Research Article
Xinle Cui, Feras Hawari, Sura Alsaaty, Marion Lawrence, Christian A. Combs, Weidong Geng, Farshid N. Rouhani, Dianne Miskinis, Stewart J. Levine
Title and authors | Publication | Year |
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Impact of endoplasmic reticulum aminopeptidases 1 (ERAP1) and 2 (ERAP2) on neutrophil cellular functions
Saulle I, Limanaqi F, Garziano M, Murno ML, Artusa V, Strizzi S, Giovarelli M, Schulte C, Aiello J, Clerici M, Vanetti C, Biasin M |
Frontiers in Cell and Developmental Biology | 2025 |
ERAP1 Activity Modulates the Immunopeptidome but Also Affects the Proteome, Metabolism, and Stress Responses in Cancer Cells
Nikopaschou M, Samiotaki M, Stylianaki EA, Król K, Gragera P, Raja A, Aidinis V, Chroni A, Fruci D, Panayotou G, Stratikos E |
Molecular & Cellular Proteomics : MCP | 2025 |
Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy.
Luo Z, Huang Y, Batra N, Chen Y, Huang H, Wang Y, Zhang Z, Li S, Chen CY, Wang Z, Sun J, Wang QJ, Yang D, Lu B, Conway JF, Li LY, Yu AM, Li S |
Nature Communications | 2024 |
The Role of Aminopeptidase ERAP1 in Human Pathology—A Review
Țiburcă L, Zaha DC, Jurca MC, Severin E, Jurca A, Jurca AD |
Current issues in molecular biology | 2024 |
Molecular signatures in prion disease: altered death receptor pathways in a mouse model
Giri RK |
Journal of Translational Medicine | 2024 |
Joint together: The etiology and pathogenesis of ankylosing spondylitis.
Xiong Y, Cai M, Xu Y, Dong P, Chen H, He W, Zhang J |
Frontiers in immunology | 2022 |
ERAP, KIR, and HLA-C Profile in Recurrent Implantation Failure
K Piekarska, P Radwan, A Tarnowska, A Wiśniewski, M Radwan, JR Wilczyński, A Malinowski, I Nowak |
Frontiers in immunology | 2021 |
ERAPs Reduce In Vitro HIV Infection by Activating Innate Immune Response
I Saulle, I Marventano, M Saresella, C Vanetti, M Garziano, C Fenizia, D Trabattoni, M Clerici, M Biasin |
Journal of immunology (Baltimore, Md. : 1950) | 2021 |
Nucleobindin-2/Nesfatin-1—A New Cancer Related Molecule?
AM Kmiecik, P Dzięgiel, M Podhorska-Okołów |
International journal of molecular sciences | 2021 |
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women
LC Ferreira, CE Gomes, P Duggal, ID Holanda, AS de Lima, PR do Nascimento, SM Jeronimo |
Scientific Reports | 2021 |
The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis
A Skorupska, R Lenda, A Ożyhar, D Bystranowska |
International journal of molecular sciences | 2021 |
Understanding the Pathogenesis of Spondyloarthritis
A Sharip, J Kunz |
Biomolecules | 2020 |
IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease
HY Ma, Yamamoto, J Xu, X Liu, D Karin, JY Kim, LB Alexandrov, Y Koyama, T Nishio, C Benner, S Heinz, SB Rosenthal, S Liang, M Sun, G Karin, P Zhao, P Brodt, IH Mckillop, O Quehenberger, E Dennis, A Saltiel, H Tsukamoto, B Gao, M Karin, DA Brenner, T Kisseleva |
Journal of Hepatology | 2020 |
ERAP1 polymorphisms interactions and their association with Behçet’s disease susceptibly: Application of Model-Based Multifactor Dimension Reduction Algorithm (MB-MDR)
P Riahi, A Kazemnejad, S Mostafaei, A Meguro, N Mizuki, A Ashraf-Ganjouei, A Javinani, ST Faezi, F Shahram, M Mahmoudi, Z Li |
PloS one | 2020 |
Revisiting TNF Receptor-Associated Periodic Syndrome (TRAPS): Current Perspectives
C Cudrici, N Deuitch, I Aksentijevich |
International journal of molecular sciences | 2020 |
Impact of Natural Occurring ERAP1 Single Nucleotide Polymorphisms within miRNA-Binding Sites on HCMV Infection.
