The ability to regulate specific genes of energy metabolism in response to fasting and feeding is an important adaptation allowing survival of intermittent food supplies. However, little is known about transcription factors involved in such responses in higher organisms. We show here that gene expression in adipose tissue for adipocyte determination differentiation dependent factor (ADD) 1/sterol regulatory element binding protein (SREBP) 1, a basic-helix-loop-helix protein that has a dual DNA-binding specificity, is reduced dramatically upon fasting and elevated upon refeeding; this parallels closely the regulation of two adipose cell genes that are crucial in energy homeostasis, fatty acid synthetase (FAS) and leptin. This elevation of ADD1/SREBP1, leptin, and FAS that is induced by feeding in vivo is mimicked by exposure of cultured adipocytes to insulin, the classic hormone of the fed state. We also show that the promoters for both leptin and FAS are transactivated by ADD1/SREBP1. A mutation in the basic domain of ADD1/SREBP1 that allows E-box binding but destroys sterol regulatory element-1 binding prevents leptin gene transactivation but has no effect on the increase in FAS promoter function. Molecular dissection of the FAS promoter shows that most if not all of this action of ADD1/SREBP1 is through an E-box motif at -64 to -59, contained with a sequence identified previously as the major insulin response element of this gene. These results indicate that ADD1/SREBP1 is a key transcription factor linking changes in nutritional status and insulin levels to the expression of certain genes that regulate systemic energy metabolism.
J B Kim, P Sarraf, M Wright, K M Yao, E Mueller, G Solanes, B B Lowell, B M Spiegelman
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Molecules (Basel, Switzerland) | 2015 |
Egg Yolks Inhibit Activation of NF-κB and Expression of Its Target Genes in Adipocytes after Partial Delipidation
Q Shen, KM Riedl, RM Cole, C Lehman, L Xu, H Alder, MA Belury, SJ Schwartz, O Ziouzenkova |
Journal of Agricultural and Food Chemistry | 2015 |
Fatty acid synthase promoter: Characterization, and transcriptional regulation by sterol regulatory element binding protein-1 in goat mammary epithelial cells
J Li, J Luo, H Xu, M Wang, J Zhu, H Shi, AB Haile, H Wang, Y Sun |
Gene | 2015 |
HIV protease inhibitors: a review of molecular selectivity and toxicity
Y Wang, Z Lv, Y Chu |
HIV/AIDS (Auckland, N.Z.) | 2015 |
Anti-Diabetic Effect of Aster sphathulifolius in C57BL/KsJ- db/db Mice
X Yin, Y Huang, DW Jung, HC Chung, SY Choung, JH Shim, IJ Kang |
Journal of Medicinal Food | 2015 |
Ferulic acid regulates hepatic GLUT2 gene expression in high fat and fructose-induced type-2 diabetic adult male rat
A Narasimhan, M Chinnaiyan, B Karundevi |
European Journal of Pharmacology | 2015 |
Effects of different roughage sources and feeding levels on adipogenesis of ovine adipocytes: Roughage Evaluation by Adipocyte Culture
DH Kim, KC Choi, T Ichinohe, SH Song |
Animal Science Journal | 2015 |
Regulation of Adipogenesis and Key Adipogenic Gene Expression by 1, 25-Dihydroxyvitamin D in 3T3-L1 Cells
S Ji, ME Doumit, RA Hill, LM Seoane |
PloS one | 2015 |
International Textbook of Diabetes Mellitus: DeFronzo/International Textbook of Diabetes Mellitus, Fourth Edition
RN Bergman, M Ader |
International Textbook of Diabetes Mellitus: DeFronzo/International Textbook of Diabetes Mellitus, Fourth Edition | 2015 |
Metabolic, Anabolic, and Mitogenic Insulin Responses: A Tissue-Specific Perspective for Insulin Receptor Activators
DH Bedinger, SH Adams |
Molecular and Cellular Endocrinology | 2015 |
Dietary conjugated linoleic acids increase intramuscular fat deposition and decrease subcutaneous fat deposition in Yellow Breed × Simmental cattle: Dietary CLA on Fat Deposition
H Zhang, X Dong, Z Wang, A Zhou, Q Peng, H Zou, B Xue, L Wang |
Animal Science Journal | 2015 |
Hepatic De Novo Lipogenesis and Regulation of Metabolism
JM Ntambi |
Hepatic De Novo Lipogenesis and Regulation of Metabolism | 2015 |
Tissue-specific insulin signaling in the regulation of metabolism and aging: Insulin Signaling in Metabolism and Aging
J Zhang, F Liu |
IUBMB Life | 2014 |
RNF20 regulates hepatic lipid metabolism through PKA-dependent SREBP1c degradation
JH Lee, GY Lee, H Jang, SS Choe, SH Koo, JB Kim |
Hepatology | 2014 |
Molecular pathways in non-alcoholic fatty liver disease
A Berlanga, E Guiu-Jurado, JA Porras, T Auguet |
Clinical and experimental gastroenterology | 2014 |
Deficiency of the Transcriptional Repressor B Cell Lymphoma 6 (Bcl6) Is Accompanied by Dysregulated Lipid Metabolism
CR LaPensee, G Lin, AL Dent, J Schwartz, X Chen |
PloS one | 2014 |
Bindings of ChREBP and SREBP1, and Histone Acetylation around the Rat Liver Fatty Acid Synthase Gene Are Associated with Induction of the Gene during the Suckling-Weaning Transition
S MORISHITA, K MOCHIZUKI, T GODA |
Journal of Nutritional Science and Vitaminology | 2014 |
Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1
YA Jung, HK Kim, KH Bae, HY Seo, HS Kim, BK Jang, GS Jung, IK Lee, MK Kim, KG Park |
Experimental & molecular medicine | 2014 |
Systems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor System
J Janssens, H Etienne, S Idriss, A Azmi, B Martin, S Maudsley |
Frontiers in Endocrinology | 2014 |
Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis.
Özkan E, Chia PH, Wang RR, Goriatcheva N, Borek D, Otwinowski Z, Walz T, Shen K, Garcia KC |
Cell | 2014 |
γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.
Aydintug MK, Zhang L, Wang C, Liang D, Wands JM, Michels AW, Hirsch B, Day BJ, Zhang G, Sun D, Eisenbarth GS, O'Brien RL, Born WK |
Molecular Immunology | 2014 |
Phosphorylation of sterol regulatory element binding protein-1a by protein kinase A (PKA) regulates transcriptional activity.
Dong Q, Giorgianni F, Deng X, Beranova-Giorgianni S, Bridges D, Park EA, Raghow R, Elam MB |
Biochemical and Biophysical Research Communications | 2014 |
Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects
Barua S, Mitragotri S |
Nano Today | 2014 |
The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.
Smith EP, An Z, Wagner C, Lewis AG, Cohen EB, Li B, Mahbod P, Sandoval D, Perez-Tilve D, Tamarina N, Philipson LH, Stoffers DA, Seeley RJ, D'Alessio DA |
Cell Metabolism | 2014 |
Osteopontin facilitates ultraviolet B-induced squamous cell carcinoma development.
Chang PL, Hsieh YH, Wang CC, Juliana MM, Tsuruta Y, Timares L, Elmets C, Ho KJ |
Journal of Dermatological Science | 2014 |
Comprehensive Physiology
SN Cheuvront, RW Kenefick |
Comprehensive Physiology | 2014 |
Unavailability of liver triacylglycerol increases serum cholesterol concentration induced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats
Y Tanaka, K Nagao, H Nakagiri, T Nagaso, Y Iwasa, H Mori, M Asahina, K Imaizumi, M Sato |
Lipids in Health and Disease | 2014 |
In vitro and in vivo enhancement of adipogenesis by Italian ryegrass (Lolium multiflorum) in 3T3-L1 cells and mice
MV Arasu, S Ilavenil, DH Kim, SG Roh, JC Lee, KC Choi |
PloS one | 2014 |
Physiological regulation of lipoprotein lipase
S Kersten |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2014 |
MicroRNA-33b downregulates the differentiation and development of porcine preadipocytes
M Taniguchi, I Nakajima, K Chikuni, M Kojima, T Awata, S Mikawa |
Molecular Biology Reports | 2014 |
Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis
S Grube, P Dünisch, D Freitag, M Klausnitzer, Y Sakr, J Walter, R Kalff, C Ewald |
Journal of Neuro-Oncology | 2014 |
Dietary macronutrients, genetic variation, and progression of coronary atherosclerosis among women
S Kalantarian, EB Rimm, DM Herrington, D Mozaffarian |
American Heart Journal | 2014 |
The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats
DM Erion, A Lapworth, PA Amor, G Bai, NB Vera, RW Clark, Q Yan, Y Zhu, TT Ross, J Purkal, M Gorgoglione, G Zhang, V Bonato, L Baker, N Barucci, T D'Aquila, A Robertson, RJ Aiello, J Yan, J Trimmer, TP Rolph, JA Pfefferkorn |
PloS one | 2014 |
Positive regulations of adipogenesis by Italian ryegrass [Lolium multiflorum] in 3T3-L1 cells
S Ilavenil, MV Arasu, JC Lee, DH Kim, M Vijayakumar, KD Lee, KC Choi |
BMC Biotechnology | 2014 |
Regulation of energy metabolism by long-chain fatty acids
MT Nakamura, BE Yudell, JJ Loor |
Progress in Lipid Research | 2014 |
Effects of different levels of protein supplementary diet on gene expressions related to intramuscular deposition in early-weaned yaks: Supplementary Protein Diet on Intramuscular Fat
H Zhang, ZS Wang, QH Peng, C Tan, HW Zou |
Animal Science Journal | 2014 |
Acute endocrine and nutritional co-regulation of the hepatic omy-miRNA-122b and the lipogenic gene fas in rainbow trout, Oncorhynchus mykiss
JA Mennigen, E Plagnes-Juan, CA Figueredo-Silva, I Seiliez, S Panserat, S Skiba-Cassy |
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology | 2014 |
Fetal and neonatal exposure to nicotine leads to augmented hepatic and circulating triglycerides in adult male offspring due to increased expression of fatty acid synthase
N Ma, CJ Nicholson, M Wong, AC Holloway, DB Hardy |
Toxicology and Applied Pharmacology | 2014 |
Suppression of adipogenesis by valproic acid through repression of USF1-activated fatty acid synthesis in adipocytes
M Yuyama, K Fujimori |
Biochemical Journal | 2014 |
GSK3β-Dependent Phosphorylation Alters DNA Binding, Transactivity and Half-Life of the Transcription Factor USF2
Tina Horbach, Tabughang Franklin Chi, Claudia Götz, Satyan Sharma, André H. Juffer, Elitsa Y. Dimova, Thomas Kietzmann |
PloS one | 2014 |
Phytic acid and myo-inositol support adipocyte differentiation and improve insulin sensitivity in 3T3-L1 cells
JN Kim, SN Han, HK Kim |
Nutrition Research | 2014 |
In Vitro and In Vivo Enhancement of Adipogenesis by Italian Ryegrass (Lolium multiflorum) in 3T3-L1 Cells and Mice
MV Arasu, S Ilavenil, DH Kim, SG Roh, JC Lee, KC Choi, V Sanchez-Margalet |
PloS one | 2014 |
Cloning, characterization and expression of Peking duck fatty acid synthase during adipocyte differentiation
F Ding, X Yuan, Q Li, W Sun, C Gan, H He, C Song, J Wang |
Electronic Journal of Biotechnology | 2014 |
Exercise, but not quercetin, ameliorates inflammation, mitochondrial biogenesis, and lipid metabolism in skeletal muscle after strenuous exercise by high-fat diet mice
SM Kwon, HG Park, JK Jun, WL Lee |
Journal of Exercise Nutrition & Biochemistry | 2014 |
Effects of Yerba maté, a Plant Extract Formulation (“YGD”) and Resveratrol in 3T3-L1 Adipogenesis
J Santos, É Gotardo, M Brianti, M Piraee, A Gambero, M Ribeiro |
Molecules (Basel, Switzerland) | 2014 |
Expression of genes involved in lipid metabolism in the muscle of beef cattle fed soybean or rumen-protected fat, with or without monensin supplementation1
DM Oliveira, A Chalfun-Junior, ML Chizzotti, HG Barreto, TC Coelho, LV Paiva, CP Coelho, PD Teixeira, JP Schoonmaker, MM Ladeira |
Journal of animal science | 2014 |
Effects of phenotypic residual feed intake on response to a glucose tolerance test and gene expression in the insulin signaling pathway in longissimus dorsi in beef cattle1
C Fitzsimons, DA Kenny, SM Waters, B Earley, M McGee |
Journal of animal science | 2014 |
PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling
GY Lee, H Jang, JH Lee, JY Huh, S Choi, J Chung, JB Kim |
Molecular and cellular biology | 2013 |
G Protein-Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors: G-PROTEIN COUPLED RECEPTORS AND ADIPOGENESIS
A Eisenstein, K Ravid |
Journal of Cellular Physiology | 2013 |
Insulin signalling mechanisms for triacylglycerol storage
MP Czech, M Tencerova, DJ Pedersen, M Aouadi |
Diabetologia | 2013 |
Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues
M Schupp, F Chen, ER Briggs, S Rao, HJ Pelzmann, AR Pessentheiner, JG Bogner-Strauss, MA Lazar, D Baldwin, A Prokesch |
BMC Genomics | 2013 |
Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP
X Xu, JS So, JG Park, AH Lee |
Seminars in liver disease | 2013 |
Current role of fenofibrate in the prevention and management of non-alcoholic fatty liver disease
MS Kostapanos, A Kei, MS Elisaf |
World journal of hepatology | 2013 |
Thyroid Hormones Decrease Plasma 1α,25-Dihydroxyvitamin D Levels Through Transcriptional Repression of the Renal 25-Hydroxyvitamin D3 1α-Hydroxylase Gene (CYP27B1)
M Kozai, H Yamamoto, M Ishiguro, N Harada, M Masuda, T Kagawa, Y Takei, A Otani, O Nakahashi, S Ikeda, Y Taketani, K Takeyama, S Kato, E Takeda |
Endocrinology | 2013 |
Loss of Phosphatase and Tensin Homolog (PTEN) Induces Leptin-mediated Leptin Gene Expression: FEED-FORWARD LOOP OPERATING IN THE LUNG
