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Citations to this article

Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation
Carmen Urbich, … , Andreas M. Zeiher, Stefanie Dimmeler
Carmen Urbich, … , Andreas M. Zeiher, Stefanie Dimmeler
Published November 15, 2001
Citation Information: J Clin Invest. 2001;108(10):1451-1458. https://doi.org/10.1172/JCI13620.
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Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation

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Abstract

Atherosclerosis is an inflammatory disease of large arteries that is initiated through the activation of endothelium by proinflammatory mediators. CD40 receptor stimulation has been implicated in the pathogenesis of atherosclerosis. One of the most important atheroprotective stimuli is the viscous drag (shear stress) generated by the streaming blood acting on the endothelial monolayer. Here, we demonstrate that shear stress prevents CD40 ligand–induced endothelial cell activation, and we identify upregulation of TNF receptor–associated factor-3 (TRAF-3) as a potent CD40-inhibitory mechanism. Shear stress specifically upregulates TRAF-3 in cultured endothelial cells. Moreover, in the endothelial cells overlying human atherosclerotic plaques, TRAF-3 expression is upregulated in areas with high shear stress. Overexpression of TRAF-3 inhibits endothelial expression of proinflammatory cytokines and tissue factor and blocks DNA-binding activity of the transcription factor AP-1; it thereby prevents CD40-induced endothelial activation. Thus, upregulation of TRAF-3 represents a novel mechanism for preserving the functional integrity of the endothelial monolayer.

Authors

Carmen Urbich, Ziad Mallat, Alain Tedgui, Matthias Clauss, Andreas M. Zeiher, Stefanie Dimmeler

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Total citations by year

Year: 2023 2022 2018 2017 2016 2012 2011 2010 2009 2008 2007 2005 2002 Total
Citations: 1 3 4 4 2 1 1 2 1 1 1 1 1 23
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Citations to this article (23)