Melaiu O, D'Amico S, Tempora P, Lucarini V, Fruci D |
International journal of molecular sciences | 2020 |
Sex-specific differences in endoplasmic reticulum aminopeptidase-1 modulation influences blood pressure and renin-angiotensin-system responses
Sanjay Ranjit, Jian Yao Wong, Jia Wei Tan, Chee Sin Tay, Jessica M Lee, Kelly Wong, Luminita Pojoga, Danielle Brooks, Amanda Garza, Stephen Maris, Isis Katayama, Jonathan Williams, Alicia Rivera, Gail Adler, Gordon H. Williams, Jose Romero |
JCI Insight | 2019 |
Ankylosing spondylitis: etiology, pathogenesis, and treatments
W Zhu, X He, K Cheng, L Zhang, D Chen, X Wang, G Qiu, X Cao, X Weng |
Bone Research | 2019 |
ERAP1 allotypes impact the epitope repertoire of virus-specific CD8+ T cell responses in acute hepatitis C virus infection
J Kemming, E Reeves, K Nitschke, V Widmeier, F Emmerich, T Hermle, E Gostick, A Walker, J Timm, DA Price, M Hofmann, R Thimme, E James, C Neumann-Haefelin |
Journal of Hepatology | 2019 |
Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection
I Saulle, SV Ibba, E Torretta, C Vittori, C Fenizia, F Piancone, D Minisci, EM Lori, D Trabattoni, C Gelfi, M Clerici, M Biasin |
Frontiers in immunology | 2019 |
Unraveling the Molecular Signature of Extracellular Vesicles From Endometrial-Derived Mesenchymal Stem Cells: Potential Modulatory Effects and Therapeutic Applications
F Marinaro, M Gómez-Serrano, I Jorge, JC Silla-Castro, J Vázquez, FM Sánchez-Margallo, R Blázquez, E López, V Álvarez, JG Casado |
Frontiers in Bioengineering and Biotechnology | 2019 |
Variant in ERAP1 promoter region is associated with low expression in a patient with a Behçet-like MHC-I-opathy
C Dimopoulou, JD Lundgren, J Sundal, H Ullum, P Aukrust, FC Nielsen, RL Marvig |
Journal of Human Genetics | 2019 |
ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han: ERAP1/ERAP2 and RUNX3 polymorphisms and AS susceptibility
W Su, L Du, S Liu, J Deng, Q Cao, G Yuan, A Kijlstra, P Yang |
Clinical & Experimental Immunology | 2018 |
The role of polymorphic ERAP1 in autoinflammatory disease
E Reeves, E James |
Bioscience Reports | 2018 |
Epistatic Interaction of ERAP1 and HLA-B*51 in Iranian Patients with Behçet’s Disease
M Mahmoudi, A Ashraf-Ganjouei, A Javinani, F Shahram, A Meguro, N Mizuki, N Ahmadzadeh, S Jafarinejad-Farsangi, S Mostafaei, H Kavosi, ST Faezi, M Akhlaghi, F Davatchi |
Scientific Reports | 2018 |
Association of , and Polymorphisms with Radiographic Severity of Ankylosing Spondylitis
G Ozen, R Deniz, F Eren, C Erzik, AU Unal, S Yavuz, SZ Aydin, N Inanc, H Direskeneli, P Atagunduz |
The open rheumatology journal | 2017 |
ERAP1 rs30187 single nucleotide polymorphism does not confer disease susceptibility in North Indian children with enthesitis-related arthritis.
