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Citations to this article

Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.
A B Waxman, … , R J Homer, J A Elias
A B Waxman, … , R J Homer, J A Elias
Published May 1, 1998
Citation Information: J Clin Invest. 1998;101(9):1970-1982. https://doi.org/10.1172/JCI1337.
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Research Article Article has an altmetric score of 3

Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.

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Abstract

Acute lung injury is a frequent and treatment-limiting consequence of therapy with hyperoxic gas mixtures. To determine if IL-11 is protective in oxygen toxicity, we compared the effects of 100% O2 on transgenic mice that overexpress IL-11 in the lung and transgene (-) controls. IL-11 markedly enhanced survival in 100% O2 with 100% of transgene (-) animals dying within 72-96 h and > 90% of transgene (+) animals surviving for more than 10 d. This protection was associated with markedly diminished alveolar-capillary protein leak, endothelial and epithelial membrane injury, lipid peroxidation, and pulmonary neutrophil recruitment. Significant differences in copper zinc superoxide dismutase and catalase activities were not noted and the levels of total, reduced and oxidized glutathione were similar in transgene (+) and (-) animals. Glutathione reductase, glutathione peroxidase, and manganese superoxide dismutase activities were slightly higher in transgene (+) as versus (-) mice after 100% O2 exposure, and IL-11 diminished hyperoxia-induced expression of IL-1 and TNF. Hyperoxia also caused cell death with DNA fragmentation in the lungs of transgene (-) animals and IL-11 markedly diminished this cell death response. These studies demonstrate that IL-11 markedly diminishes hyperoxic lung injury. They also demonstrate this protection is associated with small changes in lung antioxidants, diminished hyperoxia-induced IL-1 and TNF production, and markedly suppressed hyperoxia-induced DNA fragmentation.

Authors

A B Waxman, O Einarsson, T Seres, R G Knickelbein, J B Warshaw, R Johnston, R J Homer, J A Elias

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 Total
Citations: 2 2 2 4 4 3 3 2 1 1 6 6 10 6 7 3 10 7 8 9 6 12 11 5 7 14 5 1 157
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Citations to this article in year 2014 (6)

Title and authors Publication Year
Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection
RF Foronjy, AJ Dabo, N Cummins, P Geraghty
BMC Immunology 2014
Dual oxidase 2 in lung epithelia is essential for hyperoxia-induced acute lung injury in mice
JH Ryu, MJ Kim, JC Ryu, YH Kwon, S Lee, YS Bae, JH Yoon
Antioxidants & Redox Signaling 2014
Early Effect of Tidal Volume on Lung Injury Biomarkers in Surgical Patients with Healthy Lungs:
A Fernandez-Bustamante, J Klawitter, JE Repine, A Agazio, AJ Janocha, C Shah, M Moss, IS Douglas, ZV Tran, SC Erzurum, U Christians, T Seres
Anesthesiology 2014
Different expression profiles of Interleukin 11 (IL-11), Intelectin (ITLN) and Purine nucleoside phosphorylase 5a (PNP 5a) in crucian carp (Carassius auratus gibelio) in response to Cyprinid herpesvirus 2 and Aeromonas hydrophila
P Podok, L Xu, D Xu, L Lu
Fish & Shellfish Immunology 2014
Effects of oxygen in lungs of rats
AL Pereira, MR Ferreira, OJ Santos, EN Filho, AE Paiva, RH Santos, RA Santos
Acta Cirurgica Brasileira 2014
Mitochondrial Function in Lung Health and Disease
V Natarajan, NL Parinandi
2014

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