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Citations to this article

Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.
K M Chang, … , A Sette, F V Chisari
K M Chang, … , A Sette, F V Chisari
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2376-2385. https://doi.org/10.1172/JCI119778.
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Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.

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Abstract

Research Article

Authors

K M Chang, B Rehermann, J G McHutchison, C Pasquinelli, S Southwood, A Sette, F V Chisari

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Effective Induction of Type 1 Cytotoxic T Cell Responses in Mice with DNA Vaccine Encoding Two Hepatitis C Virus Cytotoxic T Lymphocyte Epitopes
L Shi, S Liu, GX Fan, L Sheng, HX Ren, YK Yuan
Viral Immunology 2006
Identification of hepatitis C virus (HCV) 2a-derived epitope peptides having the capacity to induce cytotoxic T lymphocytes in human leukocyte antigen-A24+ and HCV2a-infected patients
Y Wang, Y Takao, M Harada, N Komatsu, T Ono, M Sata, K Itoh, A Yamada
Cellular Immunology 2006
Do antiviral CD8+ T cells select hepatitis C virus escape mutants? Analysis in diverse epitopes targeted by human intrahepatic CD8+ T lymphocytes
H Komatsu, G Lauer, OG Pybus, K Ouchi, D Wong, S Ward, B Walker, P Klenerman
Journal of Viral Hepatitis 2006
Flow cytometry assay of myeloid dendritic cells (mDCs) in peripheral blood during acute hepatitis C: possible pathogenetic mechanisms
A Perrella, L Atripaldi, P Bellopede, T Patarino, C Sbreglia, G Tarantino, P Sorrentino, P Conca, L Ruggiero, O Perrella
World journal of gastroenterology : WJG 2006
Flow cytometry assay of myeloid dendritic cells (mDCs) in peripheral blood during acute hepatitis C: Possible pathogenetic mechanisms
A Perrella
World journal of gastroenterology : WJG 2006
Disease Progression and Disease Prevention in Hepatology and Gastroenterology
PR Galle, WE Schmidt, G Gerken, B Wiedenmann
2006
The Hypervariable Immunodominant NP 418-426 Epitope from the Influenza A Virus Nucleoprotein Is Recognized by Cytotoxic T Lymphocytes with High Functional Avidity
AC Boon, G de Mutsert, RA Fouchier, AD Osterhaus, GF Rimmelzwaan
Journal of virology 2006
Heterologous T cell immunity in severe hepatitis C virus infection
S Urbani, B Amadei, P Fisicaro, M Pilli, G Missale, A Bertoletti, C Ferrari
Journal of Experimental Medicine 2005
The impairment of CD8 responses limits the selection of escape mutations in acute hepatitis C virus infection
S Urbani, B Amadei, E Cariani, P Fisicaro, A Orlandini, G Missale, C Ferrari
Journal of immunology (Baltimore, Md. : 1950) 2005
Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infection
S Guglietta, AR Garbuglia, V Pacciani, C Scottà, MP Perrone, L Laurenti, E Spada, A Mele, MR Capobianchi, G Taliani, A Folgori, A Vitelli, L Ruggeri, A Nicosia, E Piccolella, PD Porto
European Journal of Immunology 2005
Stealth and cunning: hepatitis B and hepatitis C viruses
SF Wieland, FV Chisari
Journal of virology 2005
Cellular immune selection with hepatitis C virus persistence in humans
AL Cox, T Mosbruger, Q Mao, Z Liu, XH Wang, HC Yang, J Sidney, A Sette, D Pardoll, DL Thomas, SC Ray
Journal of Experimental Medicine 2005