Srivastava R, Phatak S, Aggarwal A |
Clinical Rheumatology | 2017 |
ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface
TM Tran, S Hong, JH Edwan, RA Colbert |
Molecular Immunology | 2016 |
Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis
YH Lee, GG Song |
Clinical Rheumatology | 2016 |
Functional Genomics and Its Bench-to-Bedside Translation Pertaining to the Identified Susceptibility Alleles and Loci in Ankylosing Spondylitis
TJ Kenna, A Hanson, ME Costello, MA Brown |
Current Rheumatology Reports | 2016 |
A case of figurate urticaria by etanercept
M Sessa, MG Sullo, A Mascolo, D Cimmaruta, F Romano, RV Puca, A Capuano, F Rossi, AL Schiavo |
Journal of pharmacology & pharmacotherapeutics | 2016 |
Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines: Cellular expression and TNF-R1 interactions of ERAP1 isoforms
N Yousaf, WY Low, A Onipinla, C Mein, M Caulfield, PB Munroe, Y Chernajovsky |
Clinical & Experimental Immunology | 2015 |
Bcl-2 Knockdown Accelerates T Cell Receptor-Triggered Activation-Induced Cell Death in Jurkat T Cells
YJ Lee, TJ Won, KE Hyung, MJ Lee, Y Moon, IH Lee, BS Go, KW Hwang |
The Korean Journal of Physiology & Pharmacology | 2014 |
Epistatic interaction of ERAP1 and HLA-B in Behçet disease: a replication study in the Spanish population
M Conde-Jaldón, MA Montes-Cano, JR García-Lozano, L Ortiz-Fernández, N Ortego-Centeno, R González-León, G Espinosa, G Graña-Gil, J Sánchez-Bursón, MA González-Gay, AC Barnosi-Marín, R Solans, P Fanlo, MR Carballeira, T Camps, S Castañeda, J Martín, MF González-Escribano |
PloS one | 2014 |
Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis
TJ Kenna, MC Lau, P Keith, F Ciccia, ME Costello, L Bradbury, PL Low, N Agrawal, G Triolo, R Alessandro, PC Robinson, GP Thomas, MA Brown |
Genes and Immunity | 2014 |
A Role for Naturally Occurring Alleles of Endoplasmic Reticulum Aminopeptidases in Tumor Immunity and Cancer Pre-Disposition
E Stratikos, A Stamogiannos, E Zervoudi, D Fruci |
Frontiers in Oncology | 2014 |
ERAP1 in the pathogenesis of ankylosing spondylitis
E Reeves, T Elliott, E James, CJ Edwards |
Immunologic Research | 2014 |
Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens
SS Seregin, DP Rastall, I Evnouchidou, CF Aylsworth, D Quiroga, RP Kamal, S Godbehere-Roosa, CF Blum, IA York, E Stratikos, A Amalfitano |
Autoimmunity | 2013 |
Ankylosing spondylitis: from cells to genes
JF Zambrano-Zaragoza, JM Agraz-Cibrian, C González-Reyes, MJ Durán-Avelar, N Vibanco-Pérez |
International Journal of Inflammation | 2013 |
Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response
YA Aldhamen, SS Seregin, DP Rastall, CF Aylsworth, Y Pepelyayeva, CJ Busuito, S Godbehere-Roosa, S Kim, A Amalfitano |
PloS one | 2013 |
Antigenic peptide trimming by ER aminopeptidases—Insights from structural studies
E Stratikos, LJ Stern |
Molecular Immunology | 2013 |
Genetics of spondyloarthritis—beyond the MHC
JD Reveille |
Nature Reviews Rheumatology | 2012 |
Role of Endoplasmic Reticulum Aminopeptidases in Health and Disease: from Infection to Cancer
L Cifaldi, P Romania, S Lorenzi, F Locatelli, D Fruci |
International journal of molecular sciences | 2012 |
Genetic Association with ERAP1 in Psoriasis Is Confined to Disease Onset after Puberty and Not Dependent on HLA-C*06
J Lysell, L Padyukov, I Kockum, P Nikamo, M Ståhle |
Journal of Investigative Dermatology | 2012 |
ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis
CM Wang, HH Ho, SW Chang, YJ Wu, JC Lin, PY Chang, J Wu, JY Chen |
Arthritis Research & Therapy | 2012 |
Don't mess with ERAAP!