RR Pathak, A Grover, P Malaney, W Quarni, A Pandit, D Allen-Gipson, V Dave |
The Journal of biological chemistry | 2013 |
Hepatic Fatty Acid Trafficking: Multiple Forks in the Road
DG Mashek |
Advances in nutrition (Bethesda, Md.) | 2013 |
Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance
SW Beaven, A Matveyenko, K Wroblewski, L Chao, D Wilpitz, TW Hsu, J Lentz, B Drew, AL Hevener, P Tontonoz |
Cell Metabolism | 2013 |
Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability
UB Pajvani, L Qiang, T Kangsamaksin, J Kitajewski, HN Ginsberg, D Accili |
Nature Medicine | 2013 |
Leptin's Pro-Angiogenic Signature in Breast Cancer
RR Gonzalez-Perez, V Lanier, G Newman |
Cancers | 2013 |
Non-classic thyroid hormone signalling involved in hepatic lipid metabolism
A Cordeiro, LL Souza, M Einicker-Lamas, CC Pazos-Moura |
Journal of Endocrinology | 2013 |
Insulin resistance and adipogenesis: Role of transcription and secreted factors
DN Penkov, AD Egorov, MN Mozgovaya, VA Tkachuk |
Biochemistry (Moscow) | 2013 |
Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor
H Jo, SS Choe, KC Shin, H Jang, JH Lee, JK Seong, SH Back, JB Kim |
Hepatology | 2013 |
Pharmacologic agents for type 2 diabetes therapy and regulation of adipogenesis
A Cignarelli, F Giorgino, R Vettor |
Archives Of Physiology And Biochemistry | 2013 |
Regulation of brown adipogenesis by the Tgf-β family: Involvement of Srebp1c in Tgf-β- and Activin-induced inhibition of adipogenesis
H Yoshida, Y Kanamori, H Asano, O Hashimoto, M Murakami, T Kawada, T Matsui, M Funaba |
Biochimica et Biophysica Acta (BBA) - General Subjects | 2013 |
Iatrogenic hyperinsulinemia in type 1 diabetes: Its effect on atherogenic risk markers
MY Wang, X Yu, Y Lee, SK McCorkle, GO Clark, S Strowig, RH Unger, P Raskin |
Journal of Diabetes and its Complications | 2013 |
MicroRNAs in Medicine
LC Edelstein, S Nagalla, PF Bray |
MicroRNAs in Medicine | 2013 |
Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice
JH Kang, SI Yun, MH Park, JH Park, SY Jeong, HO Park |
PloS one | 2013 |
Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake
M Yang, W Liu, C Pellicane, C Sahyoun, BK Joseph, C Gallo-Ebert, M Donigan, D Pandya, C Giordano, A Bata, JT Nickels |
Journal of lipid research | 2013 |
Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice
JH Kang, SI Yun, MH Park, JH Park, SY Jeong, HO Park, K Maedler |
PloS one | 2013 |
Direct Reprogramming of Adult Somatic Cells into other Lineages: Past Evidence and Future Perspectives
M Nizzardo, C Simone, M Falcone, G Riboldi, GP Comi, N Bresolin, S Corti |
Cell Transplantation | 2013 |
Current role of fenofibrate in the prevention and management of non-alcoholic fatty liver disease
MS Kostapanos |
World journal of hepatology | 2013 |
Physiologie et physiopathologie du tissu adipeux
JP Bastard, B Fève |
2013 | |
FOSL2 promotes adipocyte-specific leptin gene expression in humans and mice
Christiane Wrann, Jun Eguchi, Aline Bozec, Zhao Xu, Tarjei Mikkelsen, Jeffrey Gimble, Heike Nave, Erwin F. Wagner, Shao-en Ong, Evan Rosen |
Journal of Clinical Investigation | 2012 |
Molecular mechanisms of estrogen receptors' suppression of lipogenesis in pancreatic β-cells
JP Tiano, F Mauvais-Jarvis |
Endocrinology | 2012 |
Lipid Metabolism and Neuroinflammation in Alzheimer's Disease: A Role for Liver X Receptors
J Kang, S Rivest |
Endocrine reviews | 2012 |
Effects of sterol regulatory element-binding protein (SREBP) in chickens
FA Khesht, A Hassanabadi |
Lipids in Health and Disease | 2012 |
Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter
BN Jeon, YS Kim, WI Choi, DI Koh, MK Kim, JH Yoon, MY Kim, B Hur, PD Paik, MW Hur |
Journal of lipid research | 2012 |
Scientific side trips: six excursions from the beaten path
MS Brown, JL Goldstein |
The Journal of biological chemistry | 2012 |
New insights into adipocyte-specific leptin gene expression
CD Wrann, ED Rosen |
Adipocyte | 2012 |
Prenatal Arsenic Exposure Alters Gene Expression in the Adult Liver to a Proinflammatory State Contributing to Accelerated Atherosclerosis
JC States, AV Singh, TB Knudsen, EC Rouchka, NO Ngalame, GE Arteel, Y Piao, MS Ko |
PloS one | 2012 |
Regulatory Mechanisms in Bone Following Mechanical Loading
SM Roosa, CH Turner, Y Liu |
Gene regulation and systems biology | 2012 |
Inhibition of cannabinoid CB1 receptor upregulates Slc2a4 expression via nuclear factor- B and sterol regulatory element-binding protein-1 in adipocytes
DT Furuya, AC Poletto, HS Freitas, UF Machado |
Journal of Molecular Endocrinology | 2012 |
The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice
X Liu, H Yuan, Y Niu, W Niu, L Fu |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 |
Developmental Origins of Obesity: Programmed Adipogenesis
M Desai, M Beall, MG Ross |
Current Diabetes Reports | 2012 |
Low protein diet up-regulate intramuscular lipogenic gene expression and down-regulate lipolytic gene expression in growth–finishing pigs
J Wang, SM Zhao, XL Song, HB Pan, WZ Li, YY Zhang, SZ Gao, DW Chen |
Livestock Science | 2012 |
Role of kruppel-like transcription factors in adipogenesis
Z Wu, S Wang |
Developmental Biology | 2012 |
Current concept of reverse cholesterol transport and novel strategy for atheroprotection
K Ono |
Journal of Cardiology | 2012 |
Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter[S]
BN Jeon, YS Kim, WI Choi, DI Koh, MK Kim, JH Yoon, MY Kim, B Hur, PD Paik, MW Hur |
Journal of lipid research | 2012 |
Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis
W Li, Y Tai, J Zhou, W Gu, Z Bai, T Zhou, Z Zhong, PA McCue, N Sang, JY Ji, B Kong, J Jiang, C Wang |
Cell cycle (Georgetown, Tex.) | 2012 |
Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice
H Jang, G Lee, J Kong, G Choi, YJ Park, JB Kim |
PloS one | 2012 |
Feeding Period Restriction Alters the Expression of Peripheral Circadian Rhythm Genes without Changing Body Weight in Mice
H Jang, G Lee, J Kong, G Choi, YJ Park, JB Kim, A Xu |
PloS one | 2012 |
Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter
BN Jeon, YS Kim, WI Choi, DI Koh, MK Kim, JH Yoon, MY Kim, B Hur, PD Paik, MW Hur |
Journal of lipid research | 2012 |
Regulatory Mechanisms in Bone following Mechanical Loading
SM Roosa, CH Turner, Y Liu |
Gene regulation and systems biology | 2012 |
Protein Arginine Methyltransferase 5 (Prmt5) Promotes Gene Expression of Peroxisome Proliferator-Activated Receptor γ2 (PPARγ2) and Its Target Genes during Adipogenesis
SE LeBlanc, S Konda, Q Wu, YJ Hu, CM Oslowski, S Sif, AN Imbalzano |
Molecular Endocrinology | 2012 |
Physiology and Physiopathology of Adipose Tissue
JP Bastard, B Fève |
2012 | |
Transcriptional Control of Adipose Lipid Handling by IRF4
J Eguchi, X Wang, S Yu, EE Kershaw, PC Chiu, J Dushay, JL Estall, U Klein, E Maratos-Flier, ED Rosen |
Cell Metabolism | 2011 |
Evidence Coupling Increased Hexosamine Biosynthesis Pathway Activity to Membrane Cholesterol Toxicity and Cortical Filamentous Actin Derangement Contributing to Cellular Insulin Resistance†
P Bhonagiri, GR Pattar, KM Habegger, AM McCarthy, L Tackett, JS Elmendorf |
Endocrinology | 2011 |
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
TR Peterson, SS Sengupta, TE Harris, AE Carmack, SA Kang, E Balderas, DA Guertin, KL Madden, AE Carpenter, BN Finck, DM Sabatini |
Cell | 2011 |
Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein -1a
SS Im, L Yousef, C Blaschitz, JZ Liu, RA Edwards, SG Young, M Raffatellu, TF Osborne |
Cell Metabolism | 2011 |
MicroRNA hsa-miR-613 Targets the Human LXRα Gene and Mediates a Feedback Loop of LXRα Autoregulation
Z Ou, T Wada, R Gramignoli, S Li, SC Strom, M Huang, W Xie |
Molecular Endocrinology | 2011 |
MicroRNAs and Cardiovascular Diseases
K Ono, Y Kuwabara, J Han |
The FEBS journal | 2011 |
Physiological effects of Type 2 diabetes on mRNA processing and gene expression
FS Morrison, KA Johnstone, LW Harries |
Expert Review of Endocrinology & Metabolism | 2011 |
Dietary constituents reduce lipid accumulation in murine C3H10 T1/2 adipocytes: A novel fluorescent method to quantify fat droplets
I Warnke, R Goralczyk, E Fuhrer, J Schwager |
Nutrition & Metabolism | 2011 |
Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway
R Suzuki, M Tanaka, M Takanashi, A Hussain, B Yuan, H Toyoda, M Kuroda |
Nutrition & Metabolism | 2011 |
Nocturnin expression is induced by fasting in the white adipose tissue of restricted fed mice
MR Gilbert, N Douris, S Tongjai, CB Green |
PloS one | 2011 |
Haplotype combination ofSREBP-1cgene sequence variants is associated with growth traits in cattle
YZ Huang, H He, JJ Sun, J Wang, ZJ Li, XY Lan, CZ Lei, CL Zhang, EP Zhang, JQ Wang, H Chen, J Bell |
Genome | 2011 |
MicroRNAs and cardiovascular diseases
K Ono, Y Kuwabara, J Han |
FEBS Journal | 2011 |
Insulin induces fatty acid desaturase expression in human monocytes
I Arbo, C Halle, D Malik, HR Brattbakk, B Johansen |
Scandinavian Journal of Clinical & Laboratory Investigation | 2011 |
Transcriptional Metabolic Inflexibility in Skeletal Muscle Among Individuals With Increasing Insulin Resistance
A Jans, LM Sparks, AM van Hees, IM Gjelstad, AC Tierney, U Risérus, CA Drevon, HM Roche, P Schrauwen, EE Blaak |
Obesity | 2011 |
The Inhibitory Effect ofLactobacillus plantarumKY1032 Cell Extract on the Adipogenesis of 3T3-L1 Cells
DY Park, YT Ahn, CS Huh, SM Jeon, MS Choi |
Journal of Medicinal Food | 2011 |
Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats
A Agil, I Rosado, R Ruiz, A Figueroa, N Zen, G Fernández-Vázquez |
Journal of Pineal Research | 2011 |
Effects of dietary lipids and Clostridium butyricum on serum lipids and lipid-related gene expression in broiler chickens
B Zhang, X Yang, Y Guo, F Long |
animal | 2011 |
Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells
R Drira, S Chen, K Sakamoto |
Life Sciences | 2011 |
Roles of PPARs in NAFLD: Potential therapeutic targets
A Tailleux, K Wouters, B Staels |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2011 |
Establishment and evaluation of a new model for studying lipogenesis in grass carp (Ctenopharyngodon idella) preadipocytes
Y Li |
In Vitro Cellular & Developmental Biology - Animal | 2011 |
Fetal programming of adipose tissue: effects of intrauterine growth restriction and maternal obesity/high-fat diet
M Desai, MG Ross |
Seminars in reproductive medicine | 2011 |
Fetal Programming of Adipose Tissue: Effects of IUGR and Maternal Obesity/High Fat Diet
M Desai, MG Ross |
Seminars in reproductive medicine | 2011 |
Nocturnin Expression Is Induced by Fasting in the White Adipose Tissue of Restricted Fed Mice
MR Gilbert, N Douris, S Tongjai, CB Green, S Yamazak |
PloS one | 2011 |
Regulation of leptin synthesis during adipogenesis in males of a vespertilionid bat, Scotophilus heathi
VK Roy, A Krishna |
The Journal of experimental biology | 2011 |
Establishment and evaluation of a new model for studying lipogenesis in grass carp (Ctenopharyngodon idella) preadipocytes
Y Li |
In vitro cellular & developmental biology. Animal | 2011 |
MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo
T Horie, K Ono, M Horiguchi, H Nishi, T Nakamura, K Nagao, M Kinoshita, Y Kuwabara, H Marusawa, Y Iwanaga, K Hasegawa, M Yokode, T Kimura, T Kita |
Proceedings of the National Academy of Sciences | 2010 |
High Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass
ML Golson, AA Misfeldt, UG Kopsombut, CP Petersen, M Gannon |
The open endocrinology journal | 2010 |
Metabolic effects of obesity: A review
P Singla, A Bardoloi, AA Parkash |
World journal of diabetes | 2010 |
Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance
G Tarantino, S Savastano, A Colao |
World journal of gastroenterology : WJG | 2010 |
Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective
RH Wong, HS Sul |
Current Opinion in Pharmacology | 2010 |
A large indel mutation of the bovine ADD1/SREBP1c gene and its effects on growth traits in some native cattle breeds from China
YZ Huang, EP Zhang, J Wang, YT Huai, L Ma, FY Chen, XY Lan, CZ Lei, XT Fang, JQ Wang, H Chen |
Molecular Biology Reports | 2010 |
Gentiana manshurica Kitagawa Reverses Acute Alcohol-Induced Liver Steatosis through Blocking Sterol Regulatory Element-Binding Protein-1 Maturation
LH Lian, YL Wu, SZ Song, Y Wan, WX Xie, X Li, T Bai, BQ Ouyang, JX Nan |
Journal of Agricultural and Food Chemistry | 2010 |
Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update
JS Bae, TH Kim, MY Kim, JM Park, YH Ahn |
Sensors (Basel, Switzerland) | 2010 |
Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice
M Warrier, TD Hinds, KJ Ledford, HA Cash, PR Patel, TA Bowman, LA Stechschulte, W Yong, W Shou, SM Najjar, ER Sanchez |
Endocrinology | 2010 |
Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation.
