Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
Yong Pan, … , Karen Siu Ling Lam, Aimin Xu
Yong Pan, … , Karen Siu Ling Lam, Aimin Xu
Published January 22, 2019
Citation Information: J Clin Invest. 2019;129(2):834-849. https://doi.org/10.1172/JCI123069.
View: Text | PDF
Research Article Inflammation Metabolism Article has an altmetric score of 15

Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

  • Text
  • PDF
Abstract

Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-associated metabolic complications. However, the molecular links between lipid-overloaded adipocytes and inflammatory immune cells in obese adipose tissues remain elusive. Here we identified adipocyte-secreted microRNA-34a (miR-34a) as a key mediator through its paracrine actions on adipose-resident macrophages. The expression of miR-34a in adipose tissues was progressively increased with the development of dietary obesity. Adipose-selective or adipocyte-specific miR-34a–KO mice were resistant to obesity-induced glucose intolerance, insulin resistance, and systemic inflammation, and this was accompanied by a significant shift in polarization of adipose-resident macrophages from proinflammatory M1 to antiinflammatory M2 phenotype. Mechanistically, mature adipocyte-secreted exosomes transported miR-34a into macrophages, thereby suppressing M2 polarization by repressing the expression of Krüppel-like factor 4 (Klf4). The suppressive effects of miR-34a on M2 polarization and its stimulation of inflammatory responses were reversed by ectopic expression of Klf4 in both bone marrow–derived macrophages and adipose depots of obese mice. Furthermore, increased miR-34a expression in visceral fat of overweight/obese subjects correlated negatively with reduced Klf4 expression, but positively with the parameters of insulin resistance and metabolic inflammation. In summary, miR-34a was a key component of adipocyte-secreted exosomal vesicles that transmitted the signal of nutrient overload to the adipose-resident macrophages for exacerbation of obesity-induced systemic inflammation and metabolic dysregulation.

Authors

Yong Pan, Xiaoyan Hui, Ruby Lai Chong Hoo, Dewei Ye, Cyrus Yuk Cheung Chan, Tianshi Feng, Yu Wang, Karen Siu Ling Lam, Aimin Xu

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2009 Total
Citations: 16 47 48 49 48 27 15 1 251
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (251)

Title and authors Publication Year
Serum Exosomes miR-122-5P Induces Hepatic and Renal Injury in Septic Rats by Regulating TAK1/SIRT1 Pathway
Wang J, Jiang Y, Yuan Y, Ma X, Li T, Lv Y, Zhang J, Chen L, Zhou J, Meng Y, Zhang B, Dong X, Ma L
Infection and Drug Resistance 2025
Protection Strategies Against Palmitic Acid-Induced Lipotoxicity in Metabolic Syndrome and Related Diseases
Ceja-Galicia ZA, Cespedes-Acuña CL, El-Hafidi M
International Journal of Molecular Sciences 2025
Vitamin D modulates the content of inflammatory microRNAs in extracellular vesicles from human adipocyte cells in inflammatory context
Payet T, Astier J, Bournot L, Sicard F, Robert S, Lacroix R, Wabitsch M, Landrier J, Mounien L
Biofactors (Oxford, England) 2025
Obesity and Adipose-Derived Extracellular Vesicles: Implications for Metabolic Regulation and Disease
Malaguarnera M, Cauli O, Cabrera-Pastor A
Biomolecules 2025
Association between a body shape index and low back pain: a cross-sectional study highlighting gender-specific differences in NHANES data
Xie S, Xiao H, Li G, Zheng J, Zhang F, Lan Y, Luo M
BMC Public Health 2025
Intra and inter-organ communication through extracellular vesicles in obesity: functional role of obesesomes and steatosomes
Lago-Baameiro N, Camino T, Vazquez-Durán A, Sueiro A, Couto I, Santos F, Baltar J, Falcón-Pérez JM, Pardo M
Journal of Translational Medicine 2025
Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice
Lin YK, Pan YF, Jiang TY, Chen YB, Shang TY, Xu MY, Feng HB, Ma YH, Tan YX, Wang HY, Dong LW
Journal of Biomedical Science 2025
Short-term and long-term high-fat diet promote metabolic disorder through reprogramming mRNA m6A in white adipose tissue by gut microbiota
Liu Y, Liu J, Ren R, Xin Z, Luo Y, Chen Y, Huang C, Liu Y, Yang T, Wang X
Microbiome 2025
Mechanisms of Lipid‐Associated Macrophage Accrual in Metabolically Stressed Adipose Tissue
Reinisch I, Enzenhofer S, Prokesch A
Bioessays 2025
Recent Progress in Developing Extracellular Vesicles as Nanovehicles to Deliver Carbohydrate-Based Therapeutics and Vaccines
Puagsopa J, Tongviseskul N, Jaroentomeechai T, Meksiriporn B
Vaccines 2025
Porcine jejunal-derived extracellular vesicles participate in the regulation of lipid metabolism
Fan Y, Deng H, Zhu J, Luo J, Chen T, Sun J, Zhang Y, Xi Q
Journal of Animal Science and Biotechnology 2025
Metabolic Messengers: small extracellular vesicles.
Rohm TV, Cunha E Rocha K, Olefsky JM
Nature metabolism 2025
Cancer cell-derived exosomal miR-34a inhibits the malignant progression of pancreatic adenocarcinoma cells by restraining the M2 polarization of macrophages.
Long K, Kui X, Zeng Q, Dong W
European journal of histochemistry : EJH 2025
Extracellular vesicle-associated miR-515-5p from adipose tissue regulates placental metabolism and fetal growth in gestational diabetes mellitus.
Jayabalan N, Nair S, Lai A, Scholz-Romero K, Razo-Azamar M, Ormazabal V, Lim R, Carrion F, Guanzon D, Rice GE, McIntyre HD, Lappas M, Salomon C
Cardiovascular diabetology 2025
Extracellular Vesicle-Mediated Network in the Pathogenesis of Obesity, Diabetes, Steatotic Liver Disease, and Cardiovascular Disease
Lee J, Choi WG, Rhee M, Lee SH
Diabetes & Metabolism Journal 2025
A New Nomogram for Predicting Early Weight Loss Outcomes in Patients with Obesity Following Laparoscopic Sleeve Gastrectomy.
Wu W, Li Z, Yuan C, Yang M, Song Y, Xu Z, Li Z, Lu Y, Zhou X, Wang D, Li Y
Obesity surgery 2025
Non-bone-derived exosomes: a new perspective on regulators of bone homeostasis.
Wang P, Shao W, Li Z, Wang B, Lv X, Huang Y, Feng Y
Cell communication and signaling : CCS 2024
Adipose-derived extracellular vesicles - a novel cross-talk mechanism in insulin resistance, non-alcoholic fatty liver disease, and polycystic ovary syndrome.
Mladenović D, Vesković M, Šutulović N, Hrnčić D, Stanojlović O, Radić L, Macut JB, Macut D
Endocrine 2024
Liver-derived extracellular vesicles improve whole-body glycaemic control via inter-organ communication.
Miotto PM, Yang CH, Keenan SN, De Nardo W, Beddows CA, Fidelito G, Dodd GT, Parker BL, Hill AF, Burton PR, Loh K, Watt MJ
Nature metabolism 2024
Epigenetics in obesity: Mechanisms and advances in therapies based on natural products
Chen P, Wang Y, Chen F, Zhou B
Pharmacology Research & Perspectives 2024
Analyzing the expression pattern of the noncoding RNAs (HOTAIR, PVT-1, XIST, H19, and miRNA-34a) in PBMC samples of patients with COVID-19, according to the disease severity in Iran during 2022-2023: A cross-sectional study.
