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Misactivation of Hedgehog signaling causes inherited and sporadic cancers
David R. Raleigh, Jeremy F. Reiter
David R. Raleigh, Jeremy F. Reiter
Published February 1, 2019
Citation Information: J Clin Invest. 2019;129(2):465-475. https://doi.org/10.1172/JCI120850.
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Misactivation of Hedgehog signaling causes inherited and sporadic cancers

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Abstract

The Hedgehog pathway is critical for the development of diverse organs. Misactivation of the Hedgehog pathway can cause developmental abnormalities and cancers, including medulloblastoma, the most common pediatric brain tumor, and basal cell carcinoma, the most common cancer in the United States. Here, we review how basic, translational, and clinical studies of the Hedgehog pathway have helped reveal how cells communicate, how intercellular communication controls development, how signaling goes awry to cause cancer, and how to use targeted molecular agents to treat both inherited and sporadic cancers.

Authors

David R. Raleigh, Jeremy F. Reiter

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Figure 2

Hedgehog pathway–associated cancers.

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Hedgehog pathway–associated cancers.
(A) Basal cell carcinomas (BCCs) of...
(A) Basal cell carcinomas (BCCs) of the preauricular space (top left), temple with preoperative markings (bottom left), and upper extremity (right) of adult patients demonstrate the morphologic diversity of BCC, which may present as an open sore, red patch, pearly papule, or scar. (B) T2 magnetic resonance 3-D fast-recovery fast-spin echo cube image of medulloblastoma in the cerebellar vermis (white arrow) of a pediatric patient. (C) Coronal PET (top) and CT (bottom) images of testicular rhabdomyosarcoma (white asterisk) with regional metastases to the left renal hilum (black arrow) in a young adult patient; the bladder in both images is denoted by a black asterisk.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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