Research Article
S C Lin, T Yamate, Y Taguchi, V Z Borba, G Girasole, C A O'Brien, T Bellido, E Abe, S C Manolagas
Title and authors | Publication | Year |
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Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder
Sun T, Chen Q, Mei J, Li Y |
BMC psychiatry | 2023 |
Ovariectomy Activates Chronic Low‐Grade Inflammation Mediated by Memory T Cells, Which Promotes Osteoporosis in Mice
A ClineSmith, A Axelbaum, E Shashkova, M Chakraborty, J Sanford, P Panesar, M Peterson, L Cox, A Baldan, D Veis, R Aurora |
Journal of Bone and Mineral Research | 2020 |
Estrogen downregulates gp130 expression in HUVECs by regulating ADAM10 and ADAM17 via the estrogen receptor
M Zhou, W Dai, Y Cui, Y Li |
Biochemical and Biophysical Research Communications | 2020 |
Immune Tumor Microenvironment in Breast Cancer and the Participation of Estrogens and Its Receptors Into Cancer Physiopathology
M Segovia-Mendoza, J Morales-Montor |
Frontiers in immunology | 2019 |
Estrogen anti-inflammatory activity on human monocytes is mediated through cross-talk between estrogen receptor ERα36 and GPR30/GPER1
V Pelekanou, M Kampa, F Kiagiadaki, A Deli, P Theodoropoulos, G Agrogiannis, E Patsouris, A Tsapis, E Castanas, G Notas |
Journal of leukocyte biology | 2015 |
The role of sex hormones in induced-systemic inflammation in female albino rats
A Hassouna, E Obaia, S Marzouk, M Rateb, M Haidara |
Acta Physiologica Hungarica | 2014 |
Interleukin-6 and its receptors: A highly regulated and dynamic system
J Wolf, S Rose-John, C Garbers |
Cytokine | 2014 |
Parathyroid Hormone Receptor Signaling Induces Bone Resorption in the Adult Skeleton by Directly Regulating the RANKL Gene in Osteocytes
AN Ben-awadh, J Delgado-Calle, X Tu, K Kuhlenschmidt, MR Allen, LI Plotkin, T Bellido |
Endocrinology | 2014 |
Testosterone Delivered with a Scaffold Is as Effective as Bone Morphologic Protein-2 in Promoting the Repair of Critical-Size Segmental Defect of Femoral Bone in Mice
BH Cheng, TM Chu, C Chang, HY Kang, KE Huang, CM Isales |
PloS one | 2013 |
The role of cytokines in cardiovascular disease in menopause
G Camilleri, M Borg, S Brincat, P Schembri-Wismayer, M Brincat, J Calleja-Agius |
Climacteric | 2012 |
Hormonal contraception and bone metabolism: a systematic review
C Nappi, G Bifulco, GA Tommaselli, V Gargano, CD Carlo |
Contraception | 2012 |
Oncostatin M uses a novel receptor interaction to promote bone formation independently of resorption
Emma Walker, Narelle McGregor, Ingrid Poulton, Melissa Solano, Sueli Pompolo, Tania Fernandes, Matthew Constable, Geoff Nicholson, Jian-Guo Zhang, Nicos A. Nicola, Matthew Gillespie, Jack Martin, Natalie Sims |
Journal of Clinical Investigation | 2010 |
The Molecular Biology of Sex Steroids in Bone
S Kousteni |
Osteoporosis in Men | 2010 |
Androgens and Bone
KM Wiren, ES Orwoll |
Osteoporosis in Men | 2010 |
Commitment to the osteoblast lineage is not required for RANKL gene expression
C Galli, Q Fu, W Wang, BR Olsen, SC Manolagas, RL Jilka, CA O'Brien |
The Journal of biological chemistry | 2009 |
Proteasome inhibition up-regulates inflammatory gene transcription induced by an atypical pathway of NF-kappaB activation
SJ Cullen, S Ponnappan, U Ponnappan |
Biochemical Pharmacology | 2009 |
Catalytic activity of the proteasome fine-tunes Brg1-mediated chromatin remodeling to regulate the expression of inflammatory genes
SJ Cullen, S Ponnappan, U Ponnappan |
Molecular Immunology | 2009 |
Commitment to the Osteoblast Lineage Is Not Required for RANKL Gene Expression
C Galli, Q Fu, WF Wang, BR Olsen, SC Manolagas, RL Jilka, CA O'Brien |
The Journal of biological chemistry | 2009 |
Downregulation of cilia-localized Il-6Rα by 17β-estradiol in mouse and human fallopian tubes
R Shao, M Nutu, L Karlsson-Lindahl, A Benrick, B Weijdegård, S Lager, E Egecioglu, J Fernandez-Rodriguez, K Gemzell-Danielsson, C Ohlsson, JO Jansson, H Billig |
American journal of physiology. Cell physiology | 2009 |
Raised expression of cytokine receptor gp130 subunit on peripheral lymphocytes of patients with active lupus. A useful tool for monitoring the disease activity?