Kim AY, Lee YS, Kim KH, Lee JH, Lee HK, Jang SH, Kim SE, Lee GY, Lee JW, Jung SA, Chung HY, Jeong S, Kim JB |
Molecular Endocrinology | 2010 |
Sterol-regulatory-element-binding protein 1c mediates the effect of insulin on the expression of Cidea in mouse hepatocytes
R Wang, X Kong, A Cui, X Liu, R Xiang, Y Yang, Y Guan, F Fang, Y Chang |
Biochemical Journal | 2010 |
Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site
F Damiano, S Alemanno, GV Gnoni, L Siculella |
Biochemical Journal | 2010 |
Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice
YS Lee, BY Cha, K Yamaguchi, SS Choi, T Yonezawa, T Teruya, K Nagai, JT Woo |
Cytotechnology | 2010 |
Effect of dietary saturated fatty acids on HNF-4α DNA binding activity and ApoCIII mRNA in sedentary rat liver
V Ceccarelli, G Nocentini, C Riccardi, E Ayroldi, PD Nardo, R Roberti, L Binaglia, A Vecchini |
Molecular and Cellular Biochemistry | 2010 |
The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA
E Oliver, F McGillicuddy, C Phillips, S Toomey, HM Roche |
Proceedings of the Nutrition Society | 2010 |
Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin
SM Rae-Whitcombe, D Kennedy, M Voyles, MP Thompson |
Biochemical and Biophysical Research Communications | 2010 |
ADD1/SREBP1c activates the PGC1-α promoter in brown adipocytes
Q Hao, JB Hansen, RK Petersen, P Hallenborg, C Jørgensen, S Cinti, PJ Larsen, KR Steffensen, H Wang, S Collins, J Wang, JÅ Gustafsson, L Madsen, K Kristiansen |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2010 |
Hypotriacylglycerolemic and Antiobesity Properties of a New Fermented Tea Product Obtained by Tea-Rolling Processing of Third-Crop Green Tea (Camellia sinensis) Leaves and Loquat (Eriobotrya japonica) Leaves
K TANAKA, S TAMARU, S NISHIZONO, Y MIYATA, K TAMAYA, T MATSUI, T TANAKA, Y ECHIZEN, I IKEDA |
Bioscience, Biotechnology, and Biochemistry | 2010 |
Effects of morroniside isolated from Corni Fructus on renal lipids and inflammation in type 2 diabetic mice
CH Park, JS Noh, T Tanaka, T Yokozawa |
Journal of Pharmacy and Pharmacology | 2010 |
High glucose induces differentiation and adipogenesis in porcine muscle satellite cells via mTOR
T Yue, J Yin, F Li, D Li, M Du |
BMB Reports | 2010 |
SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism*
B Ponugoti, DH Kim, Z Xiao, Z Smith, J Miao, M Zang, SY Wu, CM Chiang, TD Veenstra, JK Kemper |
The Journal of biological chemistry | 2010 |
Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity[S]
KH Kim, GY Lee, JI Kim, M Ham, JW Lee, JB Kim |
Journal of lipid research | 2010 |
Vitamins & Hormones
KJ Hare, FK Knop |
Vitamins & Hormones | 2010 |
Two novel coding SNPs of SREBP1c gene are associated with body weight and average daily gain in bovine
Y Huang, E Zhang, J Wang, Y Huai, X Lan, L Ma, Z Li, G Ren, F Chen, C Lei, J Wang, H Chen |
Animal Biotechnology | 2010 |
Dietary polyunsaturated fatty acids slow the progression of diabetic nephropathy in streptozotocin-induced diabetic rats
M Yokoyama, K Tanigawa, T Murata, Y Kobayashi, E Tada, I Suzuki, Y Nakabou, M Kuwahata, Y Kido |
Nutrition Research | 2010 |
Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity
KH Kim, GY Lee, JI Kim, M Ham, JW Lee, JB Kim |
Journal of lipid research | 2010 |
SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism
B Ponugoti, DH Kim, Z Xiao, Z Smith, J Miao, M Zang, SY Wu, CM Chiang, TD Veenstra, JK Kemper |
The Journal of biological chemistry | 2010 |
Metabolic effects of obesity: A review
P Singla |
World journal of diabetes | 2010 |
Discovery of Glucocorticoid Receptor-β in Mice with a Role in Metabolism
TD Hinds, S Ramakrishnan, HA Cash, LA Stechschulte, G Heinrich, SM Najjar, ER Sanchez |
Molecular Endocrinology | 2010 |
Regulation of the expression of angiotensin-converting enzyme 2 by polyunsaturated fatty acids in porcine adipocytes1
YW Tseng, PH Wang, HS Lee, BH Liu, HJ Mersmann, EC Lin, ST Ding |
Journal of animal science | 2010 |
Obesity Before Birth
RH Lustig |
2010 | |
Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue
S Zhao, J Wang, X Song, , C Ge, S Gao |
Nutrition & Metabolism | 2010 |
Pathomechanisms of Type 2 Diabetes Genes
H Staiger, F Machicao, A Fritsche, HU Häring |
Endocrine reviews | 2009 |
Intersection of the unfolded protein response and hepatic lipid metabolism
AH Lee, LH Glimcher |
Cellular and Molecular Life Sciences | 2009 |
From Sugar to Fat
LH Glimcher, AH Lee |
Annals of the New York Academy of Sciences | 2009 |
Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been
TF Osborne, PJ Espenshade |
Genes & development | 2009 |
Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles
CR Yellaturu, X Deng, LM Cagen, HG Wilcox, CM 2nd, SA Siddiqi, EA Park, R Raghow, MB Elam |
The Journal of biological chemistry | 2009 |
Transcriptional targets in adipocyte biology
E Rosen, J Eguchi, Z Xu |
Expert Opinion on Therapeutic Targets | 2009 |
C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis
VA Payne, WS Au, CE Lowe, SM Rahman, JE Friedman, S O'Rahilly, JJ Rochford |
Biochemical Journal | 2009 |
Fat accumulation in Caenorhabditis elegans is mediated by SREBP homolog SBP-1
T Nomura, M Horikawa, S Shimamura, T Hashimoto, K Sakamoto |
Genes & Nutrition | 2009 |
Krüppel-like family of transcription factors: an emerging new frontier in fat biology
CW Brey, MP Nelder, T Hailemariam, R Gaugler, S Hashmi |
International journal of biological sciences | 2009 |
DNA-PK: relaying the insulin signal to USF in lipogenesis
RH Wong, HS Sul |
Cell cycle (Georgetown, Tex.) | 2009 |
Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells
SN Ramakrishnan, P Lau, LM Crowther, ME Cleasby, S Millard, GM Leong, GJ Cooney, GE Muscat |
Biochemical and Biophysical Research Communications | 2009 |
A minimal model for hepatic fatty acid balance during fasting: Application to PPAR alpha-deficient mice
P Blavy, F Gondret, H Guillou, S Lagarrigue, PG Martin, J Milgen, O Radulescu, A Siegel |
Journal of Theoretical Biology | 2009 |
Oleate induces transdifferentiation of chicken fibroblasts into adipocyte-like cells
S Liu, L Wang, N Wang, Y Wang, H Shi, H Li |
Comparative Biochemistry and Physiology - Part A Molecular & Integrative Physiology | 2009 |
The Orphan Nuclear Receptor RORα Restrains Adipocyte Differentiation through a Reduction of C/EBPβ Activity and Perilipin Gene Expression
N Ohoka, S Kato, Y Takahashi, H Hayashi, R Sato |
Molecular Endocrinology | 2009 |
Insulin Enhances Post-translational Processing of Nascent SREBP-1c by Promoting Its Phosphorylation and Association with COPII Vesicles
CR Yellaturu, X Deng, LM Cagen, HG Wilcox, CM Mansbach, SA Siddiqi, EA Park, R Raghow, MB Elam |
The Journal of biological chemistry | 2009 |
Pitavastatin in the Management of Hypercholesterolemia
S Nomura |
Clinical medicine. Therapeutics | 2009 |
Microarray gene expression profiles of fasting induced changes in liver and adipose tissues of pigs expressing the melanocortin-4 receptor D298N variant
S Lkhagvadorj, L Qu, W Cai, OP Couture, CR Barb, GJ Hausman, D Nettleton, LL Anderson, JC Dekkers, CK Tuggle |
Physiological genomics | 2009 |
Elevated Insulin Secretion from Liver X Receptor-Activated Pancreatic β-Cells Involves Increased de Novo Lipid Synthesis and Triacylglyceride Turnover
CD Green, DB Jump, LK Olson |
Endocrinology | 2009 |
Regulation of SREBP1c Gene Expression in Skeletal Muscle: Role of Retinoid X Receptor/Liver X Receptor and Forkhead-O1 Transcription Factor
Y Kamei, S Miura, T Suganami, F Akaike, S Kanai, S Sugita, A Katsumata, H Aburatani, TG Unterman, O Ezaki, Y Ogawa |
Endocrinology | 2008 |
Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin
P Bhonagiri, GR Pattar, EM Horvath, KM Habegger, AM McCarthy, JS Elmendorf |
Endocrinology | 2008 |
Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN)
WI Choi, BN Jeon, H Park, JY Yoo, YS Kim, DI Koh, MH Kim, YR Kim, CE Lee, KS Kim, TF Osborne, MW Hur |
The Journal of biological chemistry | 2008 |
Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth-restricted offspring
TR Magee, G Han, B Cherian, O Khorram, MG Ross, M Desai |
American Journal of Obstetrics and Gynecology | 2008 |
The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects
LC Hudgins, A Baday, MK Hellerstein, TS Parker, DM Levine, CE Seidman, RA Neese, JD Tremaroli, J Hirsch |
The Journal of Nutritional Biochemistry | 2008 |
Modern Nutrition
K LaPoint, M McIntosh |
Handbook of Nutrition in the Aged, Fourth Edition | 2008 |
Macronutrients and obesity: views, news and reviews
L Madsen, B Liaset, K Kristiansen |
Future Lipidology | 2008 |
Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes
S Rayalam, JY Yang, S Ambati, MA Della-Fera, CA Baile |
Phytotherapy Research | 2008 |
Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism
SM Choi, HJ Cho, H Cho, KH Kim, JB Kim, H Park |
Nucleic Acids Research | 2008 |
Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver
MK Bennett, YK Seo, S Datta, DJ Shin, TF Osborne |
The Journal of biological chemistry | 2008 |
Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fasting
M Palou, T Priego, J Sánchez, E Villegas, AM Rodríguez, A Palou, C Picó |
Pflügers Archiv - European Journal of Physiology | 2008 |
SREBPs: the crossroads of physiological and pathological lipid homeostasis
R Raghow, C Yellaturu, X Deng, EA Park, MB Elam |
Trends in Endocrinology & Metabolism | 2008 |
Adipose tissue gene expression profiles in ob/ob mice treated with leptin
W Zhang, MA Della-Fera, DL Hartzell, D Hausman, CA Baile |