Khanaliha K, Sadri Nahand J, Khatami A, Mirzaei H, Chavoshpour S, Taghizadieh M, Karimzadeh M, Donyavi T, Bokharaei-Salim F
2024
Exosomes as Emerging Regulators of Immune Responses in Type 2 Diabetes Mellitus.
Zheng W, Ji X, Yin QQ, Wu C, Xu C, Pan H, Wu C
Journal of Diabetes Research 2024
Intestinal epithelial Krüppel-like factor 4 alleviates endotoxemia and atherosclerosis through improving NF-κB/miR-34a-mediated intestinal permeability.
Nie HZ, Zhou YW, Yu XH, Yin CG, Li LF, Hao HQ, Yuan T, Pan Y
Acta Pharmacologica Sinica 2024
Obesity-induced downregulation of miR-192 exacerbates lipopolysaccharide-induced acute lung injury by promoting macrophage activation
Wu S, Tang W, Liu L, Wei K, Tang Y, Ma J, Li H, Ao Y
Cellular & Molecular Biology Letters 2024
Pan-cancer molecular signatures connecting aspartate transaminase (AST) to cancer prognosis, metabolic and immune signatures
Siwo GH, Singal AG, Waljee AK
2024
BMSCs-derived exosomes inhibit macrophage/microglia pyroptosis by increasing autophagy through the miR-21a-5p/PELI1 axis in spinal cord injury
Gu J, Wu J, Wang C, Xu Z, Jin Z, Yan D, Chen S
Aging 2024
Macrophage polarization: an important role in inflammatory diseases
Luo M, Zhao F, Cheng H, Su M, Wang Y
Frontiers in immunology 2024
Challenges and opportunities in obesity: the role of adipocytes during tissue fibrosis
Zhang Q, Lu C, Lu F, Liao Y, Cai J, Gao J
Frontiers in Endocrinology 2024
miRNAs as Interconnectors between Obesity and Cancer
González-Sánchez GD, Granados-López AJ, López-Hernández Y, Robles MJ, López JA
Non-Coding RNA 2024
The role of exosome derived miRNAs in inter-cell crosstalk among insulin-related organs in type 2 diabetes mellitus.
Lu T, Zheng Y, Chen X, Lin Z, Liu C, Yuan C
Journal of Physiology and Biochemistry 2024
The Role of Extracellular Vesicles in Metabolic Diseases.
González-Blanco C, Iglesias-Fortes S, Lockwood ÁC, Figaredo C, Vitulli D, Guillén C
Biomedicines 2024
Positive Effects of Adiponectin, BDNF, and GLP-1 on Cortical Neurons Counteracting Palmitic Acid Induced Neurotoxicity.
Jo D, Ahn SY, Choi SY, Choi Y, Lee DH, Song J
Clinical Nutrition Research 2024
Adipose tissue macrophage–derived microRNA-210-3p disrupts systemic insulin sensitivity by silencing GLUT4 in obesity
Patra D, Ramprasad P, Sharma S, Dey U, Kumar V, Singh S, Dasgupta S, Kumar A, Tikoo K, Pal D
The Journal of biological chemistry 2024
Distinct serum exosomal miRNA profiles detected in acute and asymptomatic dengue infections: A community-based study in Baiyun District, Guangzhou
Li X, Liao C, Wu J, Yi B, Zha R, Deng Q, Xu J, Guo C, Lu J
Heliyon 2024
Oxidative stress induces extracellular vesicle release by upregulation of HEXB to facilitate tumour growth in experimental hepatocellular carcinoma
Duan J, Huang Z, Qin S, Li B, Zhang Z, Liu R, Wang K, Nice EC, Jiang J, Huang C
Journal of Extracellular Vesicles 2024
Cellular Senescence and Extracellular Vesicles in the Pathogenesis and Treatment of Obesity—A Narrative Review
Liang Y, Kaushal D, Wilson RB
International journal of molecular sciences 2024
The association between the size of adipocyte-derived extracellular vesicles and fasting serum triglyceride-glucose index as proxy measures of adipose tissue insulin resistance in a rat model of early-stage obesity
Delgadillo-Velázquez J, Alday E, Aguirre-García MM, Canett-Romero R, Astiazaran-Garcia H
Frontiers in Nutrition 2024
Association between obesity and systemic immune inflammation index, systemic inflammation response index among US adults: a population-based analysis.
Zhou Y, Wang Y, Wu T, Zhang A, Li Y
Lipids in Health and Disease 2024
Molecular Morbidity Score–Can MicroRNAs Assess the Burden of Disease?
Butler T, Davey MG, Kerin MJ
International Journal of Molecular Sciences 2024
Perivascular Adipose Tissue and Perivascular Adipose Tissue-Derived Extracellular Vesicles: New Insights in Vascular Disease
Sigdel S, Udoh G, Albalawy R, Wang J
Cells 2024
Contents of exosomes derived from adipose tissue and their regulation on inflammation, tumors, and diabetes
Wang Y, Li Q, Zhou S, Tan P
Frontiers in Endocrinology 2024
MiRNA-132/212 encapsulated by adipose tissue-derived exosomes worsen atherosclerosis progression.
Guo B, Zhuang TT, Li CC, Li F, Shan SK, Zheng MH, Xu QS, Wang Y, Lei LM, Tang KX, Ouyang W, Duan JY, Wu YY, Cao YC, Ullah MHE, Zhou ZA, Lin X, Wu F, Xu F, Liao XB, Yuan LQ
Cardiovascular diabetology 2024
A Novel "Endocrine Hormone": The Diverse Role of Extracellular Vesicles in Multiorgan Insulin Resistance.
Xu F, Dou L, Yu D, Wu X, Liu L, Man Y, Huang X
International journal of medical sciences 2024
The role of FGF21 in the interplay between obesity and non-alcoholic fatty liver disease: a narrative review.
Negroiu CE, Tudoraşcu RI, Beznă MC, Ungureanu AI, Honţaru SO, Dănoiu S
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 2024
Roles of extracellular vesicles derived from healthy and obese adipose tissue in inter-organ crosstalk and potential clinical implication.
Han Y, Ye S, Liu B
Frontiers in endocrinology 2024
Message Transmission Between Adipocyte and Macrophage in Obesity.
Engin AB
Advances in experimental medicine and biology 2024
Macrophage Activation Syndrome in Coinciding Pandemics of Obesity and COVID-19: Worse than Bad.
Engin AB, Engin ED, Engin A
Advances in experimental medicine and biology 2024
Prospects and challenges of tissue-derived extracellular vesicles
Lee JC, Ray RM, Scott TA
Molecular Therapy 2024
Exosomal miRNAs and isomiRs: potential biomarkers for type 2 diabetes mellitus
Sou YL, Chilian WM, Ratnam W, Zain SM, Syed Abdul Kadir SZ, Pan Y, Pung YF
Precision Clinical Medicine 2024
Dynamic Roles and Expanding Diversity of Adipose Tissue Macrophages in Obesity
Soedono S, Julietta V, Nawaz H, Cho KW
Journal of Obesity & Metabolic Syndrome 2024
Understanding Macrophage Complexity in Metabolic Dysfunction-Associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial Dynamics
Ahamed F, Eppler N, Jones E, Zhang Y
Livers 2024
Adipose tissue‐derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity
Li B, Jin Y, Zhang B, Lu T, Li J, Zhang J, Zhou Y, Wang Y, Zhang C, Zhao Y, Li H
Clinical and Translational Medicine 2024
The negative effects of extracellular vesicles in the immune system.