MD la Torre, JM Urra, J Blanco |
Lupus | 2009 |
Handbook on Immunosenescence
T Fulop, C Franceschi, K Hirokawa, G Pawelec |
2009 | |
Osteoimmunology: interactions of the bone and immune system
J Lorenzo, M Horowitz, Y Choi |
Endocrine reviews | 2008 |
Principles of Bone Biology
CJ Rosen, T Niu |
Principles of Bone Biology | 2008 |
Osteoimmunology
M Rauner, W Sipos, P Pietschmann |
International Archives of Allergy and Immunology | 2007 |
Direct and Indirect Estrogen Actions on Osteoblasts and Osteoclasts
A Zallone |
Annals of the New York Academy of Sciences | 2006 |
Redox regulation of the proteasome in T lymphocytes during aging
R Das, S Ponnappan, U Ponnappan |
Free radical biology & medicine | 2006 |
Effects of 17β-estradiol on the expression of IL-6, IL-11 and NF-κB in human MG-63 osteoblast-like cell line
W Yunlin, L Eyuan, X Guangda, D Ruchun, X Xinhua, L Xianghang |
Journal of Huazhong University of Science and Technology [Medical Sciences] | 2006 |
Role of endocrine-immune dysregulation in osteoporosis, sarcopenia, frailty and fracture risk
C Joseph, AM Kenny, P Taxel, JA Lorenzo, G Duque, GA Kuchel |
Molecular Aspects of Medicine | 2005 |
Expression of Functional Ciliary Neurotrophic Factor Receptors in Immortalized Gonadotrophin-Releasing Hormone-Secreting Neurones
E Dozio, H Watanobe, M Ruscica, R Maggi, M Motta, P Magni |
Journal of Neuroendocrinology | 2005 |
Esteroides sexuales y hueso: ¿tiene sexo el hueso?
EG Fernández, SG Iglesias, HR Salinas, EJ Gimeno, FH Carranza |
Revista Española de Enfermedades Metabólicas Óseas | 2005 |
Interleukin-6: An osteotropic factor influencing bone formation?
