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Gunjan L. Shah, … , Genovefa Papanicolaou, Miguel-Angel Perales
Published September 8, 2020
Citation Information: J Clin Invest. 2020;130(12):6656-6667. https://doi.org/10.1172/JCI141777.
Citation Information: J Clin Invest. 2020;130(12):6656-6667. https://doi.org/10.1172/JCI141777.
Abstract
BACKGROUND Understanding outcomes and immunologic characteristics of cellular therapy recipients with SARS-CoV-2 is critical to performing these potentially life-saving therapies in the COVID-19 era. In this study of recipients of allogeneic (Allo) and autologous (Auto) hematopoietic cell transplant and CD19-directed chimeric antigen receptor T cell (CAR T) therapy at Memorial Sloan Kettering Cancer Center, we aimed to identify clinical variables associated with COVID-19 severity and assess lymphocyte populations.METHODS We retrospectively investigated patients diagnosed between March 15, 2020, and May 7, 2020. In a subset of patients, lymphocyte immunophenotyping, quantitative real-time PCR from nasopharyngeal swabs, and SARS-CoV-2 antibody status were available.RESULTS We identified 77 patients with SARS-CoV-2 who were recipients of cellular therapy (Allo, 35; Auto, 37; CAR T, 5; median time from cellular therapy, 782 days; IQR, 354–1611 days). Overall survival at 30 days was 78%. Clinical variables significantly associated with the composite endpoint of nonrebreather or higher oxygen requirement and death (n events = 25 of 77) included number of comorbidities (HR 5.41, P = 0.004), infiltrates (HR 3.08, P = 0.032), and neutropenia (HR 1.15, P = 0.04). Worsening graft-versus-host disease was not identified among Allo recipients. Immune profiling revealed reductions and rapid recovery in lymphocyte populations across lymphocyte subsets. Antibody responses were seen in a subset of patients.CONCLUSION In this series of Allo, Auto, and CAR T recipients, we report overall favorable clinical outcomes for patients with COVID-19 without active malignancy and provide preliminary insights into the lymphocyte populations that are key for the antiviral response and immune reconstitution.FUNDING NIH grant P01 CA23766 and NIH/National Cancer Institute grant P30 CA008748.
Authors
Gunjan L. Shah, Susan DeWolf, Yeon Joo Lee, Roni Tamari, Parastoo B. Dahi, Jessica A. Lavery, Josel Ruiz, Sean M. Devlin, Christina Cho, Jonathan U. Peled, Ioannis Politikos, Michael Scordo, N. Esther Babady, Tania Jain, Santosha Vardhana, Anthony Daniyan, Craig S. Sauter, Juliet N. Barker, Sergio A. Giralt, Cheryl Goss, Peter Maslak, Tobias M. Hohl, Mini Kamboj, Lakshmi Ramanathan, Marcel R.M. van den Brink, Esperanza Papadopoulos, Genovefa Papanicolaou, Miguel-Angel Perales
Citation information
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JAMA Oncology | 2021 |
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Outcomes of COVID-19 in Patients With Cancer: A Closer Look at Pre-Emptive Routine Screening Strategies
Z Xie, AN Saliba, J Abeykoon, U Majeed, DR Almquist, JE Wiedmeier-Nutor, E Bezerra, X Andrade-Gonzalez, A Hickman, K Sorenson, S Rakshit, C Wee, SH Tella, A Kommalapati, N Abdallah, J Pritchett, MD Andrade, D Uprety, A Badley, R Manochakian, S Ailawadhi, AH Bryce, JM Hubbard, N Gangat, CA Thompson, TE Witzig, RR McWilliams, K Leventakos, TR Halfdanarson |
2021 | |
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COVID-19 in immunocompromised populations: implications for prognosis and repurposing of immunotherapies
JD Goldman, PC Robinson, TS Uldrick, P Ljungman |
Journal for ImmunoTherapy of Cancer | 2021 |
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Cardio-oncology Training in the COVID-19 Era
S Feldman, J Liu, R Steingart, D Gupta |
Current Treatment Options in Oncology | 2021 |
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COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey
P Ljungman, R de la Camara, M Mikulska, G Tridello, B Aguado, MA Zahrani, J Apperley, A Berceanu, RM Bofarull, M Calbacho, F Ciceri, L Lopez-Corral, C Crippa, ML Fox, A Grassi, MJ Jimenez, SK Demir, M Kwon, CV Llamas, JL Lorenzo, S Mielke, K Orchard, RP Porras, D Vallisa, A Xhaard, NS Knelange, A Cedillo, N Kröger, JL Piñana, J Styczynski |
Leukemia | 2021 |
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Personalized at-home autologous hematopoietic stem cell transplantation during the SARS-CoV-2 outbreak
A Martínez-Roca, LG Rodríguez-Lobato, N Ballestar, C Gallego, F Fernández-Avilés |
Leukemia Research | 2021 |
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Aseptic Meningitis after Recovery from SARS-CoV-2 in an Allogeneic Stem Cell Transplant Recipient
F Basher, JF Camargo, M Diaz-Paez, LJ Lekakis, DL Pereira |
