y, Zou T, Hou Z, Jin L, Wang B |
Cell Proliferation | 2023 |
|
Human-derived air-liquid interface cultures decipher Alzheimer's disease-SARS-CoV-2 crosstalk in the olfactory mucosa.
Shahbaz MA, Kuivanen S, Lampinen R, Mussalo L, Hron T, Závodná T, Ojha R, Krejčík Z, Saveleva L, Tahir NA, Kalapudas J, Koivisto AM, Penttilä E, Löppönen H, Singh P, Topinka J, Vapalahti O, Chew S, Balistreri G, Kanninen KM |
Journal of Neuroinflammation | 2023 |
|
Application of organoids in otolaryngology: head and neck surgery.
Zhu H, Qu S, Deng Y, Gong M, Xiang Y, Teng Y, Ye D |
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery | 2023 |
|
Overview of immunological & virological factors driving the evolution & global spread of SARS-CoV-2 variants
Ramasamy R |
The Indian journal of medical research | 2023 |
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Convergent differentiation of multiciliated cells.
Chae S, Park TJ, Kwon T |
Scientific Reports | 2023 |
|
Potential Contribution of Cell Adhesion Molecule 1 to the Binding of SARS-CoV-2 Spike Protein to Mouse Nasal Mucosa
Takeuchi F, Sugano A, Yoneshige A, Hagiyama M, Inoue T, Wada A, Takaoka Y, Ito A |
Cells, tissues, organs | 2023 |
|
Three-dimensional morphologic and molecular atlases of nasal vasculature
Hong SP, Yang MJ, Bae JH, Choi DR, Kim YC, Yang MS, Oh B, Kang KW, Lee SM, Kim B, Kim YD, Ahn JH, Koh GY |
Nature Cardiovascular Research | 2023 |
|
Distributions of venous sinusoids and lymphatic vessels in the mouse nasal cavity.
|
Nature cardiovascular research | 2023 |
|
Androgen Drives the Expression of SARS-CoV-2 Entry Proteins in Sinonasal Tissue.
Huang RR, Giafaglione JM, Hashimoto T, Zhang L, Yu W, Rao J, Russo JW, Balk SP, Nickols NG, Rettig MB, Goldstein A, Ye H |
Journal of clinical and translational pathology | 2023 |
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T cell response to intact SARS-CoV-2 includes coronavirus cross-reactive and variant-specific components
Lichen Jing, Xia Wu, Maxwell P. Krist, Tien-Ying Hsiang, Victoria Campbell, Christopher McClurkan, Sydney Favors, Lawrence Hemingway, Charmie Godornes, Denise Q Tong, Stacy Selke, Angela LeClair, Chul-Woo Pyo, Daniel E. Geraghty, Kerry J. Laing, Anna Wald, Michael Gale, Jr., David Koelle |
JCI Insight | 2022 |
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Increased soluble HLA molecules in COVID-19 present a disease-related, highly diverse immunopeptidome and associate with T cell immunity
Annika Nelde, Jonas Rieth, Malte Roerden, Marissa Dubbelaar, Reinhild Klein, Tobias Hoheisel, Hartmut Mahrhofer, Siri Göpel, Michael Bitzer, Sebastian Hörber, Andreas Peter, Jonas Heitmann, Juliane Walz |
iScience | 2022 |
|
SARS-CoV-2 Infection and Lung Regeneration
F Zhao, Q Ma, Q Yue, H Chen |
Clinical microbiology reviews | 2022 |
|
Mucosal Vaccines, Sterilizing Immunity, and the Future of SARS-CoV-2 Virulence
D Focosi, F Maggi, A Casadevall |
Viruses | 2022 |
|
Symptoms COVID 19 Positive Vapers Compared to COVID 19 Positive Non-vapers
D McFadden, S Bornstein, R Vassallo, B Salonen, M Bhuiyan, D Schroeder, I Croghan |
Journal of Primary Care & Community Health | 2022 |
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Human Nasal Epithelial Cells Sustain Persistent SARS-CoV-2 Infection In Vitro , despite Eliciting a Prolonged Antiviral Response
A Gamage, K Tan, W Chan, Z Lew, J Liu, C Tan, D Rajagopalan, Q Lin, L Tan, P Venkatesh, Y Ong, M Thong, R Lin, S Prabhakar, D Wang, L Wang, K Subbarao |
mBio | 2022 |
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Expression characteristics of polymeric immunoglobulin receptor in Bactrian camel (Camelus bactrianus) lungs
W He, W Zhang, C Cheng, J Lu, L Liu, Z Chen, W Wang, S Fugmann |
PloS one | 2022 |
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COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences
B Martínez-Salazar, M Holwerda, C Stüdle, I Piragyte, N Mercader, B Engelhardt, R Rieben, Y Döring |
Frontiers in Cell and Developmental Biology | 2022 |
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A Natural Plant Source-Tea Polyphenols, a Potential Drug for Improving Immunity and Combating Virus
M Hong, L Cheng, Y Liu, Z Wu, P Zhang, X Zhang |
Nutrients | 2022 |
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Drug-Free Nasal Spray as a Barrier against SARS-CoV-2 and Its Delta Variant: In Vitro Study of Safety and Efficacy in Human Nasal Airway Epithelia
F Fais, R Juskeviciene, V Francardo, S Mateos, M Guyard, C Viollet, S Constant, M Borelli, I Hohenfeld |
International journal of molecular sciences | 2022 |
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SARS-CoV-2 Infection Dysregulates Cilia and Basal Cell Homeostasis in the Respiratory Epithelium of Hamsters
T Schreiner, L Allnoch, G Beythien, K Marek, K Becker, D Schaudien, S Stanelle-Bertram, B Schaumburg, N Kouassi, S Beck, M Zickler, G Gabriel, W Baumgärtner, F Armando, M Ciurkiewicz |
International journal of molecular sciences | 2022 |
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A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant.
