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Citations to this article

Antigenicity and immunogenicity of allogeneic retinal transplants
Natalie G. Anosova, … , Michael J. Young, Gilles Benichou
Natalie G. Anosova, … , Michael J. Young, Gilles Benichou
Published October 15, 2001
Citation Information: J Clin Invest. 2001;108(8):1175-1183. https://doi.org/10.1172/JCI12204.
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Antigenicity and immunogenicity of allogeneic retinal transplants

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Abstract

The transplantation of neuronal cells and tissues represents a promising approach for the treatment of incurable neurodegenerative diseases. Indeed, it has been reported recently that retinal transplantation can rescue photoreceptor cells and delay age-related changes in various retinal layers in rodents. However, retinal grafts deteriorate progressively after placement in recipients’ eyes. Here we investigated whether a host’s immune response elicited toward the graft contributes to its deterioration. Using an ELISA spot assay, we measured T cell responses to retinal tissues placed in the vitreous cavity of syngeneic and allogeneic mice. We found that allogeneic retinas induced potent alloimmune responses mediated by T cells secreting type 1 cytokines (IFN-γ and IL-2). No response was found in mice engrafted with syngeneic retinas. In addition, all syngeneic retinal grafts displayed no signs of tissue damage (at 55 days), while the majority of allogeneic retinas deteriorated as early as 12 days after placement. Next, we showed that anti-donor responses occurred within two phenotypically and functionally distinct T cell subsets: CD4+ T cells secreting IL-2 and CD8+ T cells producing IFN-γ. Importantly, CD4+ T cells were necessary and sufficient to cause graft deterioration, while CD8+ T cells did not contribute to this process.

Authors

Natalie G. Anosova, Ben Illigens, Florence Boisgérault, Eugenia V. Fedoseyeva, Michael J. Young, Gilles Benichou

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Total citations by year

Year: 2016 2015 2012 Total
Citations: 1 1 1 3
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article (3)

Title and authors Publication Year
Multimodal Delivery of Isogenic Mesenchymal Stem Cells Yields Synergistic Protection from Retinal Degeneration and Vision Loss: Enhanced Vision Rescue via MSC IV Adjuvant Therapy
B Bakondi, S Girman, B Lu, S Wang
Stem Cells Translational Medicine 2016
A Subsequent Human Neural Progenitor Transplant into the Degenerate Retina Does Not Compromise Initial Graft Survival or Therapeutic Efficacy
B Lu, Y Lin, Y Tsai, S Girman, G Adamus, MK Jones, B Shelley, CN Svendsen, S Wang
Translational Vision Science & Technology 2015
Good news-bad news: the Yin and Yang of immune privilege in the eye
JV Forrester, H Xu
Frontiers in immunology 2012

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ISSN: 0021-9738 (print), 1558-8238 (online)

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