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Citations to this article

Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D
Jian Zheng, … , Makoto Murakami, Stanley Perlman
Jian Zheng, … , Makoto Murakami, Stanley Perlman
Published June 1, 2021
Citation Information: J Clin Invest. 2021;131(11):e147201. https://doi.org/10.1172/JCI147201.
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Research Article Virology Article has an altmetric score of 2

Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D

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Abstract

Worse outcomes occur in aged compared with young populations after infections with respiratory viruses, including pathogenic coronaviruses (SARS-CoV, MERS-CoV, and SARS-CoV-2), and are associated with a suboptimal lung milieu (“inflammaging”). We previously showed that a single inducible phospholipase, PLA2G2D, is associated with a proresolving/antiinflammatory response in the lungs, and increases with age. Survival was increased in naive Pla2g2d–/– mice infected with SARS-CoV resulting from augmented respiratory dendritic cell (rDC) activation and enhanced priming of virus-specific T cells. Here, in contrast, we show that intranasal immunization provided no additional protection in middle-aged Pla2g2d–/– mice infected with any of the 3 pathogenic human coronaviruses because virtually no virus-specific antibodies or follicular helper CD4+ T (Tfh) cells were produced. Using MERS-CoV–infected mice, we found that these effects did not result from T or B cell intrinsic factors. Rather, they resulted from enhanced, and ultimately, pathogenic rDC activation, as manifested most prominently by enhanced IL-1β expression. Wild-type rDC transfer to Pla2g2d–/– mice in conjunction with partial IL-1β blockade reversed this defect and resulted in increased virus-specific antibody and Tfh responses. Together, these results indicate that PLA2G2D has an unexpected role in the lungs, serving as an important modulator of rDC activation, with protective and pathogenic effects in respiratory coronavirus infections and immunization, respectively.

Authors

Jian Zheng, David Meyerholz, Lok-Yin Roy Wong, Michael Gelb, Makoto Murakami, Stanley Perlman

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Total citations by year

Year: 2024 2023 2022 2021 Total
Citations: 3 3 4 1 11
Citation information
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Citations to this article (11)

Title and authors Publication Year
Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment
Koganesawa M, Dwyer D, Alhallak K, Nagai J, Zaleski K, Samuchiwal S, Hiroaki H, Nishida A, Hirsch TI, Brennan PJ, Puder M, Balestrieri B
Immunology 2024
IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo
Ghimire S, Xue B, Li K, Gannon RM, Wohlford-Lenane CL, Thurman AL, Gong H, Necker GC, Zheng J, Meyerholz DK, Perlman S, McCray PB Jr, Pezzulo AA
2024
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM
Li J, Tian Z, Zhang T, Jin J, Zhang X, Xie P, Lin H, Gu J, Wu Y, Wang X, Zhang S, Yan X, Guo D, Wang Z, Zhang Q
Cellular & Molecular Biology Letters 2024
Immunization of MERS-CoV-2-infected mice with a sublethal dose of MERS-CoV or VRP-MERS-S
Zheng J, Channappanavar R, Perlman S
2023
The Roles of sPLA2s in Skin Homeostasis and Disease
Yamamoto K, Hakoi H, Nomura S, Murakami M
Biomolecules 2023
COVID-19, Blood Lipid Changes, and Thrombosis
Farooqui AA, Farooqui T, Sun GY, Lin TN, Teh DB, Ong WY
Biomedicines 2023
Old but New: Group IIA Phospholipase A2 as a Modulator of Gut Microbiota
Y Taketomi, Y Miki, M Murakami
Metabolites 2022
Utility of CD138/syndecan-1 immunohistochemistry for localization of plasmacytes is tissue-dependent in B6 mice.
Meyerholz DK, Leidinger MR, Goeken JA, Businga TR, Akers A, Vizuett S, Kaemmer CA, Kohlmeyer JL, Dodd RD, Quelle DE
BMC Research Notes 2022
A Metabolism-Related Gene Prognostic Index Bridging Metabolic Signatures and Antitumor Immune Cycling in Head and Neck Squamous Cell Carcinoma
Du K, Zou J, Wang B, Liu C, Khan M, Xie T, Huang X, Shen P, Tian Y, Yuan Y
Frontiers in immunology 2022
COVID-19 diverse outcomes: Aggravated reinfection, type I interferons and antibodies.
Costa Silva RCM, Bandeira-Melo C, Paula Neto HA, Vale AM, Travassos LH
Medical Hypotheses 2022
What do secreted phospholipases A2 have to offer in combat against different viruses up to SARS-CoV-2?
J Pungerčar, F Bihl, G Lambeau, I Križaj
Biochimie 2021

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