Life Sciences | 2008 |
Insulin induces chaperone and CHOP gene expressions in adipocytes
Y Miyata, A Fukuhara, M Matsuda, R Komuro, I Shimomura |
Biochemical and Biophysical Research Communications | 2008 |
Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population
J Liu, J Liu, P Li, X Xie, Q Guo, L Tian, X Ma, J Zhang, J Liu, J Gao |
Diabetes Research and Clinical Practice | 2008 |
Up-Regulation of Genes Related to the Ubiquitin-Proteasome System in the Brown Adipose Tissue of 24-h-Fasted Rats
Y NAKAI, H HASHIDA, K KADOTA, M MINAMI, K SHIMIZU, I MATSUMOTO, H KATO, K ABE |
Bioscience, Biotechnology, and Biochemistry | 2008 |
Genome-wide effects of acute progressive feed restriction in liver and white adipose tissue
R Pohjanvirta, PC Boutros, ID Moffat, J Lindén, D Wendelin, AB Okey |
Toxicology and Applied Pharmacology | 2008 |
Correlation between adiponectin and reduction of cell adhesion molecules after pitavastatin treatment in hyperlipidemic patients with type 2 diabetes mellitus
S Nomura, A Shouzu, S Omoto, N Inami, A Tanaka, M Nanba, Y Shouda, N Takahashi, Y Kimura, T Iwasaka |
Thrombosis Research | 2008 |
Proto-oncogene FBI-1 (Pokemon) and SREBP-1 Synergistically Activate Transcription of Fatty-acid Synthase Gene (FASN)
WI Choi, BN Jeon, H Park, JY Yoo, YS Kim, DI Koh, MH Kim, YR Kim, CE Lee, KS Kim, TF Osborne, MW Hur |
The Journal of biological chemistry | 2008 |
Selective Binding of Sterol Regulatory Element-binding Protein Isoforms and Co-regulatory Proteins to Promoters for Lipid Metabolic Genes in Liver
MK Bennett, YK Seo, S Datta, DJ Shin, TF Osborne |
The Journal of biological chemistry | 2008 |
The Orphan Nuclear Receptor, RORα, Regulates Gene Expression That Controls Lipid Metabolism: STAGGERER (SG/SG) MICE ARE RESISTANT TO DIET-INDUCED OBESITY
P Lau, RL Fitzsimmons, S Raichur, SC Wang, A Lechtken, GE Muscat |
The Journal of biological chemistry | 2008 |
TRB3 suppresses adipocyte differentiation by negatively regulating PPARγ transcriptional activity
Y Takahashi, N Ohoka, H Hayashi, R Sato |
Journal of lipid research | 2008 |
Hepatic regulation of fatty acid synthase by insulin and T 3 : evidence for T 3 genomic and nongenomic actions
A Radenne, M Akpa, C Martel, S Sawadogo, D Mauvoisin, C Mounier |
American journal of physiology. Endocrinology and metabolism | 2008 |
Sterol regulatory element binding transcription factor 1 expression and genetic polymorphism significantly affect intramuscular fat deposition in the longissimus muscle of Erhualian and Sutai pigs1
J Chen, XJ Yang, D Xia, J Chen, J Wegner, Z Jiang, RQ Zhao |
Journal of animal science | 2008 |
Transcriptome profiling of the feeding-to-fasting transition in chicken liver
C Désert, MJ Duclos, P Blavy, F Lecerf, F Moreews, C Klopp, M Aubry, F Herault, PL Roy, C Berri, M Douaire, C Diot, S Lagarrigue |
BMC Genomics | 2008 |
Parasympathetic Response of the Heart is controlled by SREBP
Ho-Jin Park, Serban P. Georgescu, Chuang Du, Christopher Madias, Mark J. Aronovitz, C. Michael Welzig, Bo Wang, Ulrike Begley, Yali Zhang, Robert O. Blaustein, Richard D. Patten, Richard H. Karas, Herbert H. Van Tol, Timothy F. Osborne, Hitoshi Shimano, Ronglih Liao, Mark Link and Jonas B. Galper |
Journal of Clinical Investigation | 2007 |
SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling
H Shimano |
Journal of Molecular Medicine | 2007 |
Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD)
MH Ahmed, CD Byrne |
Drug Discovery Today | 2007 |
Cholesterol: from feeding to gene regulation
C Martini, V Pallottini |
Genes & Nutrition | 2007 |
Chronic Activation of Liver X Receptor Induces -Cell Apoptosis Through Hyperactivation of Lipogenesis: Liver X Receptor-Mediated Lipotoxicity in Pancreatic -Cells
SS Choe, AH Choi, JW Lee, KH Kim, JJ Chung, J Park, KM Lee, KG Park, IK Lee, JB Kim |
Diabetes | 2007 |
Chromatin Remodeling Complex Interacts with ADD1/SREBP1c To Mediate Insulin-Dependent Regulation of Gene Expression
YS Lee, DH Sohn, D Han, HW Lee, RH Seong, JB Kim |
Molecular and cellular biology | 2007 |
Adipose Tissue: A Metabolic Regulator. Potential Implications for the Metabolic Outcome of Subjects Born Small for Gestational Age (SGA)
A Maiorana, CD Bianco, S Cianfarani |
The review of diabetic studies : RDS | 2007 |
Handbook of Contemporary Neuropharmacology
A Fay, PC Haddick, LY Jan |
Handbook of Contemporary Neuropharmacology | 2007 |
Adipose tissue expandability and the metabolic syndrome
M Slawik, AJ Vidal-Puig |
Genes & Nutrition | 2007 |
In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression
Y Takeuchi, N Yahagi, Y Nakagawa, T Matsuzaka, R Shimizu, M Sekiya, Y Iizuka, K Ohashi, T Gotoda, M Yamamoto, R Nagai, T Kadowaki, N Yamada, J Osuga, H Shimano |
Biochemical and Biophysical Research Communications | 2007 |
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
JA Menendez, R Lupu |
Nature Reviews Cancer | 2007 |
Gender-specific programmed hepatic lipid dysregulation in intrauterine growth-restricted offspring
GY Choi, DN Tosh, A Garg, R Mansano, MG Ross, M Desai |
American Journal of Obstetrics and Gynecology | 2007 |
Exercise before or after refeeding prevents refeeding-induced recovery of cell size after fasting with a different pattern of metabolic gene expressions in rat epididymal adipocytes
T Sakurai, M Takei, J Ogasawara, H Ueda, T Kizaki, H Ohno, T Izawa |
Metabolism | 2007 |
Obesity: Genomics and Postgenomics
A Xu, A Butler, G Barsh |
Obesity: Genomics and Postgenomics | 2007 |
Leptine et grossesse: dogmes, questions et perspectives
J Lepercq, P Catalano, SH de Mouzon |
Gynécologie Obstétrique & Fertilité | 2007 |
A Novel Pathway to Enhance Adipocyte Differentiation of 3T3-L1 Cells by Up-regulation of Lipocalin-type Prostaglandin D Synthase Mediated by Liver X Receptor-activated Sterol Regulatory Element-binding Protein-1c
K Fujimori, K Aritake, Y Urade |
The Journal of biological chemistry | 2007 |
Wnt Signaling Stimulates Osteoblastogenesis of Mesenchymal Precursors by Suppressing CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ
S Kang, CN Bennett, I Gerin, LA Rapp, KD Hankenson, OA MacDougald |
The Journal of biological chemistry | 2007 |
Thermally Oxidized Oil Increases the Expression of Insulin-Induced Genes and Inhibits Activation of Sterol Regulatory Element-Binding Protein-2 in Rat Liver
A Koch, B König, J Spielmann, A Leitner, GI Stangl, K Eder |
The Journal of nutrition | 2007 |
The effect of dietary docosahexaenoic acid on the expression of lipogenic genes in broilers
HJ Chin, YH Ko, TF Shen, ST Ding |
Australian Journal of Agricultural Research | 2007 |
Glucocorticoid Modulation of Insulin Signaling in Human Subcutaneous Adipose Tissue
LL Gathercole, IJ Bujalska, PM Stewart, JW Tomlinson |
The Journal of clinical endocrinology and metabolism | 2007 |
Effects of Pitavastatin on Adiponectin in Patients with Hyperlipidemia
N Inami, S Nomura, A Shouzu, S Omoto, Y Kimura, N Takahashi, A Tanaka, M Nanba, Y Shouda, T Iwasaka |
Pathophysiology of Haemostasis and Thrombosis | 2007 |
Adaptor Protein SH2-B Linking Receptor-Tyrosine Kinase and Akt Promotes Adipocyte Differentiation by Regulating Peroxisome Proliferator-Activated Receptor γ Messenger Ribonucleic Acid Levels
D Yoshiga, N Sato, T Torisu, H Mori, R Yoshida, S Nakamura, G Takaesu, T Kobayashi, A Yoshimura |
Molecular Endocrinology | 2007 |
TRB3 Blocks Adipocyte Differentiation through the Inhibition of C/EBPβ Transcriptional Activity
O Bezy, C Vernochet, S Gesta, SR Farmer, CR Kahn |
Molecular and cellular biology | 2007 |
Functional Interaction of Hepatic Nuclear Factor-4 and Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α in CYP7A1 Regulation Is Inhibited by a Key Lipogenic Activator, Sterol Regulatory Element-Binding Protein-1c
B Ponugoti, S Fang, JK Kemper |
Molecular Endocrinology | 2007 |
Regulation of GLUT4 gene expression by SREBP-1c in adipocytes
SS Im, SK Kwon, SY Kang, TH Kim, HI Kim, MW Hur, KS Kim, YH Ahn |
Biochemical Journal | 2006 |
Keratinocyte growth factor induces lipogenesis in alveolar type II cells through a sterol regulatory element binding protein-1c-dependent pathway
Y Chang, K Edeen, X Lu, MD Leon, RJ Mason |
American journal of respiratory cell and molecular biology | 2006 |
Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes
AH Harding, RJ Loos, J Luan, S O'Rahilly, NJ Wareham, I Barroso |
Diabetologia | 2006 |
Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor
F Hansmannel, S Mordier, PB Iynedjian |
Biochemical Journal | 2006 |
Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle
KJ Nadeau |
American journal of physiology. Endocrinology and metabolism | 2006 |
Variation in the adiponutrin gene influences its expression and associates with obesity
LE Johansson, J Hoffstedt, H Parikh, E Carlsson, M Wabitsch, AG Bondeson, J Hedenbro, H Tornqvist, L Groop, M Ridderstråle |
Diabetes | 2006 |
Transcriptional control of adipocyte formation
SR Farmer |
Cell Metabolism | 2006 |
Functional Analysis of Hes-1 in Preadipocytes
DA Ross, S Hannenhalli, JW Tobias, N Cooch, R Shiekhattar, T Kadesch |
Molecular Endocrinology | 2006 |
Adipocyte differentiation from the inside out
ED Rosen, OA MacDougald |
Nature Reviews Molecular Cell Biology | 2006 |
The known and unknown of leptin in pregnancy
SH Mouzon, J Lepercq, P Catalano |
American Journal of Obstetrics and Gynecology | 2006 |
Effect of short-term and long-term fasting on transcriptional regulation of metabolic genes in rat tissues
