Go to
JCI Insight
Citations to this article
Rong Cai, … , Michael J. Welsh, Lei Liu
Published September 16, 2019
Citation Information: J Clin Invest. 2019;129(10):4539-4549. https://doi.org/10.1172/JCI129987.
Citation Information: J Clin Invest. 2019;129(10):4539-4549. https://doi.org/10.1172/JCI129987.
Abstract
Parkinson’s disease (PD) is a common neurodegenerative disease that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels are common features of PD. Previous studies revealed that terazosin (TZ) enhances the activity of phosphoglycerate kinase 1 (PGK1), thereby stimulating glycolysis and increasing cellular ATP levels. Therefore, we asked whether enhancement of PGK1 activity would change the course of PD. In toxin-induced and genetic PD models in mice, rats, flies, and induced pluripotent stem cells, TZ increased brain ATP levels and slowed or prevented neuron loss. The drug increased dopamine levels and partially restored motor function. Because TZ is prescribed clinically, we also interrogated 2 distinct human databases. We found slower disease progression, decreased PD-related complications, and a reduced frequency of PD diagnoses in individuals taking TZ and related drugs. These findings suggest that enhancing PGK1 activity and increasing glycolysis may slow neurodegeneration in PD.
Authors
Rong Cai, Yu Zhang, Jacob E. Simmering, Jordan L. Schultz, Yuhong Li, Irene Fernandez-Carasa, Antonella Consiglio, Angel Raya, Philip M. Polgreen, Nandakumar S. Narayanan, Yanpeng Yuan, Zhiguo Chen, Wenting Su, Yanping Han, Chunyue Zhao, Lifang Gao, Xunming Ji, Michael J. Welsh, Lei Liu
Total citations by year
Citation information
Citations to this article (124)
| Title and authors | Publication | Year |
|---|---|---|
|
Exploring glycolytic enzymes in disease: potential biomarkers and therapeutic targets in neurodegeneration, cancer and parasitic infections
Rojas-Pirela M, Andrade-Alviárez D, Rojas V, Marcos M, Salete-Granado D, Chacón-Arnaude M, Pérez-Nieto MÁ, Kemmerling U, Concepción JL, Michels PA, Quiñones W |
Open Biology | 2025 |
|
Brain network and energy imbalance in Parkinson’s disease: linking ATP reduction and α-synuclein pathology
Watanabe H, Shima S, Kawabata K, Mizutani Y, Ueda A, Ito M |
Frontiers in Molecular Neuroscience | 2025 |
|
Parkinson's disease and glucose metabolism impairment
Chen L, Wang C, Qin L, Zhang H |
Translational Neurodegeneration | 2025 |
|
α1D Adrenergic Receptor Antagonism Protects Against High Glucose-Induced Mitochondrial Dysfunction and Blood Retinal Barrier Breakdown in ARPE-19 Cells
Giuffrida E, Platania CB, Lazzara F, Conti F, Sotera L, Drago F, Herath D, Motterlini R, Foresti R, Bucolo C |
International Journal of Molecular Sciences | 2025 |
|
Energy metabolism in health and diseases
Liu H, Wang S, Wang J, Guo X, Song Y, Fu K, Gao Z, Liu D, He W, Yang LL |
Signal Transduction and Targeted Therapy | 2025 |
|
Brain Glycogen—Its Metabolic Role in Neuronal Health and Neurological Disorders—An Extensive Narrative Review
Beltran-Velasco AI |
Metabolites | 2025 |
|
Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson’s disease treatment through network pharmacology and transcriptomics
Xu QH, Wang YL, Wang C, Jiang SS, Zhang BR, Tian J |
Scientific Reports | 2025 |
|
Immune cell metabolic dysfunction in Parkinson’s disease
Mark JR, Tansey MG |
Molecular Neurodegeneration | 2025 |
|
Therapeutic Efficacy of Small Extracellular Vesicles Loaded with ROCK Inhibitor in Parkinson’s Disease
Carbajal C, Rodriguez M, Owens F, Stone N, Veeragoni D, Fan RZ, Tieu K, El-Hage N |
Pharmaceutics | 2025 |
|
Drug repurposing in amyotrophic lateral sclerosis (ALS)
Carroll E, Scaber J, Huber KV, Brennan PE, Thompson AG, Turner MR, Talbot K |
Expert Opinion on Drug Discovery | 2025 |
|
Altered Mitochondrial Bioenergetics and Calcium Kinetics in Young‐Onset PLA2G6 Parkinson's Disease iPSCs
Musthafa T, Nizami SK, Mishra A, Hasan G, Gopurappilly R |
Journal of Neurochemistry | 2025 |
|
Induced Pluripotent Stem Cells-Based Regenerative Therapies in Treating Human Aging-Related Functional Decline and Diseases
Yu P, Liu B, Dong C, Chang Y |
Cells | 2025 |
|
Evaluation of Additive Neuroprotective Effect of Combination Therapy for Parkinson’s Disease Using In Vitro Models
Shtilbans A, Esneault E, Simon F, Mazzulli JR, Quiriconi DJ, Rom D, Reintsch WE, Krahn AI, Durcan TM |
Antioxidants | 2025 |
|
Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective.
