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Hypoxia inhibits gene expression of voltage-gated K+ channel alpha subunits in pulmonary artery smooth muscle cells.
J Wang, … , L J Rubin, X J Yuan
J Wang, … , L J Rubin, X J Yuan
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2347-2353. https://doi.org/10.1172/JCI119774.
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Diversity of voltage-dependent K + channels in human pulmonary artery smooth muscle cells
O Platoshyn, CV Remillard, I Fantozzi, M Mandegar, TT Sison, S Zhang, E Burg, JX Yuan 		American journal of physiology. Lung cellular and molecular physiology 2004
Overexpression of human KCNA5 increases IK(V) and enhances apoptosis
EE Brevnova, O Platoshyn, S Zhang, JX Yuan 		American journal of physiology. Cell physiology 2004
Regulation of oxygen sensing by ion channels
J López-Barneo, R Toro, KL Levitsky, MD Chiara, P Ortega-Sáenz 		Journal of applied physiology 2004
Current Management of Pulmonary Hypertension:
HE Dincer, KW Presberg 		Clinical Pulmonary Medicine 2004
Signal Transduction and the Gasotransmitters
R Wang 		2004
Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation
L Conforti, M Petrovic, D Mohammad, S Lee, Q Ma, S Barone, AH Filipovich 		Journal of immunology (Baltimore, Md. : 1950) 2003
Chronic carbon monoxide exposure of hypoxic rats increases in vitro sensitivity of pulmonary artery smooth muscle
E Dubuis, M Gautier, A Melin, M Rebocho, C Girardin, P Bonnet, C Vandier 		Canadian Journal of Physiology and Pharmacology 2003
Pathophysiology of pulmonary hypertension due to lung disease
KW Presberg, HE Dincer 		Current Opinion in Pulmonary Medicine 2003
Kv channel subunits that contribute to voltage-gated K+ current in renal vascular smooth muscle
DJ Fergus, JR Martens, SK England 		Pflügers Archiv - European Journal of Physiology 2003
Induction of T-type Calcium Channel Gene Expression by Chronic Hypoxia
RD Toro, KL Levitsky, J López-Barneo, MD Chiara 		The Journal of biological chemistry 2003
Gene transcription of brain voltage-gated potassium channels is reversibly regulated by oxygen supply
HM Prentice, SL Milton, D Scheurle, PL Lutz 		American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2003
Acute and chronic hypoxic pulmonary vasoconstriction: a central role for endothelin-1?
LA Shimoda, JS Sham, Q Liu, JT Sylvester 		Respiratory Physiology & Neurobiology 2002
Hypoxic pulmonary vasoconstriction: cyclic adenosine diphosphate-ribose, smooth muscle Ca2+ stores and the endothelium
AM Evans, M Dipp 		Respiratory Physiology & Neurobiology 2002
Role of K+ channels in pulmonary hypertension
M Mandegar, JX Yuan 		Vascular Pharmacology 2002
Hypoxia and Carbon Monoxide in the Vasculature
S Kourembanas 		Antioxidants & Redox Signaling 2002
KV2.1 channels mediate hypoxic inhibition of IKV in native pulmonary arterial smooth muscle cells of the rat
DS Hogg, AR Davies, G McMurray, RZ Kozlowski 		Cardiovascular Research 2002
The Mechanism(s) of Hypoxic Pulmonary Vasoconstriction: Potassium Channels, Redox O 2 Sensors, and Controversies
S Archer, E Michelakis 		Physiology (Bethesda, Md.) 2002
Graded response of K + current, membrane potential, and [Ca 2+ ] i to hypoxia in pulmonary arterial smooth muscle
A Olschewski, Z Hong, DP Nelson, EK Weir 		American journal of physiology. Lung cellular and molecular physiology 2002
Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca 2+ channels
GD Thorne, L Conforti, RJ Paul 		American journal of physiology. Heart and circulatory physiology 2002
Ion channels in pulmonary arterial hypertension
M Mandegar, CV Remillard, JX Yuan 		Progress in Cardiovascular Diseases 2002
Dichloroacetate, a Metabolic Modulator, Prevents and Reverses Chronic Hypoxic Pulmonary Hypertension in Rats: Role of Increased Expression and Activity of Voltage-Gated Potassium Channels
ED Michelakis, MS McMurtry, , JR Dyck, R Moudgil, TA Hopkins, GD Lopaschuk, L Puttagunta, R Waite, SL Archer 		Circulation 2002
Oxygen Sensing
S Lahiri, NR Prabhakar, RE Forster 		Advances in experimental medicine and biology 2002
CELLULARMECHANISM OFOXYGENSENSING
J López-Barneo, R Pardal, P Ortega-Sáenz 		Annual Review of Physiology 2001
THE PATHOBIOLOGY OF PULMONARY HYPERTENSION
