Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.
J B Kim, … , B B Lowell, B M Spiegelman
J B Kim, … , B B Lowell, B M Spiegelman
Published January 1, 1998
Citation Information: J Clin Invest. 1998;101(1):1-9. https://doi.org/10.1172/JCI1411.
View: Text | PDF
Research Article Article has an altmetric score of 9

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

  • Text
  • PDF
Abstract

The ability to regulate specific genes of energy metabolism in response to fasting and feeding is an important adaptation allowing survival of intermittent food supplies. However, little is known about transcription factors involved in such responses in higher organisms. We show here that gene expression in adipose tissue for adipocyte determination differentiation dependent factor (ADD) 1/sterol regulatory element binding protein (SREBP) 1, a basic-helix-loop-helix protein that has a dual DNA-binding specificity, is reduced dramatically upon fasting and elevated upon refeeding; this parallels closely the regulation of two adipose cell genes that are crucial in energy homeostasis, fatty acid synthetase (FAS) and leptin. This elevation of ADD1/SREBP1, leptin, and FAS that is induced by feeding in vivo is mimicked by exposure of cultured adipocytes to insulin, the classic hormone of the fed state. We also show that the promoters for both leptin and FAS are transactivated by ADD1/SREBP1. A mutation in the basic domain of ADD1/SREBP1 that allows E-box binding but destroys sterol regulatory element-1 binding prevents leptin gene transactivation but has no effect on the increase in FAS promoter function. Molecular dissection of the FAS promoter shows that most if not all of this action of ADD1/SREBP1 is through an E-box motif at -64 to -59, contained with a sequence identified previously as the major insulin response element of this gene. These results indicate that ADD1/SREBP1 is a key transcription factor linking changes in nutritional status and insulin levels to the expression of certain genes that regulate systemic energy metabolism.

Authors

J B Kim, P Sarraf, M Wright, K M Yao, E Mueller, G Solanes, B B Lowell, B M Spiegelman

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 Total
Citations: 1 6 5 2 16 11 17 11 16 18 28 35 25 23 25 32 18 25 24 24 30 36 25 31 37 36 19 21 1 598
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (598)

Title and authors Publication Year
DPP-IV and FAS inhibitory peptides: therapeutic alternative against diabesity
Fabiola León-Galván M, Medina-Rojas DS
Journal of Diabetes and Metabolic Disorders 2025
Research Progress on the Mechanism of Milk Fat Synthesis in Cows and the Effect of Conjugated Linoleic Acid on Milk Fat Metabolism and Its Underlying Mechanism: A Review.
Guo Y, Wei Z, Zhang Y, Cao J
2024
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
Park SH, Baek SJ, Lee M, Shin HA, Lee HJ, Kim OK, Lee J
Food & Nutrition Research 2024
AMP-activated protein kinase activation suppresses leptin expression independently of adipogenesis in primary murine adipocytes
Bustraan S, Bennett J, Whilding C, Pennycook BR, Smith D, Barr AR, Read J, Carling D, Pollard A
Biochemical Journal 2024
Navigating Lipodystrophy: Insights from Laminopathies and Beyond
Krüger P, Hartinger R, Djabali K
International journal of molecular sciences 2024
Serum isthmin-1 is a potential biomarker for metabolic dysfunction associated fatty liver disease in patients with metabolic syndrome and type 2 diabetes mellitus
Lei X, Chen H, Xu Y, Yang Z, Zhang L, Wang C, Du H
BMJ Open Diabetes Research & Care 2024
Intermittent Fasting Regulates Metabolic Homeostasis and Improves Cardiovascular Health
Diab R, Dimachkie L, Zein O, Dakroub A, Eid AH
Cell Biochemistry and Biophysics 2024
Physiological and pathological roles of lipogenesis.
Jeon YG, Kim YY, Lee G, Kim JB
Nature metabolism 2023
Inhibition of nucleotide biosynthesis disrupts lipid accumulation and adipogenesis.
Shinde AB, Nunn ER, Wilson GA, Chvasta MT, Pinette JA, Myers JW, Peck SH, Spinelli JB, Zaganjor E
The Journal of biological chemistry 2023
Association of adipocyte size and SREBP-1c in visceral and subcutaneous adipose tissue in non-obese type 2 diabetes mellitus.
Adhikary P, Banerjee S, Dey BK, Gargari P, Chatterjee S, Chakraborty D, Chowdhury S
Endocrine 2023
Baicalein enhances immune response in TNBC by inhibiting leptin expression of adipocytes
Liu M, Li C, Qu J, Sun S, Zhao Z, Wang W, Lv W, Zhang Y, Cai Y, Zhao F, Wu F, Zhang S, Zhao X
Cancer Science 2023
Hypoxia activates SREBP2 through Golgi disassembly in bone marrow‐derived monocytes for enhanced tumor growth
Nakahara R, Aki S, Sugaya M, Hirose H, Kato M, Maeda K, Sakamoto DM, Kojima Y, Nishida M, Ando R, Muramatsu M, Pan M, Tsuchida R, Matsumura Y, Yanai H, Takano H, Yao R, Sando S, Shibuya M, Sakai J, Kodama T, Kidoya H, Shimamura T, Osawa T
The EMBO Journal 2023
Astragalus mongholicus powder, a traditional Chinese medicine formula ameliorate type 2 diabetes by regulating adipoinsular axis in diabetic mice.
Xu S, Ye B, Li J, Dou Y, Yu Y, Feng Y, Wang L, Wan DC, Rong X
Frontiers in pharmacology 2022
The interplay of transcriptional coregulator NUPR1 with SREBP1 promotes hepatocellular carcinoma progression via upregulation of lipogenesis.
Wang Y, Zhang Y, Wang Z, Yu L, Chen K, Xie Y, Liu Y, Liang W, Zheng Y, Zhan Y, Ding Y
Cell Death Discovery 2022
Insulin signaling in health and disease
Alan R Saltiel
Journal of Clinical Investigation 2021
The interaction between the gut microbiota and dietary carbohydrates in nonalcoholic fatty liver disease
G Park, S Jung, KE Wellen, C Jang
Experimental & molecular medicine 2021
Targeted Metabolomics Identifies Plasma Biomarkers in Mice with Metabolically Heterogeneous Melanoma Xenografts
DD Weber, M Thapa, S Aminzadeh-Gohari, AS Redtenbacher, L Catalano, RG Feichtinger, P Koelblinger, G Dallmann, M Emberger, B Kofler, R Lang
Cancers 2021
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
Z Jiang, M Zhao, L Voilquin, Y Jung, MA Aikio, T Sahai, FY Dou, AM Roche, I Carcamo-Orive, JW Knowles, M Wabitsch, EA Appel, CL Maikawa, JP Camporez, GI Shulman, L Tsai, ED Rosen, CD Gardner, BM Spiegelman, KJ Svensson
Cell Metabolism 2021
Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease
JY Huh, AR Saltiel
Experimental & molecular medicine 2021
Anti-Obesity Effects of Morus alba L. and Aronia melanocarpa in a High-Fat Diet-Induced Obese C57BL/6J Mouse Model
NY Kim, SS Thomas, DI Hwang, JH Lee, KA Kim, YS Cha
Foods 2021
Tm7sf2 gene promotes adipocyte differentiation of mouse embryonic fibroblasts and improves insulin sensitivity
L Gatticchi, M Petricciuolo, P Scarpelli, L Macchioni, L Corazzi, R Roberti
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2021
Regulation of Postabsorptive and Postprandial Glucose Metabolism by Insulin-Dependent and Insulin-Independent Mechanisms: An Integrative Approach
GD Dimitriadis, E Maratou, A Kountouri, M Board, V Lambadiari
Nutrients 2021
FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin
Y Takeuchi, N Yahagi, Y Aita, Z Mehrazad-Saber, M Ho, Y Huyan, Y Murayama, A Shikama, Y Masuda, Y Izumida, T Miyamoto, T Matsuzaka, Y Kawakami, H Shimano
iScience 2021
Fasting-Induced Upregulation of MKP-1 Modulates the Hepatic Response to Feeding
J Sellers, A Brooks, S Fernando, G Westenberger, S Junkins, S Smith, K Min, A Lawan
Nutrients 2021
Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload
Altamura S, Müdder K, Schlotterer A, Fleming T, Heidenreich E, Qiu R, Hammes HP, Nawroth P, Muckenthaler MU
Molecular Metabolism 2021
Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload
S Altamura, K Müdder, A Schlotterer, T Fleming, E Heidenreich, R Qiu, HP Hammes, P Nawroth, MU Muckenthaler
Molecular Metabolism 2021
Amomum villosum Lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 mice
HR Kim, P Antonisamy, YS Kim, YG Kwon, DG Ryu, YR Lee, GS Lee, HD Ham, KB Kwon
Journal of King Saud University - Science 2021
FoxO-KlLF5 Pathway Switches the Flow of Macronutrients Under the Control of Insulin
Y Takeuchi, N Yahagi, Y Aita, Z Mehrazad-Saber, MH Ho, Y Huyan, Y Murayama, A Shikama, Y Masuda, Y Izumida, T Miyamoto, T Matsuzaka, Y Kawakami, H Shimano
SSRN Electronic Journal 2021
Crocetin exerts hypocholesterolemic effect by inducing LDLR and inhibiting PCSK9 and Sortilin in HepG2 cells
AA Siddiq, A Martin
Nutrition research (New York, N.Y.) 2021
Composition and structure elucidation of bovine milk glycosaminoglycans and their anti-adipogenic activity via modulation PPAR-γ and C/EBP-α
C Rai, CD Nandini, P Priyadarshini
International Journal of Biological Macromolecules 2021
Obesity and the Impact on Cutaneous Melanoma: Friend or Foe?
LK Smith, S Arabi, EJ Lelliott, GA McArthur, KE Sheppard
Cancers 2020
The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders
I Szymczak-Pajor, J Drzewoski, A Śliwińska
International journal of molecular sciences 2020
Ursolic acid induces the production of IL6 and chemokines in both adipocytes and adipose tissue
B Feng, Y Zhu, L Yan, H Yan, X Huang, D Jiang, Z Li, L Hua, Y Zhuo, Z Fang, L Che, Y Lin, S Xu, C Huang, Y Zou, L Li, D Wu
Adipocyte 2020
Evidence-based clinical advice for nutrition and dietary weight loss strategies for the management of NAFLD and NASH
TJ Hydes, S Ravi, R Loomba, ME Gray
Clinical and Molecular Hepatology 2020
Molecular Characterization, Nutritional and Insulin Regulation of Elovl6 in Rainbow Trout (Oncorhynchus mykiss)
Y Li, Y Pang, Z Zhao, X Xiang, K Mai, Q Ai
Biomolecules 2020
M-CSF- and L929-derived macrophages present distinct metabolic profiles with similar inflammatory outcomes
L de Brito Monteiro, GG Davanzo, CF de Aguiar, FC da Silva, JR de Andrade, AC Codo, JA da Silva Pereira, LP de Freitas, PM Moraes-Vieira
Immunobiology 2020
Effect of chronic exposure to monocrotophos on white adipose tissue in rats and its association with metabolic dyshomeostasis
R Nagaraju, AK Joshi, S Vamadeva, PS Rajini
Human & Experimental Toxicology 2020
Transcriptomic signature of fasting in human adipose tissue
M Defour, CC Michielsen, SD ODonovan, LA Afman, S Kersten
Physiological genomics 2020
The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling
K Drizyte-Miller, J Chen, H Cao, MB Schott, MA McNiven
Journal of cell science 2020
Genome-Wide Screen of the Hippocampus in Aged Rats Identifies Mitochondria, Metabolism and Aging Processes Implicated in Sevoflurane Anesthesia
Y Wang, M Qian, Y Qu, N Yang, B Mu, K Liu, J Yang, Y Zhou, C Ni, J Zhong, X Guo
Frontiers in aging neuroscience 2020
Deletion of SREBF1, a Functional Bone-Muscle Pleiotropic Gene, Alters Bone Density and Lipid Signaling in Zebrafish
C Shochat, Z Wang, C Mo, S Nelson, R Donaka, J Huang, D Karasik, M Brotto
Endocrinology 2020
Zinc oxide nanoparticles attenuate hepatic steatosis development in high-fat-diet fed mice through activated AMPK signaling axis
S Dogra, AK Kar, K Girdhar, PV Daniel, S Chatterjee, A Choubey, S Ghosh, S Patnaik, D Ghosh, P Mondal
Nanomedicine : nanotechnology, biology, and medicine 2019
Pathophysiological connections between gallstone disease, insulin resistance, and obesity
VA Cortés, F Barrera, F Nervi
Obesity reviews : an official journal of the International Association for the Study of Obesity 2019
Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity
M Clemente-Postigo, W Oliva-Olivera, L Coin-Aragüez, B Ramos-Molina, RM Giraldez-Perez, S Lhamyani, J Alcaide-Torres, P Perez-Martinez, RE Bekay, F Cardona, FJ Tinahones
American journal of physiology. Endocrinology and metabolism 2019
Metabolic Association between Leptin and the Corticotropin Releasing Hormone
S Gioldasi, A Karvela, AP Rojas-Gil, M Rodi, AL de Lastic, I Thomas, BE Spiliotis, A Mouzaki
Endocrine, metabolic & immune disorders drug targets 2019
3-Hydroxyanthralinic acid metabolism controls the hepatic SREBP/lipoprotein axis, inhibits inflammasome activation in macrophages, and decreases atherosclerosis in Ldlr−/− mice
M Berg, KA Polyzos, H Agardh, R Baumgartner, MJ Forteza, I Kareinen, A Gisterå, G Bottcher, E Hurt-Camejo, GK Hansson, DF Ketelhuth
Cardiovascular Research 2019
Mechanisms of obesity-induced metabolic and vascular dysfunctions
Atawia RT, Bunch KL, Toque HA, Caldwell RB, Caldwell RW
2019
Gynostemma Pentaphyllum Extract Ameliorates High-Fat Diet-Induced Obesity in C57BL/6N Mice by Upregulating SIRT1.