Wang Z, Zhu H, Xiong W |
Frontiers of medicine | 2025 |
|
Drug Repositioning and Repurposing for Disease-Modifying Effects in Parkinson's Disease.
Jeong SH, Lee PH |
Journal of movement disorders | 2025 |
|
Targeting common disease pathomechanisms to treat amyotrophic lateral sclerosis.
Faller KME, Chaytow H, Gillingwater TH |
Nature reviews. Neurology | 2025 |
|
Neural Metabolic Networks: Key Elements of Healthy Brain Function
Madrer N, Perera ND, Uccelli NA, Abbondanza A, Andersen JV, Carsana EV, Demmings MD, Fernandez RF, de Fragas MG, Gbadamosi I, Kulshrestha D, Lima\u2010Filho RA, Marian OC, Markussen KH, McGovern AJ, Neal ES, Sarkar S, Šimončičová E, Soto\u2010Verdugo J, Yandiev S, Fernández\u2010Moncada I |
Journal of Neurochemistry | 2025 |
|
Lactate metabolism in neurodegenerative diseases.
Yang C, Pan RY, Guan F, Yuan Z |
Neural Regeneration Research | 2024 |
|
Glycolytic enzymes in non-glycolytic web: functional analysis of the key players.
Malla A, Gupta S, Sur R |
Cell Biochemistry and Biophysics | 2024 |
|
Effects of phosphoglycerate kinase 1 and pyruvate kinase M2 on metabolism and physiochemical changes in postmortem muscle.
Huang C, Zhang D, Blecker C, Zhao Y, Xiang C, Wang Z, Li S, Chen L |
2024 | |
|
Dopamine modification of glycolytic enzymes impairs glycolysis: possible implications for Parkinson's disease.
Chen B, Zhang Q, Zhong X, Zhang X, Liu X, Wang H, Yang F, Zhang J, Huang J, Wong YK, Luo P, Wang J, Sun J |
Cell communication and signaling : CCS | 2024 |
|
Insights into the management of Lewy body dementia: a scoping review
Khan SA, Khan S, Kausar H, Shah R, Luitel A, Gautam S, Parajuli SB, Rauniyar VK, Khan MA |
Annals of Medicine and Surgery | 2024 |
|
Parkinson’s Disease: Cells Succumbing to Lifelong Dopamine-Related Oxidative Stress and Other Bioenergetic Challenges
Watanabe H, Dijkstra JM, Nagatsu T |
International journal of molecular sciences | 2024 |
|
A model for stimulation of enzyme activity by a competitive inhibitor based on the interaction of terazosin and phosphoglycerate kinase 1
Riley MJ, Mitchell CC, Ernst SE, Taylor EB, Welsh MJ |
Proceedings of the National Academy of Sciences | 2024 |
|
Age-related changes after intracerebral hemorrhage: a comparative proteomics analysis of perihematomal tissue
Li X, Xiao Z, Li P, Yang W, Shen Y, Liu F, Xiong X, Wu Q, Wang P, Dang R, Gui S, Deng L, Manaenko A, Xie P, Li Q |
Experimental Biology and Medicine | 2024 |
|
A crazy trio in Parkinson's disease: metabolism alteration, α-synuclein aggregation, and oxidative stress.
Li S, Liu Y, Lu S, Xu J, Liu X, Yang D, Yang Y, Hou L, Li N |
Molecular and Cellular Biochemistry | 2024 |
|
The Contribution of Type 2 Diabetes to Parkinson’s Disease Aetiology
Ribarič S |
International journal of molecular sciences | 2024 |
|
X-Linked Levodopa-Responsive Parkinsonism-Epilepsy Syndrome: A Novel PGK1 Mutation and Literature Review.
Guimarães TG, Parmera JB, Castro MAA, Cury RG, Barbosa ER, Kok F |
Movement Disorders Clinical Practice | 2024 |
|
Dopamine Release Neuroenergetics in Mouse Striatal Slices
Msackyi M, Chen Y, Tsering W, Wang N, Zhang H |
International journal of molecular sciences | 2024 |
|
Risk of Parkinson’s disease among users of alpha-adrenergic receptor antagonists: a systematic review and meta-analysis
Lamichhane P, Tariq A, Akhtar AN, Raza M, Lamsal AB, Agrawal A |
Annals of Medicine and Surgery | 2024 |
|
The hexosamine biosynthetic pathway rescues lysosomal dysfunction in Parkinson’s disease patient iPSC derived midbrain neurons
Wani WY, Zunke F, Belur NR, Mazzulli JR |
Nature Communications | 2024 |
|
Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of Dementia With Lewy Bodies in Men
Hart A, Aldridge G, Zhang Q, Narayanan NS, Simmering JE |
Neurology | 2024 |
|
Effect of low‐dose terazosin on arterial stiffness improvement: A pilot study
Guan Y, Zhang Y, Chen L, Ren Y, Nie H, Ji T, Yan J, Zhang C, Ruan L |
Journal of Cellular and Molecular Medicine | 2024 |
|
Neurodegenerative Diseases: New Hopes and Perspectives.
Bhat MA, Dhaneshwar S |
Current molecular medicine | 2024 |
|
Novel energy optimizer, meldonium, rapidly restores acute hypobaric hypoxia-induced brain injury by targeting phosphoglycerate kinase 1
Liu F, He H, Yang W, Wang D, Sui X, Sun Y, Wang S, Yang Y, Xiao Z, Yang J, Wang Y, Luo Y |
Cell communication and signaling : CCS | 2024 |
|
Glycolytic enzyme PGK1 promotes M1 macrophage polarization and induces pyroptosis of acute lung injury via regulation of NLRP3.
Zhu G, Yu H, Peng T, Yang K, Xu X, Gu W |
Respiratory Research | 2024 |
|
Epigenetic associations of GPNMB rs199347 variant with alcohol consumption in Parkinson's disease.
Chen YC, Liaw YC, Nfor ON, Hsiao CH, Zhong JH, Wu SL, Liaw YP |
Frontiers in Psychiatry | 2024 |
|
Pre-clinical Aspects and Contemporary Treatments of Parkinson's Disease.
Chhabra P, Rishabh, Singla S, Choudhary S, Kohli S, Bansal N, Bansal S |
CNS & neurological disorders drug targets | 2024 |
|
Phosphoglycerate kinase is a central leverage point in Parkinson’s disease–driven neuronal metabolic deficits
Kokotos AC, Antoniazzi AM, Unda SR, Ko MS, Park D, Eliezer D, Kaplitt MG, De Camilli P, Ryan TA |
Science Advances | 2024 |
|
Exposure to Glycolysis-Enhancing Drugs and Risk of Parkinson’s Disease: A Meta-Analysis
Ribeiro GB, Rodrigues FR, Pasqualotto E, Dantas JM, Di Luca DG |
Journal of Parkinson's Disease | 2024 |
|
SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2
Lian B, Zhang J, Yin X, Wang J, Li L, Ju Q, Wang Y, Jiang Y, Liu X, Chen Y, Tang X, Sun C |
Cell Reports Medicine | 2024 |
|
Metabolic reprogramming: a new option for the treatment of spinal cord injury
Chen J, Chen J, Yu C, Xia K, Yang B, Wang R, Li Y, Shi K, Zhang Y, Xu H, Zhang X, Wang J, Chen Q, Liang C |
Neural Regeneration Research | 2024 |
|
Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease.
Matt RA, Martin RS, Evans AK, Gever JR, Vargas GA, Shamloo M, Ford AP |
Handbook of experimental pharmacology | 2024 |
|
A Single-Cell Atlas of the Substantia Nigra Reveals Therapeutic Effects of Icaritin in a Rat Model of Parkinson’s Disease
Wu H, Zhang ZH, Zhou P, Sui X, Liu X, Sun Y, Zhao X, Pu XP |
Antioxidants | 2024 |
|
Metabolic Dysfunction in Parkinson’s Disease: Unraveling the Glucose–Lipid Connection
Sian-Hulsmann J, Riederer P, Michel TM |
Biomedicines | 2024 |
|
Links Between Cellular Energy Metabolism and Pain Sensation
Li X, Zhao Z, Ke Y, Jiang Y, Liu Y, Liu Z |
Anesthesia and Analgesia | 2024 |
|
Update: Protective and risk factors for Parkinson disease
Grotewold N, Albin RL |
Parkinsonism & related disorders | 2024 |
|
Rurality Modifies the Association Between Symptoms and the Diagnosis of Amyotrophic Lateral Sclerosis
Hart AA, Swenson A, Narayanan NS, Simmering JE |
Amyotrophic lateral sclerosis & frontotemporal degeneration | 2024 |
|
Neuroprotective Mushrooms
Abdelmoaty MM, Kadry R, Mosley RL, Gendelman HE |
NeuroImmune pharmacology and therapeutics | 2024 |
|
Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages.
Oun A, Hoeksema E, Soliman A, Brouwer F, García-Reyes F, Pots H, Trombetta-Lima M, Kortholt A, Dolga AM |
International journal of molecular sciences | 2023 |
|
α1-Adrenergic Receptors: Insights into Potential Therapeutic Opportunities for COVID-19, Heart Failure, and Alzheimer’s Disease
Perez DM |
International journal of molecular sciences | 2023 |
|
Glycolysis-enhancing α(1)-adrenergic antagonists modify cognitive symptoms related to Parkinson's disease.
Weber MA, Sivakumar K, Tabakovic EE, Oya M, Aldridge GM, Zhang Q, Simmering JE, Narayanan NS |
npj Parkinson's Disease | 2023 |
|
Anti-Parkinson Effects of Holothuria leucospilota-Derived Palmitic Acid in Caenorhabditis elegans Model of Parkinson's Disease.
Sanguanphun T, Promtang S, Sornkaew N, Niamnont N, Sobhon P, Meemon K |
Marine drugs | 2023 |
|
Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.
Xu T, Gao P, Huang Y, Wu M, Yi J, Zhou Z, Zhao X, Jiang T, Liu H, Qin T, Yang Z, Wang X, Bao T, Chen J, Zhao S, Yin G |
Redox Biology | 2023 |
|
Overcoming mitochondrial dysfunction in neurodegenerative diseases.
Pessoa J, Duarte AI |
Neural Regeneration Research | 2023 |
|
α1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis.
Ishikawa G, Peng X, McGovern J, Woo S, Perry C, Liu A, Yu S, Ghincea A, Kishchanka A, Fiorini V, Hu B, Sun Y, Sun H, Ryu C, Herzog EL |
American journal of physiology. Lung cellular and molecular physiology | 2023 |
|
The combination of machine learning and untargeted metabolomics identifies the lipid metabolism -related gene CH25H as a potential biomarker in asthma.
Ding X, Qin J, Huang F, Feng F, Luo L |
Inflammation research : official journal of the European Histamine Research Society ... [et al.] | 2023 |
|
Multi-regional alterations in glucose and purine metabolic pathways in the Parkinson's disease dementia brain.
Scholefield M, Church SJ, Taylor G, Knight D, Unwin RD, Cooper GJS |
npj Parkinson's Disease | 2023 |
|
AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins
Shi G, Scott H, Azhar NI, Gialeli A, Clennell B, Lee KS, Hurcombe J, Whitcomb D, Coward R, Wong LF, Cordero-Llana O, Uney JB |
Scientific Reports | 2023 |
|
Transcriptomics and Proteomics Approach for the Identification of Altered Blood microRNAs and Plasma Proteins in Parkinson's Disease.
Yadav SK, Jauhari A, Singh N, Pandey A, Sarkar S, Pandey S, Garg RK, Parmar D, Yadav S |
Cellular and Molecular Neurobiology | 2023 |
|
Activation of Pgk1 Results in Reduced Protein Aggregation in Diverse Neurodegenerative Conditions.
Chen H, Li Y, Gao J, Cheng Q, Liu L, Cai R |
Molecular Neurobiology | 2023 |
|
The Role of PGK1 in Promoting Ischemia/Reperfusion Injury-Induced Microglial M1 Polarization and Inflammation by Regulating Glycolysis.
Cao W, Feng Z, Zhu D, Li S, Du M, Ye S, Qi D, Li P, Chen Y, Fang Y |
NeuroMolecular Medicine | 2023 |
|
Acanthopanax senticosus Harms improves Parkinson's disease by regulating gut microbial structure and metabolic disorders
Lu Y, Gao X, Nan Y, Mohammed SA, Fu J, Wang T, Wang C, Yuan C, Lu F, Liu S |
Heliyon | 2023 |
|
Screening and Targeting Risk Factors for Prodromal Synucleinopathy: Taking Steps toward a Prescriptive Multi-modal Framework.
Neilson LE, Quinn JF, Lim MM |
Aging and disease | 2023 |
|
Lewy Body Dementia: An Overview of Promising Therapeutics.
Skylar-Scott IA, Sha SJ |
Current Neurology and Neuroscience Reports | 2023 |
|
Extracellular Pgk1 interacts neural membrane protein enolase-2 to improve the neurite outgrowth of motor neurons.
Fu CY, Chen HY, Lin CY, Chen SJ, Sheu JC, Tsai HJ |
Communications biology | 2023 |
|
Epigenetic regulation of Parkinson’s disease risk variant GPNMB cg17274742 methylation by sex and exercise from Taiwan Biobank
Chen YC, Liaw YC, Nfor ON, Hsiao CH, Zhong JH, Wu SL, Liaw YP |
Frontiers in aging neuroscience | 2023 |
|
Clinical Trial Highlights: Modulators of Mitochondrial Function
Capriglia F, Burgess T, Bandmann O, Mortiboys H |
Journal of Parkinson's disease | 2023 |
|
Role of glycolysis in inflammatory bowel disease and its associated colorectal cancer
Xia Y, Zhang L, Ocansey DK, Tu Q, Mao F, Sheng X |
Frontiers in Endocrinology | 2023 |
|
Phosphoglycerate kinase is a central leverage point in Parkinson’s Disease driven neuronal metabolic deficits
Kokotos AC, Antoniazzi AM, Unda SR, Ko MS, Park D, Eliezer D, Kaplitt MG, Camilli PD, Ryan TA |
2023 | |
|
Omics data integration suggests a potential idiopathic Parkinson’s disease signature
Zagare A, Preciat G, Nickels SL, Luo X, Monzel AS, Gomez-Giro G, Robertson G, Jaeger C, Sharif J, Koseki H, Diederich NJ, Glaab E, Fleming RM, Schwamborn JC |
Communications biology | 2023 |
|
Diabetes: a tipping point in neurodegenerative diseases.
Santiago JA, Karthikeyan M, Lackey M, Villavicencio D, Potashkin JA |
Trends in Molecular Medicine | 2023 |
|
The potential role of glucose metabolism, lipid metabolism, and amino acid metabolism in the treatment of Parkinson's disease
Li H, Zeng F, Huang C, Pu Q, Thomas ER, Chen Y, Li X |
CNS Neuroscience & Therapeutics | 2023 |
|
Genetic modifiers of synucleinopathies—lessons from experimental models
Lee RM, Koh TW |
2023 | |
|
A blood-based marker of mitochondrial DNA damage in Parkinson's disease.
