Research Article
S D Rybalkin, K E Bornfeldt, W K Sonnenburg, I G Rybalkina, K S Kwak, K Hanson, E G Krebs, J A Beavo
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The perspective of cAMP/cGMP signaling and cyclic nucleotide phosphodiesterases in aortic aneurysm and dissection.
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Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm
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Genome-Wide Association Study Based on Random Regression Model Reveals Candidate Genes Associated with Longitudinal Data in Chinese Simmental Beef Cattle
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Insulin Resistance is Associated with Subclinical Vascular Injury in Patients with a Kidney Disease.
Adeva-Andany MM, Fernández-Fernández C, Adeva-Contreras L, Carneiro-Freire N, Domínguez-Montero A, Mouriño-Bayolo D |
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European Journal of Pharmacology | 2020 |
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Basic & Clinical Pharmacology & Toxicology | 2019 |
An EPAC1/PDE1C-Signaling Axis Regulates Formation of Leading-Edge Protrusion in Polarized Human Arterial Vascular Smooth Muscle Cells
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Cells | 2019 |
Mouse Cardiac Pde1C Is a Direct Transcriptional Target of Pparα
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International journal of molecular sciences | 2018 |
Vascular smooth muscle cell proliferation as a therapeutic target. Part 1: molecular targets and pathways
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Biotechnology Advances | 2018 |
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 2018 |
Histone demethylase JMJD6 regulates cellular migration and proliferation in adipose-derived mesenchymal stem cells
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Stem Cell Research & Therapy | 2018 |
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Journal of Cardiovascular Development and Disease | 2018 |
PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries: PDE1A inhibition mediates cGMP-induced relaxation
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British Journal of Pharmacology | 2017 |
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Mechanisms of Vascular Defects in Diabetes Mellitus | 2017 |
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Archives of Cardiovascular Diseases | 2016 |
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Clinical Science | 2015 |
Role of cAMP-Phosphodiesterase 1C Signaling in Regulating Growth Factor Receptor Stability, Vascular Smooth Muscle Cell Growth, Migration, and Neointimal HyperplasiaNovelty and Significance
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Circulation research | 2015 |
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Current Opinion in Pharmacology | 2014 |
Methods in Molecular Biology
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β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells
K Zhai, F Hubert, V Nicolas, G Ji, R Fischmeister, V Leblais |
PloS one | 2012 |
Sub-Nanomolar Sensitivity of Nitric Oxide Mediated Regulation of cGMP and Vasomotor Reactivity in Vascular Smooth Muscle
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Frontiers in pharmacology | 2012 |
Phosphodiesterases as Drug Targets
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2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterases as Drug Targets
SH Francis, M Conti, MD Houslay |
2011 | |
Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling
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PloS one | 2011 |
PDE1 isozymes, key regulators of pathological vascular remodeling
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Current Topics in Developmental Biology
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Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling
X Tian, C Vroom, HA Ghofrani, N Weissmann, E Bieniek, F Grimminger, W Seeger, RT Schermuly, SS Pullamsetti, W El-Rifai |
PloS one | 2011 |
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Physiological reviews | 2011 |
Decreased cGMP Level Contributes to Increased Contraction in Arteries From Hypertensive Rats: Role of Phosphodiesterase 1
FR Giachini, VV Lima, FS Carneiro, RC Tostes, RC Webb |
Hypertension | 2011 |
Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells
KI Jeon, H Jono, CL Miller, Y Cai, S Lim, X Liu, P Gao, JI Abe, JD Li, C Yan |
The FEBS journal | 2010 |
xPharm: The Comprehensive Pharmacology Reference
A Vinh |
xPharm: The Comprehensive Pharmacology Reference | 2010 |
Textbook of Pulmonary Vascular Disease
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2010 | |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
