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Citations to this article

Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.
P Peraldi, … , M Xu, B M Spiegelman
P Peraldi, … , M Xu, B M Spiegelman
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1863-1869. https://doi.org/10.1172/JCI119715.
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Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.

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P Peraldi, M Xu, B M Spiegelman

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Progress in Drug Research
H Wu, EJ Lien, LL Lien, RM Schultz, VJ Ram, E Domingo, P Spence, SP Gupta, SP Bhat, EC Villarreal, E Jucker
2003
Three Mitogen-Activated Protein Kinases Inhibit Insulin Signaling by Different Mechanisms in 3T3-L1 Adipocytes
M Fujishiro, Y Gotoh, H Katagiri, H Sakoda, T Ogihara, M Anai, Y Onishi, H Ono, M Abe, N Shojima, Y Fukushima, M Kikuchi, Y Oka, T Asano
Molecular Endocrinology 2003
Metabolic and Additional Vascular Effects of Thiazolidinediones:
FM Martens, FL Visseren, J Lemay, EJ de Koning, TJ Rabelink
Drugs 2002
The mechanisms of action of PPARs
J Berger, DE Moller
Annual Review of Medicine 2002
Adipogenesis and aging: does aging make fat go MAD?
JL Kirkland, T Tchkonia, T Pirtskhalava, J Han, I Karagiannides
Experimental Gerontology 2002
Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes
AS Greenberg, ML McDaniel
European Journal of Clinical Investigation 2002
Ligands of Peroxisome Proliferator-activated Receptor-γ Induce Apoptosis in AR42J Cells
A Masamune, K Satoh, Y Sakai, M Yoshida, A Satoh, T Shimosegawa
Pancreas 2002
Physiological and Therapeutic Roles of Peroxisome Proliferator-Activated Receptors
J Berger, JA Wagner
Diabetes Technology & Therapeutics 2002
Stimulation of Peroxisome Proliferator-Activated Receptors α and γ Blocks HIV-1 Replication and TNFα Production in Acutely Infected Primary Blood Cells, Chronically Infected U1 Cells, and Alveolar Macrophages From HIV-Infected Subjects
PR Skolnik, MF Rabbi, JM Mathys, AS Greenberg
JAIDS Journal of Acquired Immune Deficiency Syndromes 2002
Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus
JC Parker
Advanced Drug Delivery Reviews 2002
Thiazolidinediones in the treatment of Type 2 diabetes
AS Greenberg, AG Pittas
Expert Opinion on Pharmacotherapy 2002
Expression of PPAR and RXR Isoforms in the Developing Rat and Human Term Placentas
Q Wang, H Fujii, GT Knipp
Placenta 2002
Improved Insulin Sensitivity and Body Fat Distribution in HIV-Infected Patients Treated With Rosiglitazone: A Pilot Study
MC Gelato, DC Mynarcik, JL Quick, RT Steigbigel, J Fuhrer, CE Brathwaite, JS Brebbia, MR Wax, MA McNurlan
JAIDS Journal of Acquired Immune Deficiency Syndromes 2002
The mode of action of thiazolidinediones
H Hauner
Diabetes/Metabolism Research and Reviews 2002
Management of Rosiglitazone-Induced Edema: Two Case Reports and a Review of the Literature
F Wang, LM Aleksunes, LA Reagan, CM Vergara
Diabetes Technology & Therapeutics 2002
Differential effect of PPARγ2 variants in the development of type 2 diabetes between native Japanese and Japanese Americans
M Nemoto, T Sasaki, SS Deeb, WY Fujimoto, N Tajima
Diabetes Research and Clinical Practice 2002
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
