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Citations to this article

LRP: a multifunctional scavenger and signaling receptor
Joachim Herz, Dudley K. Strickland
Joachim Herz, Dudley K. Strickland
Published September 15, 2001
Citation Information: J Clin Invest. 2001;108(6):779-784. https://doi.org/10.1172/JCI13992.
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LRP: a multifunctional scavenger and signaling receptor

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Authors

Joachim Herz, Dudley K. Strickland

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Total
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2019
Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature
DT Au, AL Arai, WE Fondrie, SC Muratoglu, DK Strickland
Current drug targets 2018
C. elegans—An Emerging Model to Study Metal-Induced RAGE-Related Pathologies
A Pinkas, AC Martins, M Aschner
International journal of environmental research and public health 2018
Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor–Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in HumansHighlights
F Oldoni, JC van Capelleveen, N Dalila, JC Wolters, J Heeren, RJ Sinke, DY Hui, GM Dallinga-Thie, R Frikke-Schmidt, KG Hovingh, B van de Sluis, A Tybjærg-Hansen, JA Kuivenhoven
Arteriosclerosis, thrombosis, and vascular biology 2018
Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function
WJ Shen, S Asthana, FB Kraemer, S Azhar
Journal of lipid research 2018
LRP1 is required for novobiocin-mediated fibronectin turnover
NM Boel, MC Hunter, AL Edkins
Scientific Reports 2018
LRP1 expression in colon cancer predicts clinical outcome
C Boulagnon-Rombi, C Schneider, C Leandri, A Jeanne, V Grybek, AM Bressenot, C Barbe, B Marquet, S Nasri, C Coquelet, C Fichel, N Bouland, A Bonnomet, R Kianmanesh, AS Lebre, O Bouché, MD Diebold, G Bellon, S Dedieu
Oncotarget 2018
Unappreciated role of low-density lipoprotein receptor-related protein 1 in pancreatic β cells: Multiple roles of low-density lipoprotein receptor-related protein 1 in glucose and lipid metabolism
H Watada
Journal of Diabetes Investigation 2018
Mechanisms by Which LRP1 (Low-Density Lipoprotein Receptor–Related Protein-1) Maintains Arterial Integrity: Keeping Your Vascular Smooth Muscle Happy and Healthy
SL Gonias
Arteriosclerosis, thrombosis, and vascular biology 2018
LRP1 (Low-Density Lipoprotein Receptor–Related Protein 1) Regulates Smooth Muscle Contractility by Modulating Ca 2+ Signaling and Expression of Cytoskeleton-Related Proteins
DT Au, Z Ying, EO Hernández-Ochoa, WE Fondrie, B Hampton, M Migliorini, R Galisteo, MF Schneider, A Daugherty, DL Rateri, DK Strickland, SC Muratoglu
Arteriosclerosis, thrombosis, and vascular biology 2018
Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells
T Gáll, D Pethő, A Nagy, Z Hendrik, G Méhes, L Potor, M Gram, B Åkerström, A Smith, P Nagy, G Balla, J Balla
Frontiers in physiology 2018
Host Cell Proteases: Cathepsins
Brix K
2018
Chaperones: Methods and Protocols
SK Calderwood, TL Prince
Chaperones 2017
Functional Roles of the Interaction of APP and Lipoprotein Receptors
T Pohlkamp, CR Wasser, J Herz
Frontiers in molecular neuroscience 2017
Low-Density Lipoprotein Receptor-Related Protein-1 Signaling in Angiogenesis
H Mao, L Xie, X Pi
Frontiers in Cardiovascular Medicine 2017
Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition
CC Liu, J Hu, N Zhao, J Wang, N Wang, JR Cirrito, T Kanekiyo, DM Holtzman, G Bu
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017
Endothelial LRP1 – A Potential Target for the Treatment of Alzheimer’s Disease: Theme: Drug Discovery, Development and Delivery in Alzheimer’s Disease Guest Editor: Davide Brambilla
SE Storck, CU Pietrzik
Pharmaceutical Research 2017
Aging alters mRNA expression of amyloid transporter genes at the blood-brain barrier
D Osgood, MC Miller, AA Messier, L Gonzalez, GD Silverberg
Neurobiology of Aging 2017
Low-Density Lipoprotein Receptor-Related Protein-1 (LRP1) C4408R Mutant Promotes Amyloid Precursor Protein (APP) α-Cleavage in Vitro
H Hou, A Habib, D Zi, K Tian, J Tian, B Giunta, D Sawmiller, J Tan
NeuroMolecular Medicine 2017
LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis
X Xian, Y Ding, M Dieckmann, L Zhou, F Plattner, M Liu, JS Parks, RE Hammer, P Boucher, S Tsai, J Herz
eLife 2017
LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit
I Kadurin, SW Rothwell, B Lana, M Nieto-Rostro, AC Dolphin
Scientific Reports 2017
The LDL Receptor-Related Protein 1: At the Crossroads of Lipoprotein Metabolism and Insulin Signaling
DT Au, DK Strickland, SC Muratoglu
Journal of Diabetes Research 2017
Extracellular vesicles do not contribute to higher circulating levels of soluble LRP1 in idiopathic dilated cardiomyopathy
S Roura, C Gálvez-Montón, D Gonzalo-Calvo, AG Valero, P Gastelurrutia, E Revuelta-López, C Prat-Vidal, C Soler-Botija, A Llucià-Valldeperas, I Perea-Gil, O Iborra-Egea, FE Borràs, J Lupón, V Llorente-Cortés, A Bayes-Genis
Journal of Cellular and Molecular Medicine 2017
Proteome-wide Identification of Glycosylation-dependent Interactors of Galectin-1 and Galectin-3 on Mesenchymal Retinal Pigment Epithelial (RPE) Cells
J Obermann, CS Priglinger, J Merl-Pham, A Geerlof, S Priglinger, M Götz, SM Hauck
Molecular & cellular proteomics : MCP 2017
Tissue-type plasminogen activator regulates macrophage activation and innate immunity
E Mantuano, P Azmoon, C Brifault, MA Banki, AS Gilder, WM Campana, SL Gonias
Blood 2017
APP, APLP2 and LRP1 interact with PCSK9 but are not required for PCSK9-mediated degradation of the LDLR in vivo
T Fu, YY Guan, J Xu, Y Wang
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2017
Deficiency of LRP1 in Mature Adipocytes Promotes Diet-Induced Inflammation and Atherosclerosis—Brief ReportHighlights
ES Konaniah, DG Kuhel, JE Basford, NL Weintraub, DY Hui
Arteriosclerosis, thrombosis, and vascular biology 2017
Identification of the protective mechanisms of Lactoferrin in the irradiated salivary gland
M Sakai, T Matsushita, R Hoshino, H Ono, K Ikai, T Sakai
Scientific Reports 2017
The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis
D Brungs, J Chen, M Aghmesheh, KL Vine, TM Becker, MG Carolan, M Ranson
Oncotarget 2017
A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease
MR PrabhuDas, CL Baldwin, PL Bollyky, DM Bowdish, K Drickamer, M Febbraio, J Herz, L Kobzik, M Krieger, J Loike, B McVicker, TK Means, SK Moestrup, SR Post, T Sawamura, S Silverstein, RC Speth, JC Telfer, GM Thiele, XY Wang, SD Wright, JE Khoury
Journal of immunology (Baltimore, Md. : 1950) 2017
Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation
C Brifault, AS Gilder, E Laudati, M Banki, SL Gonias
The Journal of biological chemistry 2017
A Cross Talk between Neuronal Urokinase-type Plasminogen Activator (uPA) and Astrocytic uPA Receptor (uPAR) Promotes Astrocytic Activation and Synaptic Recovery in the Ischemic Brain
A Diaz, P Merino, LG Manrique, JP Ospina, L Cheng, F Wu, V Jeanneret, M Yepes
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017
LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: towards pre-clinical simulation of symptomatic ICH
B Niego, BR Broughton, H Ho, CG Sobey, RL Medcalf
Fluids and barriers of the CNS 2017
Low-density lipoprotein receptor–related protein 1 attenuates house dust mite–induced eosinophilic airway inflammation by suppressing dendritic cell–mediated adaptive immune responses
A Mishra, X Yao, A Saxena, EM Gordon, M Kaler, RA Cuento, AV Barochia, PK Dagur, JP McCoy, KJ Keeran, KR Jeffries, X Qu, ZX Yu, SJ Levine
Journal of Allergy and Clinical Immunology 2017
Phase II study of paclitaxel associated with lipid core nanoparticles (LDE) as third-line treatment of patients with epithelial ovarian carcinoma.
