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Citations to this article

Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1–deficient mice
Donnasue Graesser, … , Britta Engelhardt, Joseph A. Madri
Donnasue Graesser, … , Britta Engelhardt, Joseph A. Madri
Published February 1, 2002
Citation Information: J Clin Invest. 2002;109(3):383-392. https://doi.org/10.1172/JCI13595.
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Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1–deficient mice

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Abstract

Platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31), a 130-kDa glycoprotein member of the Ig superfamily of transmembrane proteins, is expressed on endothelial cells, platelets, and subsets of leukocytes. It functions as a cell adhesion molecule as well as a scaffolding molecule capable of modulating cellular signaling pathways. In this study, using PECAM-1–deficient (KO) mice, as well as cells derived from these mice, we demonstrate that the absence of PECAM-1 expression is associated with an early onset of clinical symptoms during experimental autoimmune encephalomyelitis (EAE), a mouse model for the human autoimmune disease multiple sclerosis. During EAE, mononuclear cell extravasation and infiltration of the CNS occur at earlier time points in PECAM-KO mice than in wild-type mice. In vitro, T lymphocyte transendothelial migration across PECAM-KO endothelial cells is enhanced, regardless of expression of PECAM-1 on transmigrating T cells. Additionally, cultured PECAM-KO endothelial cells exhibit prolonged permeability changes in response to histamine treatment compared with PECAM-1–reconstituted endothelial cells. Lastly, we demonstrate an exaggerated and prolonged CNS vascular permeability during the development of EAE and a delay in restoration of dermal vascular integrity following histamine challenge in PECAM-KO mice.

Authors

Donnasue Graesser, Anna Solowiej, Monika Bruckner, Emily Osterweil, Amy Juedes, Sandra Davis, Nancy H. Ruddle, Britta Engelhardt, Joseph A. Madri

