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P Peraldi, … , M Xu, B M Spiegelman
Published October 1, 1997
Citation Information: J Clin Invest. 1997;100(7):1863-1869. https://doi.org/10.1172/JCI119715.
Citation Information: J Clin Invest. 1997;100(7):1863-1869. https://doi.org/10.1172/JCI119715.
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Research Article
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P Peraldi, M Xu, B M Spiegelman
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Progress in Drug Research
H Wu, EJ Lien, LL Lien, RM Schultz, VJ Ram, E Domingo, P Spence, SP Gupta, SP Bhat, EC Villarreal, E Jucker |
2003 | |
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Three Mitogen-Activated Protein Kinases Inhibit Insulin Signaling by Different Mechanisms in 3T3-L1 Adipocytes
M Fujishiro, Y Gotoh, H Katagiri, H Sakoda, T Ogihara, M Anai, Y Onishi, H Ono, M Abe, N Shojima, Y Fukushima, M Kikuchi, Y Oka, T Asano |
Molecular Endocrinology | 2003 |
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Metabolic and Additional Vascular Effects of Thiazolidinediones:
FM Martens, FL Visseren, J Lemay, EJ de Koning, TJ Rabelink |
Drugs | 2002 |
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The mechanisms of action of PPARs
J Berger, DE Moller |
Annual Review of Medicine | 2002 |
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Adipogenesis and aging: does aging make fat go MAD?
JL Kirkland, T Tchkonia, T Pirtskhalava, J Han, I Karagiannides |
Experimental Gerontology | 2002 |
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Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes
AS Greenberg, ML McDaniel |
European Journal of Clinical Investigation | 2002 |
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Ligands of Peroxisome Proliferator-activated Receptor-γ Induce Apoptosis in AR42J Cells
A Masamune, K Satoh, Y Sakai, M Yoshida, A Satoh, T Shimosegawa |
Pancreas | 2002 |
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Physiological and Therapeutic Roles of Peroxisome Proliferator-Activated Receptors
J Berger, JA Wagner |
Diabetes Technology & Therapeutics | 2002 |
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Stimulation of Peroxisome Proliferator-Activated Receptors α and γ Blocks HIV-1 Replication and TNFα Production in Acutely Infected Primary Blood Cells, Chronically Infected U1 Cells, and Alveolar Macrophages From HIV-Infected Subjects
PR Skolnik, MF Rabbi, JM Mathys, AS Greenberg |
JAIDS Journal of Acquired Immune Deficiency Syndromes | 2002 |
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Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus
JC Parker |
Advanced Drug Delivery Reviews | 2002 |
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Thiazolidinediones in the treatment of Type 2 diabetes
AS Greenberg, AG Pittas |
Expert Opinion on Pharmacotherapy | 2002 |
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Expression of PPAR and RXR Isoforms in the Developing Rat and Human Term Placentas
Q Wang, H Fujii, GT Knipp |
Placenta | 2002 |
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Improved Insulin Sensitivity and Body Fat Distribution in HIV-Infected Patients Treated With Rosiglitazone: A Pilot Study
MC Gelato, DC Mynarcik, JL Quick, RT Steigbigel, J Fuhrer, CE Brathwaite, JS Brebbia, MR Wax, MA McNurlan |
JAIDS Journal of Acquired Immune Deficiency Syndromes | 2002 |
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The mode of action of thiazolidinediones
H Hauner |
Diabetes/Metabolism Research and Reviews | 2002 |
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Management of Rosiglitazone-Induced Edema: Two Case Reports and a Review of the Literature
F Wang, LM Aleksunes, LA Reagan, CM Vergara |
Diabetes Technology & Therapeutics | 2002 |
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Differential effect of PPARγ2 variants in the development of type 2 diabetes between native Japanese and Japanese Americans
M Nemoto, T Sasaki, SS Deeb, WY Fujimoto, N Tajima |
Diabetes Research and Clinical Practice | 2002 |
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Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
A Galli, DW Crabb, E Ceni, R Salzano, T Mello, G Svegliati-Baroni, F Ridolfi, L Trozzi, C Surrenti, A Casini |
