Research Article
D Wu, J Yang, W M Pardridge
Title and authors | Publication | Year |
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A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective, and anti-inflammatory properties following status epilepticus in mice
Ferhat L, Soussi R, Masse M, Kyriatzis G, Girard S, Gassiot F, Gaudin N, Laurencin M, Bernard A, Bôle A, Ferracci G, Smirnova M, Roman F, Dive V, Cisternino S, Temsamani J, David M, Lécorché P, Jacquot G, Khrestchatisky M |
eLife | 2025 |
Advances in Intrathecal Nanoparticle Delivery: Targeting the Blood–Cerebrospinal Fluid Barrier for Enhanced CNS Drug Delivery
Madadi AK, Sohn MJ |
Pharmaceuticals | 2024 |
Insulin-inspired hippocampal neuron–targeting technology for protein drug delivery
Kamei N, Ikeda K, Ohmoto Y, Fujisaki S, Shirata R, Maki M, Miyata M, Miyauchi Y, Nishiyama N, Yamada M, Ohigashi Y, Takeda-Morishita M |
Proceedings of the National Academy of Sciences of the United States of America | 2024 |
Nanoparticles for Drug and Gene Delivery in Pediatric Brain Tumors' Cancer Stem Cells: Current Knowledge and Future Perspectives.
Abballe L, Spinello Z, Antonacci C, Coppola L, Miele E, Catanzaro G, Miele E |
Pharmaceutics | 2023 |
Improving the Treatment Effect of Carotenoids on Alzheimer's Disease through Various Nano-Delivery Systems.
Su W, Xu W, Liu E, Su W, Polyakov NE |
International journal of molecular sciences | 2023 |
Nanoparticle Targeting with Antibodies in the Central Nervous System.
Lee JH, Chapman DV, Saltzman WM |
2023 | |
Enhancing Antibody Exposure in the Central Nervous System: Mechanisms of Uptake, Clearance, and Strategies for Improved Brain Delivery
Schwinghamer K, Siahaan TJ |
Journal of nanotheranostics | 2023 |
A Historical Review of Brain Drug Delivery
Pardridge WM |
Pharmaceutics | 2022 |
Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB).
Helms HCC, Kristensen M, Saaby L, Fricker G, Brodin B |
Handbook of experimental pharmacology | 2022 |
Overcoming the blood-brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches.
Mitusova K, Peltek OO, Karpov TE, Muslimov AR, Zyuzin MV, Timin AS |
Journal of nanobiotechnology | 2022 |
IgG Fusion Proteins for Brain Delivery of Biologics via Blood-Brain Barrier Receptor-Mediated Transport.
Boado RJ |
Pharmaceutics | 2022 |
Selection of single domain anti-transferrin receptor antibodies for blood-brain barrier transcytosis using a neurotensin based assay and histological assessment of target engagement in a mouse model of Alzheimer's related amyloid-beta pathology.
Su S, Esparza TJ, Brody DL |
PloS one | 2022 |
Advances in Antibody-Based Therapeutics for Cerebral Ischemia
Sun JM, Yen TL, Jan JS, Mwale PF, Teng RD, Taliyan R, Hsieh CT, Yang CH |
Pharmaceutics | 2022 |
Mathematical Models of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Transferrin Receptor and the Insulin Receptor
WM Pardridge, T Chou |
Pharmaceuticals (Basel, Switzerland) | 2021 |
Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening
SI Aguiar, JN Dias, AS André, ML Silva, D Martins, B Carrapiço, M Castanho, J Carriço, M Cavaco, MM Gaspar, RJ Nobre, LP de Almeida, S Oliveira, L Gano, JD Correia, CB rd, J Gonçalves, V Neves, F Aires-da-Silva |
Pharmaceutics | 2021 |
Evolving new-age strategies to transport therapeutics across the blood-brain-barrier
M Choudhari, S Hejmady, RN Saha, S Damle, G Singhvi, A Alexander, P Kesharwani, SK Dubey |
International Journal of Pharmaceutics | 2021 |
Bioinspired Biomaterials: Advances in Tissue Engineering and Regenerative Medicine
HJ Chun, RL Reis, A Motta, G Khang |
2020 | |
Brain Drug Delivery: Overcoming the Blood-brain Barrier to Treat Tauopathies
J Hanes, E Dobakova, P Majerova |
Current pharmaceutical design | 2020 |
Advances in Animal Health, Medicine and Production: A Research Portrait of the Centre for Interdisciplinary Research in Animal Health (CIISA), University of Lisbon, Portugal
AF Duarte, LL da Costa |
2020 | |
Novel Blood–Brain Barrier Shuttle Peptides Discovered through the Phage Display Method
P Majerova, J Hanes, D Olesova, J Sinsky, E Pilipcinec, A Kovac |
Molecules (Basel, Switzerland) | 2020 |
Treatment of Alzheