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Citations to this article

High-affinity T cell receptors for adoptive cell transfer
Ariel Isser, Jonathan P. Schneck
Ariel Isser, Jonathan P. Schneck
Published December 10, 2018
Citation Information: J Clin Invest. 2019;129(1):69-71. https://doi.org/10.1172/JCI125471.
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Commentary Article has an altmetric score of 8

High-affinity T cell receptors for adoptive cell transfer

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Abstract

Adoptive cell transfer (ACT) of engineered T cell receptors (TCRs) for cancer immunotherapy has evolved from simple gene transfer of isolated TCRs to various affinity enhancement techniques that overcome limitations imposed by central and peripheral tolerance on TCR affinity. In the current issue of the JCI, Poncette et al. used mice with human TCRαβ and HLA gene loci to discover CD4+ TCRs of optimal affinity for cancer testis antigen (CTA) NY-ESO-1. They combined this TCR with a previously discovered NY-ESO-1–specific CD8+ TCR in an ACT fibrosarcoma tumor model to demonstrate the importance of T cell help in mediating antitumor responses.

Authors

Ariel Isser, Jonathan P. Schneck

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Total citations by year

Year: 2025 2022 2021 Total
Citations: 1 1 1 3
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (3)

Title and authors Publication Year
IL-7 Immunotherapies: Current Applications and Engineering Opportunities
Ariail E, Biggs B, O\u2019Flanagan R, Schneck JP
Immunological investigations 2025
Tuning T cell receptor sensitivity through catch bond engineering.
Zhao X, Kolawole EM, Chan W, Feng Y, Yang X, Gee MH, Jude KM, Sibener LV, Fordyce PM, Germain RN, Evavold BD, Garcia KC
Science (New York, N.Y.) 2022
Identification of NY-ESO-1157–165 Specific Murine T Cell Receptors With Distinct Recognition Pattern for Tumor Immunotherapy
H Zhang, M Sun, J Wang, B Zeng, X Cao, Y Han, S Tan, GF Gao
Frontiers in immunology 2021

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Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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