Lee HS, Lim SM, Jung JI, Kim SM, Lee JK, Kim YH, Cha KM, Oh TK, Moon JM, Kim TY, Kim EJ
Nutrients 2019
Preweaning nutrient supply alters mammary gland transcriptome expression relating to morphology, lipid accumulation, DNA synthesis, and RNA expression in Holstein heifer calves
KS Hare, LN Leal, JM Romao, GJ Hooiveld, F Soberon, H Berends, ME Amburgh, J Martín-Tereso, MA Steele
Journal of Dairy Science 2019
Cyanidin-3-O-Galactoside-Enriched Aronia melanocarpa Extract Attenuates Weight Gain and Adipogenic Pathways in High-Fat Diet-Induced Obese C57BL/6 Mice
SM Lim, HS Lee, JI Jung, SM Kim, NY Kim, TS Seo, JS Bae, EJ Kim
Nutrients 2019
Effects of dietary fenugreek seed extracts on growth performance, plasma biochemical parameters, lipid metabolism, Nrf2 antioxidant capacity and immune response of juvenile blunt snout bream (Megalobrama amblycephala)
H Yu, H Liang, M Ren, K Ji, Q Yang, X Ge, , L Pan
Fish & Shellfish Immunology 2019
High level of dietary soybean oil affects the glucose and lipid metabolism in large yellow croaker Larimichthys crocea through the insulin-mediated PI3K/AKT signaling pathway
Z Gu, H Mu, H Shen, K Deng, D Liu, M Yang, Y Zhang, W Zhang, K Mai
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2019
Antihyperlipidemic Activity of Ligularia fischeri Extract in Mice Fed a High-Carbohydrate Diet
JH Park, EK Ahn, JK Kim, JS Oh
Journal of Medicinal Food 2019
Cottonseed meal protein hydrolysate stimulates feed intake and appetite in Chinese mitten crab, Eriocheir sinensis
H Cheng, M Liu, X Yuan, D Zhang, W Liu, G Jiang
Aquaculture Nutrition 2019
Mechanisms of obesity-induced metabolic and vascular dysfunctions
Reem T Atawia, Katharine L Bunch, Haroldo A Toque, Ruth B Caldwell, Robert W Caldwell
Frontiers in bioscience : a journal and virtual library 2019
The Diabetes Textbook: Clinical Principles, Patient Management and Public Health Issues
J Rodriguez-Saldana
2019
Association of the PNPLA2, SCD1 and Leptin Expression with Fat Distribution in Liver and Adipose Tissue From Obese Subjects
LD la Cruz-Color, ZH Hernández-Nazará, M Maldonado-González, E Navarro-Muñíz, JA Domínguez-Rosales, JR Torres-Baranda, E del Carmen Ruelas-Cinco, SM Ramírez-Meza, B Ruíz-Madrigal
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2019
Simple techniques to study multifaceted diabesity in the fly model
N Nayak, M Mishra
Toxicology Mechanisms and Methods 2019
Leptin and brain–adipose crosstalks
A Caron, S Lee, JK Elmquist, L Gautron
Nature Reviews Neuroscience 2018
Insulin as a hormone regulator of the synthesis and release of leptin by white adipose tissue
GH Marques-Oliveira, TM Silva, WG Lima, HM Valadares, VE Chaves
Peptides 2018
SREBP1c-PAX4 Axis Mediates Pancreatic β-Cell Compensatory Responses Upon Metabolic Stress
G Lee, H Jang, YY Kim, SS Choe, J Kong, I Hwang, J Park, SS Im, JB Kim
Diabetes 2018
Targeting stearoyl-CoA desaturase 1 to repress endometrial cancer progression
W Li, H Bai, S Liu, D Cao, H Wu, K Shen, Y Tai, J Yang
Oncotarget 2018
Effect of early calf-hood nutrition on the transcriptomic profile of subcutaneous adipose tissue in Holstein-Friesian bulls
AM English, SM Waters, P Cormican, CJ Byrne, S Fair, DA Kenny
BMC Genomics 2018
Evaluation of Oral Antiretroviral Drugs in Mice With Metabolic and Neurologic Complications
FJ Tsai, MW Ho, CH Lai, CH Chou, JP Li, CF Cheng, YC Wu, X Liu, H Tsang, TH Lin, CC Liao, SM Huang, JC Lin, CC Lin, CL Hsieh, WM Liang, YJ Lin
Frontiers in pharmacology 2018
Dietary Supplementation of Potato Peel Powders Prepared from Conventional and Organic Russet and Non-organic Gold and Red Potatoes Reduces Weight Gain in Mice on a High-Fat Diet
S Elkahoui, GE Bartley, WH Yokoyama, M Friedman
Journal of Agricultural and Food Chemistry 2018
Short-term time-restricted feeding during the resting phase is sufficient to induce leptin resistance that contributes to development of obesity and metabolic disorders in mice
K Oishi, C Hashimoto
Chronobiology International 2018
Chokeberry Extract and Its Active Polyphenols Suppress Adipogenesis in 3T3-L1 Adipocytes and Modulates Fat Accumulation and Insulin Resistance in Diet-Induced Obese Mice
NH Kim, J Jegal, Y Kim, JD Heo, JR Rho, M Yang, E Jeong
Nutrients 2018
Increased hepatic triglyceride level induced by a glucokinase activator in mice
J Namekawa, M Yasui, A Katayanagi, M Shirai, F Asai
Fundamental Toxicological Sciences 2018
Metformin attenuates lipid accumulation in hepatocytes of blunt snout bream (Megalobrama amblycephala) via activation of AMP-activated protein kinase
W Zhou, S Rahimnejad, DR Tocher, K Lu, C Zhang, Y Sun
Aquaculture 2018
ChREBP refines the hepatic response to fructose to protect the liver from injury
Angela Hall, Brian Finck
Journal of Clinical Investigation 2017
Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications
GM Fischer, YN Gopal, JL McQuade, W Peng, RJ DeBerardinis, MA Davies
Pigment Cell & Melanoma Research 2017
Biochemical and cellular properties of insulin receptor signalling
RA Haeusler, TE McGraw, D Accili
Nature Reviews Molecular Cell Biology 2017
Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes
M Markova, O Pivovarova, S Hornemann, S Sucher, T Frahnow, K Wegner, J Machann, KJ Petzke, J Hierholzer, R Lichtinghagen, C Herder, M Carstensen-Kirberg, M Roden, N Rudovich, S Klaus, R Thomann, R Schneeweiss, S Rohn, AF Pfeiffer
Gastroenterology 2017
Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations
M Pelosi, E Testet, SL Lay, I Dugail, X Tang, G Mabilleau, Y Hamel, M Madrange, T Blanc, T Odent, TP McMullen, M Alfò, DN Brindley, P Lonlay
Journal of lipid research 2017
Crosstalk of Hyperglycemia and Dyslipidemia in Diabetic Kidney Disease
W Su, R Cao, YC He, YF Guan, XZ Ruan
Kidney Diseases 2017
Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression
A Kondo, S Yamamoto, R Nakaki, T Shimamura, T Hamakubo, J Sakai, T Kodama, T Yoshida, H Aburatani, T Osawa
Cell Reports 2017
Adipose Tissue Biology
ME Symonds
Adipose Tissue Biology 2017
A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes
M Nishi-Tatsumi, N Yahagi, Y Takeuchi, N Toya, A Takarada, Y Murayama, Y Aita, Y Sawada, X Piao, Y Oya, A Shikama, Y Masuda, M Kubota, Y Izumida, T Matsuzaka, Y Nakagawa, M Sekiya, Y Iizuka, Y Kawakami, T Kadowaki, N Yamada, H Shimano
FEBS Letters 2017
Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears
S Tartu, R Lille-Langøy, TR Størseth, S Bourgeon, A Brunsvik, J Aars, A Goksøyr, BM Jenssen, A Polder, GW Thiemann, V Torget, H Routti
Scientific Reports 2017
Inhibitory activity of chokeberry, bilberry, raspberry and cranberry polyphenol-rich extract towards adipogenesis and oxidative stress in differentiated 3T3-L1 adipose cells
K Kowalska, A Olejnik, D Szwajgier, M Olkowicz, L Vanella
PloS one 2017
Phytochemicals in Citrus: Applications in Functional Foods
X Ye
Phytochemicals in Citrus: Applications in Functional Foods 2017
Biology of Domestic Animals
C Scanes, R Hill
Biology of Domestic Animals 2017
The Relationship of Fas Promoter Polymorphisms and Breast Cancer Risk in North-West of Iran: A Haplotype and in Silico Analysis
N Dastmalchi, R Safaralizadeh, MA Feizi, N Pouladi
International Journal of Cancer Management 2017
Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations
M Pelosi, E Testet, SL Lay, I Dugail, X Tang, G Mabilleau, Y Hamel, M Madrange, T Blanc, T Odent, TP McMullen, M Alfò, DN Brindley, P Lonlay
Journal of lipid research 2017
Therapeutic Potential of Peroxisome Proliferator-Activated Receptor Modulation in Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis
L Gellrich, D Merk
Nuclear Receptor Research 2017
Effects of Intracerebroventricular Administration of Neuropeptide Y on Metabolic Gene Expression and Energy Metabolism in Male Rats
Y Su, E Foppen, E Fliers, A Kalsbeek
Endocrinology 2016
Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward
KJ Williams, X Wu
Atherosclerosis 2016
miRNAs and High-Density Lipoprotein metabolism
Á Baldán, TQ de Vallim
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2016
Acute exercise regulates adipogenic gene expression in white adipose tissue
Y Shen, H Zhou, W Jin, HJ Lee
Biology of Sport 2016
Nutrition, insulin resistance and dysfunctional adipose tissue determine the different components of metabolic syndrome
JA Paniagua
World journal of diabetes 2016
E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis
X Tong, P Li, D Zhang, K VanDommelen, N Gupta, L Rui, MB Omary, L Yin
Journal of lipid research 2016
Triiodothyronine enhances accumulation of intracellular lipids in adipocytes through thyroid hormone receptor α via direct and indirect mechanisms
Y Gambo, M Matsumura, K Fujimori
Molecular and Cellular Endocrinology 2016
Recent advances in the understanding of how neuropeptide Y and α -melanocyte stimulating hormone function in adipose physiology
SL Shipp, MA Cline, ER Gilbert
Adipocyte 2016
SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding
H Jang, GY Lee, CP Selby, G Lee, YG Jeon, JH Lee, KK Cheng, P Titchenell, MJ Birnbaum, A Xu, A Sancar, JB Kim
Nature Communications 2016
KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting
Y Takeuchi, N Yahagi, Y Aita, Y Murayama, Y Sawada, X Piao, N Toya, Y Oya, A Shikama, A Takarada, Y Masuda, M Nishi, M Kubota, Y Izumida, T Yamamoto, M Sekiya, T Matsuzaka, Y Nakagawa, O Urayama, Y Kawakami, Y Iizuka, T Gotoda, K Itaka, K Kataoka, R Nagai, T Kadowaki, N Yamada, Y Lu, MK Jain, H Shimano
Cell Reports 2016
UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin
EJ Kim, YK Kim, MK Kim, S Kim, JY Kim, DH Lee, JH Chung
Scientific Reports 2016
Sanguisorba officinalis L. Extracts Exert Antiobesity Effects in 3T3-L1 Adipocytes and C57BL/6J Mice Fed High-Fat Diets
DW Jung, OH Lee, IJ Kang
Journal of Medicinal Food 2016
Effects of ω -3 Fatty Acids and Catechins on Fatty Acid Synthase in the Prostate: A Randomized Controlled Trial
Z Zhang, M Garzotto, TM Beer, P Thuillier, S Lieberman, M Mori, WA Stoller, PE Farris, J Shannon
Nutrition and Cancer 2016
RNA-binding protein HuD reduces triglyceride production in pancreatic β cells by enhancing the expression of insulin-induced gene 1
C Kim, H Lee, H Kang, JJ Shin, H Tak, W Kim, M Gorospe, EK Lee
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2016
SREBP1c-CRY1 axis suppresses hepatic gluconeogenesis upon insulin
H Jang, G Lee, JB Kim
Cell cycle (Georgetown, Tex.) 2016
Recent advances in the understanding of how neuropeptide Y and α -melanocyte stimulating hormone function in adipose physiology
SL Shipp, MA Cline, ER Gilbert
Adipocyte 2016
Effects of ω -3 Fatty Acids and Catechins on Fatty Acid Synthase in the Prostate: A Randomized Controlled Trial
Z Zhang, M Garzotto, TM Beer, P Thuillier, S Lieberman, M Mori, WA Stoller, PE Farris, J Shannon
Nutrition and Cancer 2016
Obesity and metabolic disorders as a risk factor of endometrial hyperplasia, uterine fibroids and adenomyosis
IV Stanoevich, EA Kudrina, MN Zholobova, AV Masyakina, AM Kovaleva
2016
Coactivator-dependent metabolic-reprogramming is a survival strategy required for tumor metastasis
Subhamoy Dasgupta, NAGIREDDY PUTLURI, Weiwen Long, Bin Zhang, Jianghua Wang, Akash K. Kaushik, James Arnold, Salil K. Bhowmik, Erin Stashi, Christine Brennan, Kimal Rajapakshe, Cristian Coarfa, Nicholas Mitsiades, Michael Ittmann, Arul Chinnaiyan, Arun Sreekumar, Bert W. O'Malley
Journal of Clinical Investigation 2015
Metabolic Control
S Herzig
2015
Metabolic Control
S Herzig
2015
Metabolic Control
S Herzig
2015
Metabolic Control
S Herzig
2015
Metabolic Control
S Herzig
2015
Metabolic Control
S Herzig
2015
Metabolic Control
S Herzig
2015
Metabolic Control
S Herzig
2015
Metabolic Control
S Herzig
2015
Metabolic Control
S Herzig
2015
Metabolic Control
S Herzig
2015
Human cancer: Is it linked to dysfunctional lipid metabolism?
S Hashmi, Y Wang, DS Suman, RS Parhar, K Collison, W Conca, F Al-Mohanna, R Gaugler
Biochimica et Biophysica Acta (BBA) - General Subjects 2015
Transcriptional and Translational Modulation of myo -Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES
T Tominaga, RK Dutta, D Joladarashi, T Doi, JK Reddy, YS Kanwar
The Journal of biological chemistry 2015
Transcriptional regulation of hepatic lipogenesis
Y Wang, J Viscarra, SJ Kim, HS Sul
Nature Reviews Molecular Cell Biology 2015
A Grape Seed Procyanidin Extract Ameliorates Fructose-Induced Hypertriglyceridemia in Rats via Enhanced Fecal Bile Acid and Cholesterol Excretion and Inhibition of Hepatic Lipogenesis
LE Downing, RM Heidker, GC Caiozzi, BS Wong, K Rodriguez, FD Rey, ML Ricketts, MB Aguila
PloS one 2015
Phenyllactic Acid from Lactobacillus plantarum PromotesAdipogenic Activity in 3T3-L1 Adipocyte via Up-Regulationof PPAR-γ2
S Ilavenil, D Kim, M Arasu, S Srigopalram, R Sivanesan, K Choi
Molecules (Basel, Switzerland) 2015
Egg Yolks Inhibit Activation of NF-κB and Expression of Its Target Genes in Adipocytes after Partial Delipidation
Q Shen, KM Riedl, RM Cole, C Lehman, L Xu, H Alder, MA Belury, SJ Schwartz, O Ziouzenkova
Journal of Agricultural and Food Chemistry 2015
Fatty acid synthase promoter: Characterization, and transcriptional regulation by sterol regulatory element binding protein-1 in goat mammary epithelial cells
J Li, J Luo, H Xu, M Wang, J Zhu, H Shi, AB Haile, H Wang, Y Sun
Gene 2015
HIV protease inhibitors: a review of molecular selectivity and toxicity
Y Wang, Z Lv, Y Chu
HIV/AIDS (Auckland, N.Z.) 2015
Anti-Diabetic Effect of Aster sphathulifolius in C57BL/KsJ- db/db Mice
X Yin, Y Huang, DW Jung, HC Chung, SY Choung, JH Shim, IJ Kang
Journal of Medicinal Food 2015
Ferulic acid regulates hepatic GLUT2 gene expression in high fat and fructose-induced type-2 diabetic adult male rat
A Narasimhan, M Chinnaiyan, B Karundevi
European Journal of Pharmacology 2015
Effects of different roughage sources and feeding levels on adipogenesis of ovine adipocytes: Roughage Evaluation by Adipocyte Culture
DH Kim, KC Choi, T Ichinohe, SH Song
Animal Science Journal 2015
Regulation of Adipogenesis and Key Adipogenic Gene Expression by 1, 25-Dihydroxyvitamin D in 3T3-L1 Cells
S Ji, ME Doumit, RA Hill, LM Seoane
PloS one 2015
International Textbook of Diabetes Mellitus: DeFronzo/International Textbook of Diabetes Mellitus, Fourth Edition
RN Bergman, M Ader
International Textbook of Diabetes Mellitus: DeFronzo/International Textbook of Diabetes Mellitus, Fourth Edition 2015
Metabolic, Anabolic, and Mitogenic Insulin Responses: A Tissue-Specific Perspective for Insulin Receptor Activators
DH Bedinger, SH Adams
Molecular and Cellular Endocrinology 2015
Dietary conjugated linoleic acids increase intramuscular fat deposition and decrease subcutaneous fat deposition in Yellow Breed × Simmental cattle: Dietary CLA on Fat Deposition
H Zhang, X Dong, Z Wang, A Zhou, Q Peng, H Zou, B Xue, L Wang
Animal Science Journal 2015
Hepatic De Novo Lipogenesis and Regulation of Metabolism
JM Ntambi
Hepatic De Novo Lipogenesis and Regulation of Metabolism 2015
Tissue-specific insulin signaling in the regulation of metabolism and aging: Insulin Signaling in Metabolism and Aging
J Zhang, F Liu
IUBMB Life 2014
RNF20 regulates hepatic lipid metabolism through PKA-dependent SREBP1c degradation
JH Lee, GY Lee, H Jang, SS Choe, SH Koo, JB Kim
Hepatology 2014
Molecular pathways in non-alcoholic fatty liver disease
A Berlanga, E Guiu-Jurado, JA Porras, T Auguet
Clinical and experimental gastroenterology 2014
Deficiency of the Transcriptional Repressor B Cell Lymphoma 6 (Bcl6) Is Accompanied by Dysregulated Lipid Metabolism
CR LaPensee, G Lin, AL Dent, J Schwartz, X Chen
PloS one 2014
Bindings of ChREBP and SREBP1, and Histone Acetylation around the Rat Liver Fatty Acid Synthase Gene Are Associated with Induction of the Gene during the Suckling-Weaning Transition
S MORISHITA, K MOCHIZUKI, T GODA
Journal of Nutritional Science and Vitaminology 2014
Cilostazol inhibits insulin-stimulated expression of sterol regulatory binding protein-1c via inhibition of LXR and Sp1
YA Jung, HK Kim, KH Bae, HY Seo, HS Kim, BK Jang, GS Jung, IK Lee, MK Kim, KG Park
Experimental & molecular medicine 2014
Systems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor System
J Janssens, H Etienne, S Idriss, A Azmi, B Martin, S Maudsley
Frontiers in Endocrinology 2014
Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis.
