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Citations to this article

Defining circadian disruption in neurodegenerative disorders
Christopher S. Colwell
Christopher S. Colwell
Published October 1, 2021
Citation Information: J Clin Invest. 2021;131(19):e148288. https://doi.org/10.1172/JCI148288.
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Review Series Article has an altmetric score of 17

Defining circadian disruption in neurodegenerative disorders

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Abstract

Neurodegenerative diseases encompass a large group of conditions that are clinically and pathologically diverse yet are linked by a shared pathology of misfolded proteins. The accumulation of insoluble aggregates is accompanied by a progressive loss of vulnerable neurons. For some patients, the symptoms are motor focused (ataxias), while others experience cognitive and psychiatric symptoms (dementias). Among the shared symptoms of neurodegenerative diseases is a disruption of the sleep/wake cycle that occurs early in the trajectory of the disease and may be a risk factor for disease development. In many cases, the disruption in the timing of sleep and other rhythmic physiological markers immediately raises the possibility of neurodegeneration-driven disruption of the circadian timing system. The aim of this Review is to summarize the evidence supporting the hypothesis that circadian disruption is a core symptom within neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease, and to discuss the latest progress in this field. The Review discusses evidence that neurodegenerative processes may disrupt the structure and function of the circadian system and describes circadian-based interventions as well as timed drug treatments that may improve a wide range of symptoms associated with neurodegenerative disorders. It also identifies key gaps in our knowledge.

Authors

Christopher S. Colwell

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Total citations by year

Year: 2025 2024 2023 2022 Total
Citations: 1 14 10 8 33
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (33)