Qi R, Sammler E, Gonzalez-Hunt CP, Barraza I, Pena N, Rouanet JP, Naaldijk Y, Goodson S, Fuzzati M, Blandini F, Erickson KI, Weinstein AM, Lutz MW, Kwok JB, Halliday GM, Dzamko N, Padmanabhan S, Alcalay RN, Waters C, Hogarth P, Simuni T, Smith D, Marras C, Tonelli F, Alessi DR, West AB, Shiva S, Hilfiker S, Sanders LH |
Science Translational Medicine | 2023 |
|
A metabolic biomarker for early stage of Parkinson’s disease in patients and animal models
David Mallet, Thibault Dufourd, Mélina Decourt, Carole Carcenac, Paola Bossù, Laure Verlin, Pierre-Olivier Fernagut, Marianne Benoit-Marand, Gianfranco Spalletta, Emmanuel L. Barbier, Sebastien Carnicella, Véronique Sgambato, Florence Fauvelle, Sabrina Boulet |
Journal of Clinical Investigation | 2022 |
|
Targeting PGK1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis
Helena Chaytow, Emily Carroll, David Gordon, Yu-Ting Huang, Dinja van der Hoorn, Thomas Becker, Catherina Becker, Kiterie Faller, Kevin Talbot, Thomas Gillingwater |
EBioMedicine | 2022 |
|
Defects of Nutrient Signaling and Autophagy in Neurodegeneration
Jon Ondaro, Haizea Hernandez-Eguiazu, Maddi Garciandia-Arcelus, Raúl Loera-Valencia, Laura Rodriguez-Gómez, Andrés Jiménez-Zúñiga, Julen Goikolea, Patricia Rodriguez-Rodriguez, Javier Ruiz-Martinez, Fermín Moreno, Adolfo Lopez de Munain, Ian James Holt, Francisco Javier Gil-Bea, Gorka Gereñu |
Frontiers in Cell and Developmental Biology | 2022 |
|
Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite
I Heremans, F Caligiore, I Gerin, M Bury, M Lutz, J Graff, V Stroobant, D Vertommen, A Teleman, E Schaftingen, G Bommer |
Proceedings of the National Academy of Sciences | 2022 |
|
Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson’s disease
G Novak, D Kyriakis, K Grzyb, M Bernini, S Rodius, G Dittmar, S Finkbeiner, A Skupin |
2022 | |
|
Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases
D Butterfield, M Favia, I Spera, A Campanella, M Lanza, A Castegna |
Molecules (Basel, Switzerland) | 2022 |
|
Construction and imaging of a neurovascular unit model
T Dong, M Li, F Gao, P Wei, J Wang |
NEURAL REGEN RES | 2022 |
|
Mitochondrial Sirtuins in Parkinson’s Disease
L He, J Wang, Y Yang, J Li, H Tu |
Neurochemical Research | 2022 |
|
A pilot to assess target engagement of terazosin in Parkinson's disease
J Schultz, A Brinker, J Xu, S Ernst, F Tayyari, A Rauckhorst, L Liu, E Uc, E Taylor, J Simmering, V Magnotta, M Welsh, N Narayanan |
Parkinsonism & Related Disorders | 2022 |
|
The Discovery of Novel PGK1 Activators as Apoptotic Inhibiting and Neuroprotective Agents
S Qiang, Y Shi, T Wu, J Wang, X Chen, J Su, X Chen, J Li, Z Chen |
Frontiers in pharmacology | 2022 |
|
Cerebroventricular Injection of Pgk1 Attenuates MPTP-Induced Neuronal Toxicity in Dopaminergic Cells in Zebrafish Brain in a Glycolysis-Independent Manner
C Lin, H Tseng, Y Chu, C Wu, P Zhang, H Tsai |
International journal of molecular sciences | 2022 |
|
Synapses: The Brain’s Energy-Demanding Sites
A Faria-Pereira, V Morais |
International journal of molecular sciences | 2022 |
|
The role of NURR1 in metabolic abnormalities of Parkinson's disease.
Al-Nusaif M, Yang Y, Li S, Cheng C, Le W |
Molecular Neurodegeneration | 2022 |
|
Safety and Tolerability, Dose-Escalating, Double-Blind Trial of Oral Mannitol in Parkinson's Disease
Linetsky E, Abd Elhadi S, Bauer M, Gallant A, Namnah M, Weiss S, Segal D, Sharon R, Arkadir D |
Frontiers in neurology | 2022 |
|
The Legend of ATP: From Origin of Life to Precision Medicine
Chu XY, Xu YY, Tong XY, Wang G, Zhang HY |
Metabolites | 2022 |
|
Terazosin Analogs Targeting Pgk1 as Neuroprotective Agents: Design, Synthesis, and Evaluation
Wang Y, Qian S, Zhao F, Wang Y, Li J |
Frontiers in Chemistry | 2022 |
|
NADPH and Mitochondrial Quality Control as Targets for a Circadian-Based Fasting and Exercise Therapy for the Treatment of Parkinson’s Disease
Curtis WM, Seeds WA, Mattson MP, Bradshaw PC |
Cells | 2022 |
|
Pyruvate Prevents Dopaminergic Neurodegeneration and Motor Deficits in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Model of Parkinson's Disease.