Private aspects of heterologous immunity
B Rehermann, EC Shin
Journal of Experimental Medicine 2005
Mutational escape from CD8 + T cell immunity: HCV evolution, from chimpanzees to man
DG Bowen, CM Walker
Journal of Experimental Medicine 2005
Escape Mutations Alter Proteasome Processing of Major Histocompatibility Complex Class I-Restricted Epitopes in Persistent Hepatitis C Virus Infection
Y Kimura, T Gushima, S Rawale, P Kaumaya, CM Walker
Journal of virology 2005
Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection
K Sugimoto, DE Kaplan, F Ikeda, J Ding, J Schwartz, FA Nunes, HJ Alter, KM Chang
Journal of virology 2005
Immunology of hepatitis B virus and hepatitis C virus infection
B Rehermann, M Nascimbeni
Nature Reviews Immunology 2005
T cell immunity in hepatitis B and hepatitis C virus infection: implications for autoimmunity
Y Ichiki, XS He, S Shimoda, H Ishibashi, EB Keeffe, L Rossaro, ME Gershwin
Autoimmunity Reviews 2005
T cell response in hepatitis C virus infection
C Neumann-Haefelin, HE Blum, FV Chisari, R Thimme
Journal of Clinical Virology 2005
Adaptive immune responses in acute and chronic hepatitis C virus infection
DG Bowen, CM Walker
Nature 2005
Divergent and convergent evolution after a common-source outbreak of hepatitis C virus
SC Ray, L Fanning, XH Wang, DM Netski, E Kenny-Walsh, DL Thomas
Journal of Experimental Medicine 2005
Wide range of quasispecies diversity during primary hepatitis C virus infection
BL Herring, R Tsui, L Peddada, M Busch, EL Delwart
Journal of virology 2005
Interactions between helper T-cell epitopes of hepatitis C virus
F Zhu, M Yang, DD Eckels
Vaccine 2005
Hepatitis C virus and the immune system: a concise review
C Gremion, A Cerny
Reviews in Medical Virology 2005
Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection
HC Spangenberg, S Viazov, N Kersting, C Neumann-Haefelin, D McKinney, M Roggendorf, F Weizsäcker, HE Blum, R Thimme
Hepatology 2005
The origin of quasispecies: cause or consequence of chronic hepatitis C viral infection?
DG Bowen, CM Walker
Journal of Hepatology 2005
In Vivo Modulation of T Cell Responses and Protective Immunity by TCR Antagonism during Infection
LL Lau, J Jiang, H Shen
Journal of immunology (Baltimore, Md. : 1950) 2005
Full restoration of viral fitness by multiple compensatory co-mutations in the nucleoprotein of influenza A virus cytotoxic T-lymphocyte escape mutants
GF Rimmelzwaan, EG Berkhoff, NJ Nieuwkoop, DJ Smith, RA Fouchier, AD Osterhaus
Journal of General Virology 2005
Contributions of the Viral Genetic Background and a Single Amino Acid Substitution in an Immunodominant CD8 + T-Cell Epitope to Murine Coronavirus Neurovirulence
KC MacNamara, MM Chua, JJ Phillips, SR Weiss
Journal of virology 2005
Functional Constraints of Influenza A Virus Epitopes Limit Escape from Cytotoxic T Lymphocytes
EG Berkhoff, E de Wit, MM Geelhoed-Mieras, AC Boon, J Symons, RA Fouchier, AD Osterhaus, GF Rimmelzwaan
Journal of virology 2005
Hepatitis C Virus Mutation Affects Proteasomal Epitope Processing
Ulrike Seifert, Heike Liermann, Vito Racanelli, Anne Halenius, Manfred Wiese, Heiner Wedemeyer, Thomas Ruppert, Kay Rispeter, Peter Henklein, Alice Sijts, Hartmut Hengel, Peter-M. Kloetzel and Barbara Rehermann
Journal of Clinical Investigation 2004
