Citations to this article

Cilia, mitochondria, and cardiac development
Bill Chaudhry, Deborah J. Henderson
Bill Chaudhry, Deborah J. Henderson
Published June 17, 2019
Citation Information: J Clin Invest. 2019;129(7):2666-2668. https://doi.org/10.1172/JCI129827.
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Cilia, mitochondria, and cardiac development

Abstract

Motile cilia provide propulsion, and immotile ones are enriched with receptors. Both are required to establish left-right identity in the developing embryo and are also implicated in a wide range of human diseases. Abnormalities in cilial function underlie heterotaxy congenital heart disease (CHD) occurring in individuals with laterality disturbance. Mitochondrial function and cellular energetics, through mTOR and autophagy, are now linked with cilial function, revealing new mechanisms and candidate genes for syndromic human disease. In the current issue of the JCI, Burkhalter et al. ask the question: Can mitochondrial disturbances produce ciliopathy and does this explain some cases of heterotaxy?

Authors

Bill Chaudhry, Deborah J. Henderson

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Year: 2023 2022 2021 2020 2019 Total
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Citations to this article (7)

Title and authors Publication Year
Enhanced primary ciliogenesis via mitochondrial oxidative stress activates AKT to prevent neurotoxicity in HSPA9/mortalin-depleted SH-SY5Y cells
Bae JE, Jang S, Kim JB, Hyung H, Park NY, Kim YH, Kim SH, Kim SH, Ha JM, Oh GS, Park K, Jeong K, Jang JS, Jo DS, Kim P, Lee HS, Ryoo ZY, Cho DH 		Molecular brain 2023
Pathogenic Variants in Cardiomyopathy Disorder Genes Underlie Pediatric Myocarditis-Further Impact of Heterozygous Immune Disorder Gene Variants?
Seidel F, Laser KT, Klingel K, Dartsch J, Theisen S, Pickardt T, Holtgrewe M, Gärtner A, Berger F, Beule D, Milting H, Schubert S, Klaassen S, Kühnisch J 		Journal of Cardiovascular Development and Disease 2022
CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2
Key J, Gispert S, Koornneef L, Sleddens-Linkels E, Kohli A, Torres-Odio S, Koepf G, Amr S, Reichlmeir M, Harter PN, West AP, Münch C, Baarends WM, Auburger G 		Cells 2022
Recessive ciliopathy mutations in primary endocardial fibroelastosis: a rare neonatal cardiomyopathy in a case of Alstrom syndrome
Y Zhao, L Wang, A Eskin, X Kang, VM Fajardo, Z Mehta, S Pineles, RJ Schmidt, A Nagiel, G Satou, M Garg, M Federman, LC Reardon, SL Lee, R Biniwale, WW Grody, N Halnon, N Khanlou, F Quintero-Rivera, JC Alejos, A Nakano, GA Fishbein, GS Arsdell, SF Nelson, M Touma 		Journal of Molecular Medicine 2021
Nucleoporin NUP205 plays a critical role in cilia and congenital disease
J Marquez, D Bhattacharya, CP Lusk, MK Khokha 		Developmental Biology 2021
Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes
CR Balistreri, CL Ammoscato, L Scola, T Fragapane, RM Giarratana, D Lio, M Piccione 		Genes & development 2020
Filaments and phenotypes: cellular roles and orphan effects associated with mutations in cytoplasmic intermediate filament proteins
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