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Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

Franck Mauvais-Jarvis, … , Lewis C. Cantley, C. Ronald Kahn

Franck Mauvais-Jarvis, … , Lewis C. Cantley, C. Ronald Kahn

Published January 1, 2002
Citation Information: J Clin Invest. 2002;109(1):141-149. https://doi.org/10.1172/JCI13305.

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Title and authors	Publication	Year
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant Tomlinson PR, Knox RG, Perisic O, Su H, Brierley GV, Williams RL, Semple RK	eLife	2025
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Biological effects of recombinant human growth hormone therapy on metabolism in children with growth hormone deficiency: a review. Dyrka K, Łachut K, Kolesińska Z, Niedziela M, Obara-Moszyńska M	Journal of pediatric endocrinology & metabolism : JPEM	2025
Osteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspring. Correa Pinto Junior D, Canal Delgado I, Yang H, Clemenceau A, Corvelo A, Narzisi G, Musunuri R, Meyer Berger J, Hendricks LE, Tokumura K, Luo N, Li H, Oury F, Ducy P, Yadav VK, Li X, Karsenty G	EMBO reports	2024
Divergent roles of the regulatory subunits of class IA PI3K Kim CW, Lee JM, Park SW	Frontiers in Endocrinology	2024
Upregulation of MMPs in placentas of patients with gestational diabetes mellitus: Involvement of the PI3K/Akt pathway Zhang Y, Liu Y, Shi Y, Bai C, Wang T, Ruan F, Hu C	Heliyon	2024
Targeting PI3K family with small-molecule inhibitors in cancer therapy: current clinical status and future directions Li H, Wen X, Ren Y, Fan Z, Zhang J, He G, Fu L	Molecular Cancer	2024
A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism. Thapa N, Chen M, Cryns VL, Anderson R	Cell reports	2024
Assessment of Changes in the Expression of Genes Involved in Insulin Signaling and Glucose Transport in Leukocytes of Women with Gestational Diabetes During Pregnancy and in the Postpartum Period Zieleniak A, Zurawska-Klis M, Laszcz K, Bulash K, Pacyga D, Cypryk K, Wozniak L, Wojcik M	International Journal of Molecular Sciences	2024
Integration of microRNA and mRNA analyses depicts the potential roles of Momordica charantia saponin administration in insulin resistance of juvenile common carp (Cyprinus carpio) fed with a high-starch diet Fan Z, Wang L, Li C, Wu D, Li J, Zhang H, Xiong S, Miao L, Ge X, Li Z	Frontiers in Molecular Biosciences	2023
Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes Oh J, Riek AE, Bauerle KT, Dusso A, McNerney KP, Barve RA, Darwech I, Sprague JE, Moynihan C, Zhang RM, Kutz G, Wang T, Xing X, Li D, Mrad M, Wigge NM, Castelblanco E, Collin A, Bambouskova M, Head RD, Sands MS, Bernal-Mizrachi C	Nature Communications	2023
Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant Tomlinson PR, Knox R, Perisic O, Su HC, Brierley GV, Williams RL, Semple RK		2023
Differential effects of single fatty acids and fatty acid mixtures on the phosphoinositide 3-kinase/Akt/eNOS pathway in endothelial cells. Jackson KG, Newens KJ, Fry MJ, Thompson AK, Williams CM	European Journal of Nutrition	2022
Quantitative assessment of muscle mass and gene expression analysis in dogs with glucocorticoid-induced muscle atrophy. Yoshida K, Matsuoka T, Kobatake Y, Takashima S, Nishii N	Journal of Veterinary Medical Science	2022
The impact of PIK3R1 mutations and insulin-PI3K-glycolytic pathway regulation in prostate cancer Chakraborty G, Nandakumar S, Hirani R, Nguyen B, Stopsack KH, Kreitzer C, Rajanala SH, Ghale R, Mazzu YZ, Pillarsetty NV, Mary Lee GS, Scher HI, Morris MJ, Traina T, Razavi P, Abida W, Durack JC, Solomon SB, Vander Heiden MG, Mucci LA, Wibmer AG, Schultz N, Kantoff PW	Clinical cancer research	2022