Gastroenterology | 2002 |
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Troglitazone but not Metformin Restores Insulin-Stimulated Phosphoinositide 3-Kinase Activity and Increases p110 Protein Levels in Skeletal Muscle of Type 2 Diabetic Subjects
YB Kim, TP Ciaraldi, A Kong, D Kim, N Chu, P Mohideen, S Mudaliar, RR Henry, BB Kahn |
Diabetes | 2002 |
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C2-Ceramide Influences the Expression and Insulin-Mediated Regulation of Cyclic Nucleotide Phosphodiesterase 3B and Lipolysis in 3T3-L1 Adipocytes
J Mei, LS Holst, TR Landstrom, C Holm, D Brindley, V Manganiello, E Degerman |
Diabetes | 2002 |
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Potentiation of Insulin Signaling in Tissues of Zucker Obese Rats After Acute and Long-Term Treatment With PPAR Agonists
G Jiang, Q Dallas-Yang, Z Li, D Szalkowski, F Liu, X Shen, M Wu, G Zhou, T Doebber, J Berger, DE Moller, BB Zhang |
Diabetes | 2002 |
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Tumor Necrosis Factor- Suppresses Adipocyte-Specific Genes and Activates Expression of Preadipocyte Genes in 3T3-L1 Adipocytes: Nuclear Factor- B Activation by TNF- Is Obligatory
H Ruan, N Hacohen, TR Golub, LV Parijs, HF Lodish |
Diabetes | 2002 |
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Lipolysis in the Absence of Hormone-Sensitive Lipase: Evidence for a Common Mechanism Regulating Distinct Lipases
H Okazaki, J Osuga, Y Tamura, N Yahagi, S Tomita, F Shionoiri, Y Iizuka, K Ohashi, K Harada, S Kimura, T Gotoda, H Shimano, N Yamada, S Ishibashi |
Diabetes | 2002 |
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Troglitazone: A Possible Modulator of Ovarian Steroidogenesis
MF Mitwally, SF Witchel, RF Casper |
Journal of the Society for Gynecologic Investigation | 2002 |
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Impaired (‘diabetic’) insulin signaling and action occur in fat cells long before glucose intolerance—is insulin resistance initiated in the adipose tissue?
U Smith |
International Journal of Obesity | 2002 |
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Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-α reduction and GLUT4 expression enhancement
G Mingrone, G Rosa, PD Rocco, M Manco, E Capristo, M Castagneto, R Vettor, G Gasbarrini, AV Greco |
International Journal of Obesity | 2002 |
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PPAR-γ ligands modulate effects of LPS in stimulated rat synovial fibroblasts
MA Simonin, K Bordji, S Boyault, A Bianchi, E Gouze, P Bécuwe, M Dauça, P Netter, B Terlain |
American journal of physiology. Cell physiology | 2002 |
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Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications
JC Fruchart, AM Gotto, R Paoletti, B Staels, AL Catapano |
2002 | |
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PPARadigms and PPARadoxes: expanding roles for PPARγ in the control of lipid metabolism
R Walczak, P Tontonoz |
Journal of lipid research | 2002 |
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Regulation of Semicarbazide-Sensitive Amine Oxidase Expression by Tumor Necrosis Factor-α in Adipocytes: Functional Consequences on Glucose Transport
N Mercier, M Moldes, KE Hadri, B Fève |
The Journal of pharmacology and experimental therapeutics | 2002 |
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Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease
YF Guan, MD Breyer |
Kidney International | 2001 |
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Free fatty acids - do they play a central role in type 2 diabetes?
P Arner |
Diabetes, Obesity and Metabolism | 2001 |
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Pro-inflammatory cytokines and adipose tissue
SW Coppack |
Proceedings of the Nutrition Society | 2001 |
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Synergistic Antiadipogenic Effects of HIV Type 1 Protease Inhibitors with Tumor Necrosis Factorα: Suppression of Extracellular Insulin Action Mediated by Extracellular Matrix-Degrading Proteases
D Mondal, VF Larussa, KC Agrawal |
AIDS Research and Human Retroviruses | 2001 |
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Resistin: a new link between obesity and insulin resistance?