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Brain Research 2011
Claudin-1 induced sealing of blood–brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis
F Pfeiffer, J Schäfer, R Lyck, V Makrides, S Brunner, N Schaeren-Wiemers, U Deutsch, B Engelhardt
Acta Neuropathologica 2011
Platelet-Endothelial Cell Adhesion Molecule-1 Regulates Endothelial NO Synthase Activity and Localization Through Signal Transducers and Activators of Transcription 3–Dependent NOSTRIN Expression
ME McCormick, R Goel, D Fulton, S Oess, D Newman, E Tzima
Arteriosclerosis, thrombosis, and vascular biology 2011
Relative contribution of PECAM-1 adhesion and signaling to the maintenance of vascular integrity
JR Privratsky, CM Paddock, O Florey, DK Newman, WA Muller, PJ Newman
Journal of cell science 2011
CD31 Is Required on CD4 + T Cells To Promote T Cell Survival during Salmonella Infection
EA Ross, RE Coughlan, A Flores-Langarica, S Bobat, JL Marshall, K Hussain, J Charlesworth, N Abhyankar, J Hitchcock, C Gil, C López-Macías, IR Henderson, M Khan, SP Watson, IC MacLennan, CD Buckley, AF Cunningham
Journal of immunology (Baltimore, Md. : 1950) 2011
Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance
L Ma, C Mauro, GH Cornish, JG Chai, D Coe, H Fu, D Patton, K Okkenhaug, G Franzoso, J Dyson, S Nourshargh, FM Marelli-Berg
Proceedings of the National Academy of Sciences 2010
TCR stimulation drives cleavage and shedding of the ITIM receptor CD31
G Fornasa, E Groyer, M Clement, J Dimitrov, C Compain, AT Gaston, A Varthaman, J Khallou-Laschet, DK Newman, S Graff-Dubois, A Nicoletti, G Caligiuri
Journal of immunology (Baltimore, Md. : 1950) 2010
PECAM-1 regulates proangiogenic properties of endothelial cells through modulation of cell-cell and cell-matrix interactions
SY Park, TA DiMaio, EA Scheef, CM Sorenson, N Sheibani
AJP Cell Physiology 2010
PECAM-1: conflicts of interest in inflammation
JR Privratsky, DK Newman, PJ Newman
Life Sciences 2010
Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells
SH Ramirez, S Fan, M Zhang, A Papugani, N Reichenbach, H Dykstra, AJ Mercer, RF Tuma, Y Persidsky
The American Journal of Pathology 2010
The anti-inflammatory actions of platelet endothelial cell adhesion molecule-1 do not involve regulation of endothelial cell NF-kappa B
JR Privratsky, BE Tourdot, DK Newman, PJ Newman
Journal of immunology (Baltimore, Md. : 1950) 2010
Effects of repeated restraint stress on platelet endothelial cell adhesion molecule-1 immunoreactivity and protein levels in the gerbil hippocampus after transient cerebral ischemia
OK Park, CH Lee, IK Hwang, KY Yoo, JH Choi, MH Won
Anatomy & cell biology 2010
Blocking platelet/endothelial cell adhesion molecule 1 (PECAM) inhibits disease progression and prevents joint erosion in established collagen antibody-induced arthritis
B Dasgupta, T Chew, A deRoche, WA Muller
Experimental and Molecular Pathology 2010
Role of PECAM-1 in Arteriogenesis and Specification of Preexisting Collaterals
Z Chen, J Rubin, E Tzima
Circulation research 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction
B Engelhardt, L Sorokin
Seminars in Immunopathology 2009
PECAM-independent thioglycollate peritonitis is associated with a locus on murine chromosome 2
MA Seidman, TW Chew, AR Schenkel, WA Muller
PloS one 2009
sPECAM-1 and sVCAM-1: Role in Pathogenesis and Diagnosis of Chronic Hepatitis C and Association with Response to Antiviral Therapy
M Kukla, K Zwirska-Korczala, A Gabriel, E Janczewska-Kazek, A Berdowska, A Wiczkowski, B Rybus-Kalinowska, M Kalinowski, A Ziolkowski, E Wozniak-Grygiel, M Waluga, B Nowak
Therapeutic advances in gastroenterology 2009
Functions of lipid raft membrane microdomains at the blood–brain barrier
A Dodelet-Devillers, R Cayrol, J Horssen, AS Haqqani, HE de Vries, B Engelhardt, J Greenwood, A Prat
Journal of Molecular Medicine 2009
Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal
Q Li, J Liu, M Michaud, ML Schwartz, JA Madri
The American Journal of Pathology 2009
Cellular Elements of the Blood-Brain Barrier
J Correale, A Villa
Neurochemical Research 2009
PECAM-1 Is Necessary for Flow-Induced Vascular Remodeling
Z Chen, E Tzima
Arteriosclerosis, thrombosis, and vascular biology 2009
Endothelial signaling in paracellular and transcellular leukocyte transmigration.
Wittchen ES
2009
Reprint of “The role of cytoskeleton in the regulation of vascular endothelial barrier function” [Microvascular Research 76 (2008) 202–207]
Bogatcheva NV, Verin AD
Microvascular Research 2009
Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice
BL Harry, JM Sanders, RE Feaver, M Lansey, TL Deem, A Zarbock, AC Bruce, AW Pryor, BD Gelfand, BR Blackman, MA Schwartz, K Ley
Arteriosclerosis, thrombosis, and vascular biology 2008
The role of cytoskeleton in the regulation of vascular endothelial barrier function
NV Bogatcheva, AD Verin
Microvascular Research 2008