A Galli, DW Crabb, E Ceni, R Salzano, T Mello, G Svegliati-Baroni, F Ridolfi, L Trozzi, C Surrenti, A Casini
Gastroenterology 2002
Troglitazone but not Metformin Restores Insulin-Stimulated Phosphoinositide 3-Kinase Activity and Increases p110  Protein Levels in Skeletal Muscle of Type 2 Diabetic Subjects
YB Kim, TP Ciaraldi, A Kong, D Kim, N Chu, P Mohideen, S Mudaliar, RR Henry, BB Kahn
Diabetes 2002
C2-Ceramide Influences the Expression and Insulin-Mediated Regulation of Cyclic Nucleotide Phosphodiesterase 3B and Lipolysis in 3T3-L1 Adipocytes
J Mei, LS Holst, TR Landstrom, C Holm, D Brindley, V Manganiello, E Degerman
Diabetes 2002
Potentiation of Insulin Signaling in Tissues of Zucker Obese Rats After Acute and Long-Term Treatment With PPAR  Agonists
G Jiang, Q Dallas-Yang, Z Li, D Szalkowski, F Liu, X Shen, M Wu, G Zhou, T Doebber, J Berger, DE Moller, BB Zhang
Diabetes 2002
Tumor Necrosis Factor-  Suppresses Adipocyte-Specific Genes and Activates Expression of Preadipocyte Genes in 3T3-L1 Adipocytes: Nuclear Factor- B Activation by TNF-  Is Obligatory
H Ruan, N Hacohen, TR Golub, LV Parijs, HF Lodish
Diabetes 2002
Lipolysis in the Absence of Hormone-Sensitive Lipase: Evidence for a Common Mechanism Regulating Distinct Lipases
H Okazaki, J Osuga, Y Tamura, N Yahagi, S Tomita, F Shionoiri, Y Iizuka, K Ohashi, K Harada, S Kimura, T Gotoda, H Shimano, N Yamada, S Ishibashi
Diabetes 2002
Troglitazone: A Possible Modulator of Ovarian Steroidogenesis
MF Mitwally, SF Witchel, RF Casper
Journal of the Society for Gynecologic Investigation 2002
Impaired (‘diabetic’) insulin signaling and action occur in fat cells long before glucose intolerance—is insulin resistance initiated in the adipose tissue?
U Smith
International Journal of Obesity 2002
Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-α reduction and GLUT4 expression enhancement
G Mingrone, G Rosa, PD Rocco, M Manco, E Capristo, M Castagneto, R Vettor, G Gasbarrini, AV Greco
International Journal of Obesity 2002
PPAR-γ ligands modulate effects of LPS in stimulated rat synovial fibroblasts
MA Simonin, K Bordji, S Boyault, A Bianchi, E Gouze, P Bécuwe, M Dauça, P Netter, B Terlain
American journal of physiology. Cell physiology 2002
Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications
JC Fruchart, AM Gotto, R Paoletti, B Staels, AL Catapano
2002
PPARadigms and PPARadoxes: expanding roles for PPARγ in the control of lipid metabolism
R Walczak, P Tontonoz
Journal of lipid research 2002
Regulation of Semicarbazide-Sensitive Amine Oxidase Expression by Tumor Necrosis Factor-α in Adipocytes: Functional Consequences on Glucose Transport
N Mercier, M Moldes, KE Hadri, B Fève
The Journal of pharmacology and experimental therapeutics 2002
Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease
YF Guan, MD Breyer
Kidney International 2001
Free fatty acids - do they play a central role in type 2 diabetes?
P Arner
Diabetes, Obesity and Metabolism 2001
Pro-inflammatory cytokines and adipose tissue
SW Coppack
Proceedings of the Nutrition Society 2001
Synergistic Antiadipogenic Effects of HIV Type 1 Protease Inhibitors with Tumor Necrosis Factorα: Suppression of Extracellular Insulin Action Mediated by Extracellular Matrix-Degrading Proteases
D Mondal, VF Larussa, KC Agrawal
AIDS Research and Human Retroviruses 2001
Resistin: a new link between obesity and insulin resistance?