Chiu MC, Li C, Liu X, Yu Y, Huang J, Wan Z, Xiao D, Chu H, Cai JP, Zhou B, Sit KY, Au WK, Wong KK, Li G, Chan JF, To KK, Chen Z, Jiang S, Clevers H, Yuen KY, Zhou J |
Cell Discovery | 2022 |
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Immune Response to Viruses
Herbert JA, Panagiotou S |
Reference Module in Biomedical Sciences | 2022 |
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Inter-domain communication in SARS-CoV-2 spike proteins controls protease-triggered cell entry
Qing E, Li P, Cooper L, Schulz S, Jäck HM, Rong L, Perlman S, Gallagher T |
Cell Reports | 2022 |
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Anti-Viral Activities of Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Against Human Respiratory Viruses
Oh SJ, Lee EN, Park JH, Lee JK, Cho GJ, Park IH, Shin OS |
Frontiers in Cellular and Infection Microbiology | 2022 |
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Innate and Adaptive Immune Responses in the Upper Respiratory Tract and the Infectivity of SARS-CoV-2
Ramasamy R |
Viruses | 2022 |
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SARS-CoV-2 Induces Expression of Cytokine and MUC5AC/5B in Human Nasal Epithelial Cell through ACE 2 Receptor
Lee S, Na HG, Choi YS, Bae CH, Song SY, Kim YD |
BioMed Research International | 2022 |
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A New Grand Challenge in Rhinology: An Intranasal COVID Vaccine
Scadding GK |
2022 | |
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SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations
Mitra J, Kodavati M, Provasek VE, Rao KS, Mitra S, Hamilton DJ, Horner PJ, Vahidy FS, Britz GW, Kent TA, Hegde ML |
Ageing Research Reviews | 2022 |
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Delineating COVID-19 immunological features using single-cell RNA sequencing
Liu W, Jia J, Dai Y, Chen W, Pei G, Yan Q, Zhao Z |
2022 | |
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Preclinical Immunogenicity and Efficacy of a Multiple Antigen-Presenting System (MAPSTM) SARS-CoV-2 Vaccine
Cieslewicz B, Makrinos D, Burke H, Bree D, Haridas R, Tonkiss I, Bartsch Y, Alter G, Malley R, Besin G |
Human vaccines | 2022 |
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Single cell gene expression profiling of nasal ciliated cells reveals distinctive biological processes related to epigenetic mechanisms in patients with severe COVID-19
Diambra L, Alonso AM, Sookoian S, Pirola CJ |
Computers in Biology and Medicine | 2022 |
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The nervous system during COVID‐19: Caught in the crossfire*
Natale NR, Lukens JR, Petri WA Jr |
Immunological Reviews | 2022 |
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Translational feasibility and efficacy of nasal photodynamic disinfection of SARS-CoV-2.
Pires L, Wilson BC, Bremner R, Lang A, Larouche J, McDonald R, Pearson JD, Trcka D, Wrana J, Wu J, Whyne CM |
Scientific Reports | 2022 |
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I’ve looked at gut from both sides now: Gastrointestinal tract involvement in the pathogenesis of SARS-CoV-2 and HIV/SIV infections
Pandrea I, Brooks K, Desai RP, Tare M, Brenchley JM, Apetrei C |
Frontiers in immunology | 2022 |
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SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic
Bertoletti A, Le Bert N, Tan AT |
Immunity | 2022 |
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Human Nasal Organoids Model SARS-CoV-2 Upper Respiratory Infection and Recapitulate the Differential Infectivity of Emerging Variants
Chiu MC, Li C, Liu X, Song W, Wan Z, Yu Y, Huang J, Xiao D, Chu H, Cai JP, To KK, Yuen KY, Zhou J |
mBio | 2022 |
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Photochemical Identification of Auxiliary Severe Acute Respiratory Syndrome Coronavirus 2 Host Entry Factors Using μMap.