Title and authors Publication Year
Influence of Race and High Laminar Shear Stress on TNFR1 Signaling in Endothelial Cells
Aldokhayyil M, Gomez DH, Cook MD, Kavazis AN, Roberts MD, Geetha T, Brown MD
International journal of molecular sciences 2023
The Role of Tumor Necrosis Factor Associated Factors (TRAFs) in Vascular Inflammation and Atherosclerosis
Gissler MC, Stachon P, Wolf D, Marchini T
Frontiers in Cardiovascular Medicine 2022
Disruption of retinal inflammation and the development of diabetic retinopathy in mice by a CD40-derived peptide or mutation of CD40 in Müller cells.
Portillo JC, Yu JS, Vos S, Bapputty R, Lopez Corcino Y, Hubal A, Daw J, Arora S, Sun W, Lu ZR, Subauste CS
Diabetologia 2022
Role of CD40(L)-TRAF signaling in inflammation and resolution—a double-edged sword
Strohm L, Ubbens H, Münzel T, Daiber A, Daub S
Frontiers in pharmacology 2022
CD40L promotes development of acute aortic dissection via induction of inflammation and impairment of endothelial cell function
L Han, L Dai, YF Zhao, HY Li, O Liu, F Lan, WJ Jiang, HJ Zhang
Aging 2018
Dynamic transcriptomic analysis of Ischemic Injury in a Porcine Pre-Clinical Model mimicking Donors Deceased after Circulatory Death
S Giraud, C Steichen, G Allain, P Couturier, D Labourdette, S Lamarre, V Ameteau, S Tillet, P Hannaert, R Thuillier, T Hauet
Scientific Reports 2018
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis
TT Seijkens, CM van Tiel, PJ Kusters, D Atzler, O Soehnlein, B Zarzycka, SA Aarts, M Lameijer, MJ Gijbels, L Beckers, M den Toom, B Slütter, J Kuiper, J Duchene, M Aslani, RT Megens, C van t Veer, G Kooij, R Schrijver, MA Hoeksema, L Boon, F Fay, J Tang, S Baxter, A Jongejan, PD Moerland, G Vriend, B Bleijlevens, EA Fisher, R Duivenvoorden, N Gerdes, MP de Winther, GA Nicolaes, WJ Mulder, C Weber, E Lutgens
Journal of the American College of Cardiology 2018
TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation
GA Bishop, LL Stunz, BS Hostager
Frontiers in immunology 2018
Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction
T Morishima, RM Restaino, LK Walsh, JA Kanaley, J Padilla
Clinical Science 2017
TRAF3 negatively regulates platelet activation and thrombosis
R Zhang, G Zhang, B Xiang, X Chen, L Tang, S Shi, Y Liu, X Ai, P Xie, Z Li
Scientific Reports 2017
Correlation between quantitative analysis of wall shear stress and intima-media thickness in atherosclerosis development in carotid arteries
B Zhang, J Gu, M Qian, L Niu, H Zhou, D Ghista
BioMedical Engineering OnLine 2017
Polymorphisms in inflammation-related genes and the risk of primary varicose veins in ethnic Russians
A Shadrina, E Voronina, M Smetanina, Y Tsepilov, K Sevostianova, A Shevela, E Seliverstov, E Zakharova, E Ilyukhin, A Kirienko, I Zolotukhin, M Filipenko
Immunologic Research 2017
Nuclear TRAF3 is a negative regulator of CREB in B cells
N Mambetsariev, WW Lin, LL Stunz, BM Hanson, JM Hildebrand, GA Bishop
Proceedings of the National Academy of Sciences 2016
TRAF3 as a powerful and multitalented regulator of lymphocyte functions
GA Bishop
Journal of leukocyte biology 2016
TRAF6 inhibits proangiogenic signals in endothelial cells and regulates the expression of vascular endothelial growth factor
S Bruneau, D Datta, JA Flaxenburg, S Pal, DM Briscoe
Biochemical and Biophysical Research Communications 2012
Flow-dependent Smad2 phosphorylation and TGIF nuclear localization in human aortic endothelial cells
RD Shepherd, SM Kos, KD Rinker
American journal of physiology. Heart and circulatory physiology 2011
Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall
A Missiou, N Köstlin, N Varo, P Rudolf, P Aichele, S Ernst, C Münkel, C Walter, P Stachon, B Sommer, D Pfeifer, K Zirlik, L MacFarlane, D Wolf, E Tsitsikov, C Bode, P Libby, A Zirlik
Circulation 2010
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile
E Lutgens, D Lievens, L Beckers, E Wijnands, O Soehnlein, A Zernecke, T Seijkens, D Engel, J Cleutjens, AM Keller, SH Naik, L Boon, HA Oufella, Z Mallat, CL Ahonen, RJ Noelle, MP de Winther, MJ Daemen, EA Biessen, C Weber
Journal of Experimental Medicine 2010
Molecular mechanism and function of CD40/CD40L engagement in the immune system
R Elgueta, MJ Benson, VC de Vries, A Wasiuk, Y Guo, RJ Noelle
Immunological Reviews 2009
Lymphotoxin-α1β2 and LIGHT Induce Classical and Noncanonical NF-κB-Dependent Proinflammatory Gene Expression in Vascular Endothelial Cells
Madge LA, Kluger MS, Orange JS, May MJ
Journal of immunology (Baltimore, Md. : 1950) 2008
Soluble CD40 Ligand as a Predictor of Coronary Artery Disease and Long-Term Clinical Outcomes in Stable Patients Undergoing Coronary Angiography
MT Rondina, JM Lappé, JF Carlquist, JB Muhlestein, MJ Kolek, BD Horne, RR Pearson, JL Anderson
Cardiology 2007
Differing mechanisms of leukocyte recruitment and sensitivity to conditioning by shear stress for endothelial cells treated with tumour necrosis factor-αor interleukin-1β
S Sheikh, M Rahman, Z Gale, NT Luu, PC Stone, NM Matharu, GE Rainger, GB Nash
British Journal of Pharmacology 2005
Role of NF kappa B activator Act1 in CD40-mediated signaling in epithelial cells
Y Qian, Z Zhao, Z Jiang, X Li
Proceedings of the National Academy of Sciences 2002

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