Graziani SR, Vital CG, Morikawa AT, Van Eyll BM, Fernandes Junior HJ, Kalil Filho R, Maranhão RC
Medical Oncology 2017
LRP in Endothelial Cells: A Little Goes a Long Way
DK Strickland, SC Muratoglu
Arteriosclerosis, thrombosis, and vascular biology 2016
LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
L Yang, CC Liu, H Zheng, T Kanekiyo, Y Atagi, L Jia, D Wang, A Nsongo, D Can, H Xu, XF Chen, G Bu
Journal of Neuroinflammation 2016
Tissue and urokinase plasminogen activators instigate the degeneration of retinal ganglion cells in a mouse model of glaucoma
SK Chintala
Experimental Eye Research 2016
Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood–brain barrier in vitro and in vivo
H Kafa, JT Wang, N Rubio, R Klippstein, PM Costa, HA Hassan, JK Sosabowski, SS Bansal, JE Preston, NJ Abbott, KT Al-Jamal
Journal of Controlled Release 2016
Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis
Y Ding, X Xian, WL Holland, S Tsai, J Herz
EBioMedicine 2016
BK Ca channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells
M Wakle-Prabagaran, RA Lorca, X Ma, SJ Stamnes, C Amazu, JJ Hsiao, CM Karch, KL Hyrc, ME Wright, SK England
Proceedings of the National Academy of Sciences 2016
Mesd extrinsically promotes phagocytosis by retinal pigment epithelial cells
X Chen, F Guo, ME LeBlanc, Y Ding, C Zhang, A Shakya, W Li
Cell Biology and Toxicology 2016
Roles of low-density lipoprotein receptor-related protein 1 in tumors
P Xing, Z Liao, Z Ren, J Zhao, F Song, G Wang, K Chen, J Yang
Chinese journal of cancer 2016
Lrp4 in astrocytes modulates glutamatergic transmission
XD Sun, L Li, F Liu, ZH Huang, JC Bean, HF Jiao, A Barik, SM Kim, H Wu, C Shen, Y Tian, TW Lin, R Bates, A Sathyamurthy, YJ Chen, DM Yin, L Xiong, HP Lin, JX Hu, BM Li, TM Gao, WC Xiong, L Mei
Nature Neuroscience 2016
Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function
L Auderset, LM Landowski, L Foa, KM Young
Stem Cells International 2016
IgE-tailpiece associates with α-1-antitrypsin (A1AT) to protect IgE from proteolysis without compromising its ability to interact with FcεRI
PM Quinn, DW Dunne, SC Moore, RJ Pleass
Scientific Reports 2016
The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains
E Laudati, AS Gilder, MS Lam, R Misasi, M Sorice, SL Gonias, E Mantuano
Molecular and Cellular Neuroscience 2016
LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes
AN Hamlin, JE Basford, A Jaeschke, DY Hui
The Journal of biological chemistry 2016
Neuroserpin Attenuates H2O2-Induced Oxidative Stress in Hippocampal Neurons via AKT and BCL-2 Signaling Pathways
Y Cheng, YP Loh, NP Birch
Journal of Molecular Neuroscience 2016
Role of LRP-1 in cancer cell migration in 3-dimensional collagen matrix
A Appert-Collin, A Bennasroune, P Jeannesson, C Terryn, G Fuhrmann, H Morjani, S Dedieu
Cell adhesion & migration 2016
Microglia Ontology and Signaling
A ElAli, S Rivest
Frontiers in Cell and Developmental Biology 2016
High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191
JM Prasad, PA Young, DK Strickland
The Journal of biological chemistry 2016
Nano-zymography Using Laser-Scanning Confocal Microscopy Unmasks Proteolytic Activity of Cell-Derived Microparticles
A Briens, M Gauberti, J Parcq, J Montaner, D Vivien, SM de lizarrondo
Theranostics 2016
Inactivation of Tm6sf2 , a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins
E Smagris, S Gilyard, S BasuRay, JC Cohen, HH Hobbs
The Journal of biological chemistry 2016
Predictive model of thrombospondin-1 and vascular endothelial growth factor in breast tumor tissue
JA Rohrs, CD Sulistio, SD Finley
npj Systems Biology and Applications 2016
FGFR1 and NTRK3 actionable alterations in “Wild-Type” gastrointestinal stromal tumors
E Shi, J Chmielecki, CM Tang, K Wang, MC Heinrich, G Kang, CL Corless, D Hong, KE Fero, JD Murphy, PT Fanta, SM Ali, MD Siena, AM Burgoyne, S Movva, L Madlensky, GM Heestand, JC Trent, R Kurzrock, D Morosini, JS Ross, O Harismendy, JK Sicklick
Journal of Translational Medicine 2016
High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature
F Wang, J Jia, N Lal, D Zhang, AP Chiu, A Wan, I Vlodavsky, B Hussein, B Rodrigues
Cardiovascular Research 2016
Urokinase-type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central Nervous System
P Merino, A Diaz, V Jeanneret, F Wu, E Torre, L Cheng, M Yepes
The Journal of biological chemistry 2016
Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE
PA Young, M Migliorini, DK Strickland
The Journal of biological chemistry 2016
Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP)
CD Nardis, P Lössl, M Biggelaar, PK Madoori, N Leloup, K Mertens, AJ Heck, P Gros
The Journal of biological chemistry 2016
Plasminogen-receptor KT : plasminogen activation and beyond
MJ Flick, TH Bugge
Journal of Thrombosis and Haemostasis 2016
Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage
S Cao, M Zheng, Y Hua, G Chen, RF Keep, G Xi
Stroke; a journal of cerebral circulation 2016
Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response
DF Canova, AM Pavlov, LV Norling, T Gobbetti, S Brunelleschi, PL Fauder, N Cenac, GB Sukhorukov, M Perretti
Journal of Controlled Release 2015
Germinated Brown Rice Alters A β (1-42) Aggregation and Modulates Alzheimer’s Disease-Related Genes in Differentiated Human SH-SY5Y Cells
NH Azmi, M Ismail, N Ismail, MU Imam, NB Alitheen, MA Abdullah
Evidence-Based Complementary and Alternative Medicine 2015
Lentivirus-induced knockdown of LRP1 induces osteoarthritic-like effects and increases susceptibility to apoptosis in chondrocytes via the nuclear factor-κB pathway
E Yang, H Zheng, H Peng, Y Ding
Experimental and therapeutic medicine 2015
Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain
CC Liu, J Hu, CW Tsai, M Yue, HL Melrose, T Kanekiyo, G Bu
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Discovering Molecules That Regulate Efferocytosis Using Primary Human Macrophages and High Content Imaging
S Santulli-Marotto, A Gervais, J Fisher, B Strake, CA Ogden, C Riveley, J Giles-Komar, N Palaniyar
PloS one 2015
The Significance and Management of Thrombocytopenia in Antiphospholipid Syndrome
B Artim-Esen, R Diz-Küçükkaya, M İnanç
Current Rheumatology Reports 2015
Bright expression of CD91 identifies highly activated human dendritic cells that can be expanded by defensins
M Cappelletti, P Presicce, F Calcaterra, D Mavilio, SD Bella
Immunology 2015
Genetic variations in sites of affinity between FVIII and LRP1 are not associated with high FVIII levels in venous thromboembolism
LF Bittar, LH Siqueira, FA Orsi, EV de Paula, JM Annichino-Bizzacchi
Scientific Reports 2015
Cancer and embryo expression protein�65 promotes cancer cell growth and metastasis
G Jin, L Peng, J Zhang, L Qu, C Shou
Oncology Letters 2015
Hematopoietic Stem/Progenitor Cells Directly Contribute to Arteriosclerotic Progression via Integrin β 2: Hematopoietic Stem Cells in Arteriosclerosis
X Wang, M Gao, S Schouteden, A Roebroek, K Eggermont, PP van Veldhoven, G Liu, T Peters, K Scharffetter-Kochanek, CM Verfaillie, Y Feng
Stem Cells 2015
Physiological, pathological, and structural implications of non-enzymatic protein–protein interactions of the multifunctional human transglutaminase 2
K Kanchan, M Fuxreiter, L Fésüs
Cellular and Molecular Life Sciences 2015
Association between Variants in Atopy-Related Immunologic Candidate Genes and Pancreatic Cancer Risk
M Cotterchio, E Lowcock, Z Bider-Canfield, M Lemire, C Greenwood, S Gallinger, T Hudson, JS Chang
PloS one 2015