Özkan E, Chia PH, Wang RR, Goriatcheva N, Borek D, Otwinowski Z, Walz T, Shen K, Garcia KC
Cell 2014
γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.
Aydintug MK, Zhang L, Wang C, Liang D, Wands JM, Michels AW, Hirsch B, Day BJ, Zhang G, Sun D, Eisenbarth GS, O'Brien RL, Born WK
Molecular Immunology 2014
Phosphorylation of sterol regulatory element binding protein-1a by protein kinase A (PKA) regulates transcriptional activity.
Dong Q, Giorgianni F, Deng X, Beranova-Giorgianni S, Bridges D, Park EA, Raghow R, Elam MB
Biochemical and Biophysical Research Communications 2014
Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects
Barua S, Mitragotri S
Nano Today 2014
The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs.
Smith EP, An Z, Wagner C, Lewis AG, Cohen EB, Li B, Mahbod P, Sandoval D, Perez-Tilve D, Tamarina N, Philipson LH, Stoffers DA, Seeley RJ, D'Alessio DA
Cell Metabolism 2014
Osteopontin facilitates ultraviolet B-induced squamous cell carcinoma development.
Chang PL, Hsieh YH, Wang CC, Juliana MM, Tsuruta Y, Timares L, Elmets C, Ho KJ
Journal of Dermatological Science 2014
Comprehensive Physiology
SN Cheuvront, RW Kenefick
Comprehensive Physiology 2014
Unavailability of liver triacylglycerol increases serum cholesterol concentration induced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats
Y Tanaka, K Nagao, H Nakagiri, T Nagaso, Y Iwasa, H Mori, M Asahina, K Imaizumi, M Sato
Lipids in Health and Disease 2014
In vitro and in vivo enhancement of adipogenesis by Italian ryegrass (Lolium multiflorum) in 3T3-L1 cells and mice
MV Arasu, S Ilavenil, DH Kim, SG Roh, JC Lee, KC Choi
PloS one 2014
Physiological regulation of lipoprotein lipase
S Kersten
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2014
MicroRNA-33b downregulates the differentiation and development of porcine preadipocytes
M Taniguchi, I Nakajima, K Chikuni, M Kojima, T Awata, S Mikawa
Molecular Biology Reports 2014
Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis
S Grube, P Dünisch, D Freitag, M Klausnitzer, Y Sakr, J Walter, R Kalff, C Ewald
Journal of Neuro-Oncology 2014
Dietary macronutrients, genetic variation, and progression of coronary atherosclerosis among women
S Kalantarian, EB Rimm, DM Herrington, D Mozaffarian
American Heart Journal 2014
The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats
DM Erion, A Lapworth, PA Amor, G Bai, NB Vera, RW Clark, Q Yan, Y Zhu, TT Ross, J Purkal, M Gorgoglione, G Zhang, V Bonato, L Baker, N Barucci, T D'Aquila, A Robertson, RJ Aiello, J Yan, J Trimmer, TP Rolph, JA Pfefferkorn
PloS one 2014
Positive regulations of adipogenesis by Italian ryegrass [Lolium multiflorum] in 3T3-L1 cells
S Ilavenil, MV Arasu, JC Lee, DH Kim, M Vijayakumar, KD Lee, KC Choi
BMC Biotechnology 2014
Regulation of energy metabolism by long-chain fatty acids
MT Nakamura, BE Yudell, JJ Loor
Progress in Lipid Research 2014
Effects of different levels of protein supplementary diet on gene expressions related to intramuscular deposition in early-weaned yaks: Supplementary Protein Diet on Intramuscular Fat
H Zhang, ZS Wang, QH Peng, C Tan, HW Zou
Animal Science Journal 2014
Acute endocrine and nutritional co-regulation of the hepatic omy-miRNA-122b and the lipogenic gene fas in rainbow trout, Oncorhynchus mykiss
JA Mennigen, E Plagnes-Juan, CA Figueredo-Silva, I Seiliez, S Panserat, S Skiba-Cassy
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 2014
Fetal and neonatal exposure to nicotine leads to augmented hepatic and circulating triglycerides in adult male offspring due to increased expression of fatty acid synthase
N Ma, CJ Nicholson, M Wong, AC Holloway, DB Hardy
Toxicology and Applied Pharmacology 2014
Suppression of adipogenesis by valproic acid through repression of USF1-activated fatty acid synthesis in adipocytes
M Yuyama, K Fujimori
Biochemical Journal 2014
GSK3β-Dependent Phosphorylation Alters DNA Binding, Transactivity and Half-Life of the Transcription Factor USF2
Tina Horbach, Tabughang Franklin Chi, Claudia Götz, Satyan Sharma, André H. Juffer, Elitsa Y. Dimova, Thomas Kietzmann
PloS one 2014
Phytic acid and myo-inositol support adipocyte differentiation and improve insulin sensitivity in 3T3-L1 cells
JN Kim, SN Han, HK Kim
Nutrition Research 2014
In Vitro and In Vivo Enhancement of Adipogenesis by Italian Ryegrass (Lolium multiflorum) in 3T3-L1 Cells and Mice
MV Arasu, S Ilavenil, DH Kim, SG Roh, JC Lee, KC Choi, V Sanchez-Margalet
PloS one 2014
Cloning, characterization and expression of Peking duck fatty acid synthase during adipocyte differentiation
F Ding, X Yuan, Q Li, W Sun, C Gan, H He, C Song, J Wang
Electronic Journal of Biotechnology 2014
Exercise, but not quercetin, ameliorates inflammation, mitochondrial biogenesis, and lipid metabolism in skeletal muscle after strenuous exercise by high-fat diet mice
SM Kwon, HG Park, JK Jun, WL Lee
Journal of Exercise Nutrition & Biochemistry 2014
Effects of Yerba maté, a Plant Extract Formulation (“YGD”) and Resveratrol in 3T3-L1 Adipogenesis
J Santos, É Gotardo, M Brianti, M Piraee, A Gambero, M Ribeiro
Molecules (Basel, Switzerland) 2014
Expression of genes involved in lipid metabolism in the muscle of beef cattle fed soybean or rumen-protected fat, with or without monensin supplementation1
DM Oliveira, A Chalfun-Junior, ML Chizzotti, HG Barreto, TC Coelho, LV Paiva, CP Coelho, PD Teixeira, JP Schoonmaker, MM Ladeira
Journal of animal science 2014
Effects of phenotypic residual feed intake on response to a glucose tolerance test and gene expression in the insulin signaling pathway in longissimus dorsi in beef cattle1
C Fitzsimons, DA Kenny, SM Waters, B Earley, M McGee
Journal of animal science 2014
PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling
GY Lee, H Jang, JH Lee, JY Huh, S Choi, J Chung, JB Kim
Molecular and cellular biology 2013
G Protein-Coupled Receptors and Adipogenesis: A Focus on Adenosine Receptors: G-PROTEIN COUPLED RECEPTORS AND ADIPOGENESIS
A Eisenstein, K Ravid
Journal of Cellular Physiology 2013
Insulin signalling mechanisms for triacylglycerol storage
MP Czech, M Tencerova, DJ Pedersen, M Aouadi
Diabetologia 2013
Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues
M Schupp, F Chen, ER Briggs, S Rao, HJ Pelzmann, AR Pessentheiner, JG Bogner-Strauss, MA Lazar, D Baldwin, A Prokesch
BMC Genomics 2013
Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP
X Xu, JS So, JG Park, AH Lee
Seminars in liver disease 2013
Current role of fenofibrate in the prevention and management of non-alcoholic fatty liver disease
MS Kostapanos, A Kei, MS Elisaf
World journal of hepatology 2013
Thyroid Hormones Decrease Plasma 1α,25-Dihydroxyvitamin D Levels Through Transcriptional Repression of the Renal 25-Hydroxyvitamin D3 1α-Hydroxylase Gene (CYP27B1)
M Kozai, H Yamamoto, M Ishiguro, N Harada, M Masuda, T Kagawa, Y Takei, A Otani, O Nakahashi, S Ikeda, Y Taketani, K Takeyama, S Kato, E Takeda
Endocrinology 2013
Loss of Phosphatase and Tensin Homolog (PTEN) Induces Leptin-mediated Leptin Gene Expression: FEED-FORWARD LOOP OPERATING IN THE LUNG
RR Pathak, A Grover, P Malaney, W Quarni, A Pandit, D Allen-Gipson, V Dave
The Journal of biological chemistry 2013
Hepatic Fatty Acid Trafficking: Multiple Forks in the Road
DG Mashek
Advances in nutrition (Bethesda, Md.) 2013
Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance
SW Beaven, A Matveyenko, K Wroblewski, L Chao, D Wilpitz, TW Hsu, J Lentz, B Drew, AL Hevener, P Tontonoz
Cell Metabolism 2013
Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability
UB Pajvani, L Qiang, T Kangsamaksin, J Kitajewski, HN Ginsberg, D Accili
Nature Medicine 2013
Leptin's Pro-Angiogenic Signature in Breast Cancer
RR Gonzalez-Perez, V Lanier, G Newman
Cancers 2013
Non-classic thyroid hormone signalling involved in hepatic lipid metabolism
A Cordeiro, LL Souza, M Einicker-Lamas, CC Pazos-Moura
Journal of Endocrinology 2013
Insulin resistance and adipogenesis: Role of transcription and secreted factors
DN Penkov, AD Egorov, MN Mozgovaya, VA Tkachuk
Biochemistry (Moscow) 2013
Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor
H Jo, SS Choe, KC Shin, H Jang, JH Lee, JK Seong, SH Back, JB Kim
Hepatology 2013
Pharmacologic agents for type 2 diabetes therapy and regulation of adipogenesis
A Cignarelli, F Giorgino, R Vettor
Archives Of Physiology And Biochemistry 2013
Regulation of brown adipogenesis by the Tgf-β family: Involvement of Srebp1c in Tgf-β- and Activin-induced inhibition of adipogenesis
H Yoshida, Y Kanamori, H Asano, O Hashimoto, M Murakami, T Kawada, T Matsui, M Funaba
Biochimica et Biophysica Acta (BBA) - General Subjects 2013
Iatrogenic hyperinsulinemia in type 1 diabetes: Its effect on atherogenic risk markers
MY Wang, X Yu, Y Lee, SK McCorkle, GO Clark, S Strowig, RH Unger, P Raskin
Journal of Diabetes and its Complications 2013
MicroRNAs in Medicine
LC Edelstein, S Nagalla, PF Bray
MicroRNAs in Medicine 2013
Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice
JH Kang, SI Yun, MH Park, JH Park, SY Jeong, HO Park
PloS one 2013
Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake
M Yang, W Liu, C Pellicane, C Sahyoun, BK Joseph, C Gallo-Ebert, M Donigan, D Pandya, C Giordano, A Bata, JT Nickels
Journal of lipid research 2013
Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice
JH Kang, SI Yun, MH Park, JH Park, SY Jeong, HO Park, K Maedler
PloS one 2013
Direct Reprogramming of Adult Somatic Cells into other Lineages: Past Evidence and Future Perspectives
M Nizzardo, C Simone, M Falcone, G Riboldi, GP Comi, N Bresolin, S Corti
Cell Transplantation 2013
Current role of fenofibrate in the prevention and management of non-alcoholic fatty liver disease
MS Kostapanos
World journal of hepatology 2013
Physiologie et physiopathologie du tissu adipeux
JP Bastard, B Fève
2013
FOSL2 promotes adipocyte-specific leptin gene expression in humans and mice
Christiane Wrann, Jun Eguchi, Aline Bozec, Zhao Xu, Tarjei Mikkelsen, Jeffrey Gimble, Heike Nave, Erwin F. Wagner, Shao-en Ong, Evan Rosen
Journal of Clinical Investigation 2012
Molecular mechanisms of estrogen receptors' suppression of lipogenesis in pancreatic β-cells
JP Tiano, F Mauvais-Jarvis
Endocrinology 2012
Lipid Metabolism and Neuroinflammation in Alzheimer's Disease: A Role for Liver X Receptors
J Kang, S Rivest
Endocrine reviews 2012
Effects of sterol regulatory element-binding protein (SREBP) in chickens
FA Khesht, A Hassanabadi
Lipids in Health and Disease 2012
Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter
BN Jeon, YS Kim, WI Choi, DI Koh, MK Kim, JH Yoon, MY Kim, B Hur, PD Paik, MW Hur
Journal of lipid research 2012
Scientific side trips: six excursions from the beaten path
MS Brown, JL Goldstein
The Journal of biological chemistry 2012
New insights into adipocyte-specific leptin gene expression
CD Wrann, ED Rosen
Adipocyte 2012
Prenatal Arsenic Exposure Alters Gene Expression in the Adult Liver to a Proinflammatory State Contributing to Accelerated Atherosclerosis
JC States, AV Singh, TB Knudsen, EC Rouchka, NO Ngalame, GE Arteel, Y Piao, MS Ko
PloS one 2012
Regulatory Mechanisms in Bone Following Mechanical Loading
SM Roosa, CH Turner, Y Liu
Gene regulation and systems biology 2012
Inhibition of cannabinoid CB1 receptor upregulates Slc2a4 expression via nuclear factor- B and sterol regulatory element-binding protein-1 in adipocytes
DT Furuya, AC Poletto, HS Freitas, UF Machado
Journal of Molecular Endocrinology 2012
The role of AMPK/mTOR/S6K1 signaling axis in mediating the physiological process of exercise-induced insulin sensitization in skeletal muscle of C57BL/6 mice
X Liu, H Yuan, Y Niu, W Niu, L Fu
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2012
Developmental Origins of Obesity: Programmed Adipogenesis
M Desai, M Beall, MG Ross
Current Diabetes Reports 2012
Low protein diet up-regulate intramuscular lipogenic gene expression and down-regulate lipolytic gene expression in growth–finishing pigs
J Wang, SM Zhao, XL Song, HB Pan, WZ Li, YY Zhang, SZ Gao, DW Chen
Livestock Science 2012
Role of kruppel-like transcription factors in adipogenesis
Z Wu, S Wang
Developmental Biology 2012
Current concept of reverse cholesterol transport and novel strategy for atheroprotection
K Ono
Journal of Cardiology 2012
Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter[S]
BN Jeon, YS Kim, WI Choi, DI Koh, MK Kim, JH Yoon, MY Kim, B Hur, PD Paik, MW Hur
Journal of lipid research 2012
Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis
W Li, Y Tai, J Zhou, W Gu, Z Bai, T Zhou, Z Zhong, PA McCue, N Sang, JY Ji, B Kong, J Jiang, C Wang
Cell cycle (Georgetown, Tex.) 2012
Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice
H Jang, G Lee, J Kong, G Choi, YJ Park, JB Kim
PloS one 2012
Feeding Period Restriction Alters the Expression of Peripheral Circadian Rhythm Genes without Changing Body Weight in Mice
H Jang, G Lee, J Kong, G Choi, YJ Park, JB Kim, A Xu
PloS one 2012
Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter
BN Jeon, YS Kim, WI Choi, DI Koh, MK Kim, JH Yoon, MY Kim, B Hur, PD Paik, MW Hur
Journal of lipid research 2012
Regulatory Mechanisms in Bone following Mechanical Loading
SM Roosa, CH Turner, Y Liu
Gene regulation and systems biology 2012
Protein Arginine Methyltransferase 5 (Prmt5) Promotes Gene Expression of Peroxisome Proliferator-Activated Receptor γ2 (PPARγ2) and Its Target Genes during Adipogenesis
SE LeBlanc, S Konda, Q Wu, YJ Hu, CM Oslowski, S Sif, AN Imbalzano
Molecular Endocrinology 2012
Physiology and Physiopathology of Adipose Tissue
JP Bastard, B Fève
2012
Transcriptional Control of Adipose Lipid Handling by IRF4
J Eguchi, X Wang, S Yu, EE Kershaw, PC Chiu, J Dushay, JL Estall, U Klein, E Maratos-Flier, ED Rosen
Cell Metabolism 2011
Evidence Coupling Increased Hexosamine Biosynthesis Pathway Activity to Membrane Cholesterol Toxicity and Cortical Filamentous Actin Derangement Contributing to Cellular Insulin Resistance†
P Bhonagiri, GR Pattar, KM Habegger, AM McCarthy, L Tackett, JS Elmendorf
Endocrinology 2011
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
TR Peterson, SS Sengupta, TE Harris, AE Carmack, SA Kang, E Balderas, DA Guertin, KL Madden, AE Carpenter, BN Finck, DM Sabatini
Cell 2011
Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein -1a
SS Im, L Yousef, C Blaschitz, JZ Liu, RA Edwards, SG Young, M Raffatellu, TF Osborne
Cell Metabolism 2011
MicroRNA hsa-miR-613 Targets the Human LXRα Gene and Mediates a Feedback Loop of LXRα Autoregulation
Z Ou, T Wada, R Gramignoli, S Li, SC Strom, M Huang, W Xie
Molecular Endocrinology 2011
MicroRNAs and Cardiovascular Diseases
K Ono, Y Kuwabara, J Han
The FEBS journal 2011
