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Citations to this article

Thymocyte emigration is mediated by active movement away from stroma-derived factors
Mark C. Poznansky, … , Andrew D. Luster, David T. Scadden
Mark C. Poznansky, … , Andrew D. Luster, David T. Scadden
Published April 15, 2002
Citation Information: J Clin Invest. 2002;109(8):1101-1110. https://doi.org/10.1172/JCI13853.
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Article Immunology Article has an altmetric score of 3

Thymocyte emigration is mediated by active movement away from stroma-derived factors

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Abstract

T cells leave the thymus at a specific time during differentiation and do not return despite elaboration of known T cell chemoattractants by thymic stroma. We observed differentiation stage–restricted egress of thymocytes from an artificial thymus in which vascular structures or hemodynamics could not have been playing a role. Hypothesizing that active movement of cells away from a thymic product may be responsible, we demonstrated selective reduction in emigration from primary thymus by inhibitors of active movement down a concentration gradient (chemofugetaxis). Immature intrathymic precursors were insensitive to an emigration signal, whereas mature thymocytes and peripheral blood T cells were sensitive. Thymic stroma was noted to elaborate at least two proteins capable of inducing emigration, one of which was stromal cell–derived factor-1. Thymic emigration is mediated, at least in part, by specific fugetaxis-inducing factors to which only mature cells respond.

Authors

Mark C. Poznansky, Ivona T. Olszak, Richard H. Evans, Zhengyu Wang, Russell B. Foxall, Douglas P. Olson, Kathryn Weibrecht, Andrew D. Luster, David T. Scadden

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Total citations by year

Year: 2025 2023 2022 2021 2020 2018 2017 2016 2014 2013 2012 2011 2009 2008 2006 2005 2004 2003 2002 Total
Citations: 1 2 3 2 1 4 2 2 3 3 1 2 1 2 2 2 2 1 1 37
Citation information
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Citations to this article in year 2012 (1)

Title and authors Publication Year
A dichotomy in cortical actin and chemotactic actin activity between human memory and naive T cells contributes to their differential susceptibility to HIV-1 infection
W Wang, J Guo, D Yu, PJ Vorster, WJ Chen, Y Wu
The Journal of biological chemistry 2012

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ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 14 patents
20 readers on Mendeley
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