A Vidal-Puig, S O'Rahilly |
Clinical Endocrinology | 2001 |
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TNFα Inhibits Insulin's Antiapoptotic Signaling in Vascular Smooth Muscle Cells
S Goetze, F Blaschke, P Stawowy, D Bruemmer, C Spencer, K Graf, M Gräfe, RE Law, E Fleck |
Biochemical and Biophysical Research Communications | 2001 |
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Differential Regulation of Adipocytokine mRNAs by Rosiglitazone in db/db Mice
GB Moore, H Chapman, JC Holder, CA Lister, V Piercy, SA Smith, JC Clapham |
Biochemical and Biophysical Research Communications | 2001 |
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Troglitazone Enhances Glucose Uptake Induced By alpha-Adrenoceptor Stimulation Via Phosphatidylinositol 3-Kinase In Rat Heart
J Yoshioka, H Kusuoka, K Imahashi, K Hashimoto, M Hori, T Terakawa, T Nishimura |
Clinical and Experimental Pharmacology and Physiology | 2001 |
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Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs)
MB Sporn, N Suh, DJ Mangelsdorf |
Trends in Molecular Medicine | 2001 |
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Insulin resistance induced in dairy steers by tumor necrosis factor alpha is partially reversed by 2,4–thiazolidinedione
S Kushibiki, K Hodate, H Shingu, Y Ueda, M Shinoda, Y Mori, T Itoh, Y Yokomizo |
Domestic Animal Endocrinology | 2001 |
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A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis
SH Caldwell, EE Hespenheide, JA Redick, JC Iezzoni, EH Battle, BL Sheppard |
The American Journal of Gastroenterology | 2001 |
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Enhancing insulin action: From chemical elements to thiazolidinediones
R Perfetti, K Chamie |
Journal of Endocrinological Investigation | 2001 |
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Thiazolidinedione treatment prevents free fatty acid-induced insulin resistance in male wistar rats
AL Hevener, D Reichart, A Janez, J Olefsky |
Diabetes | 2001 |
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The chlorophyll metabolite phytanic acid is a natural rexinoid – potential for treatment and prevention of diabetes
MF McCarty |
Medical Hypotheses | 2001 |
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Pioglitazone Ameliorates Tumor Necrosis Factor- -Induced Insulin Resistance by a Mechanism Independent of Adipogenic Activity of Peroxisome Proliferator-Activated Receptor-
M Iwata, T Haruta, I Usui, Y Takata, A Takano, T Uno, J Kawahara, E Ueno, T Sasaoka, O Ishibashi, M Kobayashi |
Diabetes | 2001 |
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Rosiglitazone, Insulin Treatment, and Fasting Correct Defective Activation of Protein Kinase C-ζ/λ by Insulin in Vastus Lateralis Muscles and Adipocytes of Diabetic Rats 1
Y Kanoh, G Bandyopadhyay, MP Sajan, ML Standaert, RV Farese |
Endocrinology | 2001 |
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Preferential channeling of energy fuels toward fat rather than muscle during high free fatty acid availability in rats
R Fabris, E Nisoli, A M Lombardi, C Tonello, R Serra, M Granzotto, I Cusin, F Rohner-Jeanrenaud, G Federspil, M O Carruba, R Vettor |
Diabetes | 2001 |
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Inhibition of Monocyte Chemoattractant Protein-1 Expression in Cytokine-Treated Human Lung Epithelial Cells by Thiazolidinedione
A Momoi, K Murao, H Imachi, T Ishida, WM Cao, M Sato, J Takahara |
Chest | 2001 |
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Tumor necrosis factor-α is induced through phorbol ester- and glycated human albumin-dependent pathway in THP-1 cells
T Naitoh, M Kitahara, N Tsuruzoe |
Cellular Signalling | 2001 |
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Rosiglitazone treatment of patients with extreme insulin resistance and diabetes mellitus due to insulin receptor mutations has no effects on glucose and lipid metabolism
H Vestergaard, S Lund, O Pedersen |
Journal of Internal Medicine | 2001 |
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Thiazolidinediones (PPARγ agonists) but not PPARα agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes
U Smith, SI Gogg, A Johansson, T Olausson, VI Rotter, B Svalstedt |
The FASEB Journal | 2001 |
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PPAR agonists as direct modulators of the vessel wall in cardiovascular disease
KW Buchan, DG Hassall |
Medicinal Research Reviews | 2000 |
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Alteration in Expression Profiles of a Series of Diabetes-Related Genes in db/db Mice Following Treatment With Thiazolidinediones
A Suzuki, T Yasuno, H Kojo, J Hirosumi, S Mutoh, Y Notsu |
The Japanese Journal of Pharmacology | 2000 |
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COX-2 and the cyclopentenone prostaglandins - a new chapter in the book of inflammation?
