The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis
Manabu Shirai, … , Keiko Yamauchi-Takihara, Yoshihiro Takihara
Manabu Shirai, … , Keiko Yamauchi-Takihara, Yoshihiro Takihara
Published July 15, 2002
Citation Information: J Clin Invest. 2002;110(2):177-184. https://doi.org/10.1172/JCI14839.
View: Text | PDF
Article Genetics

The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis

Abstract

Research Article

Authors

Manabu Shirai, Tomoaki Osugi, Hideyuki Koga, Yoshikazu Kaji, Eiki Takimoto, Issei Komuro, Junichi Hara, Takeshi Miwa, Keiko Yamauchi-Takihara, Yoshihiro Takihara

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
Cardiac looping morphogenesis in 9.5-dpc embryos. (a and c) Right and (b...
Cardiac looping morphogenesis in 9.5-dpc embryos. (a and c) Right and (b and d) left frontal views of whole embryos are shown. Cardiac looping was morphologically affected in the 9.5-dpc Rae28–/– embryo (c and d). IVS, interventricular sulcus; BC, bulbus cordis; TA, truncus arteriosus; AVC, AV canal; LV, left ventricle; LA, left atrium; RV, right ventricle. +/+, a wild-type embryo; –/–, a Rae28–/– embryo. Scale bar: 500 μm.