PECAM-1 isoform-specific functions in PECAM-1-deficient brain microvascular endothelial cells
TA DiMaio, N Sheibani
Microvascular Research 2008
VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF
AF Nottebaum, G Cagna, M Winderlich, AC Gamp, R Linnepe, C Polaschegg, K Filippova, R Lyck, B Engelhardt, O Kamenyeva, MG Bixel, S Butz, D Vestweber
Journal of Experimental Medicine 2008
A novel role for PECAM-1 (CD31) in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow
EA Ross, S Freeman, Y Zhao, TS Dhanjal, EJ Ross, S Lax, Z Ahmed, TZ Hou, N Kalia, S Egginton, G Nash, SP Watson, J Frampton, CD Buckley
PloS one 2008
RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1
C Garnacho, V Shuvaev, A Thomas, L McKenna, J Sun, M Koval, S Albelda, V Muzykantov, S Muro
Blood 2008
Attenuation of retinal vascular development and neovascularization in PECAM-1-deficient mice
TA DiMaio, S Wang, Q Huang, EA Scheef, CM Sorenson, N Sheibani
Developmental Biology 2008
Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor–Deficient Mice
R Goel, BR Schrank, S Arora, B Boylan, B Fleming, H Miura, PJ Newman, RC Molthen, DK Newman
Arteriosclerosis, thrombosis, and vascular biology 2008
Stepping out of the flow: capillary extravasation in cancer metastasis
FL Miles, FL Pruitt, KL van Golen, CR Cooper
Clinical & Experimental Metastasis 2007
PECAM-1: a multifaceted regulator of megakaryocytopoiesis
Y Wu, T Welte, M Michaud, JA Madri
Blood 2007
Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms
EK Reinke, JE Lee, A Zozulya, J Karman, WA Muller, M Sandor, Z Fabry
Journal of Neuroimmunology 2007
PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells2: PECAM-1 engagement inhibits ICAM-1 signaling
JP Couty, C Rampon, M Leveque, MP Laran-Chich, S Bourdoulous, J Greenwood, PO Couraud
Journal of Neurochemistry 2007
Functionally specialized junctions between endothelial cells of lymphatic vessels
P Baluk, J Fuxe, H Hashizume, T Romano, E Lashnits, S Butz, D Vestweber, M Corada, C Molendini, E Dejana, DM McDonald
Journal of Experimental Medicine 2007
Different susceptibilities of PECAM-deficient mouse strains to spontaneous idiopathic pneumonitis
AR Schenkel, TW Chew, E Chlipala, MW Harbord, WA Muller
Experimental and Molecular Pathology 2006
Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus
C Xie, P Alcaide, BV Geisbrecht, D Schneider, M Herrmann, KT Preissner, FW Luscinskas, T Chavakis
Journal of Experimental Medicine 2006
A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo
MC Ford, JP Bertram, SR Hynes, M Michaud, Q Li, M Young, SS Segal, JA Madri, EB Lavik
Proceedings of the National Academy of Sciences 2006
Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS
EA Eugenin, R Gamss, C Buckner, D Buono, RS Klein, EE Schoenbaum, TM Calderon, JW Berman
Journal of leukocyte biology 2006
PECAM-1 Affects GSK-3β-Mediated β-Catenin Phosphorylation and Degradation
P Biswas, S Canosa, D Schoenfeld, J Schoenfeld, P Li, LC Cheas, J Zhang, A Cordova, B Sumpio, JA Madri
The American Journal of Pathology 2006
The Inhibitory Co-Receptor, PECAM-1 Provides a Protective Effect in Suppression of Collagen-Induced Arthritis
MX Wong, JD Hayball, PM Hogarth, DE Jackson
Journal of Clinical Immunology 2005
Enhanced susceptibility to endotoxic shock and impaired STAT3 signaling in CD31-deficient mice.
Carrithers M, Tandon S, Canosa S, Michaud M, Graesser D, Madri JA
The American Journal of Pathology 2005
Roles of thromboxane A2 and prostacyclin in development of atherosclerosis in apoE-deficient mice
Takuya Kobayashi, Yoshio Tahara, Mayumi Matsumoto, Masako Iguchi, Hideto Sano, Toshinori Murayama, Hidenori Arai, Hiroji Oida, Takami Yurugi-Kobayashi, Jun Yamashita, Hiroyuki Katagiri, Masataka Majima, Masayuki Yokode, Toru Kita, and Shuh Narumiya
Journal of Clinical Investigation 2004
Lactosylceramide recruits PKCalpha/epsilon and phospholipase A2 to stimulate PECAM-1 expression in human monocytes and adhesion to endothelial cells
NL Gong, H Wei, SH Chowdhury, S Chatterjee
Proceedings of the National Academy of Sciences 2004
Elevated glucose inhibits VEGF-A–mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2
JM Enciso, D Gratzinger, TD Camenisch, S Canosa, E Pinter, JA Madri
The Journal of Cell Biology 2003
Lack of platelet endothelial cell adhesion molecule-1 attenuates foreign body inflammation because of decreased angiogenesis.
Solowiej A, Biswas P, Graesser D, Madri JA
The American Journal of Pathology 2003
Platelet endothelial cell adhesion molecule in cell signaling and thrombosis.
Gong N, Chatterjee S
Molecular and Cellular Biochemistry 2003
PECAM-1 (CD31) Homophilic Interaction Up-Regulates α 6 β 1 on Transmigrated Neutrophils In Vivo and Plays a Functional Role in the Ability of α 6 Integrins to Mediate Leukocyte Migration through the Perivascular Basement Membrane
J Dangerfield, KY Larbi, MT Huang, A Dewar, S Nourshargh
Journal of Experimental Medicine 2002

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