RM Tuder, CD Cool, M Yeager, L Taraseviciene-Stewart, TM Bull, NF Voelkel 		Clinics in Chest Medicine 2001
Voltage-gated K+ channels in chemoreceptor sensory neurons of rat petrosal ganglion
EM Andrews, DL Kunze 		Brain Research 2001
Cellular pathophysiology and therapy of pulmonary hypertension
H Olschewski, F Rose, E Grünig, HA Ghofrani, D Walmrath, R Schulz, R Schermuly, F Grimminger, W Seeger 		The Journal of laboratory and clinical medicine 2001
Physiologic basis for the treatment of pulmonary hypertension
H Olschewski, A Olschewski, F Rose, R Schermuly, H Schütte, N Weissmann, W Seeger, F Grimminger 		Journal of Laboratory and Clinical Medicine 2001
Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K + channels
EA Coppock, JR Martens, MM Tamkun 		American journal of physiology. Lung cellular and molecular physiology 2001
Capacitative Ca 2+ entry in agonist-induced pulmonary vasoconstriction
SS McDaniel, O Platoshyn, J Wang, Y Yu, M Sweeney, S Krick, LJ Rubin, JX Yuan 		American journal of physiology. Lung cellular and molecular physiology 2001
Differential expression of K V channel α- and β-subunits in the bovine pulmonary arterial circulation
EA Coppock, MM Tamkun 		American journal of physiology. Lung cellular and molecular physiology 2001
Oxygen-sensitive K + channel(s): where and what?
JX Yuan 		American journal of physiology. Lung cellular and molecular physiology 2001
Chronic hypoxia-induced spontaneous and rhythmic contractions in the rat main pulmonary artery
S Bonnet, JM Hyvelin, P Bonnet, R Marthan, JP Savineau 		American journal of physiology. Lung cellular and molecular physiology 2001
Chronic hypoxia decreases K V channel expression and function in pulmonary artery myocytes
O Platoshyn, Y Yu, VA Golovina, SS McDaniel, S Krick, L Li, JY Wang, LJ Rubin, JX Yuan 		American journal of physiology. Lung cellular and molecular physiology 2001
Anorexic effect of K + channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells
SS McDaniel, O Platoshyn, Y Yu, M Sweeney, VA Miriel, VA Golovina, S Krick, BR Lapp, JY Wang, JX Yuan 		Journal of applied physiology 2001
Inhibition of voltage-gated K + currents by endothelin-1 in human pulmonary arterial myocytes
LA Shimoda, JT Sylvester, GM Booth, TH Shimoda, S Meeker, BJ Undem, JS Sham 		American journal of physiology. Lung cellular and molecular physiology 2001
K V α1 channels in murine arterioles: differential cellular expression and regulation of diameter
A Cheong, AM Dedman, SZ Xu, DJ Beech 		American journal of physiology. Heart and circulatory physiology 2001
c-Jun Decreases Voltage-Gated K + Channel Activity in Pulmonary Artery Smooth Muscle Cells
Y Yu, O Platoshyn, J Zhang, S Krick, Y Zhao, LJ Rubin, A Rothman, JX Yuan 		Circulation 2001
Potassium Channels in Cardiovascular Biology
SL Archer, NJ Rusch 		2001
Hypoxia: From Genes to the Bedside
RC Roach, PD Wagner, PH Hackett 		Hypoxia 2001
Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage‐gated potassium channel Kv1.5
SL Archer, B London, V Hampl, X Wu, A Nsair, L Puttagunta, K Hashimoto, RE Waite, ED Michelakis 		The FASEB Journal 2001
Oxygen-regulated transcription factors and their role in pulmonary disease
GL Semenza 		Respiratory Research 2000
Molecular basis of voltage-dependent delayed rectifier K+ channels in smooth muscle cells from rat tail artery
C Xu, G Tang, Y Lu, R Wang 		Life Sciences 2000
Sustained membrane depolarization and pulmonary artery smooth muscle cell proliferation
O Platoshyn, VA Golovina, CL Bailey, A Limsuwan, S Krick, M Juhaszova, JE Seiden, LJ Rubin, JX Yuan 		American journal of physiology. Cell physiology 2000
O 2 -sensitive K + channels: role of the Kv1.2 α-subunit in mediating the hypoxic response
L Conforti, I Bodi, JW Nisbet, DE Millhorn 		The Journal of Physiology 2000
Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels
M Sweeney, JX Yuan 		Respiratory Research 2000
Expression of the TGF-β receptor gene and sensitivity to growth inhibition following polyamine depletion
JN Rao, L Li, BL Bass, JY Wang 		American journal of physiology. Cell physiology 2000
L-type Ca 2+ channels, resting [Ca 2+ ] i , and ET-1-induced responses in chronically hypoxic pulmonary myocytes