Wang Y, Li C, Wu F, Mao J, Zhu J, Xie H, Zhou X, Wen C, Tian J
Frontiers in immunology 2024
Role of macrophages in aortic dissection pathogenesis: insights from preclinical studies to translational prospective.
Li S, Fu W, Wang L
Science China. Life sciences 2024
Visceral Adipocyte–Derived Extracellular Vesicle miR-27a-5p Elicits Glucose Intolerance by Inhibiting Pancreatic β-Cell Insulin Secretion
Zhang Y, Qian B, Yang Y, Niu F, Lin C, Yuan H, Wang J, Wu T, Shao Y, Shao S, Liu A, Wu J, Sun P, Chang X, Bi Y, Tang W, Zhu Y, Chen F, Su D, Han X
Diabetes 2024
The Role of the AIM2 Gene in Obesity-Related Glucose and Lipid Metabolic Disorders: A Recent Update.
Zhang Y, Xuan X, Ye D, Liu D, Song Y, Gao F, Lu S
Diabetes, metabolic syndrome and obesity : targets and therapy 2024
The Role of Adipose Tissue-derived Exosomes in Chronic Metabolic Disorders.
He R, Chen Y
Current medical science 2024
Extracellular Vesicles in Viral Liver Diseases
Kouroumalis E, Tsomidis I, Voumvouraki A
Viruses 2024
Tools for regulating metabolic diseases: extracellular vesicles from adipose macrophages
Zhang L, Lou K, Zhang Y, Leng Y, Huang Y, Liao X, Liu X, Feng S, Feng G
Frontiers in Endocrinology 2024
The functions of immune system-derived miRNAs in cardiovascular diseases
Sufianov A, Agaverdiev M, Mashkin A, Ilyasova T
Non-coding RNA Research 2024
DENV-1 Infection of Macrophages Induces Pyroptosis and Causes Changes in MicroRNA Expression Profiles
Zhang Q, Yu S, Yang Z, Wang X, Li J, Su L, Zhang H, Lou X, Mao H, Sun Y, Fang L, Yan H, Zhang Y
Biomedicines 2024
Bioinformatic identification of signature miRNAs associated with fetoplacental vascular dysfunction in gestational diabetes mellitus
Lu Y, Liu C, Pang X, Chen X, Wang C, Huang H
Biochemistry and Biophysics Reports 2024
The secretory function of adipose tissues in metabolic regulation
Liu Y, Qian SW, Tang Y, Tang QQ
Life Metabolism 2024
Key circRNAs from goat: discovery, integrated regulatory network and their putative roles in the differentiation of intramuscular adipocytes
Yu D, Xin L, Qing X, Hao Z, Yong W, Jiangjiang Z, Yaqiu L
BMC Genomics 2023
Moutan Cortex Extract Modulates Macrophage Activation via Lipopolysaccharide-Induced Calcium Signaling and ER Stress-CHOP Pathway
Kim HJ, Kim DH, Park W
International journal of molecular sciences 2023
An Overview of Inter-Tissue and Inter-Kingdom Communication Mediated by Extracellular Vesicles in the Regulation of Mammalian Metabolism
Castaño C, Novials A, Párrizas M
International journal of molecular sciences 2023
Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo
Kulaj K, Harger A, Bauer M, Caliskan ÖS, Gupta TK, Chiang DM, Milbank E, Reber J, Karlas A, Kotzbeck P, Sailer DN, Volta F, Lutter D, Prakash S, Merl-Pham J, Ntziachristos V, Hauner H, Pfaffl MW, Tschöp MH, Müller TD, Hauck SM, Engel BD, Gerdes JM, Pfluger PT, Krahmer N, Stemmer K
Nature Communications 2023
The intersection of obesity and (long) COVID-19: Hypoxia, thrombotic inflammation, and vascular endothelial injury
Xiang M, Wu X, Jing H, Novakovic VA, Shi J
Frontiers in Cardiovascular Medicine 2023
Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives
Sun K, Li X, Scherer PE
Comprehensive Physiology 2023
Cellular and Molecular Mechanisms Associating Obesity to Bone Loss.
Forte YS, Renovato-Martins M, Barja-Fidalgo C
Cells 2023
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study.
Wu YL, Lin ZJ, Li CC, Lin X, Shan SK, Guo B, Zheng MH, Li F, Yuan LQ, Li ZH
Signal Transduction and Targeted Therapy 2023
Estrogen downregulates CD73/adenosine axis hyperactivity via adaptive modulation PI3K/Akt signaling to prevent myocarditis and arrhythmias during chronic catecholamines stress.
Ndzie Noah ML, Adzika GK, Mprah R, Adekunle AO, Koda S, Adu-Amankwaah J, Xu Y, Kanwore K, Wowui PI, Sun H
Cell communication and signaling : CCS 2023
Short-term fructose feeding alters tissue metabolic pathways by modulating microRNAs expression both in young and adult rats
Petito G, Giacco A, Cioffi F, Mazzoli A, Magnacca N, Iossa S, Goglia F, Senese R, Lanni A
Frontiers in Cell and Developmental Biology 2023
High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters
Yang J, Liang C, Liu L, Wang L, Yu G
Biomolecules 2023
Overview and New Insights into the Metabolic Syndrome: Risk Factors and Emerging Variables in the Development of Type 2 Diabetes and Cerebrocardiovascular Disease.
Hayden MR
2023
miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury.
Wan Y, Slevin E, Koyama S, Huang CK, Shetty AK, Li X, Harrison K, Li T, Zhou B, Lorenzo SR, Zhang Y, Salinas JM, Xu W, Klaunig JE, Wu C, Tsukamoto H, Meng F
Hepatology Communications 2023
IPMK modulates FFA-induced insulin resistance in primary mouse hepatocytes
Jung IR, Ahima RS, Kim SF
2023
Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL
Pillai SS, Pereira DG, Zhang J, Huang W, Beg MA, Knaack DA, de Souza Goncalves B, Sahoo D, Silverstein RL, Shapiro JI, Sodhi K, Chen Y
Frontiers in Cardiovascular Medicine 2023
Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems.
Spinetti G, Mutoli M, Greco S, Riccio F, Ben-Aicha S, Kenneweg F, Jusic A, de Gonzalo-Calvo D, Nossent AY, Novella S, Kararigas G, Thum T, Emanueli C, Devaux Y, Martelli F
Cardiovascular Diabetology 2023
Testicular exosomes disturb the immunosuppressive phenotype of testicular macrophages mediated by miR-155-5p in uropathogenic Escherichia coli-induced orchitis.
Xu J, He C, Fang YW, Hu ZY, Peng ML, Chen YY, Su YF, Liu CY, Zhang HP, Zhao K
Asian Journal of Andrology 2023
Mechanism of immune attack in the progression of obesity-related type 2 diabetes
Wang HW, Tang J, Sun L, Li Z, Deng M, Dai Z
World journal of diabetes 2023
Adipocyte-derived extracellular vesicles: bridging the communications between obesity and tumor microenvironment.
