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Citations to this article

Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs
Paul Ogongo, … , Alasdair Leslie, Samuel M. Behar
Paul Ogongo, … , Alasdair Leslie, Samuel M. Behar
Published November 25, 2019
Citation Information: J Clin Invest. 2020;130(1):214-230. https://doi.org/10.1172/JCI130711.
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Research Article Immunology Infectious disease Article has an altmetric score of 15

Differential skewing of donor-unrestricted and γδ T cell repertoires in tuberculosis-infected human lungs

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Abstract

Unconventional T cells that recognize mycobacterial antigens are of great interest as potential vaccine targets against tuberculosis (TB). This includes donor-unrestricted T cells (DURTs), such as mucosa-associated invariant T cells (MAITs), CD1-restricted T cells, and γδ T cells. We exploited the distinctive nature of DURTs and γδ T cell receptors (TCRs) to investigate the involvement of these T cells during TB in the human lung by global TCR sequencing. Making use of surgical lung resections, we investigated the distribution, frequency, and characteristics of TCRs in lung tissue and matched blood from individuals infected with TB. Despite depletion of MAITs and certain CD1-restricted T cells from the blood, we found that the DURT repertoire was well preserved in the lungs, irrespective of disease status or HIV coinfection. The TCRδ repertoire, in contrast, was highly skewed in the lungs, where it was dominated by Vδ1 and distinguished by highly localized clonal expansions, consistent with the nonrecirculating lung-resident γδ T cell population. These data show that repertoire sequencing is a powerful tool for tracking T cell subsets during disease.

Authors

Paul Ogongo, Adrie J.C. Steyn, Farina Karim, Kaylesh J. Dullabh, Ismael Awala, Rajhmun Madansein, Alasdair Leslie, Samuel M. Behar

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Year: 2025 2024 2023 2022 2021 2020 2019 Total
Citations: 2 5 8 4 7 5 1 32
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Citations to this article (32)