N Franchimont, S Wertz, M Malaise |
Bone | 2005 |
Bone Disease of Organ Transplantation
MR Rubin, JP Billezkian |
Bone Disease of Organ Transplantation | 2005 |
Localization of Interleukin-6 Receptor mRNA in the Pregnant and Non-pregnant Mouse Uterus
E HONDO, K KOKUBU, K KATO, Y KISO |
Journal of Reproduction and Development | 2005 |
Androgens and Bone
D Vanderschueren, L Vandenput, S Boonen, MK Lindberg, R Bouillon, C Ohlsson |
Endocrine reviews | 2004 |
PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway
SV Bukata, J Gelinas, X Wei, RN Rosier, JE Puzas, X Zhang, EM Schwarz, XR Song, DE Griswold, RJ O'Keefe |
Journal of Orthopaedic Research | 2004 |
Regulation of Cytokine Receptor Signaling by Nuclear Hormone Receptors: A New Paradigm for Receptor Interaction
KC Leung |
DNA and Cell Biology | 2004 |
Direct effects of interleukin-6 on liver progenitor oval cells in culture
VB Matthews, E Klinken, GC Yeoh |
Wound Repair and Regeneration | 2004 |
Bone Formation
F Bronner, MC Farach-Carson |
2004 | |
Prostate Cancer
WG Nelson, AM de Marzo, WB Isaacs |
New England Journal of Medicine | 2003 |
Changes in Proinflammatory Cytokine Activity after Menopause
J Pfeilschifter, R Köditz, M Pfohl, H Schatz |
Endocrine reviews | 2002 |
Expression of Interleukin-6 (IL-6) and IL-6 receptor mRNA in human bone samples from pre- and postmenopausal women
T Seck, I Diel, H Bismar, R Ziegler, J Pfeilschifter |
Bone | 2002 |
GENETIC AND ENVIRONMENTAL INFLUENCES ON IL-6 AND TNF-α PLASMA LEVELS IN APPARENTLY HEALTHY GENERAL POPULATION
I Pantsulaia, S Trofimov, E Kobyliansky, G Livshits |
Cytokine | 2002 |
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130
M Hayashi, MC Rho, A Enomoto, A Fukami, YP Kim, Y Kikuchi, T Sunazuka, T Hirose, K Komiyama, S Omura |
Proceedings of the National Academy of Sciences | 2002 |
In vivo test systems for the quantitative and qualitative analysis of the biological activity of phytoestrogens
P Diel, S Schmidt, G Vollmer |
Journal of Chromatography B | 2002 |
Oxytocin stimulates proliferation of human osteoblast-like cells
M Petersson, A Lagumdzija, A Stark, E Bucht |
Peptides | 2002 |
Sexual dimorphism in the pituitary-adrenal response to tumor necrosis factor-α, but not to interleukin-6, in the rat
H Watanobe |
Brain Research Bulletin | 2002 |
Nitric Oxide as the Mediator of the Antiosteoporotic Actions of Estrogen, Statins, and Essential Fatty Acids
UN Das |
Experimental biology and medicine (Maywood, N.J.) | 2002 |
Parathyroid Hormone Stimulates Receptor Activator of NFκB Ligand and Inhibits Osteoprotegerin Expression via Protein Kinase A Activation of cAMP-response Element-binding Protein
Q Fu, RL Jilka, SC Manolagas, CA O'Brien |
The Journal of biological chemistry | 2002 |
Androgens and Androgen Receptor
C Chang |
2002 | |
Biological Activity of a Novel Nonpeptide Antagonist to the Interleukin-6 Receptor 20 S ,21-Epoxy-resibufogenin-3-formate
M Hayashi, MC Rho, A Fukami, A Enomoto, S Nonaka, Y Sekiguchi, T Yanagisawa, A Yamashita, T Nogawa, Y Kamano, K Komiyama |
The Journal of pharmacology and experimental therapeutics | 2002 |
Increased mRNA expression and protein secretion of interleukin-6 in primary human osteoblasts differentiated in vitro from rheumatoid and osteoarthritic bone
HL Chenoufi, M Diamant, K Rieneck, B Lund, GS Stein, JB Lian |