Zhou C, Huang YQ, Da MX, Jin WL, Zhou FH
Discover. Oncology 2023
miR-10a-3p modulates adiposity and suppresses adipose inflammation through TGF-β1/Smad3 signaling pathway
Kiran S, Mandal M, Rakib A, Bajwa A, Singh UP
Frontiers in immunology 2023
Rab26 restricts insulin secretion via sequestering Synaptotagmin-1
Zhuang R, Zhou Y, Wang Z, Cao Y, Chen J, Xu L, Ren Y, Zheng Y, Wei Z, Qiu H, Li L, Han Y, Yun Y, Chen X, Hong W, Wang T
PLoS Biology 2023
UTX deletion promotes M2 macrophage polarization by epigenetically regulating endothelial cell-macrophage crosstalk after spinal cord injury
Peng W, Xie Y, Luo Z, Liu Y, Xu J, Li C, Qin T, Lu H, Hu J
Journal of nanobiotechnology 2023
Roles of extracellular vesicles on macrophages in inflammatory bone diseases.
Lin Y, Wang Z, Liu S, Liu J, Zhang Z, Ouyang Y, Su Z, Chen D, Guo L, Luo T
Molecular and Cellular Biochemistry 2023
The role of extracellular vesicle-derived miRNAs in adipose tissue function and metabolic health
Paneru BD, Hill DA
2023
Biomarkers of obesity-mediated insulin resistance: focus on microRNAs.
Cai Y, Liu P, Xu Y, Xia Y, Peng X, Zhao H, Chen Q
Diabetology & metabolic syndrome 2023
White adipose tissue mitochondrial bioenergetics in metabolic diseases.
Sabaratnam R, Hansen DR, Svenningsen P
Reviews in endocrine & metabolic disorders 2023
Energetic Stress-Induced Metabolic Regulation by Extracellular Vesicles.
Crewe C
Comprehensive Physiology 2023
Therapeutics of Extracellular Vesicles in Cardiocerebrovascular and Metabolic Diseases.
Hou Z, Lin Y, Yang X, Chen J, Li G
Advances in experimental medicine and biology 2023
Adipocyte-Derived Exosomal NOX4-Mediated Oxidative Damage Induces Premature Placental Senescence in Obese Pregnancy
Tao Y, Chen W, Xu H, Xu J, Yang H, Luo X, Chen M, He J, Bai Y, Qi H
International Journal of Nanomedicine 2023
Extracellular Vesicles and Obesity.
Wang K, Zeng C
Advances in experimental medicine and biology 2023
MicroRNA regulation of AMPK in nonalcoholic fatty liver disease.
Sun H, Kemper JK
Experimental & molecular medicine 2023
Peripheral and central macrophages in obesity
Mukherjee S, Skrede S, Haugstøyl M, López M, Fernø J
Frontiers in Endocrinology 2023
Adipose tissue‑derived extracellular vesicles: Systemic messengers in health and disease (Review)
Yang X, Hao J, Luo J, Lu X, Kong X
Molecular medicine reports 2023
The macrophage polarization by miRNAs and its potential role in the treatment of tumor and inflammation (Review)
Wang C, Wang X, Zhang D, Sun X, Wu Y, Wang J, Li Q, Jiang G
Oncology reports 2023
Circulating tumor biomarkers in early-stage breast cancer: characteristics, detection, and clinical developments
Qiu J, Qian D, Jiang Y, Meng L, Huang L
Frontiers in Oncology 2023
Research Progress Into Adipose Tissue Macrophages and Insulin Resistance
FU M, YANG L, WANG H, CHEN Y, CHEN X, HU Q, SUN H
2023
The potential role of miRNA in regulating macrophage polarization
Khayati S, Dehnavi S, Sadeghi M, Tavakol Afshari J, Esmaeili SA, Mohammadi M
Heliyon 2023
Impact of intestinal microenvironments in obesity and bariatric surgery on shaping macrophages
Leyderman M, Wilmore JR, Shope T, Cooney RN, Urao N
2023
An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications.
Ghesmati Z, Rashid M, Fayezi S, Gieseler F, Alizadeh E, Darabi M
Reviews in endocrine & metabolic disorders 2023
Apolipoprotein E (ApoE) orchestrates adipose tissue inflammation and metabolic disorders through NLRP3 inflammasome
Zhang Y, Cheng Z, Hong L, Liu J, Ma X, Wang W, Pan R, Lu W, Luo Q, Gao S, Kong Q
2023
Modulation of MicroRNAs and Exosomal MicroRNAs after Dietary Interventions for Obesity and Insulin Resistance: A Narrative Review
Hernández-Gómez KG, Avila-Nava A, González-Salazar LE, Noriega LG, Serralde-Zúñiga AE, Guizar-Heredia R, Medina-Vera I, Gutiérrez-Solis AL, Torres N, Tovar AR, Guevara-Cruz M
Metabolites 2023
Emerging mechanisms of obesity-associated immune dysfunction.
Shaikh SR, Beck MA, Alwarawrah Y, MacIver NJ, Shaikh SR, Beck MA, Alwarawrah Y, MacIver NJ
Nature reviews. Endocrinology 2023
Molecular and Metabolic Analysis of Arsenic-Exposed Humanized AS3MT Mice
Todero J, Douillet C, Shumway AJ, Koller BH, Kanke M, Phuong DJ, Stýblo M, Sethupathy P
Environmental Health Perspectives 2023
Adipose Tissue-Derived Extracellular Vesicles: A Promising Biomarker and Therapeutic Strategy for Metabolic Disorders
Liu W, Liu T, Zhao Q, Ma J, Jiang J, Shi H
Stem Cells International 2023
Role of Exosomal Modulation of Macrophages in Liver Fibrosis.
Fan B, Xie H, Tan Q, Li Q, Gong T, He B, Li Y, Chen L
Journal of Clinical and Translational Hepatology 2023
Engineered exosomes: a promising strategy for tendon-bone healing.