A Vidal-Puig, S O'Rahilly
Clinical Endocrinology 2001
TNFα Inhibits Insulin's Antiapoptotic Signaling in Vascular Smooth Muscle Cells
S Goetze, F Blaschke, P Stawowy, D Bruemmer, C Spencer, K Graf, M Gräfe, RE Law, E Fleck
Biochemical and Biophysical Research Communications 2001
Differential Regulation of Adipocytokine mRNAs by Rosiglitazone in db/db Mice
GB Moore, H Chapman, JC Holder, CA Lister, V Piercy, SA Smith, JC Clapham
Biochemical and Biophysical Research Communications 2001
Troglitazone Enhances Glucose Uptake Induced By alpha-Adrenoceptor Stimulation Via Phosphatidylinositol 3-Kinase In Rat Heart
J Yoshioka, H Kusuoka, K Imahashi, K Hashimoto, M Hori, T Terakawa, T Nishimura
Clinical and Experimental Pharmacology and Physiology 2001
Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs)
MB Sporn, N Suh, DJ Mangelsdorf
Trends in Molecular Medicine 2001
Insulin resistance induced in dairy steers by tumor necrosis factor alpha is partially reversed by 2,4–thiazolidinedione
S Kushibiki, K Hodate, H Shingu, Y Ueda, M Shinoda, Y Mori, T Itoh, Y Yokomizo
Domestic Animal Endocrinology 2001
A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis
SH Caldwell, EE Hespenheide, JA Redick, JC Iezzoni, EH Battle, BL Sheppard
The American Journal of Gastroenterology 2001
Enhancing insulin action: From chemical elements to thiazolidinediones
R Perfetti, K Chamie
Journal of Endocrinological Investigation 2001
Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats
AL Hevener, D Reichart, A Janez, J Olefsky
Diabetes 2001
The chlorophyll metabolite phytanic acid is a natural rexinoid – potential for treatment and prevention of diabetes
MF McCarty
Medical Hypotheses 2001
Pioglitazone Ameliorates Tumor Necrosis Factor- -Induced Insulin Resistance by a Mechanism Independent of Adipogenic Activity of Peroxisome Proliferator-Activated Receptor- 
M Iwata, T Haruta, I Usui, Y Takata, A Takano, T Uno, J Kawahara, E Ueno, T Sasaoka, O Ishibashi, M Kobayashi
Diabetes 2001
Rosiglitazone, Insulin Treatment, and Fasting Correct Defective Activation of Protein Kinase C-ζ/λ by Insulin in Vastus Lateralis Muscles and Adipocytes of Diabetic Rats 1
Y Kanoh, G Bandyopadhyay, MP Sajan, ML Standaert, RV Farese
Endocrinology 2001
Preferential channeling of energy fuels toward fat rather than muscle during high free fatty acid availability in rats
R Fabris, E Nisoli, A M Lombardi, C Tonello, R Serra, M Granzotto, I Cusin, F Rohner-Jeanrenaud, G Federspil, M O Carruba, R Vettor
Diabetes 2001
Inhibition of Monocyte Chemoattractant Protein-1 Expression in Cytokine-Treated Human Lung Epithelial Cells by Thiazolidinedione
A Momoi, K Murao, H Imachi, T Ishida, WM Cao, M Sato, J Takahara
Chest 2001
Tumor necrosis factor-α is induced through phorbol ester- and glycated human albumin-dependent pathway in THP-1 cells
T Naitoh, M Kitahara, N Tsuruzoe
Cellular Signalling 2001
Rosiglitazone treatment of patients with extreme insulin resistance and diabetes mellitus due to insulin receptor mutations has no effects on glucose and lipid metabolism
H Vestergaard, S Lund, O Pedersen
Journal of Internal Medicine 2001
Thiazolidinediones (PPARγ agonists) but not PPARα agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes
U Smith, SI Gogg, A Johansson, T Olausson, VI Rotter, B Svalstedt
The FASEB Journal 2001
PPAR agonists as direct modulators of the vessel wall in cardiovascular disease
KW Buchan, DG Hassall
Medicinal Research Reviews 2000
Alteration in Expression Profiles of a Series of Diabetes-Related Genes in db/db Mice Following Treatment With Thiazolidinediones
A Suzuki, T Yasuno, H Kojo, J Hirosumi, S Mutoh, Y Notsu
The Japanese Journal of Pharmacology 2000
COX-2 and the cyclopentenone prostaglandins - a new chapter in the book of inflammation?