LA Shimoda, JS Sham, TH Shimoda, JT Sylvester 		American journal of physiology. Lung cellular and molecular physiology 2000
Role of K + channel expression in polyamine-dependent intestinal epithelial cell migration
JY Wang, J Wang, VA Golovina, L Li, O Platoshyn, JX Yuan 		American journal of physiology. Cell physiology 2000
Hypoxia inhibits the Na + /Ca 2+ exchanger in pulmonary artery smooth muscle cells
YO Wang, PK Dhulipala, MI Kotlikoff 		The FASEB Journal 2000
Potential Role for Kv3.1b Channels as Oxygen Sensors
ON Osipenko, RJ Tate, AM Gurney 		Circulation research 2000
Role of potassium channels and nitric oxide in the relaxant effects elicited by beta-adrenoceptor agonists on hypoxic vasoconstriction in the isolated perfused lung of the rat
JP Dumas, F Goirand, M Bardou, M Dumas, L Rochette, C Advenier, JF Giudicelli 		British Journal of Pharmacology 1999
Identification, cloning and expression of rabbit vascular smooth muscle Kv1.5 and comparison with native delayed rectifier K+ current
O Clément-Chomienne, K Ishii, MP Walsh, WC Cole 		The Journal of Physiology 1999
Hypoxic pulmonary vasoconstriction
JP Dumas, M Bardou, F Goirand, M Dumas 		General Pharmacology: The Vascular System 1999
K+ and Ca2+ channel activity and cytosolic [Ca2+] in oxygen-sensing tissues
J López-Barneo, R Pardal, RJ Montoro, T Smani, J Garcı́a-Hirschfeld, J Ureña 		Respiration Physiology 1999
Endothelin-1 and serotonin: Mediators of primary and secondary pulmonary hypertension?
MR MacLean 		Journal of Laboratory and Clinical Medicine 1999
Oxygen-sensing potassium currents in pulmonary artery
KM McCulloch, ON Osipenko, AM Gurney 		General Pharmacology: The Vascular System 1999
Chronic hypoxia alters effects of endothelin and angiotensin on K + currents in pulmonary arterial myocytes
LA Shimoda, JT Sylvester, JS Sham 		American journal of physiology. Lung cellular and molecular physiology 1999
Chronic hypoxia abolished the postnatal increase in carotid body type I cell sensitivity to hypoxia
LM Sterni, OS Bamford, MJ Wasicko, JL Carroll 		American journal of physiology. Lung cellular and molecular physiology 1999
Effects of fluoxetine, phentermine, and venlafaxine on pulmonary arterial pressure and electrophysiology
HL Reeve, DP Nelson, SL Archer, EK Weir 		American journal of physiology. Lung cellular and molecular physiology 1999
Expression of voltage-dependent K + channel genes in mesenteric artery smooth muscle cells
C Xu, Y Lu, G Tang, R Wang 		AJP Gastrointestinal and Liver Physiology 1999
Oxygen Sensitivity of Cloned Voltage-Gated K + Channels Expressed in the Pulmonary Vasculature
JT Hulme, EA Coppock, A Felipe, JR Martens, MM Tamkun 		Circulation research 1999
Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes
SL Archer, E Souil, AT Dinh-Xuan, B Schremmer, JC Mercier, AE Yaagoubi, L Nguyen-Huu, HL Reeve, V Hampl 		Journal of Clinical Investigation 1998
Role of Potassium Channels in Regulation of Cerebral Vascular Tone
FM Faraci, CG Sobey 		Journal of Cerebral Blood Flow & Metabolism 1998
Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle
ON Osipenko, D Alexander, MR MacLean, AM Gurney 		British Journal of Pharmacology 1998
Hypoxia and Molecular Cardiovascular Medicine
JF Schmedtje, YS Ji 		Trends in Cardiovascular Medicine 1998
Intracellular acidosis differentially regulates K V channels in coronary and pulmonary vascular muscle
MG Berger, C Vandier, P Bonnet, WF Jackson, NJ Rusch 		American journal of physiology. Heart and circulatory physiology 1998
Resting potentials and potassium currents during development of pulmonary artery smooth muscle cells
AM Evans, ON Osipenko, SG Haworth, AM Gurney 		American journal of physiology. Heart and circulatory physiology 1998
Molecular basis and function of voltage-gated K + channels in pulmonary arterial smooth muscle cells
XJ Yuan, J Wang, M Juhaszova, VA Golovina, LJ Rubin 		American journal of physiology. Lung cellular and molecular physiology 1998
A maturational shift in pulmonary K + channels, from Ca 2+ sensitive to voltage dependent
HL Reeve, EK Weir, SL Archer, DN Cornfield 		American journal of physiology. Lung cellular and molecular physiology 1998

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