Kim YM, Choi SY, Hwang O, Lee JY |
Molecular Neurobiology | 2022 |
|
Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules
Wang T, Tian X, Kim HB, Jang Y, Huang Z, Na CH, Wang J |
Nature Communications | 2022 |
|
Glycolysis: The Next Big Breakthrough in Parkinson's Disease.
Naeem U, Arshad AR, Jawed A, Eqbal F, Imran L, Khan Z, Ijaz F |
Neurotoxicity Research | 2022 |
|
WWOX and metabolic regulation in normal and pathological conditions.
Baryła I, Kośla K, Bednarek AK |
Journal of Molecular Medicine | 2022 |
|
Machine learning-based characterization of cuprotosis-related biomarkers and immune infiltration in Parkinson's disease.
Zhao S, Zhang L, Ji W, Shi Y, Lai G, Chi H, Huang W, Cheng C |
Frontiers in Genetics | 2022 |
|
Use of Glycolysis-Enhancing Drugs and Risk of Parkinson’s Disease
Simmering JE, Welsh MJ, Schultz J, Narayanan NS |
Movement disorders : official journal of the Movement Disorder Society | 2022 |
|
Phosphoglycerate kinase 1 protects against ischemic damage in the gerbil hippocampus
Hahn KR, Kwon HJ, Yoon YS, Kim DW, Hwang IK |
Aging | 2022 |
|
Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders
McDonald TS, Lerskiatiphanich T, Woodruff TM, McCombe PA, Lee JD |
Journal of Cerebral Blood Flow & Metabolism | 2022 |
|
Parkinson disease among patients treated for benign prostatic hyperplasia with a1 adrenergic receptor antagonists
Rahul Sasane, Amy Bartels, Michelle Field, Maria Sierra, Sridhar Duvvuri, David L Gray, Sokhom S. Pin, John J Renger, David J. Stone |
Journal of Clinical Investigation | 2021 |
|
Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency
M Vos, M Dulovic-Mahlow, F Mandik, L Frese, Y Kanana, SH Diaw, J Depperschmidt, C Böhm, J Rohr, T Lohnau, IR König, C Klein |
Proceedings of the National Academy of Sciences | 2021 |
|
Glucose metabolic crosstalk and regulation in brain function and diseases
S Zhang, BB Lachance, MP Mattson, X Jia |
Progress in Neurobiology | 2021 |
|
Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution
AN Rindone, X Liu, S Farhat, A Perdomo-Pantoja, TF Witham, DL Coutu, M Wan, WL Grayson |
Nature Communications | 2021 |
|
CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target?
TW Tefera, FJ Steyn, ST Ngo, K Borges |
Cell & Bioscience | 2021 |
|
A Rationale for Hypoxic and Chemical Conditioning in Huntington’s Disease
J Burtscher, V Maglione, AD Pardo, GP Millet, C Schwarzer, L Zangrandi |
International journal of molecular sciences | 2021 |
|
Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinson's disease
CC Anderson, JO Marentette, AK Rauniyar, KM Prutton, M Khatri, C Matheson, JA Reisz, P Reigan, A D'Alessandro, JR Roede |
Free radical biology & medicine | 2021 |
|
Probiotic Supplementation Facilitates Recovery of 6-OHDA-Induced Motor Deficit via Improving Mitochondrial Function and Energy Metabolism
BA Nurrahma, SP Tsao, CH Wu, TH Yeh, PS Hsieh, B Panunggal, HY Huang |
Frontiers in aging neuroscience | 2021 |
|
Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing Parkinson Disease
JE Simmering, MJ Welsh, L Liu, NS Narayanan, A Pottegård |
JAMA NEUROL | 2021 |
|
Glycolytic Metabolism, Brain Resilience, and Alzheimer’s Disease
X Zhang, N Alshakhshir, L Zhao |
Frontiers in neuroscience | 2021 |
|
Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration
G Carola, D Malagarriga, C Calatayud, M Pons-Espinal, L Blasco-Agell, Y Richaud-Patin, I Fernandez-Carasa, V Baruffi, S Beltramone, E Molina, P DellEra, JJ Toledo-Aral, E Tolosa, AR Muotri, JG Ojalvo, J Soriano, A Raya, A Consiglio |
npj Parkinson's Disease | 2021 |
|
Mitochondrial Metabolism as Target of the Neuroprotective Role of Erythropoietin in Parkinson’s Disease
F Rey, S Ottolenghi, T Giallongo, A Balsari, C Martinelli, R Rey, R Allevi, AM Giulio, GV Zuccotti, S Mazzucchelli, R Foresti, M Samaja, S Carelli |
Antioxidants | 2021 |
|
Energy Metabolism and Intracellular pH Alteration in Neural Spheroids Carrying Down Syndrome
A Kashirina, A Gavrina, E Kryukov, V Elagin, Y Kolesova, A Artyuhov, E Momotyuk, V Abdyyev, N Meshcheryakova, E Zagaynova, E Dashinimaev, A Kashina |
Biomedicines | 2021 |
|
A High-Throughput Chemical Screen in DJ-1β Mutant Flies Identifies Zaprinast as a Potential Parkinson’s Disease Treatment
F Sanz, C Solana-Manrique, J Torres, E Masiá, M Vicent, N Paricio |
Neurotherapeutics | 2021 |
|
Cationic Carbosilane Dendrimers Prevent Abnormal α-Synuclein Accumulation in Parkinson’s Disease Patient-Specific Dopamine Neurons
R Ferrer-Lorente, T Lozano-Cruz, I Fernández-Carasa, K Miłowska, F de la Mata, M Bryszewska, A Consiglio, P Ortega, R Gómez, A Raya |
Biomacromolecules | 2021 |
|
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
SC Cunnane, E Trushina, C Morland, A Prigione, G Casadesus, ZB Andrews, MF Beal, LH Bergersen, RD Brinton, S de la Monte, A Eckert, J Harvey, R Jeggo, JH Jhamandas, O Kann, CM la Cour, WF Martin, G Mithieux, PI Moreira, MP Murphy, KA Nave, T Nuriel, SH Oliet, F Saudou, MP Mattson, RH Swerdlow, MJ Millan |
Nature Reviews Drug Discovery | 2020 |
|
Peripheral Glycolysis in Neurodegenerative Diseases
SM Bell, T Burgess, J Lee, DJ Blackburn, SP Allen, H Mortiboys |
International journal of molecular sciences | 2020 |
|
Sugarcane (Saccharum officinarum L.) Top Extract Ameliorates Cognitive Decline in Senescence Model SAMP8 Mice: Modulation of Neural Development and Energy Metabolism
K Iwata, Q Wu, F Ferdousi, K Sasaki, K Tominaga, H Uchida, Y Arai, FG Szele, H Isoda |
Frontiers in Cell and Developmental Biology | 2020 |
|
Metabolic Alterations in FMR1 Premutation Carriers
Y Cao, Y Peng, HE Kong, EG Allen, P Jin |
Frontiers in Molecular Biosciences | 2020 |
|
Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease
D Han, W Zheng, X Wang, Z Chen |
Frontiers in cellular neuroscience | 2020 |
|
Exploration of databases and methods supporting drug repurposing: a comprehensive survey
Z Tanoli, U Seemab, A Scherer, K Wennerberg, J Tang, M Vähä-Koskela |
Briefings in Bioinformatics | 2020 |
|
Recent developments in the treatment of Parkinson's Disease
TB Stoker, RA Barker |
F1000Research | 2020 |
|
Neuronal Metabolism and Neuroprotection: Neuroprotective Effect of Fingolimod on Menadione-Induced Mitochondrial Damage
A Gil, E Martín-Montañez, N Valverde, E Lara, F Boraldi, S Claros, SY Romero-Zerbo, O Fernández, J Pavia, M Garcia-Fernandez |
Cells | 2020 |
|
Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene
M Chumarina, K Russ, C Azevedo, A Heuer, M Pihl, A Collin, EÅ Frostner, E Elmer, P Hyttel, G Cappelletti, M Zini, S Goldwurm, L Roybon |
Acta Neuropathologica Communications | 2019 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)