Inactivation of ANGPTL3 Reduces Hepatic VLDL-triglyceride Secretion
Y Wang, V Gusarova, S Banfi, J Gromada, JC Cohen, HH Hobbs
Journal of lipid research 2015
Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway
CS Casey, Y Atagi, Y Yamazaki, M Shinohara, M Tachibana, Y Fu, G Bu, T Kanekiyo
The Journal of biological chemistry 2015
K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells
P Costales, P Fuentes-Prior, J Castellano, E Revuelta-Lopez, MÁ Corral-Rodríguez, L Nasarre, L Badimon, V Llorente-Cortes
The Journal of biological chemistry 2015
Effects and relationship of intermittent hypoxia on serum lipid levels, hepatic low-density lipoprotein receptor-related protein 1, and hypoxia-inducible factor 1α
P Li, J Wu, L Zhao, X Feng
Sleep and Breathing 2015
Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain
JM Prasad, M Migliorini, R Galisteo, DK Strickland
The Journal of biological chemistry 2015
Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising “Hot-Spot” Lysine Residues
M Biggelaar, JJ Madsen, JH Faber, MG Zuurveld, C der Zwaan, OH Olsen, HR Stennicke, K Mertens, AB Meijer
The Journal of biological chemistry 2015
Keratinocyte-Secreted Heat Shock Protein-90alpha: Leading Wound Reepithelialization and Closure
A Bhatia, K O'Brien, M Chen, DT Woodley, W Li
Advances in Skin & Wound Care 2015
Targeted Intracellular Delivery of Resveratrol to Glioblastoma Cells Using Apolipoprotein E-Containing Reconstituted HDL as a Nanovehicle
SH Kim, BB Adhikari, S Cruz, MP Schramm, JA Vinson, V Narayanaswami, Y Feng
PloS one 2015
Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells
M Nakato, M Matsuo, N Kono, M Arita, H Arai, J Ogawa, N Kioka, K Ueda
Journal of lipid research 2015
Initiating protease with modular domains interacts with β-glucan recognition protein to trigger innate immune response in insects
D Takahashi, BL Garcia, MR Kanost
Proceedings of the National Academy of Sciences 2015
Apoptotic cell recognition receptors and scavenger receptors
KK Penberthy, KS Ravichandran
Immunological Reviews 2015
Role of LRP1 and ERK and cAMP Signaling Pathways in Lactoferrin-Induced Lipolysis in Mature Rat Adipocytes
K Ikoma-Seki, K Nakamura, S Morishita, T Ono, K Sugiyama, H Nishino, H Hirano, M Murakoshi, S Martin
PloS one 2015
ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?
T Kanekiyo, H Xu, G Bu
Neuron 2014
LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo
T Grimmer, O Goldhardt, LH Guo, BH Yousefi, S Förster, A Drzezga, C Sorg, P Alexopoulos, H Förstl, A Kurz, R Perneczky
NeuroImage: Clinical 2014
The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease
T Kanekiyo, G Bu
Frontiers in aging neuroscience 2014
Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Regulates the Stability and Function of GluA1 α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid (AMPA) Receptor in Neurons
M Gan, P Jiang, P McLean, T Kanekiyo, G Bu, YP Tang
PloS one 2014
Shotgun proteomics: Identification of unique protein profiles of apoptotic bodies from biliary epithelial cells: LLEO ET AL
A Lleo, W Zhang, WH McDonald, EH Seeley, PS Leung, RL Coppel, AA Ansari, DH Adams, S Afford, P Invernizzi, ME Gershwin
Hepatology 2014
LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins
B Schorch, S Song, FR van Diemen, HH Bock, P May, J Herz, TR Brummelkamp, P Papatheodorou, K Aktories
Proceedings of the National Academy of Sciences 2014
HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca 2+ concentration via activation of Src kinase and nitric oxide signaling pathways
KA Krogh, N Wydeven, K Wickman, SA Thayer
Journal of Neurochemistry 2014
The role of choroid plexus in IVIG-induced beta-amyloid clearance
H Gu, Z Zhong, W Jiang, E Du, R Dodel, J Liu, MR Farlow, W Zheng, Y Du
Neuroscience 2014
KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae
Y Kanai, D Wang, N Hirokawa
The Journal of Cell Biology 2014
Agile Delivery of Protein Therapeutics to CNS
X Yi, DS Manickam, A Brynskikh, AV Kabanov
Journal of Controlled Release 2014
The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer
MW Hance, KD Nolan, JS Isaacs
Cancers 2014
Specific Deletion of LDL Receptor-Related Protein on Macrophages Has Skewed In Vivo Effects on Cytokine Production by Invariant Natural Killer T Cells
R Covarrubias, AJ Wilhelm, AS Major
PloS one 2014
Red blood cell, hemoglobin and heme in the progression of atherosclerosis
VÃ Jeney, GÃ Balla, JÃ Balla
Frontiers in physiology 2014
Low Density Lipoprotein Receptor-related Protein 1 (LRP1)-mediated Endocytic Clearance of a Disintegrin and Metalloproteinase with Thrombospondin Motifs-4 (ADAMTS-4): FUNCTIONAL DIFFERENCES OF NON-CATALYTIC DOMAINS OF ADAMTS-4 AND ADAMTS-5 IN LRP1 BINDING
K Yamamoto, K Owen, AE Parker, SD Scilabra, J Dudhia, DK Strickland, L Troeberg, H Nagase
The Journal of biological chemistry 2014
Anti-tissue Plasminogen Activator (tPA) as an Effective Therapy of Neonatal Hypoxia-Ischemia with and without Inflammation
D Yang, CY Kuan
CNS Neuroscience & Therapeutics 2014
Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF: Upper panel: Binding of biotinylated PEDF to control HEK293 cells ( A ) or HEK293 cells transfected with PLXDC1 ( B ), PLXDC2 ( C ), intracellular domain deleted PLXDC2 ( D , PLXDC2-dC), extracellular domain (ECD) deleted PLXDC1 ( E ), or ECD deleted PLXDC2 ( F ). Binding was detected by stretavidin-alkaline phosphatase, shown as deep purple color. Lower panel: Live cell staining of an epitope tag of control HEK293 cells ( G ) or HEK293 cells transfected with PLXDC1 ( H ), PLXDC2 ( I ), intracellular domain deleted PLXDC2 ( J , PLXDC2-dC), ECD-deleted PLXDC1 ( K ), or ECD deleted PLXDC2 ( L ). All constructs have the epitope tag engineered after the secretion signal at the N-terminus
G Cheng, M Zhong, R Kawaguchi, M Kassai, M Al-Ubaidi, J Deng, M Ter-Stepanian, H Sun
eLife 2014
Two Faces of Cathepsin D: Physiological Guardian Angel and Pathological Demon
ZK Ellis
Biology and Medicine 2014
LRP-1: Functions, Signaling and Implications in Kidney and Other Diseases
L Lin, K Hu
International journal of molecular sciences 2014
Smooth Muscle Cell Deletion of Low-Density Lipoprotein Receptor-Related Protein 1 Augments Angiotensin II-Induced Superior Mesenteric Arterial and Ascending Aortic Aneurysms
FM Davis, DL Rateri, A Balakrishnan, DA Howatt, DK Strickland, SC Muratoglu, CM Haggerty, BK Fornwalt, LA Cassis, A Daugherty
Arteriosclerosis, thrombosis, and vascular biology 2014
Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo
Gilat-Frenkel M, Boehm-Cagan A, Liraz O, Xian X, Herz J, Michaelson DM
Current Alzheimer research 2014
Immunoglobulin-like Domain Containing Receptor 1 Mediates Fat-stimulated Cholecystokinin Secretion
Rashmi Chandra, Yu Wang, Rafiq Shahid, Steven Vigna, Neil Freedman, Rodger Liddle
Journal of Clinical Investigation 2013
Establishment of Tumor-Associated Immunity Requires Interaction of Heat Shock Proteins with CD91
YJ Zhou, MN Messmer, RJ Binder
Cancer immunology research 2013
Neuronal clearance of amyloid-β by endocytic receptor LRP1
T Kanekiyo, JR Cirrito, CC Liu, M Shinohara, J Li, DR Schuler, M Shinohara, DM Holtzman, G Bu
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease
Abhay P. Sagare, Robert D. Bell, Berislav V. Zlokovic
Journal of Alzheimer's disease : JAD 2013
Low-density lipoprotein receptor-related protein 1 (LRP1)-dependent cell signaling promotes axonal regeneration
C Yoon, EA van Niekerk, K Henry, T Ishikawa, S Orita, MH Tuszynski, WM Campana
The Journal of biological chemistry 2013