PR Colville-Nash, DW Gilroy |
Prostaglandins & Other Lipid Mediators | 2000 |
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Troglitazone Inhibits Mitogenic Signaling by Insulin in Vascular Smooth Muscle Cells
S Goetze, S Kim, XP Xi, K Graf, DC Yang, E Fleck, WP Meehan, WA Hsueh, RE Law |
Journal of Cardiovascular Pharmacology | 2000 |
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PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancer
GJ Murphy, JC Holder |
Trends in Pharmacological Sciences | 2000 |
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Troglitazone reduces plasma levels of tumour necrosis factor-alpha in obese patients with type 2 diabetes
A Katsuki, Y Sumida, K Murata, M Furuta, R Araki-Sasaki, K Tsuchihashi, Y Hori, Y Yano, EC Gabazza, Y Adachi |
Diabetes, Obesity and Metabolism | 2000 |
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Transcriptional control of adipogenesis
SM Rangwala, MA Lazar |
Annual Review of Nutrition | 2000 |
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Toward a wholly nutritional therapy for type 2 diabetes
MF McCarty |
Medical Hypotheses | 2000 |
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Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells
F Marra, E Efsen, RG Romanelli, A Caligiuri, S Pastacaldi, G Batignani, A Bonacchi, R Caporale, G Laffi, M Pinzani, P Gentilini |
Gastroenterology | 2000 |
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Down-regulation by troglitazone of hepatic tumor necrosis factor-α and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes∗
S Sigrist, M Bedoucha, UA Boelsterli |
Biochemical Pharmacology | 2000 |
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Toward practical prevention of type 2 diabetes
MF McCarty |
Medical Hypotheses | 2000 |
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Tumor Necrosis Factor α Inhibits Insulin-induced Mitogenic Signaling in Vascular Smooth Muscle Cells
S Goetze, U Kintscher, H Kawano, Y Kawano, S Wakino, E Fleck, WA Hsueh, RE Law |
The Journal of biological chemistry | 2000 |
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Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity
M Guerre-Millo, P Gervois, E Raspé, L Madsen, P Poulain, B Derudas, JM Herbert, DA Winegar, TM Willson, JC Fruchart, RK Berge, B Staels |
The Journal of biological chemistry | 2000 |
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Thiazolidinedione Treatment Enhances Insulin Effects on Protein Kinase C-ζ/λ Activation and Glucose Transport in Adipocytes of Nondiabetic and Goto-Kakizaki Type II Diabetic Rats
Y Kanoh, G Bandyopadhyay, MP Sajan, ML Standaert, RV Farese |
The Journal of biological chemistry | 2000 |
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Nuovi farmaci per la terapia del diabete di tipo 2
F Santeusanio, G Perriello |
L'Endocrinologo | 2000 |
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Obesity: Pathology and Therapy
DH Lockwood, TC Heffner |
2000 | |
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The PPARs: From Orphan Receptors to Drug Discovery
TM Willson, PJ Brown, DD Sternbach, BR Henke |
Journal of Medicinal Chemistry | 2000 |
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A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response
CG Su, X Wen, ST Bailey, W Jiang, SM Rangwala, SA Keilbaugh, A Flanigan, S Murthy, MA Lazar, GD Wu |
Journal of Clinical Investigation | 1999 |
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The expression of adhesion molecules on endothelial cells is inhibited by troglitazone through its antioxidant activity
L Cominacini, U Garbin, AF Pasini, A Davoli, M Campagnola, A Rigoni, L Tosetti, VL Cascio |
Cell Communication and Adhesion | 1999 |
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Tumor necrosis factor-α as a mediator of the insulin resistance of obesity
ED Rosen, BM Spiegelman |
Current Opinion in Endocrinology & Diabetes | 1999 |
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Current Views on the Mechanism of Action of Thiazolidinedione Insulin Sensitizers
BJ Goldstein |
Diabetes Technology & Therapeutics | 1999 |
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Mechanisms by which Thiazolidinediones Enhance Insulin Action
MJ Reginato, MA Lazar |
Trends in Endocrinology & Metabolism | 1999 |
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The Emerging Role of Thiazolidinediones in the Treatment of Diabetes-Mellitus and Related Disorders
S Subramaniam |
Clinical and Experimental Hypertension | 1999 |
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Cross-Regulation of C/EBPα and PPARγ Controls the Transcriptional Pathway of Adipogenesis and Insulin Sensitivity
Z Wu, ED Rosen, R Brun, S Hauser, G Adelmant, AE Troy, C McKeon, GJ Darlington, BM Spiegelman |
Molecular Cell | 1999 |
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Thiazolidinedione inhibits the production of monocyte chemoattractant protein-1 in cytokine-treated human vascular endothelial cells
K Murao, H Imachi, A Momoi, Y Sayo, H Hosokawa, M Sato, T Ishida, J Takahara |
FEBS Letters | 1999 |
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Thiazolidinedione inhibits production of RANTES in a cytokine-treated human lung epithelial cell line
A Momoi, K Murao, H Imachi, Y Sayo, H Nakamura, H Hosokawa, M Sato, J Fujita, H Okada, T Ishida, J Takahara |
FEBS Letters | 1999 |
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Thiazolidinediones down-regulate plasminogen activator inhibitor type 1 expression in human vascular endothelial cells: A possible role for PPARgamma in endothelial function
K Kato, H Satoh, Y Endo, D Yamada, S Midorikawa, W Sato, K Mizuno, T Fujita, K Tsukamoto, T Watanabe |
Biochemical and Biophysical Research Communications | 1999 |
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Molecular basis of insulin-stimulated GLUT4 vesicle trafficking. Location! Location! Location!