RY Li, QH Zhang, Z Liu, J Qiao, SX Zhao, L Shao, HS Xiao, JL Chen, MD Chen, HD Song |
Biochemical and Biophysical Research Communications | 2006 |
Lipid and lipoprotein dysregulation in insulin resistant states
RK Avramoglu, H Basciano, K Adeli |
Clinica Chimica Acta | 2006 |
Insulin-Like Growth Factor-1 Induces Lipid Production in Human SEB-1 Sebocytes Via Sterol Response Element-Binding Protein-1
TM Smith, Z Cong, KL Gilliland, GA Clawson, DM Thiboutot |
Journal of Investigative Dermatology | 2006 |
Lipotoxicity, overnutrition and energy metabolism in aging
M Slawik, AJ Vidal-Puig |
Ageing Research Reviews | 2006 |
Leptin secretion is related to glucose-derived lipogenesis in isolated adipocytes
CG Walker, JM Bryson, DP Hancock, ID Caterson |
International Journal of Obesity | 2006 |
Transcriptional regulation by insulin: from the receptor to the geneThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference
C Mounier, BI Posner |
Canadian Journal of Physiology and Pharmacology | 2006 |
Protein Sensors for Membrane Sterols
JL Goldstein, RA DeBose-Boyd, MS Brown |
Cell | 2006 |
Sterol regulatory element binding protein (SREBP)-1 expression in brain is affected by age but not by hormones or metabolic changes
K Okamoto, T Kakuma, S Fukuchi, T Masaki, T Sakata, H Yoshimatsu |
Brain Research | 2006 |
The Emerging Functions of UCP2 in Health, Disease, and Therapeutics
G Mattiasson, PG Sullivan |
Antioxidants & Redox Signaling | 2006 |
Modulation of peroxisome proliferator-activated receptor and transcripts in swine endometrial tissue during early gestation
E Lord, BD Murphy, JA Desmarais, S Ledoux, D Beaudry, MF Palin |
Reproduction | 2006 |
Direct Interaction between USF and SREBP-1c Mediates Synergistic Activation of the Fatty-acid Synthase Promoter
MJ Griffin, RH Wong, N Pandya, HS Sul |
The Journal of biological chemistry | 2006 |
Elovl3 : a model gene to dissect homeostatic links between the circadian clock and nutritional status
A Anzulovich, A Mir, M Brewer, G Ferreyra, C Vinson, R Baler |
Journal of lipid research | 2006 |
Leucine in food mediates some of the postprandial rise in plasma leptin concentrations
CJ Lynch, B Gern, C Lloyd, SM Hutson, R Eicher, TC Vary |
American journal of physiology. Endocrinology and metabolism | 2006 |
Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation
M Lu, JY Shyy |
American journal of physiology. Cell physiology | 2006 |
Increased glucose tolerance and reduced adipocity in the absence of fasting hypoglycemia in mice with liver-specific Gs-alpha deficiency
Min Chen, Oksana Gavrilova, Wei-Qin Zhao, Annie Nguyen, Javier Lorenzo, Laura Shen, Lisa Nackers, Stephanie Pack, William Jou, Lee S. Weinstein |
Journal of Clinical Investigation | 2005 |
Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation
J Sponarova, KJ Mustard, O Horakova, P Flachs, M Rossmeisl, P Brauner, K Bardova, M Thomason-Hughes, R Braunerova, P Janovska, DG Hardie, J Kopecky |
FEBS Letters | 2005 |
Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver
H Kuriyama, G Liang, LJ Engelking, JD Horton, JL Goldstein, MS Brown |
Cell Metabolism | 2005 |
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
J Lin, R Yang, PT Tarr, PH Wu, C Handschin, S Li, W Yang, L Pei, M Uldry, P Tontonoz, CB Newgard, BM Spiegelman |
Cell | 2005 |
Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes
A Takahashi, H Shimano, Y Nakagawa, T Yamamoto, K Motomura, T Matsuzaka, H Sone, H Suzuki, H Toyoshima, N Yamada |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2005 |
SREBP-1 as a Transcriptional Integrator of Circadian and Nutritional Cues in the Liver
M Brewer, D Lange, R Baler, A Anzulovich |
Journal of Biological Rhythms | 2005 |
Regulation of adipocyte differentiation and function by polyunsaturated fatty acids
L Madsen, RK Petersen, K Kristiansen |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2005 |
Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies
F Giorgino, L Laviola, JW Eriksson |
Acta Physiologica Scandinavica | 2005 |
The fate and intermediary metabolism of stearic acid
H Sampath, JM Ntambi |
Lipids | 2005 |
Fructose, insulin resistance, and metabolic dyslipidemia
H Basciano, L Federico, K Adeli |
Nutrition & Metabolism | 2005 |
Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats
T Teruel, R Hernandez, E Rial, A Martin-Hidalgo, M Lorenzo |
Diabetologia | 2005 |
Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease
T Jiang, SE Liebman, MS Lucia, J Li, M Levi |
Kidney International | 2005 |
LXR is crucial in lipid metabolism
SM Ulven, KT Dalen, JÅ Gustafsson, HI Nebb |
Prostaglandins, Leukotrienes and Essential Fatty Acids | 2005 |
Adipose Development: From Stem Cell to Adipocyte
TC Otto, MD Lane |
Critical Reviews in Biochemistry and Molecular Biology | 2005 |
Transcriptional regulation of mouse 6-phosphogluconate dehydrogenase by ADD1/SREBP1c
HK Rho, J Park, JH Suh, JB Kim |
Biochemical and Biophysical Research Communications | 2005 |
Hypoxia inhibits adipocyte differentiation in a HDAC-independent manner
KH Kim, MJ Song, J Chung, H Park, JB Kim |
Biochemical and Biophysical Research Communications | 2005 |
Leptin promoter mutations affect leptin levels and performance traits in dairy cows1
SC Liefers, RF Veerkamp, MF Pas, C Delavaud, Y Chilliard, M Platje, T Lende |
Animal Genetics | 2005 |
The role of fat tissue in the cholesterol lowering and the pleiotropic effects of statins – statins activate the generation of metabolically more capable adipocytes
A Erol |
Medical Hypotheses | 2005 |
Adipocyte insensitivity syndromes – novel approach to nutritional metabolic problems including obesity and obesity related disorders
A Erol |
Medical Hypotheses | 2005 |
A novel SREBP-1 splice variant: Tissue abundance and transactivation potency
TK Felder, K Klein, W Patsch, H Oberkofler |
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | 2005 |
Changes in Fat Mass Influence SREBP-1c and UCP-2 Gene Expression in Formerly Obese Subjects
D Gniuli, G Rosa, M Manco, A Scarfone, N Vega, AV Greco, M Castagneto, H Vidal, G Mingrone |
Obesity research | 2005 |
Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?
JA Menendez, R Colomer, R Lupu |
Medical Hypotheses | 2005 |
Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor
HY Lin, Q Xu, S Yeh, RS Wang, JD Sparks, C Chang |
Diabetes | 2005 |
The regulation of fatty acid synthase by STAT5A
Jessica C Hogan, Jacqueline M Stephens |
Diabetes | 2005 |
Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic -Cells
A Takahashi, K Motomura, T Kato, T Yoshikawa, Y Nakagawa, N Yahagi, H Sone, H Suzuki, H Toyoshima, N Yamada, H Shimano |
Diabetes | 2005 |
CD38 as a prognostic marker in CLL
Z Matrai |
Hematology | 2005 |
Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues
Y Gosmain, N Dif, V Berbe, E Loizon, J Rieusset, H Vidal, E Lefai |
Journal of lipid research | 2005 |
Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats
AR Tovar, I Torre-Villalvazo, M Ochoa, AL Elías, V Ortíz, CA Aguilar-Salinas, N Torres |
Journal of lipid research | 2005 |
Hepatic triglyceride contents are genetically determined in mice: results of a strain survey
X Lin, P Yue, Z Chen, G Schonfeld |
AJP Gastrointestinal and Liver Physiology | 2005 |
Insulin-Mediated Down-Regulation of Apolipoprotein A5 Gene Expression through the Phosphatidylinositol 3-Kinase Pathway: Role of Upstream Stimulatory Factor
M Nowak, A Helleboid-Chapman, H Jakel, G Martin, D Duran-Sandoval, B Staels, EM Rubin, LA Pennacchio, MR Taskinen, J Fruchart-Najib, JC Fruchart |
Molecular and cellular biology | 2005 |
Role of energy charge and AMP-activated protein kinase in adipocytes in the control of body fat stores
M Rossmeisl, P Flachs, P Brauner, J Sponarova, O Matejkova, T Prazak, J Ruzickova, K Bardova, O Kuda, J Kopecky |
International Journal of Obesity | 2004 |
Insulin Action on Expression of Novel Adipose Genes in Healthy and Type 2 Diabetic Subjects
HA Koistinen, M Forsgren, H Wallberg-Henriksson, JR Zierath |
Obesity research | 2004 |
Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements
LM Cagen, X Deng, HG Wilcox, EA Park, R Raghow, MB Elam |
Biochemical Journal | 2004 |
Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression
JB Seo, HM Moon, WS Kim, YS Lee, HW Jeong, EJ Yoo, J Ham, H Kang, MG Park, KR Steffensen, TM Stulnig, JA Gustafsson, SD Park, JB Kim |
Molecular and cellular biology | 2004 |
SREBP transcription factors: master regulators of lipid homeostasis
D Eberlé, B Hegarty, P Bossard, P Ferré, F Foufelle |
Biochimie | 2004 |
Identification of Ku70/Ku80 as ADD1/SREBP1c interacting proteins
YS Lee, HY Koh, SD Park, JB Kim |
Korean Journal of Biological Sciences | 2004 |
Regulation of adipocyte differentiation and insulin action with rapamycin
HJ Cho, J Park, HW Lee, YS Lee, JB Kim |
Biochemical and Biophysical Research Communications | 2004 |
Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation
JA Menendez, I Mehmi, VA Verma, PK Teng, R Lupu |
Molecular Carcinogenesis | 2004 |
Immune Regulation and Graft Survival in Kidney Transplant Recipients Are Both Enhanced by Human Leukocyte Antigen Matching
DS Rodriguez, E Jankowska-Gan, LD Haynes, G Leverson, A Munoz, D Heisey, HW and, WJ Burlingham |
American Journal of Transplantation | 2004 |
Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K+-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats
R Alemzadeh, C Fledelius, T Bodvarsdottir, J Sturis |
Metabolism | 2004 |
Is 100% oxygen necessary for the resuscitation of newborn infants?