Decreased Expression of Hepatic Low-Density Lipoprotein Receptor–Related Protein 1 in Hypothyroidism: A Novel Mechanism of Atherogenic Dyslipidemia in Hypothyroidism
JH Moon, HJ Kim, HM Kim, SH Choi, S Lim, YJ Park, HC Jang, BS Cha
Thyroid 2013
Natural history of the bruise: formation, elimination, and biological effects of oxidized hemoglobin
V Jeney, JW Eaton, G Balla, J Balla
Oxidative Medicine & Cellular Longevity 2013
Antisense oligonucleotide inhibition of cholesteryl ester transfer protein enhances RCT in hyperlipidemic, CETP transgenic, LDLr-/- mice
TA 3rd, MJ Graham, RG Lee, AE Mullick, W Fu, D Norris, RM Crooke
Journal of lipid research 2013
The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events
J Craig, I Mikhailenko, N Noyes, M Migliorini, DK Strickland
PloS one 2013
Role of dyslipidemia in impairment of energy metabolism, oxidative stress, inflammation and cardiovascular disease in chronic kidney disease
ND Vaziri
Clinical and Experimental Nephrology 2013
Properties of human blood monocytes. I. CD91 expression and log orthogonal light scatter provide a robust method to identify monocytes that is more accurate than CD14 expression: Identification of Human Monocytes with Anti-CD91
D Hudig, KW Hunter, WJ Diamond, D Redelman
Cytometry Part B Clinical Cytometry 2013
tPA Regulates Neurite Outgrowth by Phosphorylation of LRP5/6 in Neural Progenitor Cells
SH Lee, HM Ko, KJ Kwon, J Lee, SH Han, DW Han, JH Cheong, JH Ryu, CY Shin
Molecular Neurobiology 2013
HIV-1 Tat interacts with and regulates the localization and processing of amyloid precursor protein
J Kim, JH Yoon, YS Kim
PloS one 2013
Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons
K Yamauchi, T Yamauchi, E Mantuano, K Murakami, K Henry, K Takahashi, WM Campana
PloS one 2013
LRP-1: a checkpoint for the extracellular matrix proteolysis
N Etique, L Verzeaux, S Dedieu, H Emonard
BioMed Research International 2013
LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype
W Maier, M Bednorz, S Meister, A Roebroek, S Weggen, U Schmitt, CU Pietrzik
Molecular Neurodegeneration 2013
Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture
A Hussain, M Luong, A Pooley, BP Nathan
Journal of Biomedical Science 2013
Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke
SE Lakhan, A Kirchgessner, D Tepper, A Leonard
Frontiers in neurology 2013
Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally
W Li, F Tsen, D Sahu, A Bhatia, M Chen, G Multhoff, DT Woodley
International review of cell and molecular biology 2013
Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo
F Tsen, A Bhatia, K O'Brien, CF Cheng, M Chen, N Hay, B Stiles, DT Woodley, W Li
Molecular and cellular biology 2013
Sortilin, a novel APOE receptor implicated in Alzheimer disease
AS Carlo
Prion 2013
Quantitative dissection of the binding contributions of ligand lysines of the receptor-associated protein (RAP) to the low density lipoprotein receptor-related protein (LRP1)
K Dolmer, A Campos, PG Gettins
The Journal of biological chemistry 2013
Amino acid copolymers that alleviate experimental autoimmune encephalomyelitis in vivo interact with heparan sulfates and glycoprotein 96 in APCs
PA Koenig, E Spooner, N Kawamoto, JL Strominger, HL Ploegh
Journal of immunology (Baltimore, Md. : 1950) 2013
Overexpression of hemopexin in the diabetic eye: a new pathogenic candidate for diabetic macular edema
C Hernández, M Garcia-Ramírez, R Simó
Diabetes care 2013
Alpha2-macroglobulin as a promising biomarker for cerebral small vessel disease in acute ischemic stroke patients
T Nezu, N Hosomi, S Aoki, K Deguchi, H Masugata, N Ichihara, H Ohyama, T Ohtsuki, M Kohno, M Matsumoto
Journal of Neurology 2013
The impact of autophagic processes on the intracellular fate of Helicobacter pylori: More tricks from an enigmatic pathogen?
NS Deen, SJ Huang, L Gong, T Kwok, RJ Devenish
Autophagy 2013
New horizons for lipoprotein receptors: communication by  -propellers
OM Andersen, R Dagil, BB Kragelund
Journal of lipid research 2013
Down expression of LRP1B promotes cell migration via RhoA/Cdc42 pathway and actin cytoskeleton remodeling in renal cell cancer
S Ni, J Hu, Y Duan, S Shi, R Li, H Wu, Y Qu, Y Li
Cancer Science 2013
Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1)
A Wahler, AS Beyer, IE Keller, C Schnack, B Einem, C Pröpper, TM Boeckers, ID Peltan, DK Strickland, BT Hyman, CA von Arnim
Biochemical Journal 2013
Discovery and characterization of two Nimrod superfamily members in Anopheles gambiae
J Midega, J Blight, F Lombardo, M Povelones, F Kafatos, GK Christophides
Pathogens and Global Health 2013
LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease
C Spuch, S Ortolano, C Navarro
Frontiers in physiology 2012
Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities
AP Sagare, R Deane, BV Zlokovic
Pharmacology & Therapeutics 2012
LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β
T Kanekiyo, CC Liu, M Shinohara, J Li, G Bu
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Enhanced brain amyloid-β clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease
H Qosa, AH Abuznait, RA Hill, A Kaddoumi
Journal of Alzheimer's disease : JAD 2012
Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice
G Xu, CC Green, SE Fromholt, DR Borchelt
Alzheimer's research & therapy 2012
Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease
Abhay P Sagare, Robert D Bell, Berislav V Zlokovic
2012
Nerve Growth Factor-Mediated Regulation of Low Density Lipoprotein Receptor-Related Protein Promoter Activation
TR Grana, J LaMarre, BE Kalisch
Cellular and Molecular Neurobiology 2012
Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair: Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades
CE Wilkins-Port, SP Higgins, CE Higgins, I Kobori-Hotchkiss, PJ Higgins
Biochemistry Research International 2012
Statins in the management of dyslipidemia associated with chronic kidney disease
M Epstein, ND Vaziri
Nature Reviews Nephrology 2012
TNFα-Induced Apoptosis Enabled by CCN1/CYR61: Pathways of Reactive Oxygen Species Generation and Cytochrome c Release
V Juric, CC Chen, LF Lau
PloS one 2012
Uptake Mechanism of ApoE-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model
S Wagner, A Zensi, SL Wien, SE Tschickardt, W Maier, T Vogel, F Worek, CU Pietrzik, J Kreuter, H Briesen
PloS one 2012
Low Density Lipoprotein Receptor-Related Protein 1 Dependent Endosomal Trapping and Recycling of Apolipoprotein E
A Laatsch, M Panteli, M Sornsakrin, B Hoffzimmer, T Grewal, J Heeren
PloS one 2012
Low Level of Low-Density Lipoprotein Receptor-Related Protein 1 Predicts an Unfavorable Prognosis of Hepatocellular Carcinoma after Curative Resection
XY Huang, GM Shi, RP Devbhandari, AW Ke, Y Wang, XY Wang, Z Wang, YH Shi, YS Xiao, ZB Ding, Z Dai, Y Xu, WP Jia, ZY Tang, J Fan, J Zhou
PloS one 2012
A proximal pair of positive charges provides the dominant ligand-binding contribution to complement-like domains from the LRP (low-density lipoprotein receptor-related protein)
PG Gettins, K Dolmer
Biochemical Journal 2012
Renal LRP2 expression in man and chicken is estrogen-responsive
JA Plieschnig, ET Gensberger, TM Bajari, WJ Schneider, M Hermann
Gene 2012
Dissecting mannose 6-phosphate-insulin-like growth factor 2 receptor complexes that control activation and uptake of plasminogen in cells
V Leksa, K Pfisterer, G Ondrovičová, B Binder, S Lakatošová, C Donner, HB Schiller, A Zwirzitz, K Mrvová, V Pevala, E Kutejová, H Stockinger
The Journal of biological chemistry 2012
