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Citations to this article

Chronic diarrhea, bile acids, and Clostridia
Julian R.F. Walters, Julian R. Marchesi
Julian R.F. Walters, Julian R. Marchesi
Published December 9, 2019
Citation Information: J Clin Invest. 2020;130(1):77-79. https://doi.org/10.1172/JCI133117.
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Commentary Article has an altmetric score of 2

Chronic diarrhea, bile acids, and Clostridia

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Abstract

Excessive fecal bile acid (BA) loss causes symptoms in a large proportion of people diagnosed with irritable bowel syndrome with diarrhea, a common functional bowel disorder. This BA diarrhea (BAD) results from increased hepatic synthesis of BAs, with impaired negative feedback regulation by the ileal hormone fibroblast growth factor 19 (FGF19). In this issue of the JCI, Zhao et al. investigated BA metabolism, including fecal BAs, serum BAs, and FGF19, in patients and controls. They identified associations between fecal bacterial BA metabolism and specific microbiota, especially Clostridium scindens. These findings have been tested in a mouse model using microbiota transplants and antibiotic treatment. This group of organisms has potential as a biomarker for BAD and to be a target for therapy.

Authors

Julian R.F. Walters, Julian R. Marchesi

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Total citations by year

Year: 2022 2020 Total
Citations: 2 2 4
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (4)

Title and authors Publication Year
Pathophysiology and Clinical Management of Bile Acid Diarrhea
Marasco G, Cremon C, Barbaro MR, Falangone F, Montanari D, Capuani F, Mastel G, Stanghellini V, Barbara G
Journal of Clinical Medicine 2022
Dietary fiber-based regulation of bile salt hydrolase activity in the gut microbiota and its relevance to human disease.
Kastl A, Zong W, Gershuni VM, Friedman ES, Tanes C, Boateng A, Mitchell WJ, O'Connor K, Bittinger K, Terry NA, Bales C, Albenberg L, Wu GD
Gut microbes 2022
The Role of Bile Acids in Chronic Diarrhea
M Camilleri, P Vijayvargiya
The American Journal of Gastroenterology 2020
Longitudinal profiling of the gut microbiome in patients with psoriatic arthritis and ankylosing spondylitis: a multicentre, prospective, observational study
Miguens Blanco J, Borghese F, McHugh N, Kelleher P, Sengupta R, Marchesi JR, Abraham S
BMC Rheumatology 2020

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