Qin B, Bao D, Liu Y, Zeng S, Deng K, Liu H, Fu S
Journal of advanced research 2023
Advances in the study of exosomes in cardiovascular diseases
Zhang Z, Zou Y, Song C, Cao K, Cai K, Chen S, Wu Y, Geng D, Sun G, Zhang N, Zhang X, Zhang Y, Sun Y, Zhang Y
Journal of Advanced Research 2023
RNAkines Are Secreted Messengers Shaping Health and Disease
Li J, Fang J, Jiang X, Zhang Y, Vidal-Puig A, Zhang CY
Trends in endocrinology and metabolism: TEM 2023
Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications
J Liu, Y Zhang, Y Tian, W Huang, N Tong, X Fu
Theranostics 2022
Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes
Q Ding, Z Gao, K Chen, Q Zhang, S Hu, L Zhao
Frontiers in immunology 2022
Organokines and Exosomes: Integrators of Adipose Tissue Macrophage Polarization and Recruitment in Obesity
Y Wang, Y Wang, X Qi, Z Liao, Y Mai, X Xiao
Frontiers in Endocrinology 2022
The microenvironment—a general hypothesis on the homeostatic function of extracellular vesicles
A Stratman, C Crewe, P Stahl
FASEB bioAdvances 2022
An Update in Epigenetics in Metabolic-Associated Fatty Liver Disease
J Rodríguez-Sanabria, R Escutia-Gutiérrez, R Rosas-Campos, J Armendáriz-Borunda, A Sandoval-Rodríguez
Frontiers in Medicine 2022
Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4
S Yamaguchi, D Zhang, A Katayama, N Kurooka, R Sugawara, H Albuayjan, A Nakatsuka, J Eguchi, J Wada
Frontiers in Endocrinology 2022
MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation
G Valacchi, E Pambianchi, S Coco, A Pulliero, A Izzotti
Journal of Personalized Medicine 2022
Adipocytes-Derived Extracellular Vesicle-miR-26b Promotes Apoptosis of Cumulus Cells and Induces Polycystic Ovary Syndrome
G Zhou, Y Gu, F Zhou, H Zhang, M Zhang, G Zhang, L Wu, K Hua, J Ding
Frontiers in Endocrinology 2022
Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway
T Qiu, X Yang, J Wang, C Pan, X Chu, J Xiong, J Xie, Y Chang, C Wang, J Zhang
Nutrition and Diabetes 2022
MiR-92a/KLF4/p110δ regulates titanium particles-induced macrophages inflammation and osteolysis
Z Wen, S Lin, C Li, Z Ouyang, Z Chen, S Li, Y Huang, W Luo, Z Zheng, P Guo, M Kuang, Y Ding
Cell Death Discovery 2022
Association of miR-34a and miR-143 levels with PPARγ gene expression in adipose tissues of non-diabetic adults
M Zarkesh, K Tabaei, M Akbarzadeh, A Daneshafrooz, A Zadeh-Vakili
Journal of PHYSIOLOGICAL ANTHROPOLOGY 2022
New challenges for microRNAs in acute pancreatitis: progress and treatment
W Zhou, S Dong, Z Chen, X Li, W Jiang
Journal of Translational Medicine 2022
New Insights into Adipose Tissue Macrophages in Obesity and Insulin Resistance
Z Cai, Y Huang, B He
Cells 2022
Extracellular Vesicles from Adipose Tissue Could Promote Metabolic Adaptation through PI3K/Akt/mTOR
Delgadillo-Velázquez J, Mendivil-Alvarado H, Coronado-Alvarado CD, Astiazaran-Garcia H
Cells 2022
The Regulatory Role of MicroRNAs on Phagocytes: A Potential Therapeutic Target for Chronic Diseases
Wang Y, Liu X, Xia P, Li Z, FuChen X, Shen Y, Yu P, Zhang J
Frontiers in immunology 2022
The Epigenetic Role of MiRNAs in Endocrine Crosstalk Between the Cardiovascular System and Adipose Tissue: A Bidirectional View
Soci UP, Cavalcante BR, Improta-Caria AC, Roever L
Frontiers in Cell and Developmental Biology 2022
Role of Adipose Tissue Derived Exosomes in Metabolic Disease.
Mei R, Qin W, Zheng Y, Wan Z, Liu L
Frontiers in Endocrinology 2022
Coronavirus disease 2019 (COVID‐19) update: From metabolic reprogramming to immunometabolism
Rudiansyah M, Jasim SA, Mohammad pour ZG, Athar SS, Jeda AS, doewes RI, Jalil AT, Bokov DO, Mustafa YF, Noroozbeygi M, Karampoor S, Mirzaei R
Journal of Medical Virology 2022
Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes.
Zatterale F, Raciti GA, Prevenzano I, Leone A, Campitelli M, De Rosa V, Beguinot F, Parrillo L
Biomolecules 2022
The Extracellular MicroRNAs on Inflammation: A Literature Review of Rodent Studies.
Lee S, Ko JH, Kim SN
Biomedicines 2022
RNA-seq Based Transcriptome Analysis Reveals The Cross-Talk of Macrophage and Adipocyte of Chicken Subcutaneous Adipose Tissue during The Embryonic and Post-Hatch Period.
Zhao H, Wu M, Tang X, Li Q, Yi X, Zhao W, Sun X
Frontiers in immunology 2022
Extracellular Vesicle/Macrophage Axis: Potential Targets for Inflammatory Disease Intervention.
Tang D, Cao F, Yan C, Fang K, Ma J, Gao L, Sun B, Wang G
Frontiers in immunology 2022
Angiogenesis in adipose tissue and obesity.
Corvera S, Solivan-Rivera J, Yang Loureiro Z
Angiogenesis 2022
Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Deliver miR-21 to Promote Corneal Epithelial Wound Healing through PTEN/PI3K/Akt Pathway.
Liu X, Li X, Wu G, Qi P, Zhang Y, Liu Z, Li X, Yu Y, Ye X, Li Y, Yang D, Teng Y, Shi C, Jin X, Qi S, Liu Y, Wang S, Liu Y, Cao F, Kong Q, Wang Z, Zhang H
Stem Cells International 2022
Adipose-derived exosomes block muscular stem cell proliferation in aged mouse by delivering miRNA Let-7d-3p that targets transcription factor HMGA2
Itokazu M, Onodera Y, Mori T, Inoue S, Yamagishi K, Moritake A, Iwawaki N, Shigi K, Takehara T, Higashimoto Y, Akagi M, Teramura T
The Journal of biological chemistry 2022
Circulating Extracellular Vesicles and Particles Derived From Adipocytes: The Potential Role in Spreading MicroRNAs Associated With Cellular Senescence
Siqueira IR, de Souza Rodrigues A, Flores MS, Vieira Cunha EL, Goldberg M, Harmon B, Batabyal R, Freishtat RJ, Cechinel LR
2022
Apolipoprotein C3 and circulating mediators of preadipocyte proliferation in states of lipodystrophy
Brasil BB, Masaji S, Martins BT, Jiang H, Song N, Athena A S, Lucas B, François M, Wei-Jun Q, Rohit KN, Ronald KC
Molecular Metabolism 2022
The Stress-Responsive microRNA-34a Alters Insulin Signaling and Actions in Adipocytes through Induction of the Tyrosine Phosphatase PTP1B.
Cornejo PJ, Vergoni B, Ohanna M, Angot B, Gonzalez T, Jager J, Tanti JF, Cormont M
Cells 2022
The emerging roles and mechanisms of exosomal non-coding RNAs in the mutual regulation between adipose tissue and other related tissues in obesity and metabolic diseases
Pan S, Chen Y, Yan J, Li F, Chen X, Xu X, Xing H
Frontiers in Endocrinology 2022
Exosomal miRNAs in the plasma of Cynoglossus semilaevis infected with Vibrio harveyi: Pleiotropic regulators and potential biomarkers involved in inflammatory and immune responses
Zhu T, Kong M, Li C, Shao C
Frontiers in immunology 2022
Circulating MicroRNAs Expression Profile in Lung Inflammation: A Preliminary Study.
Mirra D, Cione E, Spaziano G, Esposito R, Sorgenti M, Granato E, Cerqua I, Muraca L, Iovino P, Gallelli L, D'Agostino B
Journal of Clinical Medicine 2022
Differential expression of Ago2‐mediated microRNA signaling in adipose tissue is associated with food‐induced obesity
Zhang H, Qiao L, Liu X, Han X, Kang J, Liu Y, Lin J, Yan X
FEBS Open Bio 2022
Research progress of extracellular vesicles in type 2 diabetes and its complications
Zhang M, Wang L, Chen Z
Diabetic Medicine 2022
Elevated miR-143 and miR-34a gene expression in human visceral adipose tissue are associated with insulin resistance in non-diabetic adults: a cross-sectional study.