Genomic DNA Methylation Changes in NYGGF4-Overexpression 3T3-L1 Adipocytes
L Yang, ML Tong, X Chi, M Zhang, CM Zhang, XR Guo
International journal of molecular sciences 2012
A link between host plant adaptation and pesticide resistance in the polyphagous spider mite Tetranychus urticae
W Dermauw, N Wybouw, S Rombauts, B Menten, J Vontas, M Grbic, RM Clark, R Feyereisen, TV Leeuwen
Proceedings of the National Academy of Sciences 2012
Immunotherapy of tumors with α2-macroglobulin-antigen complexes pre-formed in vivo
S Pawaria, LE Kropp, RJ Binder
PloS one 2012
Low-density lipoprotein receptor-related protein-1 (LRP1) mediates autophagy and apoptosis caused by Helicobacter pylori VacA
K Yahiro, M Satoh, M Nakano, J Hisatsune, H Isomoto, J Sap, H Suzuki, F Nomura, M Noda, J Moss, T Hirayama
The Journal of biological chemistry 2012
Engulfment protein GULP is regulator of transforming growth factor-β response in ovarian cells
CI Ma, C Martin, Z Ma, A Hafiane, M Dai, JJ Lebrun, RS Kiss
The Journal of biological chemistry 2012
Lipoprotein Receptor–Related Protein 1 Regulates Collagen 1 Expression, Proteolysis, and Migration in Human Pleural Mesothelial Cells
TA Tucker, LT Williams, K Koenig, H Kothari, AA Komissarov, G Florova, AP Mazar, TC Allen, K Bdeir, LV Rao, S Idell
American journal of respiratory cell and molecular biology 2012
NYGGF4 (PID1) effects on insulin resistance are reversed by metformin in 3T3-L1 adipocytes
J Qiu, Y Wang, C Shi, H Yue, ZY Qin, G Zhu, X Cao, C Ji, Y Cui, X Guo
Journal of Bioenergetics and Biomembranes 2012
LRP-1-CD44, a New Cell Surface Complex Regulating Tumor Cell Adhesion
G Perrot, B Langlois, J Devy, A Jeanne, L Verzeaux, S Almagro, H Sartelet, C Hachet, C Schneider, E Sick, M David, M Khrestchatisky, H Emonard, L Martiny, S Dedieu
Molecular and cellular biology 2012
α-Lipoic acid protects 3T3-L1 adipocytes from NYGGF4 (PID1) overexpression-induced insulin resistance through increasing phosphorylation of IRS-1 and Akt.
Wang YM, Lin XF, Shi CM, Lu L, Qin ZY, Zhu GZ, Cao XG, Ji CB, Qiu J, Guo XR
Journal of Bioenergetics and Biomembranes 2012
Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer
Pires LA, Hegg R, Freitas FR, Tavares ER, Almeida CP, Baracat EC, Maranhão RC
Brazilian Journal of Medical and Biological Research 2012
Secreted heat shock protein-90 (Hsp90) in wound healing and cancer
W Li, D Sahu, F Tsen
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2011
Molecular Chaperones
SK Calderwood, TL Prince
Molecular Chaperones 2011
Association of ApoE and LRP mRNA levels with dementia and AD neuropathology
A Akram, J Schmeidler, P Katsel, PR Hof, V Haroutunian
Neurobiology of Aging 2011
Low Density Lipoprotein Receptor-Related Protein (LRP) is Decreased in Optic Neuropathy of Alzheimer’s Disease
LM Cuzzo, FN Ross-Cisneros, KM Yee, MY Wang, AA Sadun
Journal of Neuro-Ophthalmology 2011
Giardia lamblia low-density lipoprotein receptor-related protein is involved in selective lipoprotein endocytosis and parasite replication
MR Rivero, SL Miras, R Quiroga, AS Rópolo, MC Touz
Molecular Microbiology 2011
PAI-1: An Integrator of Cell Signaling and Migration
RP Czekay, CE Wilkins-Port, SP Higgins, J Freytag, JM Overstreet, RM Klein, CE Higgins, R Samarakoon, PJ Higgins
International Journal of Cell Biology 2011
Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1
Y Bertrand, JC Currie, J Poirier, M Demeule, A Abulrob, D Fatehi, D Stanimirovic, H Sartelet, JP Castaigne, R Béliveau
British Journal of Cancer 2011
A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α–positive tumors
D Sahu, Z Zhao, F Tsen, CF Cheng, R Park, AJ Situ, J Dai, A Eginli, S Shams, M Chen, TS Ulmer, P Conti, DT Woodley, W Li
Molecular biology of the cell 2011
Stromal LRP1 in lung adenocarcinoma predicts clinical outcome
H Meng, G Chen, X Zhang, Z Wang, DG Thomas, TJ Giordano, DG Beer, MM Wang
Clinical cancer research 2011
Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-β uptake
T Kanekiyo, J Zhang, Q Liu, CC Liu, L Zhang, G Bu
Journal of Neuroscience 2011
Macrophage LRP1 Suppresses Neo-Intima Formation during Vascular Remodeling by Modulating the TGF-β Signaling Pathway
SC Muratoglu, S Belgrave, AP Lillis, M Migliorini, S Robinson, E Smith, L Zhang, DK Strickland
PloS one 2011
Molecular Basis for the Interaction of Low Density Lipoprotein Receptor-related Protein 1 (LRP1) with Integrin αMβ2
S Ranganathan, C Cao, J Catania, M Migliorini, L Zhang, DK Strickland
The Journal of biological chemistry 2011
LRAD3, a Novel LDL Receptor Family Member that Modulates Amyloid Precursor Protein Trafficking
S Ranganathan, NC Noyes, M Migliorini, JA Winkles, FD Battey, BT Hyman, E Smith, M Yepes, I Mikhailenko, DK Strickland
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Premature Ligand-Receptor Interaction during Biosynthesis Limits the Production of Growth Factor Midkine and Its Receptor LDL Receptor-related Protein 1*
K Sakamoto, G Bu, S Chen, Y Takei, K Hibi, Y Kodera, LM McCormick, A Nakao, M Noda, T Muramatsu, K Kadomatsu
The Journal of biological chemistry 2011
The internal region leucine-rich repeat 6 of decorin interacts with low density lipoprotein receptor-related protein-1, modulates transforming growth factor (TGF)-β-dependent signaling, and inhibits TGF-β-dependent fibrotic response in skeletal muscles
C Cabello-Verrugio, C Santander, C Cofré, MJ Acuña, F Melo, E Brandan
The Journal of biological chemistry 2011
Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis
D Derocq, C Prébois, M Beaujouin, V Laurent-Matha, S Pattingre, GK Smith, E Liaudet-Coopman
Oncogene 2011
Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)
W Zhang, AS Coldefy, SR Hubbard, SJ Burden
The Journal of biological chemistry 2011
A role for the heat shock protein–CD91 axis in the initiation of immune responses to tumors
S Pawaria, MN Messmer, YJ Zhou, RJ Binder
Immunologic Research 2011
LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE – carrying lipoproteins
J Haas, AG Beer, P Widschwendter, J Oberdanner, K Salzmann, B Sarg, H Lindner, J Herz, JR Patsch, P Marschang
Atherosclerosis 2011
The extracellular region of Lrp4 is sufficient to mediate neuromuscular synapse formation
AM Gomez, SJ Burden
Developmental Dynamics 2011
Lead exposure increases levels of β-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice
H Gu, X Wei, AD Monnot, CV Fontanilla, M Behl, MR Farlow, W Zheng, Y Du
Neuroscience Letters 2011
Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier
K Bdeir, AA Higazi, I Kulikovskaya, M Christofidou-Solomidou, SA Vinogradov, TC Allen, S Idell, R Linzmeier, T Ganz, DB Cines
American journal of respiratory and critical care medicine 2010
tPA Activates LDL Receptor-Related Protein 1-Mediated Mitogenic Signaling Involving the p90RSK and GSK3β Pathway
L Lin, G Bu, WM Mars, WB Reeves, S Tanaka, K Hu
The American Journal of Pathology 2010
Transport characteristics of a novel peptide platform for CNS therapeutics
Y Bertrand, JC Currie, M Demeule, A Régina, C Ché, A Abulrob, D Fatehi, H Sartelet, R Gabathuler, JP Castaigne, D Stanimirovic, R Béliveau
Journal of Cellular and Molecular Medicine 2010
Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease
Y Kajiwara, S Franciosi, N Takahashi, L Krug, J Schmeidler, K Taddei, V Haroutunian, U Fried, M Ehrlich, RN Martins, S Gandy, JD Buxbaum
Molecular Neurodegeneration 2010
Low-density lipoprotein receptor-related protein-1 : a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain
BV Zlokovic, R Deane, AP Sagare, RD Bell, EA Winkler
Journal of Neurochemistry 2010
Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family
M Dieckmann, MF Dietrich, J Herz
Biological Chemistry 2010
Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease
X Han
Biochimica et Biophysica Acta 2010
Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling
H Meng, X Zhang, SJ Lee, DK Strickland, DA Lawrence, MM Wang
The Journal of biological chemistry 2010
The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment
TM Antalis, MS Buzza, KM Hodge, JD Hooper, S Netzel‑Arnett
Biochemical Journal 2010
Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator
R Jin, G Yang, G Li
Neurobiology of Disease 2010
LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways
B Langlois, G Perrot, C Schneider, P Henriet, H Emonard, L Martiny, S Dedieu
PloS one 2010
Low density lipoprotein receptor-related protein 1 (LRP1) forms a signaling complex with platelet-derived growth factor receptor-beta in endosomes and regulates activation of the MAPK pathway
SC Muratoglu, I Mikhailenko, C Newton, M Migliorini, DK Strickland
The Journal of biological chemistry 2010
Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo
MF Dietrich, L der Weyden, HM Prosser, A Bradley, J Herz, DJ Adams
PloS one 2010
tPA Is a Potent Mitogen for Renal Interstitial Fibroblasts
S Hao, H Shen, Y Hou, WM Mars, Y Liu
The American Journal of Pathology 2010
The ins and outs of cholesterol in the vertebrate retina
SJ Fliesler, L Bretillon
Journal of lipid research 2010
Signaling through LRP1: Protection from atherosclerosis and beyond
P Boucher, J Herz
Biochemical Pharmacology 2010
Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation
AR Jockheck-Clark, EV Bowers, MB Totonchy, J Neubauer, SV Pizzo, CV Nicchitta
Journal of immunology (Baltimore, Md. : 1950) 2010
Cloning, sequence identification, and tissue expression analysis of novel chicken NYGGF4 gene
C Man, X Li, D Zhao
Molecular and Cellular Biochemistry 2010
Effects of NYGGF4 knockdown on insulin sensitivity and mitochondrial function in 3T3-L1 adipocytes
CM Zhang, XQ Zeng, R Zhang, CB Ji, ML Tong, X Chi, XL Li, JZ Dai, M Zhang, Y Cui, XR Guo
Journal of Bioenergetics and Biomembranes 2010
Immunohistochemical localization of low density lipoprotein receptor-related protein 1 and α2-Macroglobulin in retinal and choroidal tissue of proliferative retinopathies
PF Barcelona, JD Luna, GA Chiabrando, CP Juarez, IA Bhutto, T Baba, DS McLeod, MC Sánchez, GA Lutty
Experimental Eye Research 2010
Localizing matrix metalloproteinase activities in the pericellular environment: MMPs in the pericellular environment
G Murphy, H Nagase
FEBS Journal 2010
Structure of the Minimal Interface Between ApoE and LRP
M Guttman, JH Prieto, TM Handel, PJ Domaille, EA Komives
Journal of Molecular Biology 2010
Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages
M Gorovoy, A Gaultier, WM Campana, GS Firestein, SL Gonias
Journal of leukocyte biology 2010
A fragment of the scaffolding protein RanBP9 is increased in Alzheimer’s disease brains and strongly potentiates amyloid-β peptide generation
MK Lakshmana, JY Chung, S Wickramarachchi, E Tak, E Bianchi, EH Koo, DE Kang
The FASEB Journal 2010
Significance of LRP and PPAR-γ Expression in Lipomatous Soft Tissue Tumors
T Tajima, T Morii, F Kikuchi, A Matsumine, H Murata, H Nobuto, K Mochizuki
The open orthopaedics journal 2010
Pro-cathepsin D interacts with the extracellular domain of the β chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth
M Beaujouin, C Prébois, D Derocq, V Laurent-Matha, O Masson, S Pattingre, P Coopman, N Bettache, J Grossfield, RE Hollingsworth, H Zhang, Z Yao, BT Hyman, P van der Geer, GK Smith, E Liaudet-Coopman
Journal of cell science 2010
Decoding of Lipoprotein−Receptor Interactions: Properties of Ligand Binding Modules Governing Interactions with Apolipoprotein E
M Guttman, JH Prieto, JE Croy, EA Komives
Biochemistry 2010
LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation
L Zhou, Y Takayama, P Boucher, MD Tallquist, J Herz
PloS one 2009
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1
M Behl, Y Zhang, AD Monnot, W Jiang, W Zheng
Toxicology and Applied Pharmacology 2009
Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1
M Guttman, GN Betts, H Barnes, M Ghassemian, P der Geer, EA Komives
PROTEOMICS 2009
MicroRNA-205 inhibits tumor cell migration through down-regulating the expression of the LDL receptor-related protein 1
H Song, G Bu
Biochemical and Biophysical Research Communications 2009
Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease
MP Marzolo, G Bu
Seminars in Cell & Developmental Biology 2009
Heparanase: busy at the cell surface
L Fux, N Ilan, RD Sanderson, I Vlodavsky
Trends in Biochemical Sciences 2009
Mammalian iron transport
GJ Anderson, CD Vulpe
Cellular and Molecular Life Sciences 2009
Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling
MP Jedrychowski, CA Gartner, SP Gygi, L Zhou, J Herz, KV Kandror, PF Pilch
The Journal of biological chemistry 2009
Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin
H Hayashi, RB Campenot, DE Vance, JE Vance
The Journal of biological chemistry 2009
Causes of dysregulation of lipid metabolism in chronic renal failure
ND Vaziri
Seminars in Dialysis 2009
The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain
C Zhang, J An, DK Strickland, M Yepes
The American Journal of Pathology 2009
Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1
BC McFarland, J Stewart, A Hamza, R Nordal, DJ Davidson, J Henkin, CL Gladson
Cancer research 2009
Specificity of binding of the low density lipoprotein receptor-related protein to different conformational states of the clade E serpins plasminogen activator inhibitor-1 and proteinase nexin-1
JK Jensen, K Dolmer, PG Gettins
The Journal of biological chemistry 2009
Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation
MK Lakshmana, IS Yoon, E Chen, E Bianchi, EH Koo, DE Kang
The Journal of biological chemistry 2009
MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway
S Chattopadhyay, VI Shubayev
Glia 2009
Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9
H Song, Y Li, J Lee, AL Schwartz, G Bu
Cancer research 2009
Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11
R Spoelgen, KW Adams, M Koker, AV Thomas, OM Andersen, PJ Hallett, KK Bercury, DF Joyner, M Deng, WH Stoothoff, DK Strickland, TE Willnow, BT Hyman
Neuroscience 2009
Smooth Muscle LDL Receptor-Related Protein-1 Inactivation Reduces Vascular Reactivity and Promotes Injury-Induced Neointima Formation
JE Basford, ZW Moore, L Zhou, J Herz, DY Hui
Arteriosclerosis, thrombosis, and vascular biology 2009
Receptor-associated protein (RAP) has two high-affinity binding sites for the low-density lipoprotein receptor-related protein (LRP): consequences for the chaperone functions of RAP
JK Jensen, K Dolmer, C Schar, PG Gettins
Biochemical Journal 2009
Processing of Pseudomonas aeruginosa Exotoxin A Is Dispensable for Cell Intoxication
J Morlon-Guyot, J Méré, A Bonhoure, B Beaumelle
Infection and immunity 2009
Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis
A Gaultier, X Wu, NL Moan, S Takimoto, G Mukandala, K Akassoglou, WM Campana, SL Gonias
Journal of cell science 2009
Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice
R Szabo, JP Hobson, K Christoph, P Kosa, K List, TH Bugge
Development (Cambridge, England) 2009
PAI-1 and kidney fibrosis
Ma LJ, Fogo AB
2009
Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease.