Suzuki S, Geri JB, Knutson SD, Bell-Temin H, Tamura T, Fernández DF, Lovett GH, Till NA, Heller BL, Guo J, MacMillan DWC, Ploss A |
Journal of the American Chemical Society | 2022 |
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Act Early and at the Right Location: SARS-CoV-2 T Cell Kinetics and Tissue Localization
Bertoletti A, Le Bert N, Tan AT |
International journal of molecular sciences | 2022 |
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SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity
Lim JM, Tan AT, Le Bert N, Hang SK, Low JG, Bertoletti A |
Journal of Experimental Medicine | 2022 |
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Membrane attachment and fusion of HIV-1, influenza A, and SARS-CoV-2: resolving the mechanisms with biophysical methods
Negi G, Sharma A, Dey M, Dhanawat G, Parveen N |
Biophysical Reviews | 2022 |
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The compartmentalized upper respiratory mucosa needs time to rally a sufficient immune force for SARS-CoV-2 clearance
Zheng X, Tang X, Li F |
Cellular and Molecular Immunology | 2022 |
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A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concern
Yang J, Liu MQ, Liu L, Li X, Xu M, Lin H, Liu S, Hu Y, Li B, Liu B, Li M, Sun Y, Chen YQ, Shi ZL, Yan H |
Cellular and Molecular Immunology | 2022 |
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SARS-CoV-2-Infection (COVID-19): Clinical Course, Viral Acute Respiratory Distress Syndrome (ARDS) and Cause(s) of Death.
Ramadori GP |
2022 | |
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Proviral role of human respiratory epithelial cell-derived small extracellular vesicles in SARS-CoV-2 infection.
Berry F, Morin-Dewaele M, Majidipur A, Jamet T, Bartier S, Ignjatovic E, Toniutti D, Gaspar Lopes J, Soyeux-Porte P, Maillé P, Saldana C, Brillet R, Ahnou N, Softic L, Couturaud B, Huet É, Ahmed-Belkacem A, Fourati S, Louis B, Coste A, Béquignon É, de la Taille A, Destouches D, Vacherot F, Pawlotsky JM, Firlej V, Bruscella P |
Journal of Extracellular Vesicles | 2022 |
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Metalloprotease-Dependent S2'-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2.
Harte JV, Wakerlin SL, Lindsay AJ, McCarthy JV, Coleman-Vaughan C |
Viruses | 2022 |
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Infection of the oral cavity with SARS-CoV-2 variants: Scope of salivary diagnostics
Iyer P, Chino T, Ojcius DM |
2022 | |
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Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models
Jeong H, Woo Lee Y, Park IH, Noh H, Kim SH, Kim J, Jeon D, Jang HJ, Oh J, On D, Uhm C, Cho K, Oh H, Yoon S, Seo JS, Kim JJ, Seok SH, Lee YJ, Hong SM, An SH, Yeon Kim S, Kim YB, Hwang JY, Lee HJ, Kim HB, Jeong DG, Song D, Song M, Park MS, Choi KS, Park JW, Seo JY, Yun JW, Shin JS, Lee HY, Nam KT, Seong JK |
Disease models & mechanisms | 2022 |
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Counter-regulatory renin-angiotensin system in hypertension: review and update in the era of COVID-19 pandemic
Chen H, Peng J, Wang T, Wen J, Chen S, Huang Y, Zhang Y |
Biochemical Pharmacology | 2022 |
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Desloratadine, an FDA-approved cationic amphiphilic drug, inhibits SARS-CoV-2 infection in cell culture and primary human nasal epithelial cells by blocking viral entry
Morin-Dewaele M, Bartier S, Berry F, Brillet R, López-Molina DS, Nguyễn CT, Maille P, Sereno K, Nevers Q, Softic L, Vaugeois JM, Louis B, Bequignon E, Bruscella P, Coste A, Pawlotsky JM, Jamain S, Ahmed-Belkacem A |
Scientific Reports | 2022 |
|
Nanomaterials to combat SARS-CoV-2: Strategies to prevent, diagnose and treat COVID-19
Valenzuela-Fernández A, Cabrera-Rodriguez R, Ciuffreda L, Perez-Yanes S, Estevez-Herrera J, González-Montelongo R, Alcoba-Florez J, Trujillo-González R, García-Martínez de Artola D, Gil-Campesino H, Díez-Gil O, Lorenzo-Salazar JM, Flores C, Garcia-Luis J |
Frontiers in Bioengineering and Biotechnology | 2022 |
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A single intranasal administration of AdCOVID protects against SARS-CoV-2 infection in the upper and lower respiratory tracts
Schultz MD, Suschak JJ, Botta D, Silva-Sanchez A, King RG, Detchemendy TW, Meshram CD, Foote JB, Zhou F, Tipper JL, Zhang J, Harrod KS, Leal SM Jr, Randall TD, Roberts MS, Georges B, Lund FE |
Human Vaccines & Immunotherapeutics | 2022 |
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Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry.