Effects of antiviral therapy on the cellular immune response in acute hepatitis C
F Rahman, T Heller, Y Sobao, E Mizukoshi, M Nascimbeni, H Alter, S Herrine, J Hoofnagle, TJ Liang, B Rehermann
Hepatology 2004
Direct Binding of Hepatitis C Virus Core to gC1qR on CD4 + and CD8 + T Cells Leads to Impaired Activation of Lck and Akt
ZQ Yao, A Eisen-Vandervelde, SN Waggoner, EM Cale, YS Hahn
Journal of virology 2004
CD8 epitope escape and reversion in acute HCV infection
J Timm, GM Lauer, DG Kavanagh, I Sheridan, AY Kim, M Lucas, T Pillay, K Ouchi, LL Reyor, JS Wiesch, RT Gandhi, RT Chung, N Bhardwaj, P Klenerman, BD Walker, TM Allen
Journal of Experimental Medicine 2004
Genetic variability of hepatitis C virus NS3 protein in human leukocyte antigen-A2 liver transplant recipients with recurrent hepatitis C
FX L�pez-Labrador, M Berenguer, A Sempere, M Prieto, R Sirera, A Gonz�lez-Molina, V Ortiz, ML Marty, J Berenguer, M Gobernado
Liver Transplantation 2004
CELL-MEDIATED IMMUNITY AND THE OUTCOME OF HEPATITIS C VIRUS INFECTION
NH Shoukry, AG Cawthon, CM Walker
Annual Review of Microbiology 2004
The molecular basis of HCV-mediated immune dysregulation
AL Eisen-Vandervelde, ZQ Yao, YS Hahn
Clinical Immunology 2004
Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance
E Spada, A Mele, A Berton, L Ruggeri, L Ferrigno, AR Garbuglia, MP Perrone, G Girelli, PD Porto, E Piccolella, MU Mondelli, P Amoroso, R Cortese, A Nicosia, A Vitelli, A Folgori
Gut 2004
Control of heterologous hepatitis C virus infection in chimpanzees is associated with the quality of vaccine-induced peripheral T-helper immune response
C Rollier, E Depla, JA Drexhage, EJ Verschoor, BE Verstrepen, A Fatmi, C Brinster, A Fournillier, JA Whelan, M Whelan, D Jacobs, G Maertens, G Inchauspé, JL Heeney
Journal of virology 2004
Role of viral and host factors in HCV persistence: which lesson for therapeutic and preventive strategies?
G Missale, E Cariani, C Ferrari
Digestive and Liver Disease 2004
Changes in TNF-α mRNA Levels in the Peripheral Blood of Patients with Chronic Hepatitis C Virus (HCV) Infection during α-Interferon and Ribavirin Therapy
D Sypniewski, M Jurzak, K Cholewa, J Gola, U Mazurek, T Wilczok, J Rożek-Kostórkiewicz, W Mazur, Z Gonciarz
Viral Immunology 2004
The immunologic basis for hepatitis C infection
J Sun, K Li, MT Shata, T Chan
Current Opinion in Gastroenterology 2004
Pathophysiology of hepatitis C virus infection and related liver disease
JM Pawlotsky
Trends in Microbiology 2004
The use of class-I HLA tetramers for the detection of hepatitis C virus NS3-specific CD8(+) T cells in patients with chronic infection
FX López-Labrador, XS He, M Berenguer, RC Cheung, TL Wright, HB Greenberg
Journal of Immunological Methods 2004
A method to increase tetramer staining efficiency of CD8+ T cells with MHC-peptide complexes: therapeutic applications in monitoring cytotoxic T lymphocyte activity during hepatitis B and C treatment
SL Tsai, TH Lee, RN Chien, SK Liao, CL Lin, GC Kuo, YF Liaw
Journal of Immunological Methods 2004
Hepatitis C virus population analysis of a single-source nosocomial outbreak reveals an inverse correlation between viral load and quasispecies complexity
A Mas, E Ulloa, M Bruguera, I Furčić, D Garriga, S Fábregas, D Andreu, JC Saiz, J Díez