S Niermeyer, M Vento |
Journal of Maternal-Fetal and Neonatal Medicine | 2004 |
Regulation of development and metabolism of adipose tissue by growth hormone and the insulin-like growth factor system
I Louveau, F Gondret |
Domestic Animal Endocrinology | 2004 |
Intercellular signaling between adipose tissue and muscle tissue
TA Kokta, MV Dodson, A Gertler, RA Hill |
Domestic Animal Endocrinology | 2004 |
Links between fatty acids and expression of UCP2 and UCP3 mRNAs
MP Thompson, D Kim |
FEBS Letters | 2004 |
Développement du tissu adipeux
I Dugail, P Ferré |
EMC - Endocrinologie - Nutrition | 2004 |
Sterol regulatory element-binding protein-1 mediates the effect of insulin on hexokinase II gene expression in human muscle cells
Yvan Gosmain, Etienne Lefai, Stephan Ryser, Marina Roques, Hubert Vidal |
Diabetes | 2004 |
Maintaining cholesterol homeostasis: Sterol regulatory element-binding proteins
LW Weber |
World journal of gastroenterology : WJG | 2004 |
Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins
Lutz-W Weber, Meinrad Boll, Andreas Stampfl |
World journal of gastroenterology : WJG | 2004 |
Unraveling Lipid Metabolism With Microarrays: Implications for Diabetes and Obesity
J Waring, C Rondinone |
Unraveling Lipid Metabolism With Microarrays: Implications for Diabetes and Obesity | 2004 |
Insulin Regulation of Sterol Regulatory Element-binding Protein-1 Expression in L-6 Muscle Cells and 3T3 L1 Adipocytes
KJ Nadeau, JW Leitner, I Gurerich, B Draznin |
The Journal of biological chemistry | 2004 |
Mlx Is the Functional Heteromeric Partner of the Carbohydrate Response Element-binding Protein in Glucose Regulation of Lipogenic Enzyme Genes
AK Stoeckman, L Ma, HC Towle |
The Journal of biological chemistry | 2004 |
Rosiglitazone Induction of Insig-1 in White Adipose Tissue Reveals a Novel Interplay of Peroxisome Proliferator-activated Receptor γ and Sterol Regulatory Element-binding Protein in the Regulation of Adipogenesis
HR Kast-Woelbern, SL Dana, RM Cesario, L Sun, LY de Grandpre, ME Brooks, DL Osburn, A Reifel-Miller, K Klausing, MD Leibowitz |
The Journal of biological chemistry | 2004 |
SREBP-1c Mediates the Insulin-dependent Hepatic Glucokinase Expression
SY Kim, H Kim, TH Kim, SS Im, SK Park, IK Lee, KS Kim, YH Ahn |
The Journal of biological chemistry | 2004 |
Adipocyte Determination- and Differentiation-dependent Factor 1/Sterol Regulatory Element-binding Protein 1c Regulates Mouse Adiponectin Expression
JB Seo, HM Moon, MJ Noh, YS Lee, HW Jeong, EJ Yoo, WS Kim, J Park, BS Youn, JW Kim, SD Park, JB Kim |
The Journal of biological chemistry | 2004 |
Regulatory Role of Glycogen Synthase Kinase 3 for Transcriptional Activity of ADD1/SREBP1c
KH Kim, MJ Song, EJ Yoo, SS Choe, SD Park, JB Kim |
The Journal of biological chemistry | 2004 |
Differential Regulation of Sterol Regulatory Element-binding Protein 1c Transcriptional Activity by Insulin and Liver X Receptor during Liver Development
A Bobard, I Hainault, P Ferré, F Foufelle, P Bossard |
The Journal of biological chemistry | 2004 |
Selective Association of Sterol Regulatory Element-binding Protein Isoforms with Target Promoters in Vivo
MK Bennett, JI Toth, TF Osborne |
The Journal of biological chemistry | 2004 |
In Vitro Suppression of the Lipogenic Pathway by the Nonnucleoside Reverse Transcriptase Inhibitor Efavirenz in 3T3 and Human Preadipocytes or Adipocytes
KE Hadri, M Glorian, C Monsempes, MN Dieudonné, R Pecquery, Y Giudicelli, M Andreani, I Dugail, B Fève |
The Journal of biological chemistry | 2004 |
Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation
C Lelliott, AJ Vidal-Puig |
International Journal of Obesity | 2004 |
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice
PM Alli, ML Pinn, EM Jaffee, JM McFadden, FP Kuhajda |
Oncogene | 2004 |
In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin
SR Commerford, L Peng, JJ Dubé, RM O'Doherty |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2004 |
Differential effect of saturated and polyunsaturated fatty acids on hepatic glucose metabolism in humans
JN Clore, JS Stillman, J Li, SJ O'Keefe, JR Levy |
American journal of physiology. Endocrinology and metabolism | 2004 |
Further Lowering of Muscle Lipid Oxidative Capacity in Obese Subjects after Biliopancreatic Diversion
R Fabris, G Mingrone, G Milan, M Manco, M Granzotto, AD Pozza, A Scarda, R Serra, AV Greco, G Federspil, R Vettor |
The Journal of clinical endocrinology and metabolism | 2004 |
Immunobiology of Organ Transplantation
DS Wilkes, WJ Burlingham |
2004 | |
Modulation of Adipoinsular Axis in Prediabetic Zucker Diabetic Fatty Rats by Diazoxide
R Alemzadeh, KM Tushaus |
Endocrinology | 2004 |
Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway
I Guillet-Deniau, AL Pichard, A Koné, C Esnous, M Nieruchalski, J Girard, C Prip-Buus |
Journal of cell science | 2004 |
Leptin replacement therapy but not dietary polyunsaturated fatty acid alleviates HIV protease inhibitor-induced dyslipidemia and lipodystrophy in mice
TM Riddle, CJ Fichtenbaum, DY Hui |
Journal of acquired immune deficiency syndromes (1999) | 2003 |
Occupancy and Function of the −150 Sterol Regulatory Element and −65 E-Box in Nutritional Regulation of the Fatty Acid Synthase Gene in Living Animals
MJ Latasa, MJ Griffin, YS Moon, C Kang, HS Sul |
Molecular and cellular biology | 2003 |
Lipoatrophic diabetes and other related syndromes
Elif Arioglu Oral |
Reviews in Endocrine and Metabolic Disorders | 2003 |
Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c
YS Lee, HH Lee, J Park, EJ Yoo, CA Glackin, YI Choi, SH Jeon, RH Seong, SD Park, JB Kim |
Nucleic Acids Research | 2003 |
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini |
International Textbook of Diabetes Mellitus | 2003 |
Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c
YA Yang, PJ Morin, WF Han, T Chen, DM Bornman, EW Gabrielson, ES Pizer |
Experimental Cell Research | 2003 |
Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet
DA Polson, MP Thompson |
Biochemical and Biophysical Research Communications | 2003 |
Effects of inhibiting transcription and protein synthesis on basal and insulin-stimulated leptin gene expression and leptin secretion in cultured rat adipocytes
MJ Moreno-Aliaga, KL Stanhope, FM Gregoire, CH Warden, PJ Havel |
Biochemical and Biophysical Research Communications | 2003 |
Transduction of Leptin Growth Signals in Placental Cells is Independent of JAK-STAT Activation
M Caüzac, D Czuba, J Girard, SH Mouzon |
Placenta | 2003 |
Immunology: Fast and feel good?
VK Kuchroo, LB Nicholson |
Nature | 2003 |
Divergent effects of soy protein diet on the expression of adipocytokines
A Nagasawa, K Fukui, M Kojima, K Kishida, N Maeda, H Nagaretani, T Hibuse, H Nishizawa, S Kihara, M Waki, K Takamatsu, T Funahashi, Y Matsuzawa |
Biochemical and Biophysical Research Communications | 2003 |
Effect of Carbohydrate Overfeeding on Whole Body and Adipose Tissue Metabolism in Humans
K Minehira, V Bettschart, H Vidal, N Vega, VD Vetta, V Rey, P Schneiter, L Tappy |
Obesity research | 2003 |
Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement
H Ono, H Shimano, H Katagiri, N Yahagi, H Sakoda, Y Onishi, M Anai, T Ogihara, M Fujishiro, AY Viana, Y Fukushima, M Abe, N Shojima, M Kikuchi, N Yamada, Y Oka, T Asano |
Diabetes | 2003 |
Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation
Nica M Borradaile, Linda E de Dreu, Murray W Huff |
Diabetes | 2003 |
The Transcription Factor SREBP-1c Is Instrumental in the Development of β-Cell Dysfunction
H Wang, P Maechler, PA Antinozzi, L Herrero, KA Hagenfeldt-Johansson, A Björklund, CB Wollheim |
The Journal of biological chemistry | 2003 |
The Transcription Factors HIF-1 and HNF-4 and the Coactivator p300 Are Involved in Insulin-regulated Glucokinase Gene Expression via the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
U Roth, K Curth, TG Unterman, T Kietzmann |
The Journal of biological chemistry | 2003 |
Role of IRS-3 in the Insulin Signaling of IRS-1-deficient Brown Adipocytes
M Arribas, AM Valverde, M Benito |
The Journal of biological chemistry | 2003 |
Insulin and Hypoxia Share Common Target Genes but Not the Hypoxia-inducible Factor-1α
S Yim, SM Choi, Y Choi, N Lee, J Chung, H Park |
The Journal of biological chemistry | 2003 |
Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue
D Letexier, C Pinteur, V Large, V Fréring, M Beylot |
Journal of lipid research | 2003 |
Integrative physiology of human adipose tissue
KN Frayn, F Karpe, BA Fielding, IA Macdonald, SW Coppack |
International Journal of Obesity | 2003 |
Adipocyte functions are modulated by cell size change: potential involvement of an integrin/ERK signalling pathway
C Farnier, S Krief, M Blache, F Diot-Dupuy, G Mory, P Ferre, R Bazin |
International Journal of Obesity | 2003 |
Study of the Alteration of Gene Expression in Adipose Tissue of Diet-Induced Obese Mice by Microarray and Reverse Transcription-Polymerase Chain Reaction Analyses
RC Moraes, A Blondet, K Birkenkamp-Demtroeder, J Tirard, TF Orntoft, A Gertler, P Durand, D Naville, M Bégeot |
Endocrinology | 2003 |
Essential Role of Insulin-Like Growth Factor I Receptor in Insulin-Induced Fetal Brown Adipocyte Differentiation
C Mur, M Arribas, M Benito, AM Valverde |
Endocrinology | 2003 |
Functional Characterization of the Human Resistin Promoter with Adipocyte Determination- and Differentiation-Dependent Factor 1/Sterol Regulatory Element Binding Protein 1c and CCAAT Enhancer Binding Protein-α
JB Seo, MJ Noh, EJ Yoo, SY Park, J Park, IK Lee, SD Park, JB Kim |
Molecular Endocrinology | 2003 |
Cloning of cDNA encoding the nuclear form of chicken sterol response element binding protein-2 (SREBP-2), chromosomal localization, and tissue expression of chicken SREBP-1 and -2 genes
S Assaf, D Hazard, F Pitel, M Morisson, M Alizadeh, F Gondret, C Diot, A Vignal, M Douaire, S Lagarrigue |
Poultry science | 2003 |
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in liver
Jay Horton, Joseph Goldstein, Michael Brown |
Journal of Clinical Investigation | 2002 |
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c
F Foufelle, P Ferré |
Biochemical Journal | 2002 |
Adipose tissue gene expression in patients with a loss of function mutation in the leptin receptor
K Clément, N Vega, M Laville, V Pelloux, B Guy-Grand, A Basdevant, H Vidal |
International Journal of Obesity | 2002 |
Encyclopedia of Molecular Biology
B Mannervik |
Encyclopedia of Molecular Biology | 2002 |
Gene therapy for rheumatoid arthritis
N Bessis, C Doucet, V Cottard, AM Douar, H Firat, C Jorgensen, M Mezzina, MC Boissier |
The Journal of Gene Medicine | 2002 |
Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin
MC Sugden, K Bulmer, GF Gibbons, BL Knight, MJ Holness |
Biochemical Journal | 2002 |
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
T Peng, TR Golub, DM Sabatini |
Molecular and cellular biology | 2002 |
Specific increase in leptin production in obese (falfa) rat adipose cells
S Turban, I Hainault, J Truccolo, J Andre, P Ferre, A Quignard-Boulange, M Guerre-Millo |
Biochemical Journal | 2002 |
The Molecular Control of Adipogenesis, with Special Reference to Lymphatic Pathology
ED Rosen |
Annals of the New York Academy of Sciences | 2002 |
The E-box like sterol regulatory element mediates the suppression of human Δ-6 desaturase gene by highly unsaturated fatty acids
TY Nara, WS He, C Tang, SD Clarke, MT Nakamura |
Biochemical and Biophysical Research Communications | 2002 |
SREBP-1: Gene Regulatory Key to Syndrome X?
