All hands on DEK
David M. Bodine
Genetics and Molecular Biology Branch, National Human Genome Research Institute, Division of Intramural Research, NIH, Bethesda, Maryland, USA.
Address correspondence to: David M. Bodine, 49 Convent Drive, MSC 4442, Bethesda, Maryland 20892-4442, USA. Phone: 301.402.0902; Email: tedyaz@mail.nih.gov.
Find articles by Bodine, D. in: JCI | PubMed | Google Scholar
First published May 20, 2019 - More info
J Clin Invest. 2019;129(6):2205–2206. https://doi.org/10.1172/JCI128986.
© 2019 American Society for Clinical Investigation
In this issue of the JCI, Capitano et al. demonstrate that the secreted form of the DNA-binding chromatin factor DEK regulates hematopoiesis. It is known that DEK can be secreted by macrophages and other cells, but no function has been attached to secreted DEK. Capitano et al. showed that extracellular DEK activates signaling through the CXCL2 receptor, which in turn enhances the proliferation of hematopoietic stem cells and decreases hematopoietic progenitor cell numbers both in vivo and in vitro. These results offer the opportunity to expand transplantable stem cells to improve outcomes in patients undergoing bone marrow transplant.
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Copyright © 2019 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)