Journal of General Virology 2004
Genetic diversity and evolution of hepatitis C virus – 15 years on
P Simmonds
Journal of General Virology 2004
Long-Term Persistence of Infection in Chimpanzees Inoculated with an Infectious Hepatitis C Virus Clone Is Associated with a Decrease in the Viral Amino Acid Substitution Rate and Low Levels of Heterogeneity
J Fernandez, D Taylor, DR Morhardt, K Mihalik, M Puig, CM Rice, SM Feinstone, ME Major
Journal of virology 2004
A Mutation in the HLA-B * 2705-Restricted NP 383-391 Epitope Affects the Human Influenza A Virus-Specific Cytotoxic T-Lymphocyte Response In Vitro
EG Berkhoff, AC Boon, NJ Nieuwkoop, RA Fouchier, K Sintnicolaas, AD Osterhaus, GF Rimmelzwaan
Journal of virology 2004
Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: Tetramer assay and therapeutic implications
SL Tsai, IS Sheen, RN Chien, CM Chu, HC Huang, YL Chuang, TH Lee, SK Liao, CL Lin, GC Kuo, YF Liaw
Journal of Biomedical Science 2003
Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity
K Herzer, CS Falk, J Encke, ST Eichhorst, A Ulsenheimer, B Seliger, PH Krammer
Journal of virology 2003
Hepatic T cells and liver tolerance
IN Crispe
Nature Reviews Immunology 2003
Kinetics of the immune response during HBV and HCV infection
A Bertoletti
Hepatology 2003
Current therapy and new molecular approaches to antiviral treatment and prevention of hepatitis C
T H�gle, A Cerny
Reviews in Medical Virology 2003
Mechanisms of Alcohol-Induced Tissue Injury
PE Molina, JB Hoek, S Nelson, DM Guidot, CH Lang, JR Wands, JM Crawford
Alcoholism: Clinical & Experimental Research 2003
Evidence for lack of cross-genotype protection of CD4+ T cell responses during chronic hepatitis C virus infection
GC Harcourt, M Lucas, AJ Godkin, M Kantzanou, RE Phillips, P Klenerman
Clinical & Experimental Immunology 2003
DNA immunization with hepatitis C virus (HCV) polycistronic genes or immunization by HCV DNA priming-recombinant canarypox virus boosting induces immune responses and protection from recombinant HCV-vaccinia virus infection in HLA-A2.1-transgenic mice
P Pancholi, M Perkus, N Tricoche, Q Liu, AM Prince
Journal of virology 2003
Viral escape and T cell exhaustion in hepatitis C virus infection analysed using Class I peptide tetramers
M Kantzanou, M Lucas, E Barnes, H Komatsu, G Dusheiko, S Ward, G Harcourt, P Klenerman
Immunology Letters 2003
Hepatitis C virus infection: when silence is deception
V Racanelli, B Rehermann
Trends in Immunology 2003
Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance1 1The Bundesministerium für Bildung und Forschung and the European Union, as sponsors of the study, had no role in study design, data collection, analysis, or interpretation or in the writing and the decision to submit the report for publication
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Gastroenterology 2003
Subversion of immune responses by hepatitis C virus: immunomodulatory strategies beyond evasion?
YS Hahn
Current Opinion in Immunology 2003
Modulation of the peripheral T-Cell response by CD4 mutants of hepatitis C virus: transition from a Th1 to a Th2 response
JH Wang, TJ Layden, DD Eckels
Human Immunology 2003
Could TCR antagonism explain associations between MHC genes and disease?