Journal of Cellular Biochemistry | 2001 |
Sex Steroids and Bone
JE Compston |
Physiological reviews | 2001 |
Altered Bax expression and decreased apoptosis in bone marrow cells of lupus-susceptible NZB/W mice
M Nazareth, P Fanti, C Schwach, K Poppenberg, K Janis, SM Aronica |
Lupus | 2001 |
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
WB Ershler, ET Keller |
Annual Review of Medicine | 2000 |
Expression levels of gp130 in bone marrow stromal cells determine the magnitude of osteoclastogenic signals generated by IL-6-type cytokines
CA O'Brien, SC Lin, T Bellido, SC Manolagas |
Journal of Cellular Biochemistry | 2000 |
Ovariectomy does not induce osteopenia through interleukin-6 in rhesus monkeys (Macaca mulatta)
ET Keller, NC Binkley, BA Stebler, DM Hall, GM Johnston, J Zhang, WB Ershler |
Bone | 2000 |
Essential Requirement of BMPs-2/4 for Both Osteoblast and Osteoclast Formation in Murine Bone Marrow Cultures from Adult Mice: Antagonism by Noggin
E Abe, M Yamamoto, Y Taguchi, B Lecka-Czernik, CA O'Brien, AN Economides, N Stahl, RL Jilka, SC Manolagas |
Journal of Bone and Mineral Research | 2000 |
Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus
I Takacs, DL Koller, M Peacock, JC Christian, WE Evans, SL Hui, PM Conneally, CC Johnston, T Foroud, MJ Econs |
Bone | 2000 |
Correlation of estradiol, parathyroid hormone, interleukin-6, and soluble interleukin-6 receptor during the normal menstrual cycle
KM Chiu, CD Arnaud, J Ju, D Mayes, P Bacchetti, S Weitz, ET Keller |
Bone | 2000 |
Androgens and osteoporosis
D Vanderschueren, L Vandenput |
Andrologia | 2000 |
Neurotrophic role of interleukin-6 and soluble interleukin-6 receptors in N1E-115 neuroblastoma cells
J Knezevic-Cuca, KB Stansberry, G Johnston, J Zhang, ET Keller, AI Vinik, GL Pittenger |
Journal of Neuroimmunology | 2000 |
Unbiased determination of cytokine localization in bone: colocalization of interleukin-6 with osteoblasts in serial sections from monkey vertebrae
CS Johnson, CP Jerome, R Brommage |
Bone | 2000 |
Cross-talk between signal transducer and activator of transcription 3 and estrogen receptor signaling
T Yamamoto, T Matsuda, A Junicho, H Kishi, F Saatcioglu, A Muraguchi |
FEBS Letters | 2000 |
gp130 CYTOKINE FAMILY AND BONE CELLS
D Heymann, AV Rousselle |
Cytokine | 2000 |
A Model for the Mechanism of Astrogliosis in Prion Disease
FB Hafiz, DR Brown |
Molecular and Cellular Neuroscience | 2000 |
Expression of adhesion molecules LFA-I and ICAM-I on osteoclast precursors during osteoclast differentiation and involvement of estrogen deficiency
Y Gao, I Morita, T Kubota, S Murota, T Aso |
Climacteric | 2000 |
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis 1
SC Manolagas |
Endocrine reviews | 2000 |
Altered bone marrow cell sensitivity in the lupus-prone NZB/W mouse: regulation of CFU-GM colony formation by estrogen, tamoxifen and thrombopoietin
SM Aronica, A Dozier, P Fanti, M Nazareth |
Lupus | 2000 |
LEUKEMIA INHIBITORY FACTOR GENE IMPROVES SKIN ALLOGRAFT SURVIVAL IN THE MOUSE MODEL1:
S Akita, H Ishihara, RM Abdur, T Fujii |
Transplantation | 2000 |
Leukemia-Inhibitory Factor—Neuroimmune Modulator of Endocrine Function*
CJ Auernhammer, S Melmed |
Endocrine reviews | 2000 |
New developments in IL-6 dependent biology and therapy: where do we stand and what are the options?
