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Kaoru Saegusa, … , Nobuhiko Katunuma, Yoshio Hayashi
Published August 1, 2002
Citation Information: J Clin Invest. 2002;110(3):361-369. https://doi.org/10.1172/JCI14682.
Citation Information: J Clin Invest. 2002;110(3):361-369. https://doi.org/10.1172/JCI14682.
Abstract
Research Article
Authors
Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Rieko Arakaki, Kouichi Ogawa, Ichiro Saito, Nobuhiko Katunuma, Yoshio Hayashi
Total citations by year
Citation information
Citations to this article (58)
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Cellular effects of splenectomy on liver regeneration after 70% resection
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Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.
Petruzzella A, Bruand M, Santamaria-Martínez A, Katanayeva N, Reymond L, Wehrle S, Georgeon S, Inel D, van Dalen FJ, Viertl D, Lau K, Pojer F, Schottelius M, Zoete V, Verdoes M, Arber C, Correia BE, Oricchio E |
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|
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|
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Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification
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|
Cathepsin S is a novel target for age-related dry eye
Yu Z, Li J, Govindarajan G, Hamm-Alvarez S, Alam J, Li DQ, de Paiva CS |
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Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics
R Brown, S Nath, A Lora, G Samaha, Z Elgamal, R Kaiser, C Taggart, S Weldon, P Geraghty |
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Increased adenosine-to-inosine RNA editing in rheumatoid arthritis
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Adenosine-to-inosine RNA editing in the immune system: friend or foe?
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Lysosomes as a therapeutic target
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Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome
P Hargreaves, D Daoudlarian, M Theron, FA Kolb, MM Young, B Reis, A Tiaden, B Bannert, D Kyburz, T Manigold |
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|
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|
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|
Immunological function of Blimp-1 in dendritic cells and relevance to autoimmune diseases
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|
Unmet medical needs in lupus nephritis: solutions through evidence-based, personalized medicine
HJ Anders, M Weidenbusch, B Rovin |
Clinical Kidney Journal | 2015 |
|
SLE-associated risk factors affect DC function
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|
Cathepsin S inhibition lowers blood glucose levels in mice
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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K Schenke-Layland, J Xie, M Magnusson, E Angelis, X Li, K Wu, DP Reinhardt, WR Maclellan, SF Hamm-Alvarez |
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|
Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse
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|
“Venopathy” at work: recasting neointimal hyperplasia in a new light
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|
The immunomodulatory action of sialostatin L on dendritic cells reveals its potential to interfere with autoimmunity
A Sá-Nunes, A Bafica, LR Antonelli, EY Choi, IM Francischetti, JF Andersen, GP Shi, T Chavakis, JM Ribeiro, M Kotsyfakis |
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|
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N Ishimaru, R Arakaki, S Yoshida, A Yamada, S Noji, Y Hayashi |
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|
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René Maehr, Justine D Mintern, Ann E Herman, Ana-Maria Lennon-Duménil, Diane Mathis, Christophe Benoist, and Hidde L Ploegh |
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|
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|
Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis
U Schurigt, N Stopfel, M Hückel, C Pfirschke, B Wiederanders, R Bräuer |
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|
Fluorescent probes for proteolysis: Tools for drug discovery
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|
Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease
Y Ban, DA Greenberg, E Concepcion, L Skrabanek, R Villanueva, Y Tomer |
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