S Vukmanović, TA Neubert, FR Santori
Trends in Molecular Medicine 2003
An HIV Type 1 Subtype B Founder Effect in Korea: gp160 Signature Patterns Infer Circulation of CTL-Escape Strains at the Population Level
RS Daniels, C Kang, D Patel, Z Xiang, NW Douglas, NN Zheng, HW Cho, JS Lee
AIDS Research and Human Retroviruses 2003
Hepatitis C virus: simply too smart to be just a liver pathogen
MU Mondelli
Digestive and Liver Disease 2003
HCV immunology--death and the maiden T cell
C Willberg, E Barnes, P Klenerman
Cell Death and Differentiation 2003
Frontiers in Viral Hepatitis
GJ Webster, GM Dusheiko
Frontiers in Viral Hepatitis 2003
Memory CD8 + T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection
NH Shoukry, A Grakoui, M Houghton, DY Chien, J Ghrayeb, KA Reimann, CM Walker
Journal of Experimental Medicine 2003
Influence of ethnicity in the outcome of hepatitis C virus infection and cellular immune response
K Sugimoto
Hepatology 2003
Hepatitis C pathogenesis: Mechanisms of viral clearance and liver injury
HR Rosen
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2003
Hepatitis C virus E2 and NS5A region variability during sequential treatment with two interferon-? preparations
ED Mangoni, DM Forton, G Ruggiero, P Karayiannis
Journal of Medical Virology 2003
Hepatitis C Virus Structural Proteins Impair Dendritic Cell Maturation and Inhibit In Vivo Induction of Cellular Immune Responses
P Sarobe, JJ Lasarte, A Zabaleta, L Arribillaga, A Arina, I Melero, F Borrás-Cuesta, J Prieto
Journal of virology 2003
Kinetics of CD4 + and CD8 + Memory T-Cell Responses during Hepatitis C Virus Rechallenge of Previously Recovered Chimpanzees
M Nascimbeni, E Mizukoshi, M Bosmann, ME Major, K Mihalik, CM Rice, SM Feinstone, B Rehermann
Journal of virology 2003
HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help
A Grakoui, NH Shoukry, DJ Woollard, JH Han, HL Hanson, J Ghrayeb, KK Murthy, CM Rice, CM Walker
Science 2003
Accumulation of B Lymphocytes with a Naive, Resting Phenotype in a Subset of Hepatitis C Patients
J Ni, E Hembrador, AM Bisceglie, IM Jacobson, AH Talal, D Butera, CM Rice, TJ Chambers, LB Dustin
Journal of immunology (Baltimore, Md. : 1950) 2003
Immunopathogenesis of Chronic Hepatitis C Virus Infection
DY Li, KB Schwarz
Journal of Pediatric Gastroenterology and Nutrition 2002
Quantitative and functional differences in CD8+ lymphocyte responses in resolved acute and chronic hepatitis C virus infection
T Lancaster, E Sanders, JM Christie, C Brooks, S Green, WM Rosenberg
Journal of Viral Hepatitis 2002
Acute hepatitis C: To treat or not to treat?
BA Piasecki, KR Reddy, KM Chang
Hepatology 2002
Cellular immune responses against hepatitis C virus: the evidence base 2002
S Ward, G Lauer, R Isba, B Walker, P Klenerman
Clinical & Experimental Immunology 2002
Immunity to hepatitis C virus: stunned but not defeated
P Klenerman, M Lucas, E Barnes, G Harcourt
Microbes and Infection 2002
Variabilidad genómica e historia natural de la infección por el virus de la hepatitis C
M García-Retortillo, X Forns
Gastroenterología y Hepatología 2002
Evolutionary trends of the first hypervariable region of the hepatitis C virus E2 protein in individuals with differing liver disease severity
BJ Thomson, JK Ball, AM Grabowska, WL Irving, A Robins, R Curran, JK Craggs, CL Jameson
Journal of General Virology 2002
Identification of the epitopes on HCV core protein recognized by HLA-A2 restricted cytotoxic T lymphocytes
H C Zhou, D Z Xu, X P Wang, J X Zhang, Y Huang, Y P Yan, Y Zhu, B Q Jin
World journal of gastroenterology : WJG 2002