Deane R, Bell RD, Sagare A, Zlokovic BV
CNS & neurological disorders drug targets 2009
Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases
L Troeberg, K Fushimi, R Khokha, H Emonard, P Ghosh, H Nagase
The FASEB Journal 2008
LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling
J Terrand, V Bruban, L Zhou, W Gong, ZE Asmar, P May, K Zurhove, P Haffner, C Philippe, E Woldt, RL Matz, C Gracia, D Metzger, J Auwerx, J Herz, P Boucher
The Journal of biological chemistry 2008
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies
AP Lillis, LB van Duyn, JE Murphy-Ullrich, DK Strickland
Physiological reviews 2008
The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells
K Yamada, T Hashimoto, C Yabuki, Y Nagae, M Tachikawa, DK Strickland, Q Liu, G Bu, JM Basak, DM Holtzman, S Ohtsuki, T Terasaki, T Iwatsubo
The Journal of biological chemistry 2008
Receptor-associated protein (RAP) plays a central role in modulating Abeta deposition in APP/PS1 transgenic mice
G Xu, C Karch, N Li, N Lin, D Fromholt, V Gonzales, DR Borchelt
PloS one 2008
Environmental Enrichment Counteracts Alzheimer’s Neurovascular Dysfunction in TgCRND8 Mice
A Herring, H Yasin, O Ambrée, N Sachser, W Paulus, K Keyvani
Brain Pathology 2008
C-terminal 37 residues of LRP promote the amyloidogenic processing of APP independent of FE65
MK Lakshmana, E Chen, IS Yoon, DE Kang
Journal of Cellular and Molecular Medicine 2008
Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration
SM Blake, V Strasser, N Andrade, S Duit, R Hofbauer, WJ Schneider, J Nimpf
The EMBO Journal 2008
Low and high affinity receptors mediate cellular uptake of heparanase
O Ben-Zaken, I Shafat, S Gingis-Velitski, H Bangio, IK Kelson, T Alergand, Y Amor, RB Maya, I Vlodavsky, N Ilan
The International Journal of Biochemistry & Cell Biology 2008
Regulation of tumor necrosis factor receptor-1 and the IKK-NF- B pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor
A Gaultier, S Arandjelovic, S Niessen, CD Overton, MR Linton, S Fazio, WM Campana, BF 3rd, SL Gonias
Blood 2008
Mechanisms regulating plasminogen activators in transformed retinal ganglion cells
N Rock, SK Chintala
Experimental Eye Research 2008
Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis
MF Galliano, E Toulza, N Jonca, SL Gonias, G Serre, M Guerrin
PloS one 2008
alpha-Macroglobulins are present in some gram-negative bacteria: characterization of the alpha2-macroglobulin from Escherichia coli
N Doan, PG Gettins
The Journal of biological chemistry 2008
Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain
J An, C Zhang, R Polavarapu, X Zhang, X Zhang, M Yepes
Blood 2008
Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families
SK Nilsson, S Christensen, MK Raarup, RO Ryan, MS Nielsen, G Olivecrona
The Journal of biological chemistry 2008
Regulated intramembrane proteolysis of the low-density lipoprotein receptor-related protein mediates ischemic cell death
R Polavarapu, J An, C Zhang, M Yepes
The American Journal of Pathology 2008
Structural and functional consequences of tyrosine phosphorylation in the LRP1 cytoplasmic domain
GN Betts, P der Geer, EA Komives
The Journal of biological chemistry 2008
Key role of tissue plasminogen activator in neurovascular coupling
L Park, EF Gallo, J Anrather, G Wang, EH Norris, J Paul, S Strickland, C Iadecola
Proceedings of the National Academy of Sciences 2008
Variation in NPC1, the gene encoding Niemann–Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population
RP Erickson, K Larson-Thomé, L Weberg, A Szybinska, M Mossakowska, M Styczynska, M Barcikowska, J Kuznicki
Neuroscience Letters 2008
The LDL receptor-related protein can form homo-dimers in neuronal cells
A Makarova, KK Bercury, KW Adams, D Joyner, M Deng, R Spoelgen, M Koker, DK Strickland, BT Hyman
Neuroscience Letters 2008
Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function
AL Samson, ST Nevin, D Croucher, B Niego, PB Daniel, TW Weiss, E Moreno, D Monard, DA Lawrence, RL Medcalf
Journal of Neurochemistry 2008
tPA Protects Renal Interstitial Fibroblasts and Myofibroblasts from Apoptosis
K Hu, L Lin, X Tan, J Yang, G Bu, WM Mars, Y Liu
Journal of the American Society of Nephrology : JASN 2008
γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1
K Zurhove, C Nakajima, J Herz, HH Bock, P May
Science signaling 2008
LRP-1 Silencing Prevents Malignant Cell Invasion despite Increased Pericellular Proteolytic Activities
S Dedieu, B Langlois, J Devy, B Sid, P Henriet, H Sartelet, G Bellon, H Emonard, L Martiny
Molecular and cellular biology 2008
LRP-1: A new modulator of cytoskeleton dynamics and adhesive complex turnover in cancer cells
Dedieu S, Langlois B
Cell adhesion & migration 2008
Cardiovascular Activity
Vogel HG
2008
Novel actions of tissue-type plasminogen activator in chronic kidney disease: a paradigm shift
Hu K, Mars WM, Liu Y
Frontiers in bioscience : a journal and virtual library 2008
Urokinase and its receptors in chronic kidney disease.
Zhang G, Eddy AA
Frontiers in bioscience : a journal and virtual library 2008
The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimer’s Disease
Deane R, Sagare A, Zlokovic B
Current pharmaceutical design 2008
A shed form of low density lipoprotein receptor-related protein regulates peripheral nerve injury and neuropathic pain
Alban Gaultier1, Sanja Arandjelovic1, Xiaoqing Li2, Julie Janes2, Nikola Dragojlovic1, George P. Zhou2, Jenny Dolkas2, Robert R. Myers1,2, Steven L. Gonias1 and W. Marie Campana2*
Journal of Clinical Investigation 2007
tPA promotes myofibroblast activation through LRP-1-mediated recruitment of integrin signaling
Kebin Hu, Chuanyue Wu, Wendy M. Mars, and Youhua Liu
Journal of Clinical Investigation 2007
Potential mechanisms contributing to sulfatide depletion at the earliest clinically recognizable stage of Alzheimer’s disease: a tale of shotgun lipidomics
X Han
Journal of Neurochemistry 2007
Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-kappaB pathway activation
X Zhang, R Polavarapu, H She, Z Mao, M Yepes
The American Journal of Pathology 2007
Mammalian heparanase: what is the message?