Choi SSA, Chan HH, Chan CM, Wang X, Webb SE, Leung KW, Tsim KWK, Miller AL |
Journal of virology | 2022 |
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Downregulation of the Protein C Signaling System Is Associated with COVID-19 Hypercoagulability—A Single-Cell Transcriptomics Analysis
Silva BR, Jara CP, Sidarta-Oliveira D, Velloso LA, Velander WH, Araújo EP |
Viruses | 2022 |
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SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming
Wu CT, Lidsky PV, Xiao Y, Cheng R, Lee IT, Nakayama T, Jiang S, He W, Demeter J, Knight MG, Turn RE, Rojas-Hernandez LS, Ye C, Chiem K, Shon J, Martinez-Sobrido L, Bertozzi CR, Nolan GP, Nayak JV, Milla C, Andino R, Jackson PK |
Cell | 2022 |
|
First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung Injury
Schiano Moriello A, Roviezzo F, Iannotti FA, Rea G, Allarà M, Camerlingo R, Verde R, Di Marzo V, Petrosino S |
Biomolecules | 2022 |
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Alpha and Omicron SARS-CoV-2 Adaptation in an Upper Respiratory Tract Model
Mathez G, Pillonel T, Bertelli C, Cagno V |
Viruses | 2022 |
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SARS‐CoV‐2 cellular tropism and direct multiorgan failure in COVID‐19 patients: Bioinformatic predictions, experimental observations, and open questions
Valyaeva AA, Zharikova AA, Sheval EV |
Cell biology international | 2022 |
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Malondialdehyde acetaldehyde adduction of surfactant protein D attenuates SARS‐CoV‐2 spike protein binding and virus neutralization
Muralidharan A, Bauer C, Katafiasz DM, Pham D, Oyewole OO, Morwitzer MJ, Roy E, Bailey KL, Reid SP, Wyatt TA |
Alcoholism, clinical and experimental research | 2022 |
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Diagnostic performance of patient self‐collected oral swab (tongue and cheek) in comparison with healthcare worker‐collected nasopharyngeal swab for severe acute respiratory syndrome coronavirus‐2 detection
Mane A, Jain S, Jain A, Nema V, Kurle S, Saxena V, Pereira M, Sirsat A, Pathak G, Bhoi V, Bhavsar S, Panda S |
APMIS | 2022 |
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SARS-CoV-2 in brief: from virus to prevention
Karami H, Karimi Z, Karami N |
Osong Public Health and Research Perspectives | 2022 |
|
Pannexin-1 channel opening is critical for COVID-19 pathogenesis
R Luu, S Valdebenito, E Scemes, A Cibelli, DC Spray, M Rovegno, J Tichauer, A Cottignies-Calamarte, A Rosenberg, C Capron, S Belouzard, J Dubuisson, D Annane, GL de la Grandmaison, E Cramer-Bordé, M Bomsel, E Eugenin |
iScience | 2021 |
|
The Journal of Clinical Investigation in the time of COVID-19
A Casadevall, S Jackson, GL Semenza, GF Tomaselli, RS Ahima |
Journal of Clinical Investigation | 2021 |
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Mechanisms of SARS-CoV-2 entry into cells
CB Jackson, M Farzan, B Chen, H Choe |
Nature Reviews Molecular Cell Biology | 2021 |
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ACE2, the Counter-Regulatory Renin–Angiotensin System Axis and COVID-19 Severity
F Triposkiadis, A Xanthopoulos, G Giamouzis, KD Boudoulas, RC Starling, J Skoularigis, H Boudoulas, E Iliodromitis |
Journal of Clinical Medicine | 2021 |
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Host Response to SARS-CoV2 and Emerging Variants in Pre-Existing Liver and Gastrointestinal Diseases
B Nayak, G Lal, S Kumar, CJ Das, A Saraya, Shalimar |
Frontiers in Cellular and Infection Microbiology | 2021 |
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Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb
M Khan, SJ Yoo, M Clijsters, W Backaert, A Vanstapel, K Speleman, C Lietaer, S Choi, TD Hether, L Marcelis, A Nam, L Pan, JW Reeves, PV Bulck, H Zhou, M Bourgeois, Y Debaveye, PD Munter, J Gunst, M Jorissen, K Lagrou, N Lorent, A Neyrinck, M Peetermans, DR Thal, C Vandenbriele, J Wauters, P Mombaerts, LV Gerven |
Cell | 2021 |
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