Physiological effects of Type 2 diabetes on mRNA processing and gene expression
FS Morrison, KA Johnstone, LW Harries
Expert Review of Endocrinology & Metabolism 2011
Dietary constituents reduce lipid accumulation in murine C3H10 T1/2 adipocytes: A novel fluorescent method to quantify fat droplets
I Warnke, R Goralczyk, E Fuhrer, J Schwager
Nutrition & Metabolism 2011
Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway
R Suzuki, M Tanaka, M Takanashi, A Hussain, B Yuan, H Toyoda, M Kuroda
Nutrition & Metabolism 2011
Nocturnin expression is induced by fasting in the white adipose tissue of restricted fed mice
MR Gilbert, N Douris, S Tongjai, CB Green
PloS one 2011
Haplotype combination ofSREBP-1cgene sequence variants is associated with growth traits in cattle
YZ Huang, H He, JJ Sun, J Wang, ZJ Li, XY Lan, CZ Lei, CL Zhang, EP Zhang, JQ Wang, H Chen, J Bell
Genome 2011
MicroRNAs and cardiovascular diseases
K Ono, Y Kuwabara, J Han
FEBS Journal 2011
Insulin induces fatty acid desaturase expression in human monocytes
I Arbo, C Halle, D Malik, HR Brattbakk, B Johansen
Scandinavian Journal of Clinical & Laboratory Investigation 2011
Transcriptional Metabolic Inflexibility in Skeletal Muscle Among Individuals With Increasing Insulin Resistance
A Jans, LM Sparks, AM van Hees, IM Gjelstad, AC Tierney, U Risérus, CA Drevon, HM Roche, P Schrauwen, EE Blaak
Obesity 2011
The Inhibitory Effect ofLactobacillus plantarumKY1032 Cell Extract on the Adipogenesis of 3T3-L1 Cells
DY Park, YT Ahn, CS Huh, SM Jeon, MS Choi
Journal of Medicinal Food 2011
Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats
A Agil, I Rosado, R Ruiz, A Figueroa, N Zen, G Fernández-Vázquez
Journal of Pineal Research 2011
Effects of dietary lipids and Clostridium butyricum on serum lipids and lipid-related gene expression in broiler chickens
B Zhang, X Yang, Y Guo, F Long
animal 2011
Oleuropein and hydroxytyrosol inhibit adipocyte differentiation in 3 T3-L1 cells
R Drira, S Chen, K Sakamoto
Life Sciences 2011
Roles of PPARs in NAFLD: Potential therapeutic targets
A Tailleux, K Wouters, B Staels
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2011
Establishment and evaluation of a new model for studying lipogenesis in grass carp (Ctenopharyngodon idella) preadipocytes
Y Li
In Vitro Cellular & Developmental Biology - Animal 2011
Fetal programming of adipose tissue: effects of intrauterine growth restriction and maternal obesity/high-fat diet
M Desai, MG Ross
Seminars in reproductive medicine 2011
Fetal Programming of Adipose Tissue: Effects of IUGR and Maternal Obesity/High Fat Diet
M Desai, MG Ross
Seminars in reproductive medicine 2011
Nocturnin Expression Is Induced by Fasting in the White Adipose Tissue of Restricted Fed Mice
MR Gilbert, N Douris, S Tongjai, CB Green, S Yamazak
PloS one 2011
Regulation of leptin synthesis during adipogenesis in males of a vespertilionid bat, Scotophilus heathi
VK Roy, A Krishna
The Journal of experimental biology 2011
Establishment and evaluation of a new model for studying lipogenesis in grass carp (Ctenopharyngodon idella) preadipocytes
Y Li
In vitro cellular & developmental biology. Animal 2011
MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo
T Horie, K Ono, M Horiguchi, H Nishi, T Nakamura, K Nagao, M Kinoshita, Y Kuwabara, H Marusawa, Y Iwanaga, K Hasegawa, M Yokode, T Kimura, T Kita
Proceedings of the National Academy of Sciences 2010
High Fat Diet Regulation of β-Cell Proliferation and β-Cell Mass
ML Golson, AA Misfeldt, UG Kopsombut, CP Petersen, M Gannon
The open endocrinology journal 2010
Metabolic effects of obesity: A review
P Singla, A Bardoloi, AA Parkash
World journal of diabetes 2010
Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance
G Tarantino, S Savastano, A Colao
World journal of gastroenterology : WJG 2010
Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective
RH Wong, HS Sul
Current Opinion in Pharmacology 2010
A large indel mutation of the bovine ADD1/SREBP1c gene and its effects on growth traits in some native cattle breeds from China
YZ Huang, EP Zhang, J Wang, YT Huai, L Ma, FY Chen, XY Lan, CZ Lei, XT Fang, JQ Wang, H Chen
Molecular Biology Reports 2010
Gentiana manshurica Kitagawa Reverses Acute Alcohol-Induced Liver Steatosis through Blocking Sterol Regulatory Element-Binding Protein-1 Maturation
LH Lian, YL Wu, SZ Song, Y Wan, WX Xie, X Li, T Bai, BQ Ouyang, JX Nan
Journal of Agricultural and Food Chemistry 2010
Transcriptional Regulation of Glucose Sensors in Pancreatic β-Cells and Liver: An Update
JS Bae, TH Kim, MY Kim, JM Park, YH Ahn
Sensors (Basel, Switzerland) 2010
Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice
M Warrier, TD Hinds, KJ Ledford, HA Cash, PR Patel, TA Bowman, LA Stechschulte, W Yong, W Shou, SM Najjar, ER Sanchez
Endocrinology 2010
Adiponectin represses colon cancer cell proliferation via AdipoR1- and -R2-mediated AMPK activation.
Kim AY, Lee YS, Kim KH, Lee JH, Lee HK, Jang SH, Kim SE, Lee GY, Lee JW, Jung SA, Chung HY, Jeong S, Kim JB
Molecular Endocrinology 2010
Sterol-regulatory-element-binding protein 1c mediates the effect of insulin on the expression of Cidea in mouse hepatocytes
R Wang, X Kong, A Cui, X Liu, R Xiang, Y Yang, Y Guan, F Fang, Y Chang
Biochemical Journal 2010
Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site
F Damiano, S Alemanno, GV Gnoni, L Siculella
Biochemical Journal 2010
Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice
YS Lee, BY Cha, K Yamaguchi, SS Choi, T Yonezawa, T Teruya, K Nagai, JT Woo
Cytotechnology 2010
Effect of dietary saturated fatty acids on HNF-4α DNA binding activity and ApoCIII mRNA in sedentary rat liver
V Ceccarelli, G Nocentini, C Riccardi, E Ayroldi, PD Nardo, R Roberti, L Binaglia, A Vecchini
Molecular and Cellular Biochemistry 2010
The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA
E Oliver, F McGillicuddy, C Phillips, S Toomey, HM Roche
Proceedings of the Nutrition Society 2010
Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulin
SM Rae-Whitcombe, D Kennedy, M Voyles, MP Thompson
Biochemical and Biophysical Research Communications 2010
ADD1/SREBP1c activates the PGC1-α promoter in brown adipocytes
Q Hao, JB Hansen, RK Petersen, P Hallenborg, C Jørgensen, S Cinti, PJ Larsen, KR Steffensen, H Wang, S Collins, J Wang, JÅ Gustafsson, L Madsen, K Kristiansen
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2010
Hypotriacylglycerolemic and Antiobesity Properties of a New Fermented Tea Product Obtained by Tea-Rolling Processing of Third-Crop Green Tea (Camellia sinensis) Leaves and Loquat (Eriobotrya japonica) Leaves
K TANAKA, S TAMARU, S NISHIZONO, Y MIYATA, K TAMAYA, T MATSUI, T TANAKA, Y ECHIZEN, I IKEDA
Bioscience, Biotechnology, and Biochemistry 2010
Effects of morroniside isolated from Corni Fructus on renal lipids and inflammation in type 2 diabetic mice
CH Park, JS Noh, T Tanaka, T Yokozawa
Journal of Pharmacy and Pharmacology 2010
High glucose induces differentiation and adipogenesis in porcine muscle satellite cells via mTOR
T Yue, J Yin, F Li, D Li, M Du
BMB Reports 2010
SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism*
B Ponugoti, DH Kim, Z Xiao, Z Smith, J Miao, M Zang, SY Wu, CM Chiang, TD Veenstra, JK Kemper
The Journal of biological chemistry 2010
Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity[S]
KH Kim, GY Lee, JI Kim, M Ham, JW Lee, JB Kim
Journal of lipid research 2010
Vitamins & Hormones
KJ Hare, FK Knop
Vitamins & Hormones 2010
Two novel coding SNPs of SREBP1c gene are associated with body weight and average daily gain in bovine
Y Huang, E Zhang, J Wang, Y Huai, X Lan, L Ma, Z Li, G Ren, F Chen, C Lei, J Wang, H Chen
Animal Biotechnology 2010
Dietary polyunsaturated fatty acids slow the progression of diabetic nephropathy in streptozotocin-induced diabetic rats
M Yokoyama, K Tanigawa, T Murata, Y Kobayashi, E Tada, I Suzuki, Y Nakabou, M Kuwahata, Y Kido
Nutrition Research 2010
Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity
KH Kim, GY Lee, JI Kim, M Ham, JW Lee, JB Kim
Journal of lipid research 2010
SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism
B Ponugoti, DH Kim, Z Xiao, Z Smith, J Miao, M Zang, SY Wu, CM Chiang, TD Veenstra, JK Kemper
The Journal of biological chemistry 2010
Metabolic effects of obesity: A review
P Singla
World journal of diabetes 2010
Discovery of Glucocorticoid Receptor-β in Mice with a Role in Metabolism
TD Hinds, S Ramakrishnan, HA Cash, LA Stechschulte, G Heinrich, SM Najjar, ER Sanchez
Molecular Endocrinology 2010
Regulation of the expression of angiotensin-converting enzyme 2 by polyunsaturated fatty acids in porcine adipocytes1
YW Tseng, PH Wang, HS Lee, BH Liu, HJ Mersmann, EC Lin, ST Ding
Journal of animal science 2010
Obesity Before Birth
RH Lustig
2010
Impact of dietary protein on lipid metabolism-related gene expression in porcine adipose tissue
S Zhao, J Wang, X Song, , C Ge, S Gao
Nutrition & Metabolism 2010
Pathomechanisms of Type 2 Diabetes Genes
H Staiger, F Machicao, A Fritsche, HU Häring
Endocrine reviews 2009
Intersection of the unfolded protein response and hepatic lipid metabolism
AH Lee, LH Glimcher
Cellular and Molecular Life Sciences 2009
From Sugar to Fat
LH Glimcher, AH Lee
Annals of the New York Academy of Sciences 2009
Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been
TF Osborne, PJ Espenshade
Genes & development 2009
Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles
CR Yellaturu, X Deng, LM Cagen, HG Wilcox, CM 2nd, SA Siddiqi, EA Park, R Raghow, MB Elam
The Journal of biological chemistry 2009
Transcriptional targets in adipocyte biology
E Rosen, J Eguchi, Z Xu
Expert Opinion on Therapeutic Targets 2009
C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis
VA Payne, WS Au, CE Lowe, SM Rahman, JE Friedman, S O'Rahilly, JJ Rochford
Biochemical Journal 2009
Fat accumulation in Caenorhabditis elegans is mediated by SREBP homolog SBP-1
T Nomura, M Horikawa, S Shimamura, T Hashimoto, K Sakamoto
Genes & Nutrition 2009
Krüppel-like family of transcription factors: an emerging new frontier in fat biology
CW Brey, MP Nelder, T Hailemariam, R Gaugler, S Hashmi
International journal of biological sciences 2009
DNA-PK: relaying the insulin signal to USF in lipogenesis
RH Wong, HS Sul
Cell cycle (Georgetown, Tex.) 2009
Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells
SN Ramakrishnan, P Lau, LM Crowther, ME Cleasby, S Millard, GM Leong, GJ Cooney, GE Muscat
Biochemical and Biophysical Research Communications 2009
A minimal model for hepatic fatty acid balance during fasting: Application to PPAR alpha-deficient mice
P Blavy, F Gondret, H Guillou, S Lagarrigue, PG Martin, J Milgen, O Radulescu, A Siegel
Journal of Theoretical Biology 2009
Oleate induces transdifferentiation of chicken fibroblasts into adipocyte-like cells
S Liu, L Wang, N Wang, Y Wang, H Shi, H Li
Comparative Biochemistry and Physiology - Part A Molecular & Integrative Physiology 2009
The Orphan Nuclear Receptor RORα Restrains Adipocyte Differentiation through a Reduction of C/EBPβ Activity and Perilipin Gene Expression
N Ohoka, S Kato, Y Takahashi, H Hayashi, R Sato
Molecular Endocrinology 2009
Insulin Enhances Post-translational Processing of Nascent SREBP-1c by Promoting Its Phosphorylation and Association with COPII Vesicles
CR Yellaturu, X Deng, LM Cagen, HG Wilcox, CM Mansbach, SA Siddiqi, EA Park, R Raghow, MB Elam
The Journal of biological chemistry 2009
Pitavastatin in the Management of Hypercholesterolemia
S Nomura
Clinical medicine. Therapeutics 2009
Microarray gene expression profiles of fasting induced changes in liver and adipose tissues of pigs expressing the melanocortin-4 receptor D298N variant
S Lkhagvadorj, L Qu, W Cai, OP Couture, CR Barb, GJ Hausman, D Nettleton, LL Anderson, JC Dekkers, CK Tuggle
Physiological genomics 2009
Elevated Insulin Secretion from Liver X Receptor-Activated Pancreatic β-Cells Involves Increased de Novo Lipid Synthesis and Triacylglyceride Turnover
CD Green, DB Jump, LK Olson
Endocrinology 2009
Regulation of SREBP1c Gene Expression in Skeletal Muscle: Role of Retinoid X Receptor/Liver X Receptor and Forkhead-O1 Transcription Factor
Y Kamei, S Miura, T Suganami, F Akaike, S Kanai, S Sugita, A Katsumata, H Aburatani, TG Unterman, O Ezaki, Y Ogawa
Endocrinology 2008
Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin
P Bhonagiri, GR Pattar, EM Horvath, KM Habegger, AM McCarthy, JS Elmendorf
Endocrinology 2008
Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN)
WI Choi, BN Jeon, H Park, JY Yoo, YS Kim, DI Koh, MH Kim, YR Kim, CE Lee, KS Kim, TF Osborne, MW Hur
The Journal of biological chemistry 2008
Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth-restricted offspring
TR Magee, G Han, B Cherian, O Khorram, MG Ross, M Desai
American Journal of Obstetrics and Gynecology 2008
The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects
LC Hudgins, A Baday, MK Hellerstein, TS Parker, DM Levine, CE Seidman, RA Neese, JD Tremaroli, J Hirsch
The Journal of Nutritional Biochemistry 2008
Modern Nutrition
K LaPoint, M McIntosh
Handbook of Nutrition in the Aged, Fourth Edition 2008
Macronutrients and obesity: views, news and reviews
L Madsen, B Liaset, K Kristiansen
Future Lipidology 2008
Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes
S Rayalam, JY Yang, S Ambati, MA Della-Fera, CA Baile
Phytotherapy Research 2008
Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism
SM Choi, HJ Cho, H Cho, KH Kim, JB Kim, H Park
Nucleic Acids Research 2008
Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver
MK Bennett, YK Seo, S Datta, DJ Shin, TF Osborne
The Journal of biological chemistry 2008
Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fasting
M Palou, T Priego, J Sánchez, E Villegas, AM Rodríguez, A Palou, C Picó
Pflügers Archiv - European Journal of Physiology 2008
SREBPs: the crossroads of physiological and pathological lipid homeostasis
R Raghow, C Yellaturu, X Deng, EA Park, MB Elam
Trends in Endocrinology & Metabolism 2008
Adipose tissue gene expression profiles in ob/ob mice treated with leptin
W Zhang, MA Della-Fera, DL Hartzell, D Hausman, CA Baile
Life Sciences 2008
Insulin induces chaperone and CHOP gene expressions in adipocytes
Y Miyata, A Fukuhara, M Matsuda, R Komuro, I Shimomura
Biochemical and Biophysical Research Communications 2008
Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population
J Liu, J Liu, P Li, X Xie, Q Guo, L Tian, X Ma, J Zhang, J Liu, J Gao
Diabetes Research and Clinical Practice 2008
Up-Regulation of Genes Related to the Ubiquitin-Proteasome System in the Brown Adipose Tissue of 24-h-Fasted Rats
Y NAKAI, H HASHIDA, K KADOTA, M MINAMI, K SHIMIZU, I MATSUMOTO, H KATO, K ABE