Yuzbashian E, de Campos Zani SC, Zarkash M, Asghari G, Hedayati M, Khalaj A, Chan CB
Eating and weight disorders : EWD 2022
Hypertension Related to Obesity: Pathogenesis, Characteristics and Factors for Control.
El Meouchy P, Wahoud M, Allam S, Chedid R, Karam W, Karam S
International journal of molecular sciences 2022
Adipose tissue macrophages: Regulators of adipose tissue immunometabolism during obesity
Nance SA, Muir L, Lumeng C
Molecular Metabolism 2022
Small extracellular vesicles from Ptpn1-deficient macrophages alleviate intestinal inflammation by reprogramming macrophage polarization via lactadherin enrichment
Han D, Lu D, Huang S, Pang J, Wu Y, Hu J, Zhang X, Pi Y, Zhang G, Wang J
Redox Biology 2022
The crosstalk between parenchymal cells and macrophages: A keeper of tissue homeostasis
Chen Y, Tang L
Frontiers in immunology 2022
Role of Adipose Tissue microRNAs in the Onset of Metabolic Diseases and Implications in the Context of the DOHaD
Kappeler L
Cells 2022
Involvement of miRNA-34a regulated Krüppel-like factor 4 expression in hyperoxia-induced senescence in lung epithelial cells.
Maeda H, Yao H, Go H, Huntington KE, De Paepe ME, Dennery PA
Respiratory Research 2022
MicroRNAs: a crossroad that connects obesity to immunity and aging
Rakib A, Kiran S, Mandal M, Singh UP
Immunity & ageing : I & A 2022
Advances in the research of the role of macrophage/microglia polarization-mediated inflammatory response in spinal cord injury
Fu SP, Chen SY, Pang QM, Zhang M, Wu XC, Wan X, Wan WH, Ao J, Zhang T
Frontiers in immunology 2022
Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects
Chen K, Cheong LY, Gao Y, Zhang Y, Feng T, Wang Q, Jin L, Honoré E, Lam KS, Wang W, Hui X, Xu A
Nature Communications 2022
The potential function and clinical application of FGF21 in metabolic diseases
Chen Z, Yang L, Liu Y, Huang P, Song H, Zheng P
Frontiers in pharmacology 2022
Extracellular RNAs from immune cells under obesity—a narrative review
Karlinsey K, Matz A, Qu L, Zhou B
2022
miR‐548ag functions as an oncogene by suppressing MOB1B in the development of obesity‐related endometrial cancer
Pang H, Wang J, Wei Q, Liu J, Chu X, Yuan C, Yang B, Li M, Ma D, Tang Y, Wang C, Zhang J
Cancer Science 2022
Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology: An Endocrine Society Scientific Statement
Salomon C, Das S, Erdbrügger U, Kalluri R, Kiang Lim S, Olefsky JM, Rice GE, Sahoo S, Andy Tao W, Vader P, Wang Q, Weaver AM
Endocrine reviews 2022
Krüppel样因子4对脓毒症小鼠炎症反应与脏器损伤的作用
Zhonghua Shaoshang yu Chuangmian Xiufu Zazhi 2022
Efficacy of electro-acupuncture at “Weizhong” (BL40) on macrophage polarization in rats with injured lumbar multifidus
TIAN Y, BU H, WANG T, YANG D, ZHANG W, LIU T, ZHANG L, HUO Z
Journal of Traditional Chinese Medicine 2022
T Regulatory Cells in Human Health and Diseases
SG Zheng
2021
Contributions of microRNAs to Peripheral Insulin Sensitivity
K Kim, S Hartig
Endocrinology 2021
MicroRNAs: The Link between the Metabolic Syndrome and Oncogenesis
A Fodor, AL Lazar, C Buchman, B Tiperciuc, OH Orasan, A Cozma
International journal of molecular sciences 2021
Composition, isolation, identification and function of adipose tissue-derived exosomes
R Zhao, T Zhao, Z He, R Cai, W Pang
Adipocyte 2021
Perivascular Adipose-Derived Exosomes Reduce Foam Cell Formation by Regulating Expression of Cholesterol Transporters
Y Liu, Y Sun, X Lin, D Zhang, C Hu, J Liu, Y Zhu, A Gao, H Han, M Chai, J Zhang, Y Zhou, Y Zhao
Frontiers in Cardiovascular Medicine 2021
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 3
D Li, C Yang, J Zhu, E Lopez, T Zhang, Q Tong, C Peng, LL
Acta Pharmacologica Sinica 2021
Adipose Tissue Macrophage Polarization in Healthy and Unhealthy Obesity
AD Ruggiero, CC Key, K Kavanagh
Frontiers in Nutrition 2021
The impact of obesity on adipocyte-derived extracellular vesicles
HY Kwan, M Chen, K Xu, B Chen
Cellular and Molecular Life Sciences 2021
Adipose Extracellular Vesicles in Intercellular and Inter-Organ Crosstalk in Metabolic Health and Diseases
Z Huang, A Xu
Frontiers in immunology 2021
Adipose Extracellular Vesicles: Messengers From and to Macrophages in Regulating Immunometabolic Homeostasis or Disorders
Z Zhou, Y Tao, H Zhao, Q Wang
Frontiers in immunology 2021
Adipocyte-Derived Extracellular Vesicles: State of the Art
S Rome, A Blandin, SL Lay
International journal of molecular sciences 2021
Maternal obesity and developmental programming of neuropsychiatric disorders: An inflammatory hypothesis
J Davis, E Mire
2021
Adipocyte, Immune Cells, and miRNA Crosstalk: A Novel Regulator of Metabolic Dysfunction and Obesity
S Kiran, V Kumar, S Kumar, RL Price, UP Singh
Cells 2021
Adipocyte‐derived extracellular vesicles in health and diseases: Nano‐packages with vast biological properties
SL Lay, S Rome, X Loyer, L Nieto
FASEB bioAdvances 2021
A Review of miRNAs as Biomarkers and Effect of Dietary Modulation in Obesity Associated Cognitive Decline and Neurodegenerative Disorders
M Perdoncin, A Konrad, JR Wyner, S Lohana, SS Pillai, DG Pereira, HV Lakhani, K Sodhi
Frontiers in molecular neuroscience 2021
Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation
MR Spalinger, M Crawford, SD Bobardt, J Li, A Sayoc-Becerra, AN Santos, A Shawki, P Chatterjee, MG Nair, DF McCole
Mucosal Immunology 2021
Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions
Y Liu, C Wang, M Wei, G Yang, L Yuan
Frontiers in physiology 2021
Diverse RNAs in adipose-derived extracellular vesicles and their therapeutic potential
P Hong, M Yu, W Tian
Molecular Therapy — Nucleic Acids 2021
MicroRNA expression profile and identification of novel microRNA biomarkers for metabolic syndrome
G Liu, Y Lei, S Luo, Z Huang, C Chen, K Wang, P Yang, X Huang
Bioengineered 2021
Therapeutic Application of Exosomes in Inflammatory Diseases
JH Suh, HS Joo, EB Hong, HJ Lee, JM Lee
International journal of molecular sciences 2021
Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease
Z Michailidou, M Gomez-Salazar, V Alexaki
Journal of Innate Immunity 2021
Modulation of the Wound Healing through Noncoding RNA Interplay and GSK-3β/NF-κB Signaling Interaction
X Wang, W Li, S Lu, Z Ma, L Falzone
International Journal of Genomics 2021
Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future
H Abreu, E Canciani, D Raineri, G Cappellano, L Rimondini, A Chiocchetti
