Unconventional T cell subsets, including donor-unrestricted T cells (DURTs) and γδ T cells, are promising new players in the treatment and prevention of infectious diseases. In this issue of the JCI, Ogongo et al. used T cell receptor (TCR) sequencing to characterize unconventional T cell subsets in surgical lung resections and blood from Mycobacterium tuberculosis–infected (Mtb-infected) individuals with and without HIV coinfection. The study revealed highly localized expansions of γδ T cell clonotypes not previously associated with the immune response to Mtb and demonstrates the power of high-throughput analysis of the TCR repertoire directly from infected tissue. The findings contribute to our understanding of tuberculosis control and have implications for the development of both therapeutic and vaccination strategies.
Corinna A. Kulicke, Deborah A. Lewinsohn, David M. Lewinsohn
Title and authors | Publication | Year |
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An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis.
Paterson RL, La Manna MP, Arena De Souza V, Walker A, Gibbs-Howe D, Kulkarni R, Fergusson JR, Mulakkal NC, Monteiro M, Bunjobpol W, Dembek M, Martin-Urdiroz M, Grant T, Barber C, Garay-Baquero DJ, Tezera LB, Lowne D, Britton-Rivet C, Pengelly R, Chepisiuk N, Singh PK, Woon AP, Powlesland AS, McCully ML, Caccamo N, Salio M, Badami GD, Dorrell L, Knox A, Robinson R, Elkington P, Dieli F, Lepore M, Leonard S, Godinho LF |
Proceedings of the National Academy of Sciences | 2024 |
Functional and biological implications of clonotypic diversity among human donor-unrestricted T cells
Maerz MD, Cross DL, Seshadri C |
Immunology and Cell Biology | 2024 |
Deep characterization of human γδ T cell subsets defines shared and lineage-specific traits
Sanz M, Mann BT, Ryan PL, Bosque A, Pennington DJ, Hackstein H, Soriano-Sarabia N |
Frontiers in immunology | 2023 |
γδ T cells: origin and fate, subsets, diseases and immunotherapy
Hu Y, Hu Q, Li Y, Lu L, Xiang Z, Yin Z, Kabelitz D, Wu Y |
Signal Transduction and Targeted Therapy | 2023 |
BCG-activation of leukocytes is sufficient for the generation of donor-independent innate anti-tumor NK and γδ T-cells that can be further expanded in vitro
Esteso G, Felgueres MJ, García-Jiménez ÁF, Reyburn-Valés C, Benguría A, Vázquez E, Reyburn HT, Aguiló N, Martín C, Puentes E, Murillo I, Rodríguez E, Valés-Gómez M |
OncoImmunology | 2022 |
Higher frequency of circulating Vδ1 γδT cells in patients with advanced schistosomiasis
Zheng L, Wang L, Hu Y, Yi J, Wan L, Shen Y, Liu S, Zhou X, Cao J |
Parasite Immunology | 2021 |