Bioscience, Biotechnology, and Biochemistry 2008
Genome-wide effects of acute progressive feed restriction in liver and white adipose tissue
R Pohjanvirta, PC Boutros, ID Moffat, J Lindén, D Wendelin, AB Okey
Toxicology and Applied Pharmacology 2008
Correlation between adiponectin and reduction of cell adhesion molecules after pitavastatin treatment in hyperlipidemic patients with type 2 diabetes mellitus
S Nomura, A Shouzu, S Omoto, N Inami, A Tanaka, M Nanba, Y Shouda, N Takahashi, Y Kimura, T Iwasaka
Thrombosis Research 2008
Proto-oncogene FBI-1 (Pokemon) and SREBP-1 Synergistically Activate Transcription of Fatty-acid Synthase Gene (FASN)
WI Choi, BN Jeon, H Park, JY Yoo, YS Kim, DI Koh, MH Kim, YR Kim, CE Lee, KS Kim, TF Osborne, MW Hur
The Journal of biological chemistry 2008
Selective Binding of Sterol Regulatory Element-binding Protein Isoforms and Co-regulatory Proteins to Promoters for Lipid Metabolic Genes in Liver
MK Bennett, YK Seo, S Datta, DJ Shin, TF Osborne
The Journal of biological chemistry 2008
The Orphan Nuclear Receptor, RORα, Regulates Gene Expression That Controls Lipid Metabolism: STAGGERER (SG/SG) MICE ARE RESISTANT TO DIET-INDUCED OBESITY
P Lau, RL Fitzsimmons, S Raichur, SC Wang, A Lechtken, GE Muscat
The Journal of biological chemistry 2008
TRB3 suppresses adipocyte differentiation by negatively regulating PPARγ transcriptional activity
Y Takahashi, N Ohoka, H Hayashi, R Sato
Journal of lipid research 2008
Hepatic regulation of fatty acid synthase by insulin and T 3 : evidence for T 3 genomic and nongenomic actions
A Radenne, M Akpa, C Martel, S Sawadogo, D Mauvoisin, C Mounier
American journal of physiology. Endocrinology and metabolism 2008
Sterol regulatory element binding transcription factor 1 expression and genetic polymorphism significantly affect intramuscular fat deposition in the longissimus muscle of Erhualian and Sutai pigs1
J Chen, XJ Yang, D Xia, J Chen, J Wegner, Z Jiang, RQ Zhao
Journal of animal science 2008
Transcriptome profiling of the feeding-to-fasting transition in chicken liver
C Désert, MJ Duclos, P Blavy, F Lecerf, F Moreews, C Klopp, M Aubry, F Herault, PL Roy, C Berri, M Douaire, C Diot, S Lagarrigue
BMC Genomics 2008
Parasympathetic Response of the Heart is controlled by SREBP
Ho-Jin Park, Serban P. Georgescu, Chuang Du, Christopher Madias, Mark J. Aronovitz, C. Michael Welzig, Bo Wang, Ulrike Begley, Yali Zhang, Robert O. Blaustein, Richard D. Patten, Richard H. Karas, Herbert H. Van Tol, Timothy F. Osborne, Hitoshi Shimano, Ronglih Liao, Mark Link and Jonas B. Galper
Journal of Clinical Investigation 2007
SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling
H Shimano
Journal of Molecular Medicine 2007
Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD)
MH Ahmed, CD Byrne
Drug Discovery Today 2007
Cholesterol: from feeding to gene regulation
C Martini, V Pallottini
Genes & Nutrition 2007
Chronic Activation of Liver X Receptor Induces  -Cell Apoptosis Through Hyperactivation of Lipogenesis: Liver X Receptor-Mediated Lipotoxicity in Pancreatic  -Cells
SS Choe, AH Choi, JW Lee, KH Kim, JJ Chung, J Park, KM Lee, KG Park, IK Lee, JB Kim
Diabetes 2007
Chromatin Remodeling Complex Interacts with ADD1/SREBP1c To Mediate Insulin-Dependent Regulation of Gene Expression
YS Lee, DH Sohn, D Han, HW Lee, RH Seong, JB Kim
Molecular and cellular biology 2007
Adipose Tissue: A Metabolic Regulator. Potential Implications for the Metabolic Outcome of Subjects Born Small for Gestational Age (SGA)
A Maiorana, CD Bianco, S Cianfarani
The review of diabetic studies : RDS 2007
Handbook of Contemporary Neuropharmacology
A Fay, PC Haddick, LY Jan
Handbook of Contemporary Neuropharmacology 2007
Adipose tissue expandability and the metabolic syndrome
M Slawik, AJ Vidal-Puig
Genes & Nutrition 2007
In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression
Y Takeuchi, N Yahagi, Y Nakagawa, T Matsuzaka, R Shimizu, M Sekiya, Y Iizuka, K Ohashi, T Gotoda, M Yamamoto, R Nagai, T Kadowaki, N Yamada, J Osuga, H Shimano
Biochemical and Biophysical Research Communications 2007
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
JA Menendez, R Lupu
Nature Reviews Cancer 2007
Gender-specific programmed hepatic lipid dysregulation in intrauterine growth-restricted offspring
GY Choi, DN Tosh, A Garg, R Mansano, MG Ross, M Desai
American Journal of Obstetrics and Gynecology 2007
Exercise before or after refeeding prevents refeeding-induced recovery of cell size after fasting with a different pattern of metabolic gene expressions in rat epididymal adipocytes
T Sakurai, M Takei, J Ogasawara, H Ueda, T Kizaki, H Ohno, T Izawa
Metabolism 2007
Obesity: Genomics and Postgenomics
A Xu, A Butler, G Barsh
Obesity: Genomics and Postgenomics 2007
Leptine et grossesse: dogmes, questions et perspectives
J Lepercq, P Catalano, SH de Mouzon
Gynécologie Obstétrique & Fertilité 2007
A Novel Pathway to Enhance Adipocyte Differentiation of 3T3-L1 Cells by Up-regulation of Lipocalin-type Prostaglandin D Synthase Mediated by Liver X Receptor-activated Sterol Regulatory Element-binding Protein-1c
K Fujimori, K Aritake, Y Urade
The Journal of biological chemistry 2007
Wnt Signaling Stimulates Osteoblastogenesis of Mesenchymal Precursors by Suppressing CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ
S Kang, CN Bennett, I Gerin, LA Rapp, KD Hankenson, OA MacDougald
The Journal of biological chemistry 2007
Thermally Oxidized Oil Increases the Expression of Insulin-Induced Genes and Inhibits Activation of Sterol Regulatory Element-Binding Protein-2 in Rat Liver
A Koch, B König, J Spielmann, A Leitner, GI Stangl, K Eder
The Journal of nutrition 2007
The effect of dietary docosahexaenoic acid on the expression of lipogenic genes in broilers
HJ Chin, YH Ko, TF Shen, ST Ding
Australian Journal of Agricultural Research 2007
Glucocorticoid Modulation of Insulin Signaling in Human Subcutaneous Adipose Tissue
LL Gathercole, IJ Bujalska, PM Stewart, JW Tomlinson
The Journal of clinical endocrinology and metabolism 2007
Effects of Pitavastatin on Adiponectin in Patients with Hyperlipidemia
N Inami, S Nomura, A Shouzu, S Omoto, Y Kimura, N Takahashi, A Tanaka, M Nanba, Y Shouda, T Iwasaka
Pathophysiology of Haemostasis and Thrombosis 2007
Adaptor Protein SH2-B Linking Receptor-Tyrosine Kinase and Akt Promotes Adipocyte Differentiation by Regulating Peroxisome Proliferator-Activated Receptor γ Messenger Ribonucleic Acid Levels
D Yoshiga, N Sato, T Torisu, H Mori, R Yoshida, S Nakamura, G Takaesu, T Kobayashi, A Yoshimura
Molecular Endocrinology 2007
TRB3 Blocks Adipocyte Differentiation through the Inhibition of C/EBPβ Transcriptional Activity
O Bezy, C Vernochet, S Gesta, SR Farmer, CR Kahn
Molecular and cellular biology 2007
Functional Interaction of Hepatic Nuclear Factor-4 and Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α in CYP7A1 Regulation Is Inhibited by a Key Lipogenic Activator, Sterol Regulatory Element-Binding Protein-1c
B Ponugoti, S Fang, JK Kemper
Molecular Endocrinology 2007
Regulation of GLUT4 gene expression by SREBP-1c in adipocytes
SS Im, SK Kwon, SY Kang, TH Kim, HI Kim, MW Hur, KS Kim, YH Ahn
Biochemical Journal 2006
Keratinocyte growth factor induces lipogenesis in alveolar type II cells through a sterol regulatory element binding protein-1c-dependent pathway
Y Chang, K Edeen, X Lu, MD Leon, RJ Mason
American journal of respiratory cell and molecular biology 2006
Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes
AH Harding, RJ Loos, J Luan, S O'Rahilly, NJ Wareham, I Barroso
Diabetologia 2006
Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor
F Hansmannel, S Mordier, PB Iynedjian
Biochemical Journal 2006
Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle
KJ Nadeau
American journal of physiology. Endocrinology and metabolism 2006
Variation in the adiponutrin gene influences its expression and associates with obesity
LE Johansson, J Hoffstedt, H Parikh, E Carlsson, M Wabitsch, AG Bondeson, J Hedenbro, H Tornqvist, L Groop, M Ridderstråle
Diabetes 2006
Transcriptional control of adipocyte formation
SR Farmer
Cell Metabolism 2006
Functional Analysis of Hes-1 in Preadipocytes
DA Ross, S Hannenhalli, JW Tobias, N Cooch, R Shiekhattar, T Kadesch
Molecular Endocrinology 2006
Adipocyte differentiation from the inside out
ED Rosen, OA MacDougald
Nature Reviews Molecular Cell Biology 2006
The known and unknown of leptin in pregnancy
SH Mouzon, J Lepercq, P Catalano
American Journal of Obstetrics and Gynecology 2006
Effect of short-term and long-term fasting on transcriptional regulation of metabolic genes in rat tissues
RY Li, QH Zhang, Z Liu, J Qiao, SX Zhao, L Shao, HS Xiao, JL Chen, MD Chen, HD Song
Biochemical and Biophysical Research Communications 2006
Lipid and lipoprotein dysregulation in insulin resistant states
RK Avramoglu, H Basciano, K Adeli
Clinica Chimica Acta 2006
Insulin-Like Growth Factor-1 Induces Lipid Production in Human SEB-1 Sebocytes Via Sterol Response Element-Binding Protein-1
TM Smith, Z Cong, KL Gilliland, GA Clawson, DM Thiboutot
Journal of Investigative Dermatology 2006
Lipotoxicity, overnutrition and energy metabolism in aging
M Slawik, AJ Vidal-Puig
Ageing Research Reviews 2006
Leptin secretion is related to glucose-derived lipogenesis in isolated adipocytes
CG Walker, JM Bryson, DP Hancock, ID Caterson
International Journal of Obesity 2006
Transcriptional regulation by insulin: from the receptor to the geneThis paper is one of a selection of papers published in this Special issue, entitled Second Messengers and Phosphoproteins—12th International Conference
C Mounier, BI Posner
Canadian Journal of Physiology and Pharmacology 2006
Protein Sensors for Membrane Sterols
JL Goldstein, RA DeBose-Boyd, MS Brown
Cell 2006
Sterol regulatory element binding protein (SREBP)-1 expression in brain is affected by age but not by hormones or metabolic changes
K Okamoto, T Kakuma, S Fukuchi, T Masaki, T Sakata, H Yoshimatsu
Brain Research 2006
The Emerging Functions of UCP2 in Health, Disease, and Therapeutics
G Mattiasson, PG Sullivan
Antioxidants & Redox Signaling 2006
Modulation of peroxisome proliferator-activated receptor   and   transcripts in swine endometrial tissue during early gestation
E Lord, BD Murphy, JA Desmarais, S Ledoux, D Beaudry, MF Palin
Reproduction 2006
Direct Interaction between USF and SREBP-1c Mediates Synergistic Activation of the Fatty-acid Synthase Promoter
MJ Griffin, RH Wong, N Pandya, HS Sul
The Journal of biological chemistry 2006
Elovl3 : a model gene to dissect homeostatic links between the circadian clock and nutritional status
A Anzulovich, A Mir, M Brewer, G Ferreyra, C Vinson, R Baler
Journal of lipid research 2006
Leucine in food mediates some of the postprandial rise in plasma leptin concentrations
CJ Lynch, B Gern, C Lloyd, SM Hutson, R Eicher, TC Vary
American journal of physiology. Endocrinology and metabolism 2006
Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation
M Lu, JY Shyy
American journal of physiology. Cell physiology 2006
Increased glucose tolerance and reduced adipocity in the absence of fasting hypoglycemia in mice with liver-specific Gs-alpha deficiency
Min Chen, Oksana Gavrilova, Wei-Qin Zhao, Annie Nguyen, Javier Lorenzo, Laura Shen, Lisa Nackers, Stephanie Pack, William Jou, Lee S. Weinstein
Journal of Clinical Investigation 2005
Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation
J Sponarova, KJ Mustard, O Horakova, P Flachs, M Rossmeisl, P Brauner, K Bardova, M Thomason-Hughes, R Braunerova, P Janovska, DG Hardie, J Kopecky
FEBS Letters 2005
Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver
H Kuriyama, G Liang, LJ Engelking, JD Horton, JL Goldstein, MS Brown
Cell Metabolism 2005
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
J Lin, R Yang, PT Tarr, PH Wu, C Handschin, S Li, W Yang, L Pei, M Uldry, P Tontonoz, CB Newgard, BM Spiegelman
Cell 2005
Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes
A Takahashi, H Shimano, Y Nakagawa, T Yamamoto, K Motomura, T Matsuzaka, H Sone, H Suzuki, H Toyoshima, N Yamada
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2005
SREBP-1 as a Transcriptional Integrator of Circadian and Nutritional Cues in the Liver
M Brewer, D Lange, R Baler, A Anzulovich
Journal of Biological Rhythms 2005
Regulation of adipocyte differentiation and function by polyunsaturated fatty acids
L Madsen, RK Petersen, K Kristiansen
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2005
Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies
F Giorgino, L Laviola, JW Eriksson
Acta Physiologica Scandinavica 2005
The fate and intermediary metabolism of stearic acid
H Sampath, JM Ntambi
Lipids 2005
Fructose, insulin resistance, and metabolic dyslipidemia
H Basciano, L Federico, K Adeli
Nutrition & Metabolism 2005
Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats
T Teruel, R Hernandez, E Rial, A Martin-Hidalgo, M Lorenzo
Diabetologia 2005
Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease
T Jiang, SE Liebman, MS Lucia, J Li, M Levi
Kidney International 2005
LXR is crucial in lipid metabolism
SM Ulven, KT Dalen, JÅ Gustafsson, HI Nebb
Prostaglandins, Leukotrienes and Essential Fatty Acids 2005
Adipose Development: From Stem Cell to Adipocyte
TC Otto, MD Lane
Critical Reviews in Biochemistry and Molecular Biology 2005
Transcriptional regulation of mouse 6-phosphogluconate dehydrogenase by ADD1/SREBP1c
HK Rho, J Park, JH Suh, JB Kim
Biochemical and Biophysical Research Communications 2005
Hypoxia inhibits adipocyte differentiation in a HDAC-independent manner
KH Kim, MJ Song, J Chung, H Park, JB Kim
Biochemical and Biophysical Research Communications 2005
Leptin promoter mutations affect leptin levels and performance traits in dairy cows1
SC Liefers, RF Veerkamp, MF Pas, C Delavaud, Y Chilliard, M Platje, T Lende
Animal Genetics 2005
The role of fat tissue in the cholesterol lowering and the pleiotropic effects of statins – statins activate the generation of metabolically more capable adipocytes
A Erol
Medical Hypotheses 2005
Adipocyte insensitivity syndromes – novel approach to nutritional metabolic problems including obesity and obesity related disorders
A Erol
Medical Hypotheses 2005
A novel SREBP-1 splice variant: Tissue abundance and transactivation potency
TK Felder, K Klein, W Patsch, H Oberkofler
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 2005
Changes in Fat Mass Influence SREBP-1c and UCP-2 Gene Expression in Formerly Obese Subjects
D Gniuli, G Rosa, M Manco, A Scarfone, N Vega, AV Greco, M Castagneto, H Vidal, G Mingrone
Obesity research 2005
Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?