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cGMP: Generators, Effectors and Therapeutic Implications
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Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
cGMP: Generators, Effectors and Therapeutic Implications
HH Schmidt, F Hofmann, JP Stasch |
Handbook of experimental pharmacology | 2009 |
Therapeutic targets in pulmonary arterial hypertension
CJ Rhodes, A Davidson, JS Gibbs, J Wharton, MR Wilkins |
Pharmacology & Therapeutics | 2009 |
The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue
RL Gonçalves, C Lugnier, T Keravis, MJ Lopes, FA Fantini, M Schmitt, SF Cortes, VS Lemos |
European Journal of Pharmacology | 2009 |
Effects of KF19514, a Phosphodiesterase 4 and 1 Inhibitor, on Bronchial Inflammation and Remodeling in a Murine Model of Chronic Asthma
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Allergology International | 2009 |
Expression, activity, and function of phosphodiesterases in the mature and immature ductus arteriosus
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Pediatric Research | 2008 |
ABCD of the phosphodiesterase family: interaction and differential activity in COPD
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International journal of chronic obstructive pulmonary disease | 2008 |
Fosinopril Prevents the Pulmonary Arterial Remodeling in Sinoaortic-denervated Rats by Regulating Phosphodiesterase
X Tao, YJ Zhang, FM Shen, YF Guan, DF Su |
Journal of Cardiovascular Pharmacology | 2008 |
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries
AJ Santos-Silva, E Cairrão, M Morgado, E Álvarez, I Verde |
European Journal of Pharmacology | 2008 |
Rosiglitazone Inhibits Acyl-CoA Synthetase Activity and Fatty Acid Partitioning to Diacylglycerol and Triacylglycerol via a Peroxisome Proliferator-Activated Receptor- -Independent Mechanism in Human Arterial Smooth Muscle Cells and Macrophages
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2007 | |
Differential display fingerprints: new approach to characterize smooth muscle cells and human coronary atherectomy tissues
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Pathologie Biologie | 2007 |
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E Littler, XX Zhou |
Comprehensive Medicinal Chemistry II | 2007 |
Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1
F Murray, HH Patel, RY Suda, S Zhang, PA Thistlethwaite, JX Yuan, PA Insel |
American journal of physiology. Lung cellular and molecular physiology | 2007 |
Subcellular localization and regulation of type-1C and type-5 phosphodiesterases
S Dolci, A Belmonte, R Santone, M Giorgi, M Pellegrini, E Carosa, E Piccione, A Lenzi, EA Jannini |
Biochemical and Biophysical Research Communications | 2006 |
Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells
CV Garat, D Fankell, PF Erickson, JE Reusch, NN Bauer, IF McMurtry, DJ Klemm |
Molecular and cellular biology | 2006 |
Cyclic Nucleotide Phosphodiesterases in Health and Disease
E Aandahl, O Witczak, K Tasken |
Cyclic Nucleotide Phosphodiesterases in Health and Disease | 2006 |
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D Tilley, D Maurice |
Cyclic Nucleotide Phosphodiesterases in Health and Disease: Role in Controlling Vascular Cyclic Nucleotide Signaling | 2006 |
Cyclic Nucleotide Phosphodiesterases in Health and Disease: Nonselective Phosphodiesterase Inhibitors for Chronic Inflammatory Diseases
M Giembycz |
Cyclic Nucleotide Phosphodiesterases in Health and Disease: Nonselective Phosphodiesterase Inhibitors for Chronic Inflammatory Diseases | 2006 |
Role of Nuclear Ca 2+ /Calmodulin-Stimulated Phosphodiesterase 1A in Vascular Smooth Muscle Cell Growth and Survival
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Circulation research | 2006 |
Cardiovascular system as a ‘core’ of sexual life
AI El-Sakka |
Expert Opinion on Pharmacotherapy | 2005 |
Phosphodiesterase 5 and effects of sildenafil on cerebral arteries of man and guinea pig
C Kruuse, TS Khurana, SD Rybalkin, S Birk, U Engel, L Edvinsson, J Olesen |
European Journal of Pharmacology | 2005 |
Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors
RT Schermuly, C Inholte, AH Ghofrani, H Gall, N Weissmann, A Weidenbach, W Seeger, F Grimminger |
Respiratory Research | 2005 |
Cardiovascular implications in the use of PDE5 inhibitor therapy
DH Maurice |
International Journal of Impotence Research | 2004 |
Cyclic Nucleotide Phosphodiesterase Activity, Expression, and Targeting in Cells of the Cardiovascular System
DH Maurice, D Palmer, DG Tilley, HA Dunkerley, SJ Netherton, DR Raymond, HS Elbatarny, SL Jimmo |
Molecular pharmacology | 2003 |
Oleate, not ligands of the receptor for advanced glycation end-products, promotes proliferation of human arterial smooth muscle cells.