V Ribon, JH Johnson, HS Camp, AR Saltiel |
The Journal of biological chemistry | 1999 |
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Peroxisome proliferator-activated receptor-γ: a versatile metabolic regulator
S Rocchi, J Auwerx |
Annals of Medicine | 1999 |
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Tumor Necrosis Factor α-induced Pancreatic β-Cell Insulin Resistance Is Mediated by Nitric Oxide and Prevented by 15-Deoxy-Δ 12,14 -prostaglandin J 2 and Aminoguanidine: A ROLE FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ ACTIVATION AND iNOS EXPRESSION
G Kwon, G Xu, CA Marshall, ML McDaniel |
The Journal of biological chemistry | 1999 |
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TNF-α–Induced Migration of Vascular Smooth Muscle Cells Is MAPK Dependent
S Goetze, , Y Kawano, H Kawano, E Fleck, WA Hsueh, RE Law |
Hypertension | 1999 |
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Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*
B Desvergne, W Wahli |
Endocrine reviews | 1999 |
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Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system
S Hunter |
The American Journal of Medicine | 1998 |
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Insulin action enhancement normalizes brachial artery vasoactivity in patients with peripheral vascular disease and occult diabetes
R Avena, ME Mitchell, ES Nylen, KM Curry, AN Sidawy |
Journal of Vascular Surgery | 1998 |
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Catabolic proinflammatory cytokines
JM Argilés, FJ López-Soriano |
Current Opinion in Clinical Nutrition and Metabolic Care | 1998 |
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Transcriptional control of adipogenesis
L Fajas, JC Fruchart, J Auwerx |
Current Opinion in Cell Biology | 1998 |
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The nuclear receptor PPARγ-bigger than fat
SA Kliewer, TM Willson |
Current Opinion in Genetics & Development | 1998 |
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Insulin Resistance in Cancer Patients Is Associated with Enhanced Tumor Necrosis Factor-α Expression in Skeletal Muscle
Y Noguchi, T Yoshikawa, D Marat, C Doi, T Makino, K Fukuzawa, A Tsuburaya, S Satoh, T Ito, S Mitsuse |
Biochemical and Biophysical Research Communications | 1998 |
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A Potent Antidiabetic Thiazolidinedione with Unique Peroxisome Proliferator-activated Receptor γ-activating Properties
MJ Reginato, ST Bailey, SL Krakow, C Minami, S Ishii, H Tanaka, MA Lazar |
The Journal of biological chemistry | 1998 |
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Overexpression of Perilipin A and B Blocks the Ability of Tumor Necrosis Factor α to Increase Lipolysis in 3T3-L1 Adipocytes
SC Souza, LM de Vargas, MT Yamamoto, P Lien, MD Franciosa, LG Moss, AS Greenberg |
The Journal of biological chemistry | 1998 |
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Transcription-Modulating Drugs: A New Frontier in the Treatment of Essential Hypertension
TW Kurtz, DG Gardner |
Hypertension | 1998 |
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Adipose Tissue-Derived Tumor Necrosis Factor Activity Correlates with Fat Cell Size But Not Insulin Action in Aging Rats**This work was supported by National Institutes of Aging Grant KO1-AG00645 (to C.M.) and the National Institutes of Health Grant DK-47416 (to M.P.)
CL Morin, EC Gayles, DA Podolin, Y Wei, M Xu, MJ Pagliassotti |
Endocrinology | 1998 |
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The New Antidiabetic Drug MCC-555 Acutely Sensitizes Insulin Signaling in Isolated Cardiomyocytes**This work was supported by the Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen, the Bundesministerium für Gesundheit, EU COST Action B5, and a grant from Mitsubishi Chemical (Yokohama, Japan)
LS Liu, H Tanaka, S Ishii, J Eckel |
Endocrinology | 1998 |
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