(A) COVID-19 poses new institutional responsibilities and challenges, including the need to ensure continuity of ongoing clinical research, increase COVID-19–related research, ensure safety of employees and students, enforce social distancing measures, ensure continuing the education of undergraduates and graduate students, restrict nonessential, non–COVID-19 research activities, and maintain required animal care resources. (B) Investigators have employed multiple approaches to cope with onsite lab restrictions and shutdowns. Researchers have maintained critical research activities, continued to submit publications, balanced work and family responsibilities, initiated or collaborated on COVID-19–related research, ensured limited onsite lab staffing, engaged in remote research opportunities, maintained regular and frequent communication with trainees and coworkers, and continued to plan and write research grants. Illustrated by Rachel Davidowitz.