Evolution of viral quasispecies in four dominant HlA-A2 restricted T cell epitopes is not a major reason for viral persistence in interferon-treated patients with chronic hepatitis C: HCV Quasispecies Evolution in CTL Epitopes
S Pingel, S Weyer, PR Galle, HF Löhr
Journal of Medical Virology 2002
Increased frequency of IFN-?-producing peripheral CD8+ T cells with memory-phenotype in patients with chronic hepatitis C
M Murata, S Nabeshima, N Maeda, H Nakashima, S Kashiwagi, J Hayashi
Journal of Medical Virology 2002
Molecular and Immunological Significance of Chimpanzee Major Histocompatibility Complex Haplotypes for Hepatitis C Virus Immune Response and Vaccination Studies
E Mizukoshi, M Nascimbeni, JB Blaustein, K Mihalik, CM Rice, TJ Liang, SM Feinstone, B Rehermann
Journal of virology 2002
A longitudinal analysis of t-cell epitope-coding regions of hepatitis C virus after liver transplantation1:
HR Rosen, G Marousek, S Chou
Transplantation 2002
Recent Advances in the Management of Hepatitis C in the Dialysis Population
F Fabrizi, G Lunghi, P Martin
The International Journal of Artificial Organs 2002
Hepatitis Viruses
JH Ou
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Impaired Effector Function of Hepatitis C Virus-Specific CD8 + T Cells in Chronic Hepatitis C Virus Infection
H Wedemeyer, XS He, M Nascimbeni, AR Davis, HB Greenberg, JH Hoofnagle, TJ Liang, H Alter, B Rehermann
Journal of immunology (Baltimore, Md. : 1950) 2002
Sequence Variation in a Newly Identified HLA-B35-Restricted Epitope in the Influenza A Virus Nucleoprotein Associated with Escape from Cytotoxic T Lymphocytes
AC Boon, G de Mutsert, YM Graus, RA Fouchier, K Sintnicolaas, AD Osterhaus, GF Rimmelzwaan
Journal of virology 2002
Functional measurement of hepatitis C virus core-specific CD8(+) T-cell responses in the livers or peripheral blood of patients by using autologous peripheral blood mononuclear cells as targets or stimulators
SH Fang, BL Chiang, MH Wu, H Iba, MY Lai, PM Yang, DS Chen, LH Hwang
Journal of clinical microbiology 2001
Hepatitis C Virus Core and Envelope Proteins Do Not Suppress the Host's Ability To Clear a Hepatic Viral Infection
J Sun, F Bodola, X Fan, H Irshad, L Soong, SM Lemon, TS Chan
Journal of virology 2001
Viral, host and interferon-related factors modulating the effect of interferon therapy for hepatitis C virus infection
KQ Hu, JM Vierling, AG Redeker
Journal of Viral Hepatitis 2001
Immunopathogenesis of hepatitis C virus infection
AJ Freeman, G Marinos, RA Ffrench, AR Lloyd
Immunology and Cell Biology 2001
The Outcome of Hepatitis C Virus Infection Is Predicted by Escape Mutations in Epitopes Targeted by Cytotoxic T Lymphocytes
AL Erickson, Y Kimura, S Igarashi, J Eichelberger, M Houghton, J Sidney, D McKinney, A Sette, AL Hughes, CM Walker
Immunity 2001
Hepatitis B and hepatitis C co-infection in patients with HIV
EH Mart�nez
Reviews in Medical Virology 2001
Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells
H Wedemeyer, E Mizukoshi, AR Davis, JR Bennink, B Rehermann
Journal of virology 2001
Determinants of viral clearance and persistence during acute hepatitis C virus infection
R Thimme, D Oldach, KM Chang, C Steiger, SC Ray, FV Chisari
Journal of Experimental Medicine 2001
Virus-specific CD8+ T cells with type 1 or type 2 cytokine profile are related to different disease activity in chronic hepatitis C virus infection
C Prezzi, MA Casciaro, V Francavilla, E Schiaffella, L Finocchi, LV Chircu, G Bruno, A Sette, S Abrignani, V Barnaba
European Journal of Immunology 2001