Title and authors Publication Year
Characterization and anti-tuberculosis effects of γδ T cells expanded and activated by Mycobacterium tuberculosis heat-resistant antigen
Guo F, Song Y, Dong S, Wei J, Li B, Xu T, Wang H
Virulence 2025
Diverse Subsets of γδT Cells and Their Specific Functions Across Liver Diseases
Zhan C, Peng C, Wei H, Wei K, Ou Y, Zhang Z
International Journal of Molecular Sciences 2025
An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis.
Paterson RL, La Manna MP, Arena De Souza V, Walker A, Gibbs-Howe D, Kulkarni R, Fergusson JR, Mulakkal NC, Monteiro M, Bunjobpol W, Dembek M, Martin-Urdiroz M, Grant T, Barber C, Garay-Baquero DJ, Tezera LB, Lowne D, Britton-Rivet C, Pengelly R, Chepisiuk N, Singh PK, Woon AP, Powlesland AS, McCully ML, Caccamo N, Salio M, Badami GD, Dorrell L, Knox A, Robinson R, Elkington P, Dieli F, Lepore M, Leonard S, Godinho LF
Proceedings of the National Academy of Sciences 2024
B cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles.
Krause R, Ogongo P, Tezera L, Ahmed M, Mbano I, Chambers M, Ngoepe A, Magnoumba M, Muema D, Karim F, Khan K, Lumamba K, Nargan K, Madansein R, Steyn A, Shalek AK, Elkington P, Leslie A
Communications biology 2024
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the lifespan
Gray JI, Caron DP, Wells SB, Guyer R, Szabo P, Rainbow D, Ergen C, Rybkina K, Bradley MC, Matsumoto R, Pethe K, Kubota M, Teichmann S, Jones J, Yosef N, Atkinson M, Brusko M, Brusko TM, Connors TJ, Sims PA, Farber DL
Science immunology 2024
Research progress on V delta 1(+) T cells and their effect on pathogen infection.
Li Y, Liu Y, Bu X, Qin Y, Zhang Y
PeerJ 2024
γδ T Cells Mediate Protection against Neutrophil-associated Lung Inflammation in Pulmonary Melioidosis
Wright SW, Sengyee S, Ekchariyawat P, Phunpang R, Dulsuk A, Rerolle G, Bashmail A, Chantratita N, Gharib SA, West TE
American Journal of Respiratory Cell and Molecular Biology 2024
Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles.
Contreras AV, Wiest DL
Methods in molecular biology (Clifton, N.J.) 2023
T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection
Musvosvi M, Huang H, Wang C, Xia Q, Rozot V, Krishnan A, Acs P, Cheruku A, Obermoser G, Leslie A, Behar SM, Hanekom WA, Bilek N, Fisher M, Kaufmann SH, Walzl G, Hatherill M, Davis MM, Scriba TJ
Nature Medicine 2023
Impact of BCG vaccination on the repertoire of human γδ T cell receptors
Xia M, Blazevic A, Fiore-Gartland A, Hoft DF
Frontiers in immunology 2023
CD8+ lymphocytes are critical for early control of tuberculosis in macaques
Winchell CG, Nyquist SK, Chao MC, Maiello P, Myers AJ, Hopkins F, Chase M, Gideon HP, Patel KV, Bromley JD, Simonson AW, Floyd-O\u2019Sullivan R, Wadsworth M, Rosenberg JM, Uddin R, Hughes T, Kelly RJ, Griffo J, Tomko J, Klein E, Berger B, Scanga CA, Mattila J, Fortune SM, Shalek AK, Lin PL, Flynn JL
Journal of Experimental Medicine 2023
γδ T cells: origin and fate, subsets, diseases and immunotherapy
Hu Y, Hu Q, Li Y, Lu L, Xiang Z, Yin Z, Kabelitz D, Wu Y
Signal Transduction and Targeted Therapy 2023
Vaccine development against tuberculosis before and after Covid-19
Kaufmann SH
Frontiers in immunology 2023
Feasibility and acceptability of undertaking postmortem studies for tuberculosis medical research in a low income country
Ahimbisibwe G, Nakibuule M, Martin Ssejoba M, Oyamo D, Mulwana R, Nabulime J, Babirye F, Kizito MA, Lekuya HM, Adakun AS, Nalumansi D, Muryasingura S, Lukande R, Kyazze A, Baluku JB, Biraro IA, Cose S
Frontiers in immunology 2023
From snoot to tail - A brief review of influenza virus infection and immunity in pigs
Ma W, Loving CL, Driver JP
Journal of immunology (Baltimore, Md. : 1950) 2023
It Takes a Village: The Multifaceted Immune Response to Mycobacterium tuberculosis Infection and Vaccine-Induced Immunity
S Larsen, B Williams, M Rais, R Coler, S Baldwin
Frontiers in immunology 2022
Durable Expansion of TCR-δ Meta-Clonotypes After BCG Revaccination in Humans
C James, K Yu, K Mayer-Blackwell, A Fiore-Gartland, M Smith, E Layton, J Johnson, W Hanekom, T Scriba, C Seshadri
Frontiers in immunology 2022
T Cell Receptor Repertoire Analysis Reveals Signatures of T Cell Responses to Human Mycobacterium tuberculosis
M Shao, F Yi, Z Huang, P Peng, F Wu, H Shi, K Zhai
Frontiers in microbiology 2022
BCG-activation of leukocytes is sufficient for the generation of donor-independent innate anti-tumor NK and γδ T-cells that can be further expanded in vitro
Esteso G, Felgueres MJ, García-Jiménez ÁF, Reyburn-Valés C, Benguría A, Vázquez E, Reyburn HT, Aguiló N, Martín C, Puentes E, Murillo I, Rodríguez E, Valés-Gómez M
OncoImmunology 2022
The role of donor‐unrestricted T‐cells, innate lymphoid cells, and NK cells in anti‐mycobacterial immunity
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Immunological Reviews 2021
Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection
RV Moriarty, AL Ellis, SL OConnor
Viruses 2021
CD1 and MR1 recognition by human γδ T cells
IV Rhijn, JL Nours
Molecular Immunology 2021
T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette–Guérin Vaccination
ED Layton, S Barman, DB Wilburn, KK Yu, MT Smith, JD Altman, TJ Scriba, N Tahiri, AJ Minnaard, M Roederer, RA Seder, PA Darrah, C Seshadri
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P Elkington, ME Polak, MT Reichmann, A Leslie
Trends in Molecular Medicine 2021
A simple assay to quantify mycobacterial lipid antigen-specific T cell receptors in human tissues and blood
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Role of Group 1 CD1-restricted T Cells in Host Defense and Inflammatory Diseases
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