V Vreys, G David
Journal of Cellular and Molecular Medicine 2007
Heparanase induces Akt phosphorylation via a lipid raft receptor
O Ben-Zaken, S Gingis-Velitski, I Vlodavsky, N Ilan
Biochemical and Biophysical Research Communications 2007
Modulation of glomerulosclerosis
LJ Ma, AB Fogo
Seminars in Immunopathology 2007
Binding and clustering of glycosaminoglycans: a common property of mono- and multivalent cell-penetrating compounds
A Ziegler, J Seelig
Biophysical Journal 2007
LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome
P Boucher, WP Li, RL Matz, Y Takayama, J Auwerx, RG Anderson, J Herz
PloS one 2007
A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells
DR Croucher, DN Saunders, GE Stillfried, M Ranson
Biochemical Journal 2007
HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes
EA Eugenin, JE King, A Nath, TM Calderon, RS Zukin, MV Bennett, JW Berman
Proceedings of the National Academy of Sciences 2007
Strategies to Improve Drug Delivery Across the Blood-Brain Barrier:
AG de Boer, PJ Gaillard
Clinical Pharmacokinetics 2007
Mechanisms of Disease: protease functions in intestinal mucosal pathobiology
TM Antalis, T Shea-Donohue, SN Vogel, C Sears, A Fasano
Nature Clinical Practice Gastroenterology & Hepatology 2007
The structure of receptor-associated protein (RAP)
D Lee, JD Walsh, M Migliorini, P Yu, T Cai, CD Schwieters, S Krueger, DK Strickland, YX Wang
Protein Science 2007
Apolipoprotein E-Containing Lipoproteins Protect Neurons from Apoptosis via a Signaling Pathway Involving Low-Density Lipoprotein Receptor-Related Protein-1
H Hayashi, RB Campenot, DE Vance, JE Vance
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Protein Kinase C-α–Mediated Regulation of Low-Density Lipoprotein Receptor–Related Protein and Urokinase Increases Astrocytoma Invasion
S Amos, M Mut, CG diPierro, JE Carpenter, A Xiao, ZA Kohutek, GT Redpath, Y Zhao, J Wang, ME Shaffrey, IM Hussaini
Cancer research 2007
Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration
C Cao, DA Lawrence, Y Li, CA von Arnim, J Herz, EJ Su, A Makarova, BT Hyman, DK Strickland, L Zhang
The EMBO Journal 2006
Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathway
LC Wilsie, AM Gonzales, RA Orlando
Lipids in Health and Disease 2006
Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein
MJ LaDu, WB Stine, M Narita, GS Getz, CA Reardon, G Bu
Biochemistry 2006
Major Involvement of Low-Density Lipoprotein Receptor-Related Protein 1 in the Clearance of Plasma Free Amyloid β-Peptide by the Liver
C Tamaki, S Ohtsuki, T Iwatsubo, T Hashimoto, K Yamada, C Yabuki, T Terasaki
Pharmaceutical Research 2006
Genetic Analysis of Mint/X11 Proteins: Essential Presynaptic Functions of a Neuronal Adaptor Protein Family
A Ho, W Morishita, D Atasoy, X Liu, K Tabuchi, RE Hammer, RC Malenka, TC Sudhof
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells
S Azhar, S Medicherla, WJ Shen, Y Fujioka, LG Fong, E Reaven, AD Cooper
Journal of lipid research 2006
ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages
AW Jehle, SJ Gardai, S Li, P Linsel-Nitschke, K Morimoto, WJ Janssen, RW Vandivier, N Wang, S Greenberg, BM Dale, C Qin, PM Henson, AR Tall
The Journal of Cell Biology 2006
Mutant Lrp1 Knock-In Mice Generated by Recombinase-Mediated Cassette Exchange Reveal Differential Importance of the NPXY Motifs in the Intracellular Domain of LRP1 for Normal Fetal Development
AJ Roebroek, S Reekmans, A Lauwers, N Feyaerts, L Smeijers, D Hartmann
Molecular and cellular biology 2006
Tissue-type plasminogen activator–mediated shedding of astrocytic low-density lipoprotein receptor–related protein increases the permeability of the neurovascular unit
R Polavarapu, MC Gongora, H Yi, S Ranganthan, DA Lawrence, D Strickland, M Yepes
Blood 2006
Adenovirus binding to blood factors results in liver cell infection and hepatotoxicity
DM Shayakhmetov, A Gaggar, S Ni, ZY Li, A Lieber
Journal of virology 2005
Heat-shock response is associated with decreased production of interleukin-6 in murine aortic vascular smooth muscle cells
IK Kim, HM Shin, W Baek
Naunyn-Schmiedeberg's Archives of Pharmacology 2005
Fibronectin Matrix Turnover Occurs through a Caveolin-1–dependent Process
J Sottile, J Chandler
Molecular biology of the cell 2005
Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-κB–dependent manner
G Yu, AH Rux, P Ma, K Bdeir, BS Sachais
Blood 2005
Pharmacokinetic and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice.
Takemoto S, Nishikawa M, Takakura Y
Pharmaceutical Research 2005
FE65 Constitutes the Functional Link between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein
CU Pietrzik
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Essential role of CD91 in re-presentation of gp96-chaperoned peptides
RJ Binder, PK Srivastava
Proceedings of the National Academy of Sciences 2004
Regulation of Brain Proteolytic Activity Is Necessary for the In Vivo Function of NMDA Receptors
M Kvajo
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice
P May, A Rohlmann, HH Bock, K Zurhove, JD Marth, ED Schomburg, JL Noebels, U Beffert, JD Sweatt, EJ Weeber, J Herz
Molecular and cellular biology 2004
Normal Development and Fertility of Knockout Mice Lacking the Tumor Suppressor Gene LRP1b Suggest Functional Compensation by LRP1
P Marschang, J Brich, EJ Weeber, JD Sweatt, JM Shelton, JA Richardson, RE Hammer, J Herz
Molecular and cellular biology 2004
The cellular biochemistry of cholesterol and statins: insights into the pathophysiology and therapy of Alzheimer's disease.
Wolozin B, Brown J 3rd, Theisler C, Silberman S
CNS Drug Reviews 2004
CD91 up-regulates upon immune stimulation in Xenopus adult but not larval peritoneal leukocytes.
Marr S, Goyos A, Gantress J, Maniero GD, Robert J
Immunogenetics 2004
Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly
AW Orr, CE Pedraza, MA Pallero, CA Elzie, S Goicoechea, DK Strickland, JE Murphy-Ullrich
The Journal of Cell Biology 2003
Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans
DM Kamikura, JA Cooper
Genes & development 2003
LRP: a bright beacon at the blood-brain barrier
J Herz
Journal of Clinical Investigation 2003
Regulation of tissue factor-factor VIIa expression on cell surfaces: a role for tissue factor-factor VIIa endocytosis
L Vijaya Mohan Rao, Usha R Pendurthi
Molecular and Cellular Biochemistry 2003
Genetic and metabolic determinants of increased plasma plasminogen activator inhibitor-1 activity in children with renal transplants.
Aldámiz-Echevarría L, Sanjurjo P, Vallo A, Aguirre M, Pérez-Nanclares G, Gimeno P, Rueda M, Ruiz JI, Rodríguez-Soriano J
Pediatric nephrology (Berlin, Germany) 2003
C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer.
Benes P, Jurajda M, Zaloudík J, Izakovicová-Hollá L, Vácha J
Breast Cancer Research 2003
Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients.
McCarthy JJ, Meyer J, Moliterno DJ, Newby LK, Rogers WJ, Topol EJ
Human Genetics 2003
Proteasome Regulates the Delivery of LDL Receptor-related Protein into the Degradation Pathway
L Melman, HJ Geuze, Y Li, LM McCormick, P van Kerkhof, GJ Strous, AL Schwartz, G Bu, M Krieger
Molecular biology of the cell 2002
The Role of the Macrophage in Apoptosis: Hunter, Gatherer, and Regulator
FJ Geske, J Monks, L Lehman, VA Fadok
International Journal of Hematology 2002
Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis
J Gent, P Kerkhof, M Roza, G Bu, GJ Strous
Proceedings of the National Academy of Sciences 2002
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
M Kato, MS Patel, R Levasseur, I Lobov, BH Chang, DA 2nd, C Hartmann, L Li, TH Hwang, CF Brayton, RA Lang, G Karsenty, L Chan
The Journal of Cell Biology 2002
Increased Extracellular Amyloid Deposition and Neurodegeneration in Human Amyloid Precursor Protein Transgenic Mice Deficient in Receptor-Associated Protein
Van Uden E, Mallory M, Veinbergs I, Alford M, Rockenstein E, Masliah E
Journal of Neuroscience 2002
Is the Class A macrophage scavenger receptor (SR-A) multifunctional? Ð The Mouse's tale
Nick Platt, Siamon Gordon
Journal of Clinical Investigation 2001
Multigland receptors and human disease
David Stern, Monty Krieger
Journal of Clinical Investigation 2001
Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences
Valarie A. Fadok, Donna L. Bratton, Peter Henson
Journal of Clinical Investigation 2001
Scavenger receptor class B type I is a multigland high density lipoprotein receptor that influences diverse physiologic systems
Monty Krieger
Journal of Clinical Investigation 2001

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