Interferon therapy in haemodialysis patients with acute hepatitis C virus infection and factors that predict response to treatment
M Gursoy, G Gur, H Arslan, N Ozdemir, S Boyacioglu
Journal of Viral Hepatitis 2001
Viral escape mechanisms – escapology taught by viruses
M Lucas, U Karrer, A Lucas, P Klenerman
International Journal of Experimental Pathology 2001
Characterization of an immunologically conserved epitope from hepatitis C virus E2 glycoprotein recognized by HLA-A2 restricted cytotoxic T lymphocytes
P Sarobe, E Huarte, JJ Lasarte, AL de Cerio, N Garcı́a, F Borrás-Cuesta, J Prieto
Journal of Hepatology 2001
The Chimpanzee Model of Hepatitis C Virus Infections
RE Lanford, C Bigger, S Bassett, G Klimpel
ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2001
HEPATITIS C VIRUS
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Clinics in Liver Disease 2001
Oral immunization with HCV-NS3—transformed Salmonella: Induction of HCV-specific CTL in a transgenic mouse model
H Wedemeyer, S Gagneten, A Davis, R Bartenschlager, S Feinstone, B Rehermann
Gastroenterology 2001
Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection
R Thimme, D Oldach, KM Chang, C Steiger, SC Ray, FV Chisari
Journal of Experimental Medicine 2001
Identification of the epitopes on HCV core protein recognized by HLA-A 2 restricted cytotoxic T lymphocytes
HC Zhou
World journal of gastroenterology : WJG 2001
Hepatitis C
SA Sarbah, ZM Younossi
Journal of Clinical Gastroenterology 2000
Increased frequency of interferon-gamma-producing peripheral blood CD4+ T cells in chronic hepatitis C virus infection
Y Kawakami, S Nabeshima, N Furusyo, Y Sawayama, J Hayashi, S Kashiwagi
The American Journal of Gastroenterology 2000
Effects of immunosuppression and organ transplantation on the natural history and immunopathogenesis of hepatitis C virus infection
GW McCaughan, A Zekry
Transplant Infectious Disease 2000
Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees
X Forns, R Thimme, S Govindarajan, SU Emerson, RH Purcell, FV Chisari, J Bukh
Proceedings of the National Academy of Sciences 2000
Analysis of successful immune responses in persons infected with hepatitis C virus
F Lechner, DK Wong, PR Dunbar, R Chapman, RT Chung, P Dohrenwend, G Robbins, R Phillips, P Klenerman, BD Walker
Journal of Experimental Medicine 2000
Vigorous Peripheral Blood Cytotoxic T Cell Response during the Acute Phase of Hepatitis C Virus Infection
M Cucchiarini, AR Kammer, B Grabscheid, HM Diepolder, TJ Gerlach, N Grüner, T Santantonio, J Reichen, GR Pape, A Cerny
Cellular Immunology 2000
Immunology of hepatitis C virus infection
L Huang, MJ Koziel
Current Opinion in Gastroenterology 2000
Identification of a pre-S2 mutant in hepatocytes expressing a novel marginal pattern of surface antigen in advanced diseases of chronic hepatitis B virus infection
YF Fan, CC Lu, YC Chang, TT Chang, PW Lin, HY Lei, IJ Su
Journal of Gastroenterology and Hepatology 2000
Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus
F Lechner, DK Wong, PR Dunbar, R Chapman, RT Chung, P Dohrenwend, G Robbins, R Phillips, P Klenerman, BD Walker
Journal of Experimental Medicine 2000
Use of Conventional or Replicating Nucleic Acid-Based Vaccines and Recombinant Semliki Forest Virus-Derived Particles for the Induction of Immune Responses Against Hepatitis C Virus Core and E2 Antigens
O Vidalin, A Fournillier, N Renard, M Chen, E Depla, D Boucreux, C Brinster, T Baumert, I Nakano, Y Fukuda, P Liljeström, C Trépo, G Inchauspé
Virology 2000
Biomedical Research Reports