PR Colville-Nash, DW Gilroy
Prostaglandins & Other Lipid Mediators 2000
Troglitazone Inhibits Mitogenic Signaling by Insulin in Vascular Smooth Muscle Cells
S Goetze, S Kim, XP Xi, K Graf, DC Yang, E Fleck, WP Meehan, WA Hsueh, RE Law
Journal of Cardiovascular Pharmacology 2000
PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancer
GJ Murphy, JC Holder
Trends in Pharmacological Sciences 2000
Troglitazone reduces plasma levels of tumour necrosis factor-alpha in obese patients with type 2 diabetes
A Katsuki, Y Sumida, K Murata, M Furuta, R Araki-Sasaki, K Tsuchihashi, Y Hori, Y Yano, EC Gabazza, Y Adachi
Diabetes, Obesity and Metabolism 2000
Transcriptional control of adipogenesis
SM Rangwala, MA Lazar
Annual Review of Nutrition 2000
Toward a wholly nutritional therapy for type 2 diabetes
MF McCarty
Medical Hypotheses 2000
Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells
F Marra, E Efsen, RG Romanelli, A Caligiuri, S Pastacaldi, G Batignani, A Bonacchi, R Caporale, G Laffi, M Pinzani, P Gentilini
Gastroenterology 2000
Down-regulation by troglitazone of hepatic tumor necrosis factor-α and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes∗
S Sigrist, M Bedoucha, UA Boelsterli
Biochemical Pharmacology 2000
Toward practical prevention of type 2 diabetes
MF McCarty
Medical Hypotheses 2000
Tumor Necrosis Factor α Inhibits Insulin-induced Mitogenic Signaling in Vascular Smooth Muscle Cells
S Goetze, U Kintscher, H Kawano, Y Kawano, S Wakino, E Fleck, WA Hsueh, RE Law
The Journal of biological chemistry 2000
Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity
M Guerre-Millo, P Gervois, E Raspé, L Madsen, P Poulain, B Derudas, JM Herbert, DA Winegar, TM Willson, JC Fruchart, RK Berge, B Staels
The Journal of biological chemistry 2000
Thiazolidinedione Treatment Enhances Insulin Effects on Protein Kinase C-ζ/λ Activation and Glucose Transport in Adipocytes of Nondiabetic and Goto-Kakizaki Type II Diabetic Rats
Y Kanoh, G Bandyopadhyay, MP Sajan, ML Standaert, RV Farese
The Journal of biological chemistry 2000
Nuovi farmaci per la terapia del diabete di tipo 2
F Santeusanio, G Perriello
L'Endocrinologo 2000
Obesity: Pathology and Therapy
DH Lockwood, TC Heffner
2000
The PPARs: From Orphan Receptors to Drug Discovery
TM Willson, PJ Brown, DD Sternbach, BR Henke
Journal of Medicinal Chemistry 2000
A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response
CG Su, X Wen, ST Bailey, W Jiang, SM Rangwala, SA Keilbaugh, A Flanigan, S Murthy, MA Lazar, GD Wu
Journal of Clinical Investigation 1999
The expression of adhesion molecules on endothelial cells is inhibited by troglitazone through its antioxidant activity
L Cominacini, U Garbin, AF Pasini, A Davoli, M Campagnola, A Rigoni, L Tosetti, VL Cascio
Cell Communication and Adhesion 1999
Tumor necrosis factor-α as a mediator of the insulin resistance of obesity
ED Rosen, BM Spiegelman
Current Opinion in Endocrinology & Diabetes 1999
Current Views on the Mechanism of Action of Thiazolidinedione Insulin Sensitizers
BJ Goldstein
Diabetes Technology & Therapeutics 1999
Mechanisms by which Thiazolidinediones Enhance Insulin Action
MJ Reginato, MA Lazar
Trends in Endocrinology & Metabolism 1999
The Emerging Role of Thiazolidinediones in the Treatment of Diabetes-Mellitus and Related Disorders
S Subramaniam
Clinical and Experimental Hypertension 1999
Cross-Regulation of C/EBPα and PPARγ Controls the Transcriptional Pathway of Adipogenesis and Insulin Sensitivity
Z Wu, ED Rosen, R Brun, S Hauser, G Adelmant, AE Troy, C McKeon, GJ Darlington, BM Spiegelman
Molecular Cell 1999
Thiazolidinedione inhibits the production of monocyte chemoattractant protein-1 in cytokine-treated human vascular endothelial cells
K Murao, H Imachi, A Momoi, Y Sayo, H Hosokawa, M Sato, T Ishida, J Takahara
FEBS Letters 1999
Thiazolidinedione inhibits production of RANTES in a cytokine-treated human lung epithelial cell line
A Momoi, K Murao, H Imachi, Y Sayo, H Nakamura, H Hosokawa, M Sato, J Fujita, H Okada, T Ishida, J Takahara
FEBS Letters 1999
Thiazolidinediones down-regulate plasminogen activator inhibitor type 1 expression in human vascular endothelial cells: A possible role for PPARgamma in endothelial function
K Kato, H Satoh, Y Endo, D Yamada, S Midorikawa, W Sato, K Mizuno, T Fujita, K Tsukamoto, T Watanabe
Biochemical and Biophysical Research Communications 1999
Molecular basis of insulin-stimulated GLUT4 vesicle trafficking. Location! Location! Location!