Current Studies on Molecular Mechanisms of Insulin Resistance Pei J, Wang B, Wang D	Journal of Diabetes Research	2022
The adipocyte supersystem of insulin and cAMP signaling. Guilherme A, Rowland LA, Wang H, Czech MP	Trends in Cell Biology	2022
Is type 2 diabetes an adiposity-based metabolic disease? From the origin of insulin resistance to the concept of dysfunctional adipose tissue P Sbraccia, M DAdamo, V Guglielmi	Eating and weight disorders : EWD	2021
The role of striated muscle Pik3r1 in glucose and protein metabolism following chronic glucocorticoid exposure TC Chen, T Kuo, M Dandan, RA Lee, M Chang, SD Villivalam, SC Liao, D Costello, M Shankaran, H Mohammed, S Kang, MK Hellerstein, JC Wang	The Journal of biological chemistry	2021
The regulatory subunits of PI3K, p85α and p85β, differentially affect BRD7-mediated regulation of insulin signaling Lee JM, Liu R, Park SW	Journal of Molecular Cell Biology	2021
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling BY Shorning, MS Dass, MJ Smalley, HB Pearson	International journal of molecular sciences	2020
Specific knockout of p85α in brown adipose tissue induces resistance to high-fat diet–induced obesity and its metabolic complications in male mice A Gomez-Hernandez, AR Lopez-, C Rubio-Longas, P Majewski, N Beneit, V Viana-Huete, G García-Gómez, S Fernandez, ML Hribal, G Sesti, O Escribano, M Benito	Molecular Metabolism	2020
Mechanisms of insulin resistance related to white, beige, and brown adipocytes MP Czech	Molecular Metabolism	2020
Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure A Kwok, I Zvetkova, S Virtue, I Luijten, I Huang-Doran, P Tomlinson, DA Bulger, J West, S Murfitt, J Griffin, R Alam, D Hart, R Knox, P Voshol, A Vidal-Puig, J Jensen, S O'Rahilly, RK Semple	Molecular Metabolism	2020
Loss of PI3 kinase association improves the sensitivity of secondary mutation of KIT to Imatinib G Zhu, J Shi, S Zhang, Y Guo, L Huang, H Zhao, Y Jiang, J Sun	Cell & Bioscience	2020
Oleic Acid Protects Against Insulin Resistance by Regulating the Genes Related to the PI3K Signaling Pathway C López-Gómez, C Santiago-Fernández, S García-Serrano, E García-Escobar, C Gutiérrez-Repiso, C Rodríguez-Díaz, A Ho-Plágaro, F Martín-Reyes, L Garrido-Sánchez, S Valdés, A Rodríguez-Cañete, F Rodríguez-Pacheco, E García-Fuentes	Journal of Clinical Medicine	2020
Muscle-Specific Insulin Receptor Overexpression Protects Mice From Diet-Induced Glucose Intolerance but Leads to Postreceptor Insulin Resistance G Wang, Y Yu, W Cai, TM Batista, S Suk, HL Noh, M Hirshman, P Nigro, ME Li, S Softic, L Goodyear, JK Kim, CR Kahn	Diabetes	2020
Class IA PI3K regulatory subunits: p110-independent roles and structures M Fox, HR Mott, D Owen	Biochemical Society Transactions	2020
Gene Expression Profiling of Type 2 Diabetes Mellitus by Bioinformatics Analysis H Zhu, X Zhu, Y Liu, F Jiang, M Chen, L Cheng, X Cheng, L Chen	Computational and mathematical methods in medicine	2020
Emerging Roles of BRD7 in Pathophysiology SW Park, JM Lee	International journal of molecular sciences	2020
Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality MA Mendenhall, S Liu, MK Portley, D OMard, R Fattah, R Szabo, TH Bugge, JS Khillan, SH Leppla, M Moayeri	Nature Microbiology	2020
Mice Carrying a Dominant-Negative Human PI 3-Kinase Mutation are Protected From Obesity and Hepatic Steatosis But Not Diabetes MH Solheim, JN Winnay, TM Batista, A Molven, PR Njølstad, CR Kahn	Diabetes	2018