JY Lau, DN Standring
Biomedical Research Reports 2000
Activation of nuclear factor kappaB in hepatitis C virus infection: implications for pathogenesis and hepatocarcinogenesis
DI Tai, SL Tsai, YM Chen, YL Chuang, CY Peng, IS Sheen, CT Yeh, KS Chang, SN Huang, GC Kuo, YF Liaw
Hepatology 2000
Virus de l'hépatite C: interactions virus-hôte et diagnostic biologique
JM Pawlotsky
Médecine et Maladies Infectieuses 2000
Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C
TJ Liang, B Rehermann, LB Seeff, JH Hoofnagle
Annals of internal medicine 2000
Why do cytotoxic T lymphocytes fail to eliminate hepatitis C virus? Lessons from studies using major histocompatibility complex class I peptide tetramers
CR Bangham, RM May, MA Novak, F Lechner, J Sullivan, H Spiegel, DF Nixon, B Ferrari, A Davis, B Borkowsky, H Pollack, E Barnes, G Dusheiko, P Klenerman
Philosophical Transactions of The Royal Society B Biological Sciences 2000
Immunology and Liver
MP Manns, G Paumgartner, U Leuschner
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Viral Escape and the Failure of Cellular Immune Responses
P Klenerman, F Lechner, M Kantzanou, A Ciurea, H Hengartner, R Zinkernagel
Science 2000
Immune selection and genetic sequence variation in core and envelope regions of hepatitis C virus
JM Christie, H Chapel, RW Chapman, WM Rosenberg
Hepatology 1999
Quasispecies in viral persistence and pathogenesis of hepatitis C virus
X Forns, RH Purcell, J Bukh
Trends in Microbiology 1999
Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers
XS He, B Rehermann, FX López-Labrador, J Boisvert, R Cheung, J Mumm, H Wedemeyer, M Berenguer, TL Wright, MM Davis, HB Greenberg
Proceedings of the National Academy of Sciences 1999
Long-term follow-up of chimpanzees inoculated with the first infectious clone for hepatitis C virus
ME Major, K Mihalik, J Fernandez, J Seidman, D Kleiner, AA Kolykhalov, CM Rice, SM Feinstone
Journal of virology 1999
Mechanisms of immune escape in viral hepatitis
W Rosenberg
Gut 1999
Stimulating protection
SJ Polyak, DR Gretch
Trends in Microbiology 1999
In vitro human Th-cell responses to a recombinant Hepatitis C Virus antigen: failure in IL-2 production despite proliferation
DD Eckels, N Tabatabail, TH Bian, H Wang, SS Muheisen, CM Rice, K Yoshizawa, J Gill
Human Immunology 1999
Origin and Evolution of Viruses
JI Esteban, M Martell, WF Carman, J Gómez
Origin and Evolution of Viruses 1999
Quantitative analysis of hepatitis C virus-specific CD8+ T cells in peripheral blood and liver using peptide-MHC tetramers
XS He, B Rehermann, FX Lopez-Labrador, J Boisvert, R Cheung, J Mumm, H Wedemeyer, M Berenguer, TL Wright, MM Davis, HB Greenberg
Proceedings of the National Academy of Sciences 1999
Identification of antigenic escape variants in an immunodominant epitope of hepatitis C virus
DD Eckels, H Zhou, TH Bian, H Wang
International Immunology 1999
Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
SL Tsai, YM Chen, MH Chen, CY Huang, IS Sheen, CT Yeh, JH Huang, GC Kuo, YF Liaw
Gastroenterology 1998
The mechanisms of chronicity in hepatitis C virus infection
KM Chang
Gastroenterology 1998
Hepatitis C virus infection: virus/host interactions
JM Pawlotsky
Journal of Viral Hepatitis 1998
Inefficient Recognition of Autologous Viral Sequences by Intrahepatic Hepatitis C Virus-Specific Cytotoxic T Lymphocytes in Chronically Infected Subjects
VM Giuggio, HL Bonkovsky, J Smith, AL Rothman
Virology 1998
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Disease-a-Month 1961

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