V Ribon, JH Johnson, HS Camp, AR Saltiel
The Journal of biological chemistry 1999
Peroxisome proliferator-activated receptor-γ: a versatile metabolic regulator
S Rocchi, J Auwerx
Annals of Medicine 1999
Tumor Necrosis Factor α-induced Pancreatic β-Cell Insulin Resistance Is Mediated by Nitric Oxide and Prevented by 15-Deoxy-Δ 12,14 -prostaglandin J 2 and Aminoguanidine: A ROLE FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ACTIVATION AND iNOS EXPRESSION
G Kwon, G Xu, CA Marshall, ML McDaniel
The Journal of biological chemistry 1999
TNF-α–Induced Migration of Vascular Smooth Muscle Cells Is MAPK Dependent
S Goetze, , Y Kawano, H Kawano, E Fleck, WA Hsueh, RE Law
Hypertension 1999
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*
B Desvergne, W Wahli
Endocrine reviews 1999
Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system
S Hunter
The American Journal of Medicine 1998
Insulin action enhancement normalizes brachial artery vasoactivity in patients with peripheral vascular disease and occult diabetes
R Avena, ME Mitchell, ES Nylen, KM Curry, AN Sidawy
Journal of Vascular Surgery 1998
Catabolic proinflammatory cytokines
JM Argilés, FJ López-Soriano
Current Opinion in Clinical Nutrition and Metabolic Care 1998
Transcriptional control of adipogenesis
L Fajas, JC Fruchart, J Auwerx
Current Opinion in Cell Biology 1998
The nuclear receptor PPARγ-bigger than fat
SA Kliewer, TM Willson
Current Opinion in Genetics & Development 1998
Insulin Resistance in Cancer Patients Is Associated with Enhanced Tumor Necrosis Factor-α Expression in Skeletal Muscle
Y Noguchi, T Yoshikawa, D Marat, C Doi, T Makino, K Fukuzawa, A Tsuburaya, S Satoh, T Ito, S Mitsuse
Biochemical and Biophysical Research Communications 1998
A Potent Antidiabetic Thiazolidinedione with Unique Peroxisome Proliferator-activated Receptor γ-activating Properties
MJ Reginato, ST Bailey, SL Krakow, C Minami, S Ishii, H Tanaka, MA Lazar
The Journal of biological chemistry 1998
Overexpression of Perilipin A and B Blocks the Ability of Tumor Necrosis Factor α to Increase Lipolysis in 3T3-L1 Adipocytes
SC Souza, LM de Vargas, MT Yamamoto, P Lien, MD Franciosa, LG Moss, AS Greenberg
The Journal of biological chemistry 1998
Transcription-Modulating Drugs: A New Frontier in the Treatment of Essential Hypertension
TW Kurtz, DG Gardner
Hypertension 1998
Adipose Tissue-Derived Tumor Necrosis Factor Activity Correlates with Fat Cell Size But Not Insulin Action in Aging Rats**This work was supported by National Institutes of Aging Grant KO1-AG00645 (to C.M.) and the National Institutes of Health Grant DK-47416 (to M.P.)
CL Morin, EC Gayles, DA Podolin, Y Wei, M Xu, MJ Pagliassotti
Endocrinology 1998
The New Antidiabetic Drug MCC-555 Acutely Sensitizes Insulin Signaling in Isolated Cardiomyocytes**This work was supported by the Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen, the Bundesministerium für Gesundheit, EU COST Action B5, and a grant from Mitsubishi Chemical (Yokohama, Japan)
LS Liu, H Tanaka, S Ishii, J Eckel
Endocrinology 1998

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