JW Yewdell, X Lu |
Nature Immunology | 2012 |
The transition of acute to chronic bowel inflammation in spondyloarthritis
LV Praet, P Jacques, FV Bosch, D Elewaut |
Nature Reviews Rheumatology | 2012 |
Endoplasmic Reticulum Aminopeptidase 1 and Interleukin-23 Receptor in Ankylosing Spondylitis
N Haroon |
Current Rheumatology Reports | 2012 |
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming
G Kochan, T Krojer, D Harvey, R Fischer, L Chen, M Vollmar, F Delft, KL Kavanagh, MA Brown, P Bowness, P Wordsworth, BM Kessler, U Oppermann |
Proceedings of the National Academy of Sciences | 2011 |
Identification of novel susceptibility Loci for kawasaki disease in a han chinese population by a genome-wide association study
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PloS one | 2011 |
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
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Nature Genetics | 2011 |
Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme
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Journal of immunology (Baltimore, Md. : 1950) | 2011 |
Susceptibility to ankylosing spondylitis: evidence for the role of ERAP1, TGFb1 and TLR9 gene polymorphisms
W Wu, Y Ding, Y Chen, Z Hua, H Liu, H Wang, G Jiao |
Rheumatology International | 2011 |
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Cellular and Molecular Life Sciences | 2011 |
Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
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Inflammation Research | 2011 |
The association between seven ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis involving 8,530 cases and 12,449 controls
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Rheumatology International | 2011 |
Secretion of Endoplasmic Reticulum Aminopeptidase 1 Is Involved in the Activation of Macrophages Induced by Lipopolysaccharide and Interferon-γ
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The Journal of biological chemistry | 2011 |
Endoplasmic reticulum aminopeptidases: biology and pathogenic potential
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Nature Reviews Rheumatology | 2010 |
From HLA-B27 to spondyloarthritis: a journey through the ER
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Protective action of taurine, given as a pretreatment or as a posttreatment, against endotoxin-induced acute lung inflammation in hamsters
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14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway
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British Journal of Pharmacology | 2010 |
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
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Nature Genetics | 2010 |
Molecular and Cellular Mechanisms of Ectodomain Shedding
K Hayashida, AH Bartlett, Y Chen, PW Park |
The Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology | 2010 |
Tumor Necrosis Factor- (TNF- ) Regulates Shedding of TNF- Receptor 1 by the Metalloprotease-Disintegrin ADAM8: Evidence for a Protease-Regulated Feedback Loop in Neuroprotection
JW Bartsch, D Wildeboer, G Koller, S Naus, A Rittger, ML Moss, Y Minai, H Jockusch |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2010 |
Double-Stranded RNA Induces Shedding of the 34-kDa Soluble TNFR1 from Human Airway Epithelial Cells via TLR3–TRIF–RIP1-Dependent Signaling: Roles for Dual Oxidase 2- and Caspase-Dependent Pathways
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Journal of immunology (Baltimore, Md. : 1950) | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
An overview of genetics of paediatric rheumatic diseases
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Genetics of rheumatic disease
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Arthritis Research & Therapy | 2009 |
Investigating the genetic association between ERAP1 and ankylosing spondylitis
D Harvey, JJ Pointon, DM Evans, T Karaderi, C Farrar, LH Appleton, RD Sturrock, MA Stone, U Oppermann, MA Brown, BP Wordsworth |
Human Molecular Genetics | 2009 |
IL-1β Augments TNF-α–Mediated Inflammatory Responses from Lung Epithelial Cells
S Saperstein, L Chen, D Oakes, G Pryhuber, J Finkelstein |
Journal of Interferon & Cytokine Research | 2009 |
Entheses and Bones in Spondyloarthritis: 2008 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN)
RA Colbert, AA Deodhar, DA Fox, EM Gravallese, MA Khan, DE McGONAGLE, JD Reveille, G Schett, M Weisman, DO Clegg |
The Journal of rheumatology | 2009 |
HLA-B27 misfolding and spondyloarthropathies.
Colbert RA, DeLay ML, Layh-Schmitt G, Sowders DP |
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Molecular mechanisms of soluble cytokine receptor generation
SJ Levine |
The Journal of biological chemistry | 2008 |
An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release
B Adamik, A Islam, FN Rouhani, FI Hawari, J Zhang, SJ Levine |
Biochemical and Biophysical Research Communications | 2008 |
cAMP-dependent Protein Kinase A (PKA) Signaling Induces TNFR1 Exosome-like Vesicle Release via Anchoring of PKA Regulatory Subunit RIIβ to BIG2
A Islam, H Jones, T Hiroi, J Lam, J Zhang, J Moss, M Vaughan, SJ Levine |
The Journal of biological chemistry | 2008 |
Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure
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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.
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Nature Genetics | 2007 |
L-selectin: mechanisms and physiological significance of ectodomain cleavage
DM Smalley, K Ley |
Journal of Cellular and Molecular Medicine | 2005 |
Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors
FI Hawari, FN Rouhani, X Cui, ZX Yu, C Buckley, M Kaler, SJ Levine |
Proceedings of the National Academy of Sciences | 2004 |
Mutant forms of tumour necrosis factor receptor I that occur in TNF-receptor-associated periodic syndrome retain signalling functions but show abnormal behaviour
I Todd, PM Radford, KA Draper-Morgan, R McIntosh, S Bainbridge, P Dickinson, L Jamhawi, M Sansaridis, ML Huggins, PJ Tighe, RJ Powell |
Immunology | 2004 |
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