JA Menendez, R Colomer, R Lupu
Medical Hypotheses 2005
Insulin and Leptin Resistance With Hyperleptinemia in Mice Lacking Androgen Receptor
HY Lin, Q Xu, S Yeh, RS Wang, JD Sparks, C Chang
Diabetes 2005
The regulation of fatty acid synthase by STAT5A
Jessica C Hogan, Jacqueline M Stephens
Diabetes 2005
Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic  -Cells
A Takahashi, K Motomura, T Kato, T Yoshikawa, Y Nakagawa, N Yahagi, H Sone, H Suzuki, H Toyoshima, N Yamada, H Shimano
Diabetes 2005
CD38 as a prognostic marker in CLL
Z Matrai
Hematology 2005
Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues
Y Gosmain, N Dif, V Berbe, E Loizon, J Rieusset, H Vidal, E Lefai
Journal of lipid research 2005
Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats
AR Tovar, I Torre-Villalvazo, M Ochoa, AL Elías, V Ortíz, CA Aguilar-Salinas, N Torres
Journal of lipid research 2005
Hepatic triglyceride contents are genetically determined in mice: results of a strain survey
X Lin, P Yue, Z Chen, G Schonfeld
AJP Gastrointestinal and Liver Physiology 2005
Insulin-Mediated Down-Regulation of Apolipoprotein A5 Gene Expression through the Phosphatidylinositol 3-Kinase Pathway: Role of Upstream Stimulatory Factor
M Nowak, A Helleboid-Chapman, H Jakel, G Martin, D Duran-Sandoval, B Staels, EM Rubin, LA Pennacchio, MR Taskinen, J Fruchart-Najib, JC Fruchart
Molecular and cellular biology 2005
Role of energy charge and AMP-activated protein kinase in adipocytes in the control of body fat stores
M Rossmeisl, P Flachs, P Brauner, J Sponarova, O Matejkova, T Prazak, J Ruzickova, K Bardova, O Kuda, J Kopecky
International Journal of Obesity 2004
Insulin Action on Expression of Novel Adipose Genes in Healthy and Type 2 Diabetic Subjects
HA Koistinen, M Forsgren, H Wallberg-Henriksson, JR Zierath
Obesity research 2004
Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements
LM Cagen, X Deng, HG Wilcox, EA Park, R Raghow, MB Elam
Biochemical Journal 2004
Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression
JB Seo, HM Moon, WS Kim, YS Lee, HW Jeong, EJ Yoo, J Ham, H Kang, MG Park, KR Steffensen, TM Stulnig, JA Gustafsson, SD Park, JB Kim
Molecular and cellular biology 2004
SREBP transcription factors: master regulators of lipid homeostasis
D Eberlé, B Hegarty, P Bossard, P Ferré, F Foufelle
Biochimie 2004
Identification of Ku70/Ku80 as ADD1/SREBP1c interacting proteins
YS Lee, HY Koh, SD Park, JB Kim
Korean Journal of Biological Sciences 2004
Regulation of adipocyte differentiation and insulin action with rapamycin
HJ Cho, J Park, HW Lee, YS Lee, JB Kim
Biochemical and Biophysical Research Communications 2004
Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation
JA Menendez, I Mehmi, VA Verma, PK Teng, R Lupu
Molecular Carcinogenesis 2004
Immune Regulation and Graft Survival in Kidney Transplant Recipients Are Both Enhanced by Human Leukocyte Antigen Matching
DS Rodriguez, E Jankowska-Gan, LD Haynes, G Leverson, A Munoz, D Heisey, HW and, WJ Burlingham
American Journal of Transplantation 2004
Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K+-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats
R Alemzadeh, C Fledelius, T Bodvarsdottir, J Sturis
Metabolism 2004
Is 100% oxygen necessary for the resuscitation of newborn infants?
S Niermeyer, M Vento
Journal of Maternal-Fetal and Neonatal Medicine 2004
Regulation of development and metabolism of adipose tissue by growth hormone and the insulin-like growth factor system
I Louveau, F Gondret
Domestic Animal Endocrinology 2004
Intercellular signaling between adipose tissue and muscle tissue
TA Kokta, MV Dodson, A Gertler, RA Hill
Domestic Animal Endocrinology 2004
Links between fatty acids and expression of UCP2 and UCP3 mRNAs
MP Thompson, D Kim
FEBS Letters 2004
Développement du tissu adipeux
I Dugail, P Ferré
EMC - Endocrinologie - Nutrition 2004
Sterol regulatory element-binding protein-1 mediates the effect of insulin on hexokinase II gene expression in human muscle cells
Yvan Gosmain, Etienne Lefai, Stephan Ryser, Marina Roques, Hubert Vidal
Diabetes 2004
Maintaining cholesterol homeostasis: Sterol regulatory element-binding proteins
LW Weber
World journal of gastroenterology : WJG 2004
Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins
Lutz-W Weber, Meinrad Boll, Andreas Stampfl
World journal of gastroenterology : WJG 2004
Unraveling Lipid Metabolism With Microarrays: Implications for Diabetes and Obesity
J Waring, C Rondinone
Unraveling Lipid Metabolism With Microarrays: Implications for Diabetes and Obesity 2004
Insulin Regulation of Sterol Regulatory Element-binding Protein-1 Expression in L-6 Muscle Cells and 3T3 L1 Adipocytes
KJ Nadeau, JW Leitner, I Gurerich, B Draznin
The Journal of biological chemistry 2004
Mlx Is the Functional Heteromeric Partner of the Carbohydrate Response Element-binding Protein in Glucose Regulation of Lipogenic Enzyme Genes
AK Stoeckman, L Ma, HC Towle
The Journal of biological chemistry 2004
Rosiglitazone Induction of Insig-1 in White Adipose Tissue Reveals a Novel Interplay of Peroxisome Proliferator-activated Receptor γ and Sterol Regulatory Element-binding Protein in the Regulation of Adipogenesis
HR Kast-Woelbern, SL Dana, RM Cesario, L Sun, LY de Grandpre, ME Brooks, DL Osburn, A Reifel-Miller, K Klausing, MD Leibowitz
The Journal of biological chemistry 2004
SREBP-1c Mediates the Insulin-dependent Hepatic Glucokinase Expression
SY Kim, H Kim, TH Kim, SS Im, SK Park, IK Lee, KS Kim, YH Ahn
The Journal of biological chemistry 2004
Adipocyte Determination- and Differentiation-dependent Factor 1/Sterol Regulatory Element-binding Protein 1c Regulates Mouse Adiponectin Expression
JB Seo, HM Moon, MJ Noh, YS Lee, HW Jeong, EJ Yoo, WS Kim, J Park, BS Youn, JW Kim, SD Park, JB Kim
The Journal of biological chemistry 2004
Regulatory Role of Glycogen Synthase Kinase 3 for Transcriptional Activity of ADD1/SREBP1c
KH Kim, MJ Song, EJ Yoo, SS Choe, SD Park, JB Kim
The Journal of biological chemistry 2004
Differential Regulation of Sterol Regulatory Element-binding Protein 1c Transcriptional Activity by Insulin and Liver X Receptor during Liver Development
A Bobard, I Hainault, P Ferré, F Foufelle, P Bossard
The Journal of biological chemistry 2004
Selective Association of Sterol Regulatory Element-binding Protein Isoforms with Target Promoters in Vivo
MK Bennett, JI Toth, TF Osborne
The Journal of biological chemistry 2004
In Vitro Suppression of the Lipogenic Pathway by the Nonnucleoside Reverse Transcriptase Inhibitor Efavirenz in 3T3 and Human Preadipocytes or Adipocytes
KE Hadri, M Glorian, C Monsempes, MN Dieudonné, R Pecquery, Y Giudicelli, M Andreani, I Dugail, B Fève
The Journal of biological chemistry 2004
Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation
C Lelliott, AJ Vidal-Puig
International Journal of Obesity 2004
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice
PM Alli, ML Pinn, EM Jaffee, JM McFadden, FP Kuhajda
Oncogene 2004
In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin
SR Commerford, L Peng, JJ Dubé, RM O'Doherty
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2004
Differential effect of saturated and polyunsaturated fatty acids on hepatic glucose metabolism in humans
JN Clore, JS Stillman, J Li, SJ O'Keefe, JR Levy
American journal of physiology. Endocrinology and metabolism 2004
Further Lowering of Muscle Lipid Oxidative Capacity in Obese Subjects after Biliopancreatic Diversion
R Fabris, G Mingrone, G Milan, M Manco, M Granzotto, AD Pozza, A Scarda, R Serra, AV Greco, G Federspil, R Vettor
The Journal of clinical endocrinology and metabolism 2004
Immunobiology of Organ Transplantation
DS Wilkes, WJ Burlingham
2004
Modulation of Adipoinsular Axis in Prediabetic Zucker Diabetic Fatty Rats by Diazoxide
R Alemzadeh, KM Tushaus
Endocrinology 2004
Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway
I Guillet-Deniau, AL Pichard, A Koné, C Esnous, M Nieruchalski, J Girard, C Prip-Buus
Journal of cell science 2004
Leptin replacement therapy but not dietary polyunsaturated fatty acid alleviates HIV protease inhibitor-induced dyslipidemia and lipodystrophy in mice
TM Riddle, CJ Fichtenbaum, DY Hui
Journal of acquired immune deficiency syndromes (1999) 2003
Occupancy and Function of the −150 Sterol Regulatory Element and −65 E-Box in Nutritional Regulation of the Fatty Acid Synthase Gene in Living Animals
MJ Latasa, MJ Griffin, YS Moon, C Kang, HS Sul
Molecular and cellular biology 2003
Lipoatrophic diabetes and other related syndromes
Elif Arioglu Oral
Reviews in Endocrine and Metabolic Disorders 2003
Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c
YS Lee, HH Lee, J Park, EJ Yoo, CA Glackin, YI Choi, SH Jeon, RH Seong, SD Park, JB Kim
Nucleic Acids Research 2003
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini
International Textbook of Diabetes Mellitus 2003
Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c
YA Yang, PJ Morin, WF Han, T Chen, DM Bornman, EW Gabrielson, ES Pizer
Experimental Cell Research 2003
Adiponutrin mRNA expression in white adipose tissue is rapidly induced by meal-feeding a high-sucrose diet
DA Polson, MP Thompson
Biochemical and Biophysical Research Communications 2003
Effects of inhibiting transcription and protein synthesis on basal and insulin-stimulated leptin gene expression and leptin secretion in cultured rat adipocytes
MJ Moreno-Aliaga, KL Stanhope, FM Gregoire, CH Warden, PJ Havel
Biochemical and Biophysical Research Communications 2003
Transduction of Leptin Growth Signals in Placental Cells is Independent of JAK-STAT Activation
M Caüzac, D Czuba, J Girard, SH Mouzon
Placenta 2003
Immunology: Fast and feel good?