Title and authors Publication Year
IL‐17A Induces Circadian Disruptions Through the Epigenetic Repression of BMAL1 in Mice With Alzheimer's Disease
Liu T, Mao T, Fan J, Shen Y, Xue L, Du K, Li Y, Wang L, Wang X
Journal of Cellular and Molecular Medicine 2025
Circadian disruption during fetal development promotes pathological cardiac remodeling in male mice
Yu Y, Liu JY, Yang HJ, Luo XQ, Gao XP, Huang XX, Tang AX, Mary Cheng HY, Liu WC, Zhang P
iScience 2024
Retinal dysfunction in Huntington’s disease mouse models concurs with local gliosis and microglia activation
Cano-Cano F, Martín-Loro F, Gallardo-Orihuela A, González-Montelongo MD, Ortuño-Miquel S, Hervás-Corpión I, de la Villa P, Ramón-Marco L, Navarro-Calvo J, Gómez-Jaramillo L, Arroba AI, Valor LM
Scientific Reports 2024
Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer's Disease.
Voigt RM, Ouyang B, Keshavarzian A
medRxiv : the preprint server for health sciences 2024
Regulation of headache response and transcriptomic network by the trigeminal ganglion clock
Han C, Lim JY, Koike N, Kim SY, Ono K, Tran CK, Mangutov E, Kim E, Zhang Y, Li L, Pradhan AA, Yagita K, Chen Z, Yoo SH, Burish MJ
Headache: The Journal of Head and Face Pain 2024
Modulation of the Circadian Rhythm and Oxidative Stress as Molecular Targets to Improve Vascular Dementia: A Pharmacological Perspective.
Trujillo-Rangel WÁ, Acuña-Vaca S, Padilla-Ponce DJ, García-Mercado FG, Torres-Mendoza BM, Pacheco-Moises FP, Escoto-Delgadillo M, García-Benavides L, Delgado-Lara DLC
International journal of molecular sciences 2024
Scheduled feeding improves sleep in a mouse model of Huntington’s disease
Chiem E, Zhao K, Dell\u2019Angelica D, Ghiani CA, Paul KN, Colwell CS
2024
The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective.
Huang W, Zong J, Zhang Y, Zhou Y, Zhang L, Wang Y, Shan Z, Xie Q, Li M, Pan S, Xiao Z
Aging and disease 2024
Scheduled feeding improves sleep in a mouse model of Huntington's disease.
Chiem E, Zhao K, Dell'Angelica D, Ghiani CA, Paul KN, Colwell CS
Frontiers in neuroscience 2024
Outdoor nighttime light exposure (light pollution) is associated with Alzheimer’s disease
Voigt RM, Ouyang B, Keshavarzian A
Frontiers in Neuroscience 2024
Neuron-Astrocyte Interactions and Circadian Time-keeping in Mammals
Smyllie NJ, Hastings MH, Patton AP
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2024
Circadian disruption promotes the neurotoxicity of oligomeric alpha-synuclein in mice
Zhang JB, Wan XJ, Duan WX, Dai XQ, Xia D, Fu X, Hu LF, Wang F, Liu CF
NPJ Parkinson's Disease 2024
Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases
Hussain Y, Dar MI, Pan X
Metabolites 2024
Circadian Intervention Improves Parkinson’s Disease and May Slow Disease Progression: A Ten Year Retrospective Study
Willis G, Endo T, Waldman M
Brain Sciences 2024
Sex differences in sleep architecture in a mouse model of Huntington’s disease
Chiem E, Zhao K, Stark G, Ghiani CA, Colwell CS, Paul KN
Journal of neuroscience research 2024
Circadian disruption and sleep disorders in neurodegeneration
Shen Y, Lv QK, Xie WY, Gong SY, Zhuang S, Liu JY, Mao CJ, Liu CF
Translational Neurodegeneration 2023
Sex Differences in Sleep Phenotypes in the BACHD Mouse Model of Huntington’s Disease
Chiem E, Zhao K, Stark G, Ghiani CA, Colwell CS, Paul KN
2023
Melatonin as a Chronobiotic/Cytoprotective Agent in REM Sleep Behavior Disorder
Cardinali DP, Garay A
Brain Sciences 2023
The circadian clock and extracellular matrix homeostasis in aging and age-related diseases
Dudek M, Swift J, Meng QJ
AJP Cell Physiology 2023
Restoration of Sleep and Circadian Behavior by Autophagy Modulation in Huntington's Disease.
Sharma A, Narasimha K, Manjithaya R, Sheeba V
The Journal of neuroscience : the official journal of the Society for Neuroscience 2023
FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function.
Gerstner JR, Flores CC, Lefton M, Rogers B, Davis CJ
Frontiers in systems neuroscience 2023
Role of neuroinflammation in neurodegeneration development
Zhang W, Xiao D, Mao Q, Xia H
Signal Transduction and Targeted Therapy 2023
Melatonin as a Harmonizing Factor of Circadian Rhythms, Neuronal Cell Cycle and Neurogenesis: Additional Arguments for Its Therapeutic Use in Alzheimer’s Disease
Shukla M, Vincent B
Current neuropharmacology 2023
Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease
Whittaker DS, Akhmetova L, Carlin D, Romero H, Welsh DK, Colwell CS, Desplats P
Cell Metabolism 2023
Circadian clocks: It’s time for chronobiology
Merrow M
PLoS Biology 2023
Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer’s Disease
A da Silva, C Lemos, H Silva, I Ferreira, A Tomé, A Rego, R Cunha
Frontiers in aging neuroscience 2022
Hsp40 overexpression in pacemaker neurons delays circadian dysfunction in a Drosophila model of Huntington's disease
Prakash P, Pradhan AK, Sheeba V
Disease models & mechanisms 2022
Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer’s disease
Muñoz-Moreno E, Simões RV, Tudela R, López-Gil X, Soria G
Scientific Reports 2022
Circadian stabilization loop: the regulatory hub and therapeutic target promoting circadian resilience and physiological health
Kim E, Yoo SH, Chen Z
F1000Research 2022
Examination of Diurnal Variation and Sex Differences in Hippocampal Neurophysiology and Spatial Memory
Goode LK, Fusilier AR, Remiszewski N, Reeves JM, Abiraman K, Defenderfer M, Paul JR, McMahon LL, Gamble KL
eNeuro 2022
Dietary ketosis improves circadian dysfunction as well as motor symptoms in the BACHD mouse model of Huntington’s disease
Whittaker DS, Tamai TK, Bains RS, Villanueva SA, Luk SH, Dell\u2019Angelica D, Block GD, Ghiani CA, Colwell CS
Frontiers in Nutrition 2022
Chronobiology of Parkinson's disease: Past, present and future.
Asadpoordezaki Z, Coogan AN, Henley BM, Asadpoordezaki Z, Coogan AN, Henley BM
The European journal of neuroscience 2022
Circadian Rhythm Changes in Healthy Aging and Mild Cognitive Impairment.
Keihani A, Mayeli A, Ferrarelli F
2022

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