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Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity Chaudhari A, Ejeskär K, Wettergren Y, Kahn CR, Rotter Sopasakis V	F1000Research	2018
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A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes Z Du, V Uversky	International journal of molecular sciences	2017
PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α LM Thorpe, JM Spangle, CE Ohlson, H Cheng, TM Roberts, LC Cantley, JJ Zhao	Proceedings of the National Academy of Sciences	2017
The node-weighted Steiner tree approach to identify elements of cancer-related signaling pathways Y Sun, C Ma, S Halgamuge	BMC bioinformatics	2017
PI 3-kinase Mutation Linked to Insulin and Growth Factor Resistance in vivo Jonathon Winnay, Marie Holm Solheim, Ercument Dirice, Masaji Sakaguchi, Hye-Lim Noh, Hee Joon Kang, Hirokazu Takahashi, Kishan Kumar Chudasama, Jason Kim, Anders Molven, C. Ronald Kahn, Pål R. Njølstad	Journal of Clinical Investigation	2016
Insulin resistance uncoupled from dyslipidemia in humans with C-terminal mutations in PIK3R1 Isabel Huang – Doran, Patsy Tomlinson, Felicity Payne, Alexandra Gast, Alison Sleigh, William Bottomley, Julie Harris, Allan Daly, Nuno Rocha, Simon Rudge, Jonathan Clark, Albert Kwok, stefano romeo, Emma McCann, Barbara Muksch, Mehul Dattani, Stefano Zucchini, Michael Wakelam, Lazaros Foukas, David Savage, Rinki Murphy, Stephen O'Rahilly, Inês Barroso, Robert Semple	JCI Insight	2016
Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice Z Zhang, E Turer, X Li, X Zhan, M Choi, M Tang, A Press, SR Smith, A Divoux, EM Moresco, B Beutler	Proceedings of the National Academy of Sciences	2016
Glucocorticoid Signaling JC Wang, C Harris	Glucocorticoid Signaling	2015
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Identification and Characterization of a Novel Constitutional PIK3CA Mutation in a Child Lacking the Typical Segmental Overgrowth of “ PIK3CA -Related Overgrowth Spectrum” ND Donato, A Rump, GM Mirzaa, D Alcantara, A Oliver, E Schrock, WB Dobyns, M O'Driscoll	Human Mutation	2015
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Differential Effects of Exposure to Maternal Obesity or Maternal Weight Loss during the Periconceptional Period in the Sheep on Insulin Signalling Molecules in Skeletal Muscle of the Offspring at 4 Months of Age LM Nicholas, JL Morrison, L Rattanatray, SE Ozanne, DO Kleemann, SK Walker, SM Maclaughlin, S Zhang, MS Martin-Gronert, IC McMillen	PloS one	2013
Mechanistic target of rapamycin controls homeostasis of adipogenesis MS Yoon, C Zhang, Y Sun, CJ Schoenherr, J Chen	Journal of lipid research	2013
Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice CE McCurdy, S Schenk, MJ Holliday, A Philp, JA Houck, D Patsouris, PS MacLean, SM Majka, DJ Klemm, JE Friedman	Diabetes	2012
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Genome-wide analysis of glucocorticoid receptor-binding sites in myotubes identifies gene networks modulating insulin signaling T Kuo, MJ Lew, O Mayba, CA Harris, TP Speed, JC Wang	Proceedings of the National Academy of Sciences	2012
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Zinc Finger Protein Zbtb20 Is Essential for Postnatal Survival and Glucose Homeostasis AP Sutherland, H Zhang, Y Zhang, M Michaud, Z Xie, ME Patti, MJ Grusby, WJ Zhang	Molecular and cellular biology	2009
Insulin sensitivity: Modulation by nutrients and inflammation Simon Schenk, Maziyar Saberi and Jerrold M. Olefsky	Journal of Clinical Investigation	2008