KJ Kallen, PR Galle, S Rose-John |
Expert Opinion on Investigational Drugs | 1999 |
Oestrogens prevent the increase of human serum soluble interleukin-6 receptor induced by ovariectomy in vivo and decrease its release in human osteoblastic cells in vitro
G Girasole, N Giuliani, AB Modena, G Passeri, M Pedrazzoni |
Clinical Endocrinology | 1999 |
CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorption
L Sun, OA Adebanjo, BS Moonga, S Corisdeo, HK Anandatheerthavarada, G Biswas, T Arakawa, Y Hakeda, A Koval, B Sodam, PJ Bevis, AJ Moser, FA Lai, S Epstein, BR Troen, M Kumegawa, M Zaidi |
The Journal of Cell Biology | 1999 |
Expression of the vitamin D receptor, of estrogen and thyroid hormone receptor α- and β-isoforms, and of the androgen receptor in cultures of native mouse bone marrow and of stromal/osteoblastic cells
R Gruber, K Czerwenka, F Wolf, GM Ho, M Willheim, M Peterlik |
Bone | 1999 |
The Aging Skeleton
AB Hodsman, LJ Fraher, PH Watson |
The Aging Skeleton | 1999 |
Cytokine pleiotropy and redundancy – gp130 cytokines in human implantation
J Sánchez-Cuenca, JC Martı́n, A Pellicer, C Simón |
Immunology Today | 1999 |
Vascular nitric oxide, sex hormone replacement, and fish oil may help to prevent Alzheimer's disease by suppressing synthesis of acute-phase cytokines
MF McCarty |
Medical Hypotheses | 1999 |
Estrogen receptors in bone:
MF Young, SC Dieudonné |
Current Opinion in Orthopaedics | 1999 |
STAT3 Activation in Stromal/Osteoblastic Cells Is Required for Induction of the Receptor Activator of NF-κB Ligand and Stimulation of Osteoclastogenesis by gp130-utilizing Cytokines or Interleukin-1 but Not 1,25-Dihydroxyvitamin D 3 or Parathyroid Hormone
CA OBrien, I Gubrij, SC Lin, RL Saylors, SC Manolagas |
The Journal of biological chemistry | 1999 |
The Expression of Interleukin-6 (IL-6), IL-6 Receptor, and gp130-Kilodalton Glycoprotein in the Rat Decidua and a Decidual Cell Line: Regulation by 17β-Estradiol and Prolactin1
S Deb, C Tessier, A Prigent-Tessier, U Barkai, S Ferguson-Gottschall, RK Srivastava, J Faliszek, G Gibori |
Endocrinology | 1999 |
Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption
RL Jilka, K Takahashi, M Munshi, DC Williams, PK Roberson, SC Manolagas |
Journal of Clinical Investigation | 1998 |
The Role of IL-6 Type Cytokines and Their Receptors in Boneaa
SC Manolagas |
Annals of the New York Academy of Sciences | 1998 |
Osteoblast Programmed Cell Death (Apoptosis): Modulation by Growth Factors and Cytokines
RL Jilka, RS Weinstein, T Bellido, AM Parfitt, SC Manolagas |
Journal of Bone and Mineral Research | 1998 |
Expression of IL-6 Receptor and GP130 in Mouse Bone Marrow Cells During Osteoclast Differentiation
Y Gao, I Morita, N Maruo, T Kubota, S Murota, T Aso |
Bone | 1998 |
Cytokines, bone remodeling, and estrogen deficiency: a 1998 update
R Jilka |
Bone | 1998 |
Mode of Action of Interleukin-6 on Mature Osteoclasts. Novel Interactions with Extracellular Ca 2+ Sensing in the Regulation of Osteoclastic Bone Resorption
OA Adebanjo, BS Moonga, T Yamate, L Sun, C Minkin, E Abe, M Zaidi |
The Journal of Cell Biology | 1998 |
Osteoporosis
DL Glaser, FS Kaplan |
Spine | 1997 |
The Endocrinology of Aging
SW Lamberts, AW van Beld, AJ van der Lely |
Science | 1997 |