D Müller-Wieland, J Kotzka |
Annals of the New York Academy of Sciences | 2002 |
Adipogenesis: forces that tip the scales
OA MacDougald, S Mandrup |
Trends in Endocrinology & Metabolism | 2002 |
Intracellular fatty acid downregulates ob gene expression in 3T3-L1 adipocytes
T Arai, Y Kawakami, T Matsushima, Y Okuda, K Yamashita |
Biochemical and Biophysical Research Communications | 2002 |
Insulin-Stimulated Fatty Acid Synthase Gene Expression Does Not Require Increased Sterol Response Element Binding Protein 1 Transcription in Primary Adipocytes
DG Palmer, GA Rutter, JM Tavaré |
Biochemical and Biophysical Research Communications | 2002 |
Activation of MAP kinase by insulin and vanadate in adipocytes from young and old rats
JC Molero, C Pérez, C Martı́nez, M Villar, A Andrés, Y Fermı́n, JM Carrascosa |
Molecular and Cellular Endocrinology | 2002 |
Sterol regulatory element binding proteins: relationship of adipose tissue gene expression with obesity in humans
H Oberkofler, N Fukushima, H Esterbauer, F Krempler, W Patsch |
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | 2002 |
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes
M Amemiya-Kudo, H Shimano, AH Hasty, N Yahagi, T Yoshikawa, T Matsuzaka, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, J Osuga, K Harada, T Gotoda, R Sato, S Kimura, S Ishibashi, N Yamada |
Journal of lipid research | 2002 |
Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol
MC Desco, M Asensi, R Márquez, J Martínez-Valls, M Vento, FV Pallardó, J Sastre, J Viña |
Diabetes | 2002 |
Human Obesity and Type 2 Diabetes Are Associated With Alterations in SREBP1 Isoform Expression That Are Reproduced Ex Vivo by Tumor Necrosis Factor-
C Sewter, D Berger, RV Considine, G Medina, J Rochford, T Ciaraldi, R Henry, L Dohm, JS Flier, S O'Rahilly, AJ Vidal-Puig |
Diabetes | 2002 |
Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis
CM Rondinone, JM Trevillyan, J Clampit, RJ Gum, C Berg, P Kroeger, L Frost, BA Zinker, R Reilly, R Ulrich, M Butler, BP Monia, MR Jirousek, JF Waring |
Diabetes | 2002 |
Sterol Regulatory Element Binding Protein-1c Expression and Action in Rat Muscles: Insulin-Like Effects on the Control of Glycolytic and Lipogenic Enzymes and UCP3 Gene Expression
I Guillet-Deniau, V Mieulet, SL Lay, Y Achouri, D Carre, J Girard, F Foufelle, P Ferre |
Diabetes | 2002 |
The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways
EM Conway, MV de Wouwer, S Pollefeyt, K Jurk, HV Aken, AD Vriese, JI Weitz, H Weiler, PW Hellings, P Schaeffer, JM Herbert, D Collen, G Theilmeier |
Journal of Experimental Medicine | 2002 |
Insulin and Sterol-regulatory Element-binding Protein-1c (SREBP-1C) Regulation of Gene Expression in 3T3-L1 Adipocytes: IDENTIFICATION OF CCAAT/ENHANCER-BINDING PROTEIN β AS AN SREBP-1C TARGET
SL Lay, I Lefrère, C Trautwein, I Dugail, S Krief |
The Journal of biological chemistry | 2002 |
A Chemical Switch Regulates Fibrate Specificity for Peroxisome Proliferator-activated Receptor α (PPARα) Versus Liver X Receptor
J Thomas, KS Bramlett, C Montrose, P Foxworthy, PI Eacho, D McCann, G Cao, A Kiefer, J McCowan, K Yu, T Grese, WW Chin, TP Burris, LF Michael |
The Journal of biological chemistry | 2002 |
Serum leptin and its adipose gene expression during pubertal development, the estrous cycle, and different seasons in cattle1
MR Garcia, M Amstalden, SW Williams, RL Stanko, CD Morrison, DH Keisler, SE Nizielski, GL Williams |
Journal of animal science | 2002 |
Training down-regulates fatty acid synthase and body fat in obese Zucker rats:
RG Fiebig, JM Hollander, D Ney, R Boileau, E Jeffery, LL Ji |
Medicine and Science in Sports and Exercise | 2002 |
Feeding intensity and dietary protein level affect adipocyte cellularity and lipogenic capacity of muscle homogenates in growing pigs, without modification of the expression of sterol regulatory element binding protein1,2
F Gondret, B Lebret |
Journal of animal science | 2002 |
HMG-CoA Reductase Inhibitors
G Schmitz, M Torzewski |
2002 | |
Brain Somatic Cross-Talk and the Central Control of Metabolism
C Kordon, I Robinson, J Hanoune, R Dantzer, Y Christen |
2002 | |
Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα
T Matsuzaka, H Shimano, N Yahagi, M Amemiya-Kudo, T Yoshikawa, AH Hasty, Y Tamura, J Osuga, H Okazaki, Y Iizuka, A Takahashi, H Sone, T Gotoda, S Ishibashi, N Yamada |
Journal of lipid research | 2002 |
Suppression of fatty acid synthase promoter by polyunsaturated fatty acids
YS Moon, MJ Latasa, MJ Griffin, HS Sul |
Journal of lipid research | 2002 |
Mechanisms of nutritional and hormonal regulation of lipogenesis
S Kersten |
EMBO reports | 2001 |
Nutrient Sensing, Leptin and Insulin Action
J Ukropec, E Šeböková, I Klimeš |
Archives Of Physiology And Biochemistry | 2001 |
New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes
AR Saltiel |
Cell | 2001 |
Antecedent protein restriction and high-fat feeding interactively sensitise the leptin response to elevated insulin
MJ Holness, MC Sugden |
Molecular and Cellular Endocrinology | 2001 |
Semicarbazide-sensitive amine oxidase activation promotes adipose conversion of 3T3-L1 cells
N Mercier, M Moldes, KE Hadri, B Fève |
Biochemical Journal | 2001 |
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands
RA DeBose-Boyd, J Ou, JL Goldstein, MS Brown |
Proceedings of the National Academy of Sciences | 2001 |
Promoter I of the ovine acetyl-CoA carboxylase-alpha gene: an E-box motif at -114 in the proximal promoter binds upstream stimulatory factor (USF)-1 and USF-2 and acts as an insulin-response sequence in differentiating adipocytes
MT Travers, AJ Vallance, HT Gourlay, CA Gill, I Klein, CB Bottema, MC Barber |
Biochemical Journal | 2001 |
Angiotensin II-responsive element is the insulin-responsive element in the adipocyte fatty acid synthase gene: role of adipocyte determination and differentiation factor 1/sterol-regulatory-element-binding protein 1c
S Kim, I Dugail, M Standridge, K Claycombe, J Chun, N Moustaïd-Moussa |
Biochemical Journal | 2001 |
Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes
H Shimano |
Progress in Lipid Research | 2001 |
Proteolytic Activation of SREBPs during Adipocyte Differentiation
J Inoue, H Kumagai, T Terada, M Maeda, M Shimizu, R Sato |
Biochemical and Biophysical Research Communications | 2001 |
Sterol Regulatory Element Binding Protein 1c (SREBP-1c) Expression in Human Obesity
M Kolehmainen, H Vidal, E Alhava, MI Uusitupa |
Obesity | 2001 |
The FIRE3-Mediated Sterol Response of the FAS Promoter Requires NF-Y/CBF as a Coactivator
SS Wolf, K Roder, S Sickinger, M Schweizer |
Biological Chemistry | 2001 |
Antiretroviral therapy-associated hyperlipidaemia in HIV disease
V Mooser, A Carr |
Current Opinion in Lipidology | 2001 |
The roles of PPARs in adipocyte differentiation
PA Grimaldi |
Progress in Lipid Research | 2001 |
Role of Sp1 and Sp3 in the Transcriptional Regulation of the Rat Fatty Acid Synthase Gene
SS Wolf, K Roder, M Schweizer |
Archives of Biochemistry and Biophysics | 2001 |
Obesity and the regulation of energy balance
BM Spiegelman, JS Flier |
Cell | 2001 |
Transcriptional Regulation of the Leptin Promoter by Insulin-Stimulated Glucose Metabolism in 3T3-L1 Adipocytes
MJ Moreno-Aliaga, KL Stanhope, PJ Havel |
Biochemical and Biophysical Research Communications | 2001 |
Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue: Evidence for Specific Defects in Type 2 Diabetes
PH Ducluzeau, N Perretti, M Laville, F Andreelli, N Vega, JP Riou, H Vidal |
Diabetes | 2001 |
Adenovirus-Mediated Overexpression of Sterol Regulatory Element Binding Protein-1c Mimics Insulin Effects on Hepatic Gene Expression and Glucose Homeostasis in Diabetic Mice
D Becard, I Hainault, D Azzout-Marniche, L Bertry-Coussot, P Ferre, F Foufelle |
Diabetes | 2001 |
Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements
T Yoshikawa, H Shimano, N Yahagi, T Ide, M Amemiya-Kudo, T Matsuzaka, M Nakakuki, S Tomita, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, A Takahashi, H Sone, J Osuga, T Gotoda, S Ishibashi, N Yamada |
The Journal of biological chemistry | 2001 |
Cholesterol, a Cell Size-dependent Signal That Regulates Glucose Metabolism and Gene Expression in Adipocytes
SL Lay, S Krief, C Farnier, I Lefrère, XL Liepvre, R Bazin, P Ferré, I Dugail |
The Journal of biological chemistry | 2001 |
Progesterone Stimulates Adipocyte Determination and Differentiation 1/Sterol Regulatory Element-binding Protein 1c Gene Expression: POTENTIAL MECHANISM FOR THE LIPOGENIC EFFECT OF PROGESTERONE IN ADIPOSE TISSUE
D Lacasa, XL Liepvre, P Ferre, I Dugail |
The Journal of biological chemistry | 2001 |
Adiponutrin, a Transmembrane Protein Corresponding to a Novel Dietary- and Obesity-linked mRNA Specifically Expressed in the Adipose Lineage
S Baulande, F Lasnier, M Lucas, J Pairault |
The Journal of biological chemistry | 2001 |
Glucose Regulation of the Acetyl-CoA Carboxylase Promoter PI in Rat Hepatocytes
BL O'Callaghan, SH Koo, Y Wu, HC Freake, HC Towle |
The Journal of biological chemistry | 2001 |
Leptin signaling and aging: insight from caloric restriction
I Shimokawa, Y Higami |
Mechanisms of Ageing and Development | 2001 |
Enhanced glucose uptake into adipose tissue induced by early growth restriction augments excursions in plasma leptin response evoked by changes in insulin status
MJ Holness |
International Journal of Obesity | 2001 |
Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
T Yoshikawa, H Shimano, M Amemiya-Kudo, N Yahagi, AH Hasty, T Matsuzaka, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, JI Osuga, K Harada, T Gotoda, S Kimura, S Ishibashi, N Yamada |
Molecular and cellular biology | 2001 |
Diseases of liporegulation: new perspective on obesity and related disorders
RH Unger, L Orci |
The FASEB Journal | 2001 |
Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes
M Buyse, S VIENGCHAREUN, A Bado, M Lombès |
The FASEB Journal | 2001 |
Exercise Down-Regulates Hepatic Fatty Acid Synthase in Streptozotocin-Treated Rats
RG Fiebig, JM Hollander, LL Ji |
The Journal of nutrition | 2001 |
HUMAN LIVER ALLOGRAFT ACCEPTANCE AND THE ???TOLERANCE ASSAY???: IN VITRO ANTI-DONOR T CELL ASSAYS SHOW HYPOREACTIVITY TO DONOR CELLS, BUT UNLIKE DTH, FAIL TO DETECT LINKED SUPPRESSION1:
F Geissler, E Jankowska-Gan, LD DeVito-Haynes, T Rhein, M Kalayoglu, HW Sollinger, WJ Burlingham |
Transplantation | 2001 |
Activation of Extracellular Signal-Regulated Kinases and CREB/ATF-1 Mediate the Expression of CCAAT/Enhancer Binding Proteins β and -δ in Preadipocytes
N Belmonte, BW Phillips, F Massiera, P Villageois, B Wdziekonski, P Saint-Marc, J Nichols, J Aubert, K Saeki, A Yuo, S Narumiya, G Ailhaud, C Dani |
Molecular Endocrinology | 2001 |
Increased hepatic VLDL secretion, lipogenesis, and SREBP-1 expression in the corpulent JCR:LA-cp rat
MB Elam, HG Wilcox, LM Cagen, X Deng, R Raghow, P Kumar, M Heimberg, JC Russell |
Journal of lipid research | 2001 |
Phosphatidylinositol-3,4,5-Trisphosphate Is Required for Insulin-Like Growth Factor 1-Mediated Survival of 3T3-L1 Preadipocytes**This work was supported by a grant (to A.S.) from the Medical Research Council of Canada
AM Gagnon, P Dods, N Roustan-Delatour, CS Chen, A Sorisky |
Endocrinology | 2001 |
A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
M Miyazaki, YC Kim, JM Ntambi |
Journal of lipid research | 2001 |
ADD-1/SREBP-1 is a major determinant of tissue differential lipogenic capacity in mammalian and avian species
F Gondret, P Ferré, I Dugail |
Journal of lipid research | 2001 |
Molecular mechanisms of adipocyte differentiation
Q Tong, G S Hotamisligil |
Reviews in Endocrine and Metabolic Disorders | 2001 |
Obesity and insulin resistance
BB Kahn, JS Flier |
Journal of Clinical Investigation | 2000 |
Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction
MD Michael, RN Kulkarni, C Postic, SF Previs, GI Shulman, MA Magnuson, CR Kahn |
Molecular Cell | 2000 |
MOLECULARREGULATION OFADIPOGENESIS
ED Rosen, BM Spiegelman |
Annual Review of Cell and Developmental Biology | 2000 |
Diurnal variation in circulating leptin is dependent on gender, food intake and circulating insulin in mice
Ahrén |
Acta Physiologica Scandinavica | 2000 |
REGULATION OFMETABOLISM ANDBODYFATMASS BYLEPTIN
CA Baile, MA Della-Fera, RJ Martin |
Annual Review of Nutrition | 2000 |
Genetics of aspirin induced asthma
M Sanak, A Szczeklik |
Thorax | 2000 |
Clinical features and diagnosis of aspirin induced asthma
A Szczeklik, E Nizankowska |
Thorax | 2000 |
Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt
M Fleischmann, PB Iynedjian |
Biochemical Journal | 2000 |
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