Cells 2021
Exosomes and Obesity-Related Insulin Resistance
LM Lei, X Lin, F Xu, SK Shan, B Guo, FX Li, MH Zheng, Y Wang, QS Xu, LQ Yuan
Frontiers in Cell and Developmental Biology 2021
Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan, JY He, S Li, YS Liu
Signal Transduction and Targeted Therapy 2021
Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease
X Wang, H Rao, F Liu, L Wei, H Li, C Wu
Cells 2021
Innate Immune System Orchestrates Metabolic Homeostasis and Dysfunction in Visceral Adipose Tissue During Obesity
Y Zhen, W Shu, X Hou, Y Wang
Frontiers in immunology 2021
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes
C Crewe, JB Funcke, S Li, N Joffin, CM Gliniak, AL Ghaben, YA An, HA Sadek, R Gordillo, Y Akgul, S Chen, D Samovski, P Fischer-Posovszky, CM Kusminski, S Klein, PE Scherer
Cell Metabolism 2021
Extracellular vesicles: mediators of intercellular communication in tissue injury and disease
GB Sánchez, KE Bunn, HH Pua, M Rafat
Cell Communication and Signaling 2021
Metabolic dysfunction and immunometabolism in COVID-19 pathophysiology and therapeutics
R Batabyal, N Freishtat, E Hill, M Rehman, R Freishtat, I Koutroulis
International Journal of Obesity 2021
An update on the roles of immune system-derived microRNAs in cardiovascular diseases
LB Roberts, P Kapoor, JK Howard, AM Shah, G M
Cardiovascular Research 2021
Intercellular and interorgan crosstalk through adipocyte extracellular vesicles
C Crewe, PE Scherer
Reviews in Endocrine and Metabolic Disorders 2021
MicroRNA-223 inhibits neutrophil extracellular traps formation through regulating calcium influx and small extracellular vesicles transmission
TL Liao, YM Chen, KT Tang, PK Chen, HJ Liu, DY Chen
Scientific Reports 2021
Macrophage Polarization and Its Role in Liver Disease
C Wang, C Ma, L Gong, Y Guo, K Fu, Y Zhang, H Zhou, Y Li
Frontiers in immunology 2021
Exosomes as mediators of intercellular crosstalk in metabolism
R Isaac, FC Reis, W Ying, JM Olefsky
Cell Metabolism 2021
Circulating Exosomal miR-221 from Maternal Obesity Inhibits Angiogenesis via Targeting Angptl2
Y Zhou, M Xia, C Cui, H Wei, S Jiang, J Peng
International journal of molecular sciences 2021
Role of the miR-133a-5p/FBXO6 axis in the regulation of intervertebral disc degeneration
XF Du, HT Cui, HH Pan, J Long, HW Cui, SL Chen, JR Wang, ZM Li, H Liu, YC Huang, H Wang, ZM Zheng
Journal of Orthopaedic Translation 2021
Adipose-Derived Exosomes as Possible Players in the Development of Insulin Resistance
A Żbikowski, A Błachnio-Zabielska, M Galli, P Zabielski
International journal of molecular sciences 2021
Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies
T Ruskovska, I Budić-Leto, KF Corral-Jara, V Ajdžanović, A Arola-Arnal, FI Bravo, GE Deligiannidou, J Havlik, M Janeva, E Kistanova, C Kontogiorgis, I Krga, M Massaro, M Miler, V Milosevic, C Morand, E Scoditti, M Suárez, D Vauzour, D Milenkovic
Nutrients 2021
MicroRNA in extracellular vesicles regulates inflammation through macrophages under hypoxia
Y Li, J Tan, Y Miao, Q Zhang
Cell Death Discovery 2021
Obesity, leptin, and deregulation of microRNA in lipid metabolisms: their contribution to breast cancer prognosis
KW Taroeno-Hariadi, MS Hardianti, H Sinorita, T Aryandono
Diabetology & metabolic syndrome 2021
Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice
Donghui Zhang, Hong Zhu, Enbo Zhan, Fan Wang, Yue Liu, Wei Xu, Xian Liu, Jingjin Liu, Shufeng Li, Yong Pan, Yongshun Wang, Wei Cao
Frontiers in Cell and Developmental Biology 2021
Long-Term Consequences of Placental Vascular Pathology on the Maternal and Offspring Cardiovascular Systems
M Benagiano, S Mancuso, JJ Brosens, G Benagiano
Biomolecules 2021
Secretome of Stem Cells: Roles of Extracellular Vesicles in Diseases, Stemness, Differentiation, and Reprogramming
HJ Kim, G Kim, J Lee, Y Lee, JH Kim
Tissue Engineering and Regenerative Medicine 2021
Secret messengers: Extracellular RNA communication in the immune system*
G Nation, C Saffold, H Pua
Immunological Reviews 2021
Potential of Hibiscus sabdariffa Linn. in managing FGF21 resistance in diet‐induced‐obesity rats via miR‐34a regulation
N Kartinah, N Komara, N Noviati, S Dewi, S Yolanda, A Radhina, H Heriyanto, I Sianipar
Veterinary Medicine and Science 2021
MicroRNA‐34a in coronary heart disease: Correlation with disease risk, blood lipid, stenosis degree, inflammatory cytokines, and cell adhesion molecules
H Li, M Chen, Q Feng, L Zhu, Z Bai, B Wang, Z Guo, A Hou, H Li
Journal of Clinical Laboratory Analysis 2021
No small matter: emerging roles for exosomal miRNAs in the immune system
Bauer KM, Round JL, O'Connell RM
The FEBS journal 2021
Aberrant expression of miR-214 is associated with obesity-induced insulin resistance as a biomarker and therapeutic
F Cheng, G Yuan, J He, Y Shao, J Zhang, X Guo
Diagnostic Pathology 2020
The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
L Geng, KS Lam, A Xu
Nature Reviews Endocrinology 2020
Potential Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance
Y Kim, OK Kim
Advances in Nutrition 2020
Exosomal MicroRNA-374b-5p From Tubular Epithelial Cells Promoted M1 Macrophages Activation and Worsened Renal Ischemia/Reperfusion Injury
C Ding, J Zheng, B Wang, Y Li, H Xiang, M Dou, Y Qiao, P Tian, X Ding, W Xue
Frontiers in Cell and Developmental Biology 2020
Fibroblast growth factor 1 ameliorates adipose tissue inflammation and systemic insulin resistance via enhancing adipocyte mTORC2/Rictor signal
L Zhao, M Fan, L Zhao, H Yun, Y Yang, C Wang, D Qin
Journal of Cellular and Molecular Medicine 2020
Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver
S Seok, H Sun, YC Kim, B Kemper, JK Kemper
Diabetes 2020
miRNAs in Adipocyte-Derived Extracellular Vesicles: Multiple Roles in Development of Obesity-Associated Disease
Y Zhou, C Tan
Frontiers in Molecular Biosciences 2020
Metabolic regulation of aging and age-related disease
MW Hamrick, AM Stranahan
Ageing Research Reviews 2020
Immune checkpoint inhibitor induces cardiac injury through polarizing macrophages via modulating microRNA-34a/Kruppel-like factor 4 signaling
W Xia, C Zou, H Chen, C Xie, M Hou
Cell Death and Disease 2020
Inhibition of miRNA-34a Promotes M2 Macrophage Polarization and Improves LPS-Induced Lung Injury by Targeting Klf4
MJ Khan, P Singh, R Dohare, R Jha, AH Rahmani, SA Almatroodi, S Ali, MA Syed