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The development of insulin resistance in Type 2 diabetes: insights from knockout studies. Pattaranit R, van den Berg HA, Spanswick D	Science Progress	2008
Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance Simon Schenk Jeffrey F. Horowitz	Journal of Clinical Investigation	2007
The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance CM Taniguchi, JO Aleman, K Ueki, J Luo, T Asano, H Kaneto, G Stephanopoulos, LC Cantley, CR Kahn	Molecular and cellular biology	2007
Endocrine Regulation of Energy Metabolism by the Skeleton NK Lee, H Sowa, E Hinoi, M Ferron, JD Ahn, C Confavreux, R Dacquin, PJ Mee, MD McKee, DY Jung, Z Zhang, JK Kim, F Mauvais-Jarvis, P Ducy, G Karsenty	Cell	2007
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers B Geering, PR Cutillas, G Nock, SI Gharbi, B Vanhaesebroeck	Proceedings of the National Academy of Sciences	2007
Increased Skeletal Muscle Tumor Necrosis Factor- and Impaired Insulin Signaling Persist in Obese Women With Gestational Diabetes Mellitus 1 Year Postpartum JE Friedman, JP Kirwan, M Jing, L Presley, PM Catalano	Diabetes	2007
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The Farnesoid X Receptor is Essential for Normal Glucose Homeostasis Ke Ma, Pradip K. Saha, Lawrence Chan, and David D. Moore	Journal of Clinical Investigation	2006
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Nutritional upregulation of p85alpha expression is an early molecular manifestation of insulin resistance MA Cornier, DH Bessesen, I Gurevich, JW Leitner, B Draznin	Diabetologia	2006
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Glucocorticoid-induced insulin resistance in skeletal muscles: defects in insulin signalling and the effects of a selective glycogen synthase kinase-3 inhibitor J Ruzzin, AS Wagman, J Jensen	Diabetologia	2005
Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase J Luo, CL Sobkiw, NM Logsdon, JM Watt, S Signoretti, F O'Connell, E Shin, Y Shim, L Pao, BG Neel, RA Depinho, M Loda, LC Cantley	Proceedings of the National Academy of Sciences	2005
Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice SM Brachmann, K Ueki, JA Engelman, RC Kahn, LC Cantley	Molecular and cellular biology	2005
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Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo LC Foukas, CA Beeton, J Jensen, WA Phillips, PR Shepherd	Molecular and cellular biology	2004
Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle CE McCurdy, RT Davidson, GD Cartee	American journal of physiology. Endocrinology and metabolism	2003
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Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver Kazuaki Miyake, Wataru Ogawa, Michihiro Mastumoto, Takehiro Nakamura, Hiroshi Sakaue, Masato Kasuga	Journal of Clinical Investigation	2002
Tissue-Specific Targeting of the Insulin Receptor Gene RN Kulkarni, T Okada	Endocrine	2002
Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alpha K Almind, L Delahaye, T Hansen, EV Obberghen, O Pedersen, CR Kahn	Proceedings of the National Academy of Sciences	2002
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival K Ueki, DA Fruman, SM Brachmann, YH Tseng, LC Cantley, CR Kahn	Molecular and cellular biology	2002
Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85α* D Hallmann, K Trümper, H Trusheim, K Ueki, CR Kahn, LC Cantley, DA Fruman, D Hörsch	The Journal of biological chemistry	2002
Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC	Proceedings of the National Academy of Sciences	2001

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