JJ Repa, G Liang, J Ou, Y Bashmakov, JM Lobaccaro, I Shimomura, B Shan, MS Brown, JL Goldstein, DJ Mangelsdorf |
Genes & development | 2000 |
Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element
MJ Latasa, YS Moon, KH Kim, HS Sul |
Proceedings of the National Academy of Sciences | 2000 |
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
T Kakuma, Y Lee, M Higa, Z Wang, W Pan, I Shimomura, RH Unger |
Proceedings of the National Academy of Sciences | 2000 |
Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes
D Azzout-Marniche, D Bécard, C Guichard, M Foretz, P Ferré, F Foufelle |
Biochemical Journal | 2000 |
Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
I Shimomura, M Matsuda, RE Hammer, Y Bashmakov, MS Brown, JL Goldstein |
Molecular Cell | 2000 |
PHYSIOLOGICAL ANDNUTRITIONALREGULATION OFENZYMES OFTRIACYLGLYCEROLSYNTHESIS
RA Coleman, TM Lewin, DM Muoio |
Annual Review of Nutrition | 2000 |
Nutritional and insulin regulation of leptin gene expression
N Iritani |
Current Opinion in Clinical Nutrition and Metabolic Care | 2000 |
Cell and Molecular Response to Stress
KA Webster |
Cell and Molecular Response to Stress | 2000 |
Nutritional regulation of the fatty acid synthase promoter in vivo: Sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element
MJ Latasa, YS Moon, KH Kim, HS Sul |
Proceedings of the National Academy of Sciences | 2000 |
Transcriptional control of adipogenesis
SM Rangwala, MA Lazar |
Annual Review of Nutrition | 2000 |
Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes
K Schoonjans, L Gelman, C Haby, M Briggs, J Auwerx |
Journal of Molecular Biology | 2000 |
Transcriptional regulation of the adipocyte fatty acid synthase gene by agouti: interaction with insulin
KJ Claycombe, Y Wang, BH Jones, S Kim, WO Wilkison, MB Zemel, J Chun, N Moustaid-Moussa |
Physiological genomics | 2000 |
Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects
LC Hudgins, MK Hellerstein, CE Seidman, RA Neese, JD Tremaroli, J Hirsch |
Journal of lipid research | 2000 |
Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action
TF Osborne |
The Journal of biological chemistry | 2000 |
Glucose Regulation of Mouse S 14 Gene Expression in Hepatocytes: INVOLVEMENT OF A NOVEL TRANSCRIPTION FACTOR COMPLEX
SH Koo, HC Towle |
The Journal of biological chemistry | 2000 |
Different Sterol Regulatory Element-binding Protein-1 Isoforms Utilize Distinct Co-regulatory Factors to Activate the Promoter for Fatty Acid Synthase
MM Magaña, SH Koo, HC Towle, TF Osborne |
The Journal of biological chemistry | 2000 |
Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene
M Amemiya-Kudo, H Shimano, T Yoshikawa, N Yahagi, AH Hasty, H Okazaki, Y Tamura, F Shionoiri, Y Iizuka, K Ohashi, J Osuga, K Harada, T Gotoda, R Sato, S Kimura, S Ishibashi, N Yamada |
The Journal of biological chemistry | 2000 |
Suppression of Preadipocyte Differentiation and Promotion of Adipocyte Death by HIV Protease Inhibitors
P Dowell, C Flexner, PO Kwiterovich, MD Lane |
The Journal of biological chemistry | 2000 |
The Roles of Sterol Regulatory Element-binding Proteins in the Transactivation of the Rat ATP Citrate-Lyase Promoter
YA Moon, JJ Lee, SW Park, YH Ahn, KS Kim |
The Journal of biological chemistry | 2000 |
Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay
J Xu, M Teran-Garcia, JH Park, MT Nakamura, SD Clarke |
The Journal of biological chemistry | 2000 |
Sterol Regulatory Element-binding Protein-1 Is Regulated by Glucose at the Transcriptional Level
AH Hasty, H Shimano, N Yahagi, M Amemiya-Kudo, S Perrey, T Yoshikawa, J Osuga, H Okazaki, Y Tamura, Y Iizuka, F Shionoiri, K Ohashi, K Harada, T Gotoda, R Nagai, S Ishibashi, N Yamada |
The Journal of biological chemistry | 2000 |
Defect in Peroxisome Proliferator-activated Receptor α-inducible Fatty Acid Oxidation Determines the Severity of Hepatic Steatosis in Response to Fasting
T Hashimoto, WS Cook, C Qi, AV Yeldandi, JK Reddy, MS Rao |
The Journal of biological chemistry | 2000 |
Two 5′-Regions Are Required for Nutritional and Insulin Regulation of the Fatty-acid Synthase Promoter in Transgenic Mice
YS Moon, MJ Latasa, KH Kim, D Wang, HS Sul |
The Journal of biological chemistry | 2000 |
Oxysterols: Modulators of Cholesterol Metabolism and Other Processes
GJ Schroepfer |
Physiological reviews | 2000 |
The adipoinsular axis: effects of leptin on pancreatic β-cells
TJ Kieffer, JF Habener |
American journal of physiology. Endocrinology and metabolism | 2000 |
Regulation of the Fatty Acid Synthase Promoter by Insulin
HS Sul, MJ Latasa, Y Moon, KH Kim |
The Journal of nutrition | 2000 |
Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats
M Standridge, R Alemzadeh, M Zemel, J Koontz, N Moustaid-Moussa |
The FASEB Journal | 2000 |
An indirect role for upstream stimulatory factor in glucose-mediated induction of pyruvate kinase and S14 gene expression
E N Kaytor, J Qian, H C Towle, L K Olson |
Molecular and Cellular Biochemistry | 2000 |
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
H Shimano, JD Horton, RE Hammer, I Shimomura, MS Brown, JL Goldstein |
Journal of Clinical Investigation | 1999 |
Peroxisome proliferator activated receptor-γ, leptin and tumor necrosis factor-α mRNA expression during very low calorie diet in subcutaneous adipose tissue in obese women
JP Bastard, B Hainque, E Dusserre, E Bruckert, D Robin, P Vallier, S Perche, P Robin, G Turpin, C Jardel, M Laville, C Forest, H Vidal |
Diabetes/Metabolism Research and Reviews | 1999 |
STEROLS AND ISOPRENOIDS: Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway
PA Edwards, J Ericsson |
Annual Review of Biochemistry | 1999 |
T-cell recognition of lipid peroxidation products breaks tolerance to self proteins
DM Wuttge, M Bruzelius, S Stemme |
Immunology | 1999 |
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders
TC Leone, CJ Weinheimer, DP Kelly |
Proceedings of the National Academy of Sciences | 1999 |
ADD-1 provides major new insight into the mechanism of insulin action
JS Flier, AN Hollenberg |
Proceedings of the National Academy of Sciences | 1999 |
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
M Foretz, C Guichard, P Ferré, F Foufelle |
Proceedings of the National Academy of Sciences | 1999 |
Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes
M Moldes, M Boizard, XL Liepvre, B Fève, I Dugail, J Pairault |
Biochemical Journal | 1999 |
Fatty acids: links between genes involved in fatty acid and cholesterol metabolism
TS Worgall, RJ Deckelbaum |
Current Opinion in Clinical Nutrition and Metabolic Care | 1999 |
Regulation of gene expression by glucose
P Ferré |
Proceedings of the Nutrition Society | 1999 |
Cell surface receptors, nuclear receptors and ligands that regulate adipose tissue development
G Ailhaud |
Clinica Chimica Acta | 1999 |
FIRE3 in the promoter of the rat fatty acid synthase (FAS) gene binds the ubiquitous transcription factors CBF and USF but does not mediate an insulin response in a rat hepatoma cell line
K Roder, SS Wolf, S Sickinger, M Schweizer |
European Journal of Biochemistry | 1999 |
A critical role for the peroxisome proliferator-activated receptor (PPAR ) in the cellular fasting response: The PPAR -null mouse as a model of fatty acid oxidation disorders
TC Leone, CJ Weinheimer, DP Kelly |
Proceedings of the National Academy of Sciences | 1999 |
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
H Shimano, JD Horton, RE Hammer, I Shimomura, MS Brown, JL Goldstein |
Journal of Biological Chemistry | 1999 |
From Preadipocyte to Adipocyte: Differentiation-Directed Signals of Insulin from the Cell Surface to the Nucleus
A Sorisky |
Critical Reviews in Clinical Laboratory Sciences | 1999 |
Sterol Response Element-binding Protein 1c (SREBP1c) Is Involved in the Polyunsaturated Fatty Acid Suppression of Hepatic S14 Gene Transcription
MK Mater, AP Thelen, DA Pan, DB Jump |
The Journal of biological chemistry | 1999 |
Essential Role in Vivo of Upstream Stimulatory Factors for a Normal Dietary Response of the Fatty Acid Synthase Gene in the Liver
M Casado, VS Vallet, A Kahn, S Vaulont |
The Journal of biological chemistry | 1999 |
Sterol Regulatory Element Binding Protein-1 Expression Is Suppressed by Dietary Polyunsaturated Fatty Acids: A MECHANISM FOR THE COORDINATE SUPPRESSION OF LIPOGENIC GENES BY POLYUNSATURATED FATS
J Xu, MT Nakamura, HP Cho, SD Clarke |
The Journal of biological chemistry | 1999 |
ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose
M Foretz, C Pacot, I Dugail, P Lemarchand, C Guichard, X le Lièpvre, C Berthelier-Lubrano, B Spiegelman, JB Kim, P Ferré, F Foufelle |
Molecular and cellular biology | 1999 |
"Spot 14" Protein: A Metabolic Integrator in Normal and Neoplastic Cells
BA Cunningham, JT Moncur, JT Huntington, WB Kinlaw |
Thyroid | 1998 |
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy
I Shimomura, RE Hammer, JA Richardson, S Ikemoto, Y Bashmakov, JL Goldstein, MS Brown |
Genes & development | 1998 |
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
JD Horton, Y Bashmakov, I Shimomura, H Shimano |
Proceedings of the National Academy of Sciences | 1998 |
Specificity in cholesterol regulation of gene expression by coevolution of sterol regulatory DNA element and its binding protein
JN Athanikar, TF Osborne |
Proceedings of the National Academy of Sciences | 1998 |
Role of NF-kappaB in immune and inflammatory responses in the gut
MF Neurath, C Becker, K Barbulescu |
Gut | 1998 |
Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease
PA Edwards, J Ericsson |
Current Opinion in Lipidology | 1998 |
Glucose regulation of gene expression
F Foufelle, J Girard, P Ferré |
Current Opinion in Clinical Nutrition and Metabolic Care | 1998 |
ADD1/SREBP-1c Mediates Insulin-Induced Gene Expression Linked to the MAP Kinase Pathway
J Kotzka, D Müller-Wieland, A Koponen, D Njamen, L Kremer, G Roth, M Munck, B Knebel, W Krone |
Biochemical and Biophysical Research Communications | 1998 |
Leptin and its receptors: regulators of whole-body energy homeostasis
KL Houseknecht, CP Portocarrero |
Domestic Animal Endocrinology | 1998 |
Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins
JT Pai, O Guryev, MS Brown, JL Goldstein |
The Journal of biological chemistry | 1998 |
Specific immunosuppression of the indirect recognition pathway
N Suciu-Foca, R Cortesini |
Transplantation Proceedings | 1998 |
ADD1/SREBP1 activates PPAR through the production of endogenous ligand
JB Kim, HM Wright, M Wright, BM Spiegelman |
Proceedings of the National Academy of Sciences | 1998 |
ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand
J B Kim, H M Wright, M Wright, B M Spiegelman |
Proceedings of the National Academy of Sciences | 1998 |
ADD1/SREBP1 activates PPARγ through the production of endogenous ligand
Jae Bum Kim, Harold M. Wright, Margaret Wright, Bruce M. Spiegelman |
Proceedings of the National Academy of Sciences | 1998 |
Obesity-related Overexpression of Fatty-acid Synthase Gene in Adipose Tissue Involves Sterol Regulatory Element-binding Protein Transcription Factors
M Boizard, XL Liepvre, P Lemarchand, F Foufelle, P Ferré, I Dugail |
The Journal of biological chemistry | 1998 |
Oleate Potentiates Oxysterol Inhibition of Transcription from Sterol Regulatory Element-1-regulated Promoters and Maturation of Sterol Regulatory Element-binding Proteins
DP Thewke, SR Panini, M Sinensky |
The Journal of biological chemistry | 1998 |
Transcriptional Activation of the Stearoyl-CoA Desaturase 2 Gene by Sterol Regulatory Element-binding Protein/Adipocyte Determination and Differentiation Factor 1
DE Tabor, JB Kim, BM Spiegelman, PA Edwards |
The Journal of biological chemistry | 1998 |
Sterol Regulatory Element Binding Protein-1 Activates the Cholesteryl Ester Transfer Protein Gene in Vivo but Is Not Required for Sterol Up-regulation of Gene Expression
RA Chouinard, Y Luo, TF Osborne, A Walsh, AR Tall |
The Journal of biological chemistry | 1998 |
Glucose-dependent Translocation of Insulin Promoter Factor-1 (IPF-1) between the Nuclear Periphery and the Nucleoplasm of Single MIN6 β-Cells
I Rafiq, HJ Kennedy, GA Rutter |
The Journal of biological chemistry | 1998 |
Identification of Diazepam-binding Inhibitor/Acyl-CoA-binding Protein as a Sterol Regulatory Element-binding Protein-responsive Gene
JV Swinnen, P Alen, W Heyns, G Verhoeven |
The Journal of biological chemistry | 1998 |
STABLE LUNG ALLOGRAFT OUTCOME CORRELATES WITH THE PRESENCE OF INTRAGRAFT DONOR-DERIVED LEUKOCYTES1:
PJ O'Connell, A Mba-Jonas, GE Leverson, DM Heisey, KC Meyer, RB Love, WJ Burlingham |
Transplantation | 1998 |
Advances in Molecular and Cellular Endocrinology
MR Pollak, EM Brown |
Advances in Molecular and Cellular Endocrinology | 1997 |