Clinical medicine insights. Case reports | 2021 |
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Clinical course and outcomes of COVID‐19 in hematopoietic cell transplant patients, a regional report from the Middle East
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Bone Marrow Transplantation | 2021 |
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Transplant Infectious Disease | 2021 |
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COVID-19 and Hematopoietic Cell Transplantation Center-Specific Survival Analysis: Can We Adjust for the Impact of the Pandemic? Recommendations of the COVID-19 Task Force of the 2020 Center for International Blood and Marrow Transplantation Research Center Outcomes Forum
JR Wingard, KW Ahn, C Dandoy, MA Perales, WA Wood, B Logan, M Riches, JD Rizzo |
2021 | |
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COVID-19 vaccines for patients with haematological conditions
C Sun, C Pleyer, A Wiestner |
The Lancet Haematology | 2021 |
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Risk factors for seasonal human coronavirus lower respiratory tract infection after hematopoietic cell transplantation
C Ogimi, H Xie, A Waghmare, MU Oshima, KK Mallhi, KR Jerome, WM Leisenring, JA Englund, M Boeckh |
Blood Advances | 2021 |
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Immune reconstitution and severity of COVID‐19 among hematopoietic cell transplant recipients
AE Malek, JA Adachi, VE Mulanovich, J Sassine, II Raad, K McConn, GT Seiler, U Dhal, F Khawaja, RF Chemaly |
Transplant Infectious Disease | 2021 |
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Cellular Therapy During COVID-19: Lessons Learned and Preparing for Subsequent Waves
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2021 | |
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Oncologic immunomodulatory agents in patients with cancer and COVID-19
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Scientific Reports | 2021 |
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Case Discussion and Literature Review: Cancer Immunotherapy, Severe Immune-Related Adverse Events, Multi-Inflammatory Syndrome, and Severe Acute Respiratory Syndrome Coronavirus 2
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Frontiers in Oncology | 2021 |
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Use of Telehealth for Domiciliary Follow-up After Hematopoietic Cell Transplantation During the COVID-19 Pandemic: Prospective Pilot Study
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2021 | |
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Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study
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The Lancet Haematology | 2021 |
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CD19+IgD+CD27- Naïve B Cells as Predictors of Humoral Response to COVID 19 mRNA Vaccination in Immunocompromised Patients
E Schulz, I Hodl, P Forstner, S Hatzl, N Sareban, M Moritz, J Fessler, B Dreo, B Uhl, C Url, AJ Grisold, M Khalil, B Kleinhappl, C Enzinger, MH Stradner, HT Greinix, P Schlenke, I Steinmetz |
Frontiers in immunology | 2021 |
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Coronavirus disease 2019 in immunocompromised patients: a comprehensive review of coronavirus disease 2019 in hematopoietic stem cell recipients
A Lafarge, A Mabrouki, E Yvin, S Bredin, Y Binois, R Clere-Jehl, E Azoulay |
Current Opinion in Critical Care | 2021 |
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MIS-C clinical guidance released amid race to define the condition
J Clarke |
Nature Reviews Rheumatology | 2020 |
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COVID-19—Lessons Learned and Questions Remaining
FC Fang, CA Benson, C del Rio, KM Edwards, VG Fowler, DN Fredricks, AP Limaye, BE Murray, S Naggie, PG Pappas, R Patel, DL Paterson, DA Pegues, WA Petri, RT Schooley |
Clinical Infectious Diseases | 2020 |
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Expanding the toolbox to combat a pandemic
SE Prockop |
Blood | 2020 |
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Complications after CD19+ CAR T-Cell Therapy
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Cancers | 2020 |
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Humoral serologic response to the BNT162b2 vaccine is abrogated in lymphoma patients within the first 12 months following treatment with anti-CD2O antibodies
R Gurion, U Rozovski, G Itchaki, A Gafter-Gvili, C Leibovitch, P Raanani, H Ben-Zvi, M Szwarcwort, M Taylor-Abigadol, E Dann, N Horesh, T Inbar, I Tzoran, N Lavi, R Fineman, S Ringelstein-Harlev, N Horowitz |
Haematologica | 2020 |
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