Renard CB, Askari B, Suzuki LA, Kramer F, Bornfeldt KE |
Diabetologia | 2003 |
PDE5 is converted to an activated state upon cGMP binding to the GAF A domain
SD Rybalkin, IG Rybalkina, M Shimizu-Albergine, XB Tang, JA Beavo |
The EMBO Journal | 2003 |
Norepinephrine induces slow calcium signalling in murine brown preadipocytes through the β-adrenoceptor/cAMP/protein kinase A pathway
LP Dolgacheva, BB Abzhalelov, SJ Zhang, VP Zinchenko, GE Bronnikov |
Cellular Signalling | 2003 |
Handbook of Cell Signaling
MF White |
Handbook of Cell Signaling | 2003 |
Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation
Masami Shimizu-Albergine, Sergei D Rybalkin, Irina G Rybalkina, Robert Feil, Wiebke Wolfsgruber, Franz Hofmann, Joseph A Beavo |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2003 |
Individual Cerebellar Purkinje Cells Express Different cGMP Phosphodiesterases (PDEs): In Vivo Phosphorylation of cGMP-Specific PDE (PDE5) as an Indicator of cGMP-dependent protein kinase (PKG) Activation
Shimizu-Albergine M, Rybalkin SD, Rybalkina IG, Feil R, Wolfsgruber W, Hofmann F, Beavo JA |
Journal of Neuroscience | 2003 |
Cyclic Nucleotide Phosphodiesterase 1C Promotes Human Arterial Smooth Muscle Cell Proliferation
SD Rybalkin, I Rybalkina, JA Beavo, KE Bornfeldt |
Circulation research | 2002 |
Reduced Phosphodiesterase 3 Activity and Phosphodiesterase 3A Level in Synthetic Vascular Smooth Muscle Cells: Implications for Use of Phosphodiesterase 3 Inhibitors in Cardiovascular Tissues
HA Dunkerley, DG Tilley, D Palmer, H Liu, SL Jimmo, DH Maurice |
Molecular pharmacology | 2002 |
The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation
C Kruuse, SD Rybalkin, TS Khurana, I Jansen-Olesen, J Olesen, L Edvinsson |
European Journal of Pharmacology | 2001 |
Blunted peripheral vasodilatory response is a hallmark of progressive deterioration in mild to moderate congestive heart failure
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Journal of Cardiac Failure | 2001 |
Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization
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Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | 2001 |
Regulation of cGMP-specific Phosphodiesterase (PDE5) Phosphorylation in Smooth Muscle Cells
SD Rybalkin, IG Rybalkina, R Feil, F Hofmann, JA Beavo |
The Journal of biological chemistry | 2001 |
Upregulation of Phosphodiesterase 1A1 Expression Is Associated With the Development of Nitrate Tolerance
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Circulation | 2001 |
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Biochemical Pharmacology | 2000 |
Expression of Phosphodiesterase 4D ( PDE4D ) Is Regulated by Both the Cyclic AMP-dependent Protein Kinase and Mitogen-activated Protein Kinase Signaling Pathways: A POTENTIAL MECHANISM ALLOWING FOR THE COORDINATED REGULATION OF PDE4D ACTIVITY AND EXPRESSION IN CELLS
H Liu, D Palmer, SL Jimmo, DG Tilley, HA Dunkerley, SC Pang, DH Maurice |
The Journal of biological chemistry | 2000 |
Dual Expression and Differential Regulation of Phosphodiesterase 3A and Phosphodiesterase 3B in Human Vascular Smooth Muscle: Implications for Phosphodiesterase 3 Inhibition in Human Cardiovascular Tissues
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Molecular pharmacology | 2000 |
Cyclic-3′,5′-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney
TP Dousa |
Kidney International | 1999 |
Pentoxifylline Inhibits Neointimal Formation and Stimulates Constrictive Vascular Remodeling After Arterial Injury
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Journal of Cardiovascular Pharmacology | 1999 |
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Biochemical Pharmacology | 1999 |
Therapeutic Potential of Selective PDE Inhibitors in Asthma
C Schudt, F Gantner, H Tenors, A Hatzelmann |
Pulmonary Pharmacology & Therapeutics | 1999 |
Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro
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The American Journal of Cardiology | 1999 |
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Anti-Inflammatory Drugs in Asthma
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1999 | |
Identification, Quantitation, and Cellular Localization of PDE1 Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterases
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Calmodulin and Signal Transduction | 1998 |
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