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Parathyroid hormone is essential for normal fetal bone formation
Dengshun Miao, … , Andrew C. Karaplis, David Goltzman
Dengshun Miao, … , Andrew C. Karaplis, David Goltzman
Published May 1, 2002
Citation Information: J Clin Invest. 2002;109(9):1173-1182. https://doi.org/10.1172/JCI14817.
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Article Endocrinology Article has an altmetric score of 9

Parathyroid hormone is essential for normal fetal bone formation

Abstract

Parathyroid hormone (PTH) is a potent pharmacologic inducer of new bone formation, but no physiologic anabolic effect of PTH on adult bone has been described. We investigated the role of PTH in fetal skeletal development by comparing newborn mice lacking either PTH, PTH-related peptide (PTHrP), or both peptides. PTH-deficient mice were dysmorphic but viable, whereas mice lacking PTHrP died at birth with dyschondroplasia. PTH-deficient mice uniquely demonstrated diminished cartilage matrix mineralization, decreased neovascularization with reduced expression of angiopoietin-1, and reduced metaphyseal osteoblasts and trabecular bone. Compound mutants displayed the combined cartilaginous and osseous defects of both single mutants. These results indicate that coordinated action of both PTH and PTHrP are required to achieve normal fetal skeletal morphogenesis, and they demonstrate an essential function for PTH at the cartilage-bone interface. The effect of PTH on fetal osteoblasts may be relevant to its postnatal anabolic effects on trabecular bone.

Authors

Dengshun Miao, Bin He, Andrew C. Karaplis, David Goltzman

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