Genes & development 2020
Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments
G Morris, BK Puri, L Olive, A Carvalho, M Berk, K Walder, LT Gustad, M Maes
BMC Medicine 2020
The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer Cells
L Rios-Colon, E Arthur, S Niture, Q Qi, JT Moore, D Kumar
Cells 2020
The crosstalk: exosomes and lipid metabolism
W Wang, N Zhu, T Yan, YN Shi, J Chen, CJ Zhang, XJ Xie, DF Liao, L Qin
Cell Communication and Signaling 2020
Novel Applications of Mesenchymal Stem Cell-Derived Exosomes for Myocardial Infarction Therapeutics
SJ Tan, JF Floriano, L Nicastro, C Emanueli, F Catapano
Biomolecules 2020
Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition
O Ramos-Lopez, FI Milagro, JI Riezu-Boj, JA Martinez
Inflammation Research 2020
Exosomal Secretion of Adipose Tissue during Various Physiological States
M Quan, S Kuang
Pharmaceutical Research 2020
A review on the biology and properties of adipose tissue macrophages involved in adipose tissue physiological and pathophysiological processes
Y Li, K Yun, R Mu
Lipids in Health and Disease 2020
Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses
Q Hu, CJ Lyon, JK Fletcher, W Tang, M Wan, TY Hu
Acta pharmaceutica Sinica. B 2020
Sex-specific microRNAs in women with diabetes and left ventricular diastolic dysfunction or HFpEF associate with microvascular injury
BW Florijn, GB Valstar, JM Duijs, R Menken, MJ Cramer, AJ Teske, C Ghossein-Doha, FH Rutten, ME Spaanderman, HM den Ruijter, R Bijkerk, AJ van Zonneveld
Scientific Reports 2020
The emerging roles of exosomal circRNAs in diseases
X Guo, W Tan, C Wang
Clinical and Translational Oncology 2020
Response by Gan et al to Letter Regarding Article, “Small Extracellular Microvesicles Mediated Pathological Communications Between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanism Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice”
L Gan, D Xie, WB Lau, XL Ma, Y Wang
Circulation 2020
Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis
L Zhang, F Li, Q Guo, Y Duan, W Wang, Y Zhong, Y Yang, Y Yin
Nutrients 2020
Identification of MicroRNA-Target Gene-Transcription Factor Regulatory Networks in Colorectal Adenoma Using Microarray Expression Data
Y Gao, S Zhang, Y Zhang, J Qian
Frontiers in Genetics 2020
Cardioprotective effects of miR-34a silencing in a rat model of doxorubicin toxicity
E Piegari, A Cozzolino, LP Ciuffreda, D Cappetta, AD Angelis, K Urbanek, F Rossi, L Berrino
Scientific Reports 2020
Characterization and Transcriptome Analysis of Exosomal and Nonexosomal RNAs in Bovine Adipocytes
B Yue, H Yang, J Wu, J Wang, W Ru, J Cheng, Y Huang, C Lei, X Lan, H Chen
International journal of molecular sciences 2020
Deciphering Adipose Tissue Extracellular Vesicles Protein Cargo and Its Role in Obesity
T Camino, N Lago-Baameiro, A Martis-Sueiro, I Couto, F Santos, J Baltar, M Pardo
International journal of molecular sciences 2020
Exosomal circular RNA sorting mechanisms and their function in promoting or inhibiting cancer (Review)
X Geng, X Lin, Y Zhang, Q Li, Y Guo, C Fang, H Wang
Oncology Letters 2020
Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome
Shunbun Kita, Norikazu Maeda, Iichiro Shimomura
Journal of Clinical Investigation 2019
Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer
Changhao Chen, Yuming Luo, Wang He, Yue Zhao, Yao Kong, Hongwei Liu, Guangzheng Zhong, Yuting Li, Jun Li, Jian Huang, Rufu Chen, Tianxin Lin
Journal of Clinical Investigation 2019
Kruppel‐like factor 4 improves obesity‐related nephropathy through increasing mitochondrial biogenesis and activities
L Jin, H Ye, M Pan, Y Chen, B Ye, Y Zheng, W Huang, S Pan, Z Shi, J Zhang
Journal of Cellular and Molecular Medicine 2019
MiR-495 regulates macrophage M1/M2 polarization and insulin resistance in high-fat diet-fed mice via targeting FTO
F Hu, J Tong, B Deng, J Zheng, C Lu
Pflügers Archiv - European Journal of Physiology 2019
Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis
Y Xu, Y Xu, Y Zhu, H Sun, C Juguilon, F Li, D Fan, L Yin, Y Zhang
Molecular Therapy 2019
Extrinsic and Intrinsic Immunometabolism Converge: Perspectives on Future Research and Therapeutic Development for Obesity
HL Caslin, AH Hasty
Current Obesity Reports 2019
Metabolism, Obesity, and Diabetes Mellitus: Recent Studies in Cellular and Animal Models and Human Subjects Highlight Mechanisms and Consequences of Metabolic Dysfunction
HH Ruiz, RL Díez, L Arivazahagan, R Ramasamy, AM Schmidt
Arteriosclerosis, thrombosis, and vascular biology 2019
Hydroxytyrosol Modulates Adipocyte Gene and miRNA Expression Under Inflammatory Condition
E Scoditti, S Carpi, M Massaro, M Pellegrino, B Polini, MA Carluccio, M Wabitsch, T Verri, P Nieri, RD Caterina
Nutrients 2019
Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰
G Lian, X Li, L Zhang, Y Zhang, L Sun, X Zhang, H Liu, Y Pang, W Kong, T Zhang, X Wang, C Jiang
EBioMedicine 2019
Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis
JM Alves, RH Teles, C do Valle Gomes Gatto, VR Muñoz, MR Cominetti, AC de Oliveira Duarte
Cells 2019
Immunometabolic Links between Estrogen, Adipose Tissue and Female Reproductive Metabolism
SA Eaton, JK Sethi
Biology : open access journal 2019
The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis
Z Ni, L Kuang, H Chen, Y Xie, B Zhang, J Ouyang, J Wu, S Zhou, L Chen, N Su, QY Tan, X Luo, B Chen, S Chen, L Yin, H Huang, X Du, L Chen
Cell Death and Disease 2019
Integrative roles of microRNAs in lipid metabolism and dyslipidemia:
LR Sedgeman, DL Michell, KC Vickers
Current Opinion in Lipidology 2019
Risk Factors Influencing the Thickness and Stranding of Perinephric Fat of Mayo Adhesive Probability Score in Minimally Invasive Nephrectomy
Y Yao, H Gong, Y Pang, L Gu, S Niu, Y Xu, P Li, K Liu, L Tang, Y Xuan, Y Gao, X Zhang
Medical science monitor : international medical journal of experimental and clinical research 2019
Over-expression of miR-34c leads to early-life visceral fat accumulation and insulin resistance
PH Jones, B Deng, J Winkler, AL Zirnheld, S Ehringer, V Shetty, M Cox, H Nguyen, WJ Shen, TT Huang, E Wang
Scientific Reports 2019
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

← Previous 1 2 3 4 5 6 … 10 11 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Posted by 28 X users
263 readers on Mendeley
See more details