VK Kuchroo, LB Nicholson
Nature 2003
Divergent effects of soy protein diet on the expression of adipocytokines
A Nagasawa, K Fukui, M Kojima, K Kishida, N Maeda, H Nagaretani, T Hibuse, H Nishizawa, S Kihara, M Waki, K Takamatsu, T Funahashi, Y Matsuzawa
Biochemical and Biophysical Research Communications 2003
Effect of Carbohydrate Overfeeding on Whole Body and Adipose Tissue Metabolism in Humans
K Minehira, V Bettschart, H Vidal, N Vega, VD Vetta, V Rey, P Schneiter, L Tappy
Obesity research 2003
Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement
H Ono, H Shimano, H Katagiri, N Yahagi, H Sakoda, Y Onishi, M Anai, T Ogihara, M Fujishiro, AY Viana, Y Fukushima, M Abe, N Shojima, M Kikuchi, N Yamada, Y Oka, T Asano
Diabetes 2003
Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation
Nica M Borradaile, Linda E de Dreu, Murray W Huff
Diabetes 2003
The Transcription Factor SREBP-1c Is Instrumental in the Development of β-Cell Dysfunction
H Wang, P Maechler, PA Antinozzi, L Herrero, KA Hagenfeldt-Johansson, A Björklund, CB Wollheim
The Journal of biological chemistry 2003
The Transcription Factors HIF-1 and HNF-4 and the Coactivator p300 Are Involved in Insulin-regulated Glucokinase Gene Expression via the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
U Roth, K Curth, TG Unterman, T Kietzmann
The Journal of biological chemistry 2003
Role of IRS-3 in the Insulin Signaling of IRS-1-deficient Brown Adipocytes
M Arribas, AM Valverde, M Benito
The Journal of biological chemistry 2003
Insulin and Hypoxia Share Common Target Genes but Not the Hypoxia-inducible Factor-1α
S Yim, SM Choi, Y Choi, N Lee, J Chung, H Park
The Journal of biological chemistry 2003
Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue
D Letexier, C Pinteur, V Large, V Fréring, M Beylot
Journal of lipid research 2003
Integrative physiology of human adipose tissue
KN Frayn, F Karpe, BA Fielding, IA Macdonald, SW Coppack
International Journal of Obesity 2003
Adipocyte functions are modulated by cell size change: potential involvement of an integrin/ERK signalling pathway
C Farnier, S Krief, M Blache, F Diot-Dupuy, G Mory, P Ferre, R Bazin
International Journal of Obesity 2003
Study of the Alteration of Gene Expression in Adipose Tissue of Diet-Induced Obese Mice by Microarray and Reverse Transcription-Polymerase Chain Reaction Analyses
RC Moraes, A Blondet, K Birkenkamp-Demtroeder, J Tirard, TF Orntoft, A Gertler, P Durand, D Naville, M Bégeot
Endocrinology 2003
Essential Role of Insulin-Like Growth Factor I Receptor in Insulin-Induced Fetal Brown Adipocyte Differentiation
C Mur, M Arribas, M Benito, AM Valverde
Endocrinology 2003
Functional Characterization of the Human Resistin Promoter with Adipocyte Determination- and Differentiation-Dependent Factor 1/Sterol Regulatory Element Binding Protein 1c and CCAAT Enhancer Binding Protein-α
JB Seo, MJ Noh, EJ Yoo, SY Park, J Park, IK Lee, SD Park, JB Kim
Molecular Endocrinology 2003
Cloning of cDNA encoding the nuclear form of chicken sterol response element binding protein-2 (SREBP-2), chromosomal localization, and tissue expression of chicken SREBP-1 and -2 genes
S Assaf, D Hazard, F Pitel, M Morisson, M Alizadeh, F Gondret, C Diot, A Vignal, M Douaire, S Lagarrigue
Poultry science 2003
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in liver
Jay Horton, Joseph Goldstein, Michael Brown
Journal of Clinical Investigation 2002
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c
F Foufelle, P Ferré
Biochemical Journal 2002
Adipose tissue gene expression in patients with a loss of function mutation in the leptin receptor
K Clément, N Vega, M Laville, V Pelloux, B Guy-Grand, A Basdevant, H Vidal
International Journal of Obesity 2002
Encyclopedia of Molecular Biology
B Mannervik
Encyclopedia of Molecular Biology 2002
Gene therapy for rheumatoid arthritis
N Bessis, C Doucet, V Cottard, AM Douar, H Firat, C Jorgensen, M Mezzina, MC Boissier
The Journal of Gene Medicine 2002
Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin
MC Sugden, K Bulmer, GF Gibbons, BL Knight, MJ Holness
Biochemical Journal 2002
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
T Peng, TR Golub, DM Sabatini
Molecular and cellular biology 2002
Specific increase in leptin production in obese (falfa) rat adipose cells
S Turban, I Hainault, J Truccolo, J Andre, P Ferre, A Quignard-Boulange, M Guerre-Millo
Biochemical Journal 2002
The Molecular Control of Adipogenesis, with Special Reference to Lymphatic Pathology
ED Rosen
Annals of the New York Academy of Sciences 2002
The E-box like sterol regulatory element mediates the suppression of human Δ-6 desaturase gene by highly unsaturated fatty acids
TY Nara, WS He, C Tang, SD Clarke, MT Nakamura
Biochemical and Biophysical Research Communications 2002
SREBP-1: Gene Regulatory Key to Syndrome X?
D Müller-Wieland, J Kotzka
Annals of the New York Academy of Sciences 2002
Adipogenesis: forces that tip the scales
OA MacDougald, S Mandrup
Trends in Endocrinology & Metabolism 2002
Intracellular fatty acid downregulates ob gene expression in 3T3-L1 adipocytes
T Arai, Y Kawakami, T Matsushima, Y Okuda, K Yamashita
Biochemical and Biophysical Research Communications 2002
Insulin-Stimulated Fatty Acid Synthase Gene Expression Does Not Require Increased Sterol Response Element Binding Protein 1 Transcription in Primary Adipocytes
DG Palmer, GA Rutter, JM Tavaré
Biochemical and Biophysical Research Communications 2002
Activation of MAP kinase by insulin and vanadate in adipocytes from young and old rats
JC Molero, C Pérez, C Martı́nez, M Villar, A Andrés, Y Fermı́n, JM Carrascosa
Molecular and Cellular Endocrinology 2002
Sterol regulatory element binding proteins: relationship of adipose tissue gene expression with obesity in humans
H Oberkofler, N Fukushima, H Esterbauer, F Krempler, W Patsch
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 2002
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes
M Amemiya-Kudo, H Shimano, AH Hasty, N Yahagi, T Yoshikawa, T Matsuzaka, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, J Osuga, K Harada, T Gotoda, R Sato, S Kimura, S Ishibashi, N Yamada
Journal of lipid research 2002
Xanthine oxidase is involved in free radical production in type 1 diabetes: protection by allopurinol
MC Desco, M Asensi, R Márquez, J Martínez-Valls, M Vento, FV Pallardó, J Sastre, J Viña
Diabetes 2002
Human Obesity and Type 2 Diabetes Are Associated With Alterations in SREBP1 Isoform Expression That Are Reproduced Ex Vivo by Tumor Necrosis Factor- 
C Sewter, D Berger, RV Considine, G Medina, J Rochford, T Ciaraldi, R Henry, L Dohm, JS Flier, S O'Rahilly, AJ Vidal-Puig
Diabetes 2002
Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis
CM Rondinone, JM Trevillyan, J Clampit, RJ Gum, C Berg, P Kroeger, L Frost, BA Zinker, R Reilly, R Ulrich, M Butler, BP Monia, MR Jirousek, JF Waring
Diabetes 2002
Sterol Regulatory Element Binding Protein-1c Expression and Action in Rat Muscles: Insulin-Like Effects on the Control of Glycolytic and Lipogenic Enzymes and UCP3 Gene Expression
I Guillet-Deniau, V Mieulet, SL Lay, Y Achouri, D Carre, J Girard, F Foufelle, P Ferre
Diabetes 2002
The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways
EM Conway, MV de Wouwer, S Pollefeyt, K Jurk, HV Aken, AD Vriese, JI Weitz, H Weiler, PW Hellings, P Schaeffer, JM Herbert, D Collen, G Theilmeier
Journal of Experimental Medicine 2002
Insulin and Sterol-regulatory Element-binding Protein-1c (SREBP-1C) Regulation of Gene Expression in 3T3-L1 Adipocytes: IDENTIFICATION OF CCAAT/ENHANCER-BINDING PROTEIN β AS AN SREBP-1C TARGET
SL Lay, I Lefrère, C Trautwein, I Dugail, S Krief
The Journal of biological chemistry 2002
A Chemical Switch Regulates Fibrate Specificity for Peroxisome Proliferator-activated Receptor α (PPARα) Versus Liver X Receptor
J Thomas, KS Bramlett, C Montrose, P Foxworthy, PI Eacho, D McCann, G Cao, A Kiefer, J McCowan, K Yu, T Grese, WW Chin, TP Burris, LF Michael
The Journal of biological chemistry 2002
Serum leptin and its adipose gene expression during pubertal development, the estrous cycle, and different seasons in cattle1
MR Garcia, M Amstalden, SW Williams, RL Stanko, CD Morrison, DH Keisler, SE Nizielski, GL Williams
Journal of animal science 2002
Training down-regulates fatty acid synthase and body fat in obese Zucker rats:
RG Fiebig, JM Hollander, D Ney, R Boileau, E Jeffery, LL Ji
Medicine and Science in Sports and Exercise 2002
Feeding intensity and dietary protein level affect adipocyte cellularity and lipogenic capacity of muscle homogenates in growing pigs, without modification of the expression of sterol regulatory element binding protein1,2
F Gondret, B Lebret
Journal of animal science 2002
HMG-CoA Reductase Inhibitors
G Schmitz, M Torzewski
2002
Brain Somatic Cross-Talk and the Central Control of Metabolism
C Kordon, I Robinson, J Hanoune, R Dantzer, Y Christen
2002
Dual regulation of mouse Δ5- and Δ6-desaturase gene expression by SREBP-1 and PPARα
T Matsuzaka, H Shimano, N Yahagi, M Amemiya-Kudo, T Yoshikawa, AH Hasty, Y Tamura, J Osuga, H Okazaki, Y Iizuka, A Takahashi, H Sone, T Gotoda, S Ishibashi, N Yamada
Journal of lipid research 2002
Suppression of fatty acid synthase promoter by polyunsaturated fatty acids
YS Moon, MJ Latasa, MJ Griffin, HS Sul
Journal of lipid research 2002
Mechanisms of nutritional and hormonal regulation of lipogenesis
S Kersten
EMBO reports 2001
Nutrient Sensing, Leptin and Insulin Action
J Ukropec, E Šeböková, I Klimeš
Archives Of Physiology And Biochemistry 2001
New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes
AR Saltiel
Cell 2001
Antecedent protein restriction and high-fat feeding interactively sensitise the leptin response to elevated insulin
MJ Holness, MC Sugden
Molecular and Cellular Endocrinology 2001
Semicarbazide-sensitive amine oxidase activation promotes adipose conversion of 3T3-L1 cells
N Mercier, M Moldes, KE Hadri, B Fève
Biochemical Journal 2001
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands
RA DeBose-Boyd, J Ou, JL Goldstein, MS Brown
Proceedings of the National Academy of Sciences 2001
Promoter I of the ovine acetyl-CoA carboxylase-alpha gene: an E-box motif at -114 in the proximal promoter binds upstream stimulatory factor (USF)-1 and USF-2 and acts as an insulin-response sequence in differentiating adipocytes
MT Travers, AJ Vallance, HT Gourlay, CA Gill, I Klein, CB Bottema, MC Barber
Biochemical Journal 2001
Angiotensin II-responsive element is the insulin-responsive element in the adipocyte fatty acid synthase gene: role of adipocyte determination and differentiation factor 1/sterol-regulatory-element-binding protein 1c
S Kim, I Dugail, M Standridge, K Claycombe, J Chun, N Moustaïd-Moussa
Biochemical Journal 2001
Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes
H Shimano
Progress in Lipid Research 2001
Proteolytic Activation of SREBPs during Adipocyte Differentiation
J Inoue, H Kumagai, T Terada, M Maeda, M Shimizu, R Sato
Biochemical and Biophysical Research Communications 2001
Sterol Regulatory Element Binding Protein 1c (SREBP-1c) Expression in Human Obesity
M Kolehmainen, H Vidal, E Alhava, MI Uusitupa
Obesity 2001
The FIRE3-Mediated Sterol Response of the FAS Promoter Requires NF-Y/CBF as a Coactivator
SS Wolf, K Roder, S Sickinger, M Schweizer
Biological Chemistry 2001
Antiretroviral therapy-associated hyperlipidaemia in HIV disease
V Mooser, A Carr
Current Opinion in Lipidology 2001
The roles of PPARs in adipocyte differentiation
PA Grimaldi
Progress in Lipid Research 2001
Role of Sp1 and Sp3 in the Transcriptional Regulation of the Rat Fatty Acid Synthase Gene
SS Wolf, K Roder, M Schweizer
Archives of Biochemistry and Biophysics 2001
Obesity and the regulation of energy balance
BM Spiegelman, JS Flier
Cell 2001
Transcriptional Regulation of the Leptin Promoter by Insulin-Stimulated Glucose Metabolism in 3T3-L1 Adipocytes
MJ Moreno-Aliaga, KL Stanhope, PJ Havel
Biochemical and Biophysical Research Communications 2001
Regulation by Insulin of Gene Expression in Human Skeletal Muscle and Adipose Tissue: Evidence for Specific Defects in Type 2 Diabetes
PH Ducluzeau, N Perretti, M Laville, F Andreelli, N Vega, JP Riou, H Vidal
Diabetes 2001
Adenovirus-Mediated Overexpression of Sterol Regulatory Element Binding Protein-1c Mimics Insulin Effects on Hepatic Gene Expression and Glucose Homeostasis in Diabetic Mice
D Becard, I Hainault, D Azzout-Marniche, L Bertry-Coussot, P Ferre, F Foufelle
Diabetes 2001
Polyunsaturated Fatty Acids Suppress Sterol Regulatory Element-binding Protein 1c Promoter Activity by Inhibition of Liver X Receptor (LXR) Binding to LXR Response Elements
T Yoshikawa, H Shimano, N Yahagi, T Ide, M Amemiya-Kudo, T Matsuzaka, M Nakakuki, S Tomita, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, A Takahashi, H Sone, J Osuga, T Gotoda, S Ishibashi, N Yamada
The Journal of biological chemistry 2001
Cholesterol, a Cell Size-dependent Signal That Regulates Glucose Metabolism and Gene Expression in Adipocytes
SL Lay, S Krief, C Farnier, I Lefrère, XL Liepvre, R Bazin, P Ferré, I Dugail
The Journal of biological chemistry 2001
Progesterone Stimulates Adipocyte Determination and Differentiation 1/Sterol Regulatory Element-binding Protein 1c Gene Expression: POTENTIAL MECHANISM FOR THE LIPOGENIC EFFECT OF PROGESTERONE IN ADIPOSE TISSUE
D Lacasa, XL Liepvre, P Ferre, I Dugail
The Journal of biological chemistry 2001
Adiponutrin, a Transmembrane Protein Corresponding to a Novel Dietary- and Obesity-linked mRNA Specifically Expressed in the Adipose Lineage
S Baulande, F Lasnier, M Lucas, J Pairault
The Journal of biological chemistry 2001
Glucose Regulation of the Acetyl-CoA Carboxylase Promoter PI in Rat Hepatocytes
BL O'Callaghan, SH Koo, Y Wu, HC Freake, HC Towle
The Journal of biological chemistry 2001
Leptin signaling and aging: insight from caloric restriction
I Shimokawa, Y Higami
Mechanisms of Ageing and Development 2001
Enhanced glucose uptake into adipose tissue induced by early growth restriction augments excursions in plasma leptin response evoked by changes in insulin status
MJ Holness
International Journal of Obesity 2001
Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
T Yoshikawa, H Shimano, M Amemiya-Kudo, N Yahagi, AH Hasty, T Matsuzaka, H Okazaki, Y Tamura, Y Iizuka, K Ohashi, JI Osuga, K Harada, T Gotoda, S Kimura, S Ishibashi, N Yamada
Molecular and cellular biology 2001
Diseases of liporegulation: new perspective on obesity and related disorders
RH Unger, L Orci
The FASEB Journal 2001
Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes
M Buyse, S VIENGCHAREUN, A Bado, M Lombès
The FASEB Journal 2001
Exercise Down-Regulates Hepatic Fatty Acid Synthase in Streptozotocin-Treated Rats
RG Fiebig, JM Hollander, LL Ji
The Journal of nutrition 2001
HUMAN LIVER ALLOGRAFT ACCEPTANCE AND THE ???TOLERANCE ASSAY???: IN VITRO ANTI-DONOR T CELL ASSAYS SHOW HYPOREACTIVITY TO DONOR CELLS, BUT UNLIKE DTH, FAIL TO DETECT LINKED SUPPRESSION1:
F Geissler, E Jankowska-Gan, LD DeVito-Haynes, T Rhein, M Kalayoglu, HW Sollinger, WJ Burlingham
Transplantation 2001
Activation of Extracellular Signal-Regulated Kinases and CREB/ATF-1 Mediate the Expression of CCAAT/Enhancer Binding Proteins β and -δ in Preadipocytes
N Belmonte, BW Phillips, F Massiera, P Villageois, B Wdziekonski, P Saint-Marc, J Nichols, J Aubert, K Saeki, A Yuo, S Narumiya, G Ailhaud, C Dani
Molecular Endocrinology 2001
Increased hepatic VLDL secretion, lipogenesis, and SREBP-1 expression in the corpulent JCR:LA-cp rat
MB Elam, HG Wilcox, LM Cagen, X Deng, R Raghow, P Kumar, M Heimberg, JC Russell
Journal of lipid research 2001
Phosphatidylinositol-3,4,5-Trisphosphate Is Required for Insulin-Like Growth Factor 1-Mediated Survival of 3T3-L1 Preadipocytes**This work was supported by a grant (to A.S.) from the Medical Research Council of Canada
AM Gagnon, P Dods, N Roustan-Delatour, CS Chen, A Sorisky
Endocrinology 2001
A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis
M Miyazaki, YC Kim, JM Ntambi
Journal of lipid research 2001
ADD-1/SREBP-1 is a major determinant of tissue differential lipogenic capacity in mammalian and avian species
F Gondret, P Ferré, I Dugail
Journal of lipid research 2001
Molecular mechanisms of adipocyte differentiation
Q Tong, G S Hotamisligil
Reviews in Endocrine and Metabolic Disorders 2001
Obesity and insulin resistance
BB Kahn, JS Flier
Journal of Clinical Investigation 2000
Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction
MD Michael, RN Kulkarni, C Postic, SF Previs, GI Shulman, MA Magnuson, CR Kahn
Molecular Cell 2000
MOLECULARREGULATION OFADIPOGENESIS
ED Rosen, BM Spiegelman
Annual Review of Cell and Developmental Biology 2000
Diurnal variation in circulating leptin is dependent on gender, food intake and circulating insulin in mice
Ahrén
Acta Physiologica Scandinavica 2000
REGULATION OFMETABOLISM ANDBODYFATMASS BYLEPTIN
CA Baile, MA Della-Fera, RJ Martin
Annual Review of Nutrition 2000
Genetics of aspirin induced asthma
M Sanak, A Szczeklik
Thorax 2000
Clinical features and diagnosis of aspirin induced asthma
A Szczeklik, E Nizankowska
Thorax 2000
Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt
M Fleischmann, PB Iynedjian
Biochemical Journal 2000
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
JJ Repa, G Liang, J Ou, Y Bashmakov, JM Lobaccaro, I Shimomura, B Shan, MS Brown, JL Goldstein, DJ Mangelsdorf
Genes & development 2000
Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element
MJ Latasa, YS Moon, KH Kim, HS Sul
Proceedings of the National Academy of Sciences 2000
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
T Kakuma, Y Lee, M Higa, Z Wang, W Pan, I Shimomura, RH Unger
Proceedings of the National Academy of Sciences 2000
Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes
D Azzout-Marniche, D Bécard, C Guichard, M Foretz, P Ferré, F Foufelle
Biochemical Journal 2000
Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
I Shimomura, M Matsuda, RE Hammer, Y Bashmakov, MS Brown, JL Goldstein
Molecular Cell 2000
PHYSIOLOGICAL ANDNUTRITIONALREGULATION OFENZYMES OFTRIACYLGLYCEROLSYNTHESIS
RA Coleman, TM Lewin, DM Muoio
Annual Review of Nutrition 2000
Nutritional and insulin regulation of leptin gene expression
N Iritani
Current Opinion in Clinical Nutrition and Metabolic Care 2000
Cell and Molecular Response to Stress
KA Webster
Cell and Molecular Response to Stress 2000
Nutritional regulation of the fatty acid synthase promoter in vivo: Sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element
MJ Latasa, YS Moon, KH Kim, HS Sul
Proceedings of the National Academy of Sciences 2000
Transcriptional control of adipogenesis
SM Rangwala, MA Lazar
Annual Review of Nutrition 2000
Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes
K Schoonjans, L Gelman, C Haby, M Briggs, J Auwerx
Journal of Molecular Biology 2000
Transcriptional regulation of the adipocyte fatty acid synthase gene by agouti: interaction with insulin
KJ Claycombe, Y Wang, BH Jones, S Kim, WO Wilkison, MB Zemel, J Chun, N Moustaid-Moussa
Physiological genomics 2000
Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects
LC Hudgins, MK Hellerstein, CE Seidman, RA Neese, JD Tremaroli, J Hirsch
Journal of lipid research 2000
Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action
TF Osborne
The Journal of biological chemistry 2000
Glucose Regulation of Mouse S 14 Gene Expression in Hepatocytes: INVOLVEMENT OF A NOVEL TRANSCRIPTION FACTOR COMPLEX
SH Koo, HC Towle
The Journal of biological chemistry 2000
Different Sterol Regulatory Element-binding Protein-1 Isoforms Utilize Distinct Co-regulatory Factors to Activate the Promoter for Fatty Acid Synthase
MM Magaña, SH Koo, HC Towle, TF Osborne
The Journal of biological chemistry 2000
Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene
M Amemiya-Kudo, H Shimano, T Yoshikawa, N Yahagi, AH Hasty, H Okazaki, Y Tamura, F Shionoiri, Y Iizuka, K Ohashi, J Osuga, K Harada, T Gotoda, R Sato, S Kimura, S Ishibashi, N Yamada
The Journal of biological chemistry 2000
Suppression of Preadipocyte Differentiation and Promotion of Adipocyte Death by HIV Protease Inhibitors
P Dowell, C Flexner, PO Kwiterovich, MD Lane
The Journal of biological chemistry 2000
The Roles of Sterol Regulatory Element-binding Proteins in the Transactivation of the Rat ATP Citrate-Lyase Promoter
YA Moon, JJ Lee, SW Park, YH Ahn, KS Kim
The Journal of biological chemistry 2000
Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay
J Xu, M Teran-Garcia, JH Park, MT Nakamura, SD Clarke
The Journal of biological chemistry 2000
Sterol Regulatory Element-binding Protein-1 Is Regulated by Glucose at the Transcriptional Level
AH Hasty, H Shimano, N Yahagi, M Amemiya-Kudo, S Perrey, T Yoshikawa, J Osuga, H Okazaki, Y Tamura, Y Iizuka, F Shionoiri, K Ohashi, K Harada, T Gotoda, R Nagai, S Ishibashi, N Yamada
The Journal of biological chemistry 2000
Defect in Peroxisome Proliferator-activated Receptor α-inducible Fatty Acid Oxidation Determines the Severity of Hepatic Steatosis in Response to Fasting
T Hashimoto, WS Cook, C Qi, AV Yeldandi, JK Reddy, MS Rao
The Journal of biological chemistry 2000
Two 5′-Regions Are Required for Nutritional and Insulin Regulation of the Fatty-acid Synthase Promoter in Transgenic Mice
YS Moon, MJ Latasa, KH Kim, D Wang, HS Sul
The Journal of biological chemistry 2000
Oxysterols: Modulators of Cholesterol Metabolism and Other Processes
GJ Schroepfer
Physiological reviews 2000
The adipoinsular axis: effects of leptin on pancreatic β-cells
TJ Kieffer, JF Habener
American journal of physiology. Endocrinology and metabolism 2000
Regulation of the Fatty Acid Synthase Promoter by Insulin
HS Sul, MJ Latasa, Y Moon, KH Kim
The Journal of nutrition 2000
Diazoxide down-regulates leptin and lipid metabolizing enzymes in adipose tissue of Zucker rats
M Standridge, R Alemzadeh, M Zemel, J Koontz, N Moustaid-Moussa
The FASEB Journal 2000
An indirect role for upstream stimulatory factor in glucose-mediated induction of pyruvate kinase and S14 gene expression
E N Kaytor, J Qian, H C Towle, L K Olson
Molecular and Cellular Biochemistry 2000
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
H Shimano, JD Horton, RE Hammer, I Shimomura, MS Brown, JL Goldstein
Journal of Clinical Investigation 1999
Peroxisome proliferator activated receptor-γ, leptin and tumor necrosis factor-α mRNA expression during very low calorie diet in subcutaneous adipose tissue in obese women
JP Bastard, B Hainque, E Dusserre, E Bruckert, D Robin, P Vallier, S Perche, P Robin, G Turpin, C Jardel, M Laville, C Forest, H Vidal
Diabetes/Metabolism Research and Reviews 1999
STEROLS AND ISOPRENOIDS: Signaling Molecules Derived from the Cholesterol Biosynthetic Pathway
PA Edwards, J Ericsson
Annual Review of Biochemistry 1999
T-cell recognition of lipid peroxidation products breaks tolerance to self proteins
DM Wuttge, M Bruzelius, S Stemme
Immunology 1999
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders
TC Leone, CJ Weinheimer, DP Kelly
Proceedings of the National Academy of Sciences 1999
ADD-1 provides major new insight into the mechanism of insulin action
JS Flier, AN Hollenberg
Proceedings of the National Academy of Sciences 1999
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
M Foretz, C Guichard, P Ferré, F Foufelle
Proceedings of the National Academy of Sciences 1999
Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes
M Moldes, M Boizard, XL Liepvre, B Fève, I Dugail, J Pairault
Biochemical Journal 1999
Fatty acids: links between genes involved in fatty acid and cholesterol metabolism
TS Worgall, RJ Deckelbaum
Current Opinion in Clinical Nutrition and Metabolic Care 1999
Regulation of gene expression by glucose
P Ferré
Proceedings of the Nutrition Society 1999
Cell surface receptors, nuclear receptors and ligands that regulate adipose tissue development
G Ailhaud
Clinica Chimica Acta 1999
FIRE3 in the promoter of the rat fatty acid synthase (FAS) gene binds the ubiquitous transcription factors CBF and USF but does not mediate an insulin response in a rat hepatoma cell line
K Roder, SS Wolf, S Sickinger, M Schweizer
European Journal of Biochemistry 1999
A critical role for the peroxisome proliferator-activated receptor   (PPAR ) in the cellular fasting response: The PPAR -null mouse as a model of fatty acid oxidation disorders
TC Leone, CJ Weinheimer, DP Kelly
Proceedings of the National Academy of Sciences 1999
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
H Shimano, JD Horton, RE Hammer, I Shimomura, MS Brown, JL Goldstein
Journal of Biological Chemistry 1999
From Preadipocyte to Adipocyte: Differentiation-Directed Signals of Insulin from the Cell Surface to the Nucleus
A Sorisky
Critical Reviews in Clinical Laboratory Sciences 1999
Sterol Response Element-binding Protein 1c (SREBP1c) Is Involved in the Polyunsaturated Fatty Acid Suppression of Hepatic S14 Gene Transcription
MK Mater, AP Thelen, DA Pan, DB Jump
The Journal of biological chemistry 1999
Essential Role in Vivo of Upstream Stimulatory Factors for a Normal Dietary Response of the Fatty Acid Synthase Gene in the Liver
M Casado, VS Vallet, A Kahn, S Vaulont
The Journal of biological chemistry 1999
Sterol Regulatory Element Binding Protein-1 Expression Is Suppressed by Dietary Polyunsaturated Fatty Acids: A MECHANISM FOR THE COORDINATE SUPPRESSION OF LIPOGENIC GENES BY POLYUNSATURATED FATS
J Xu, MT Nakamura, HP Cho, SD Clarke
The Journal of biological chemistry 1999
ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose
M Foretz, C Pacot, I Dugail, P Lemarchand, C Guichard, X le Lièpvre, C Berthelier-Lubrano, B Spiegelman, JB Kim, P Ferré, F Foufelle
Molecular and cellular biology 1999
"Spot 14" Protein: A Metabolic Integrator in Normal and Neoplastic Cells
BA Cunningham, JT Moncur, JT Huntington, WB Kinlaw
Thyroid 1998
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy
I Shimomura, RE Hammer, JA Richardson, S Ikemoto, Y Bashmakov, JL Goldstein, MS Brown
Genes & development 1998
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
JD Horton, Y Bashmakov, I Shimomura, H Shimano
Proceedings of the National Academy of Sciences 1998
Specificity in cholesterol regulation of gene expression by coevolution of sterol regulatory DNA element and its binding protein
JN Athanikar, TF Osborne
Proceedings of the National Academy of Sciences 1998
Role of NF-kappaB in immune and inflammatory responses in the gut
MF Neurath, C Becker, K Barbulescu
Gut 1998
Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease
PA Edwards, J Ericsson
Current Opinion in Lipidology 1998
Glucose regulation of gene expression
F Foufelle, J Girard, P Ferré
Current Opinion in Clinical Nutrition and Metabolic Care 1998
ADD1/SREBP-1c Mediates Insulin-Induced Gene Expression Linked to the MAP Kinase Pathway
J Kotzka, D Müller-Wieland, A Koponen, D Njamen, L Kremer, G Roth, M Munck, B Knebel, W Krone
Biochemical and Biophysical Research Communications 1998
Leptin and its receptors: regulators of whole-body energy homeostasis
KL Houseknecht, CP Portocarrero
Domestic Animal Endocrinology 1998
Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins
JT Pai, O Guryev, MS Brown, JL Goldstein
The Journal of biological chemistry 1998
Specific immunosuppression of the indirect recognition pathway
N Suciu-Foca, R Cortesini
Transplantation Proceedings 1998
ADD1/SREBP1 activates PPAR  through the production of endogenous ligand
JB Kim, HM Wright, M Wright, BM Spiegelman
Proceedings of the National Academy of Sciences 1998
ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand
J B Kim, H M Wright, M Wright, B M Spiegelman
Proceedings of the National Academy of Sciences 1998
ADD1/SREBP1 activates PPARγ through the production of endogenous ligand
Jae Bum Kim, Harold M. Wright, Margaret Wright, Bruce M. Spiegelman
Proceedings of the National Academy of Sciences 1998
Obesity-related Overexpression of Fatty-acid Synthase Gene in Adipose Tissue Involves Sterol Regulatory Element-binding Protein Transcription Factors
M Boizard, XL Liepvre, P Lemarchand, F Foufelle, P Ferré, I Dugail
The Journal of biological chemistry 1998
Oleate Potentiates Oxysterol Inhibition of Transcription from Sterol Regulatory Element-1-regulated Promoters and Maturation of Sterol Regulatory Element-binding Proteins
DP Thewke, SR Panini, M Sinensky
The Journal of biological chemistry 1998
Transcriptional Activation of the Stearoyl-CoA Desaturase 2 Gene by Sterol Regulatory Element-binding Protein/Adipocyte Determination and Differentiation Factor 1
DE Tabor, JB Kim, BM Spiegelman, PA Edwards
The Journal of biological chemistry 1998
Sterol Regulatory Element Binding Protein-1 Activates the Cholesteryl Ester Transfer Protein Gene in Vivo but Is Not Required for Sterol Up-regulation of Gene Expression
RA Chouinard, Y Luo, TF Osborne, A Walsh, AR Tall
The Journal of biological chemistry 1998
Glucose-dependent Translocation of Insulin Promoter Factor-1 (IPF-1) between the Nuclear Periphery and the Nucleoplasm of Single MIN6 β-Cells
I Rafiq, HJ Kennedy, GA Rutter
The Journal of biological chemistry 1998
Identification of Diazepam-binding Inhibitor/Acyl-CoA-binding Protein as a Sterol Regulatory Element-binding Protein-responsive Gene
JV Swinnen, P Alen, W Heyns, G Verhoeven
The Journal of biological chemistry 1998
STABLE LUNG ALLOGRAFT OUTCOME CORRELATES WITH THE PRESENCE OF INTRAGRAFT DONOR-DERIVED LEUKOCYTES1:
PJ O'Connell, A Mba-Jonas, GE Leverson, DM Heisey, KC Meyer, RB Love, WJ Burlingham
Transplantation 1998
Advances in Molecular and Cellular Endocrinology
MR Pollak, EM Brown
Advances in Molecular and Cellular Endocrinology 1997

← Previous 1 2 3 … 23 24 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 1 policy sources
Referenced in 4 patents
Referenced in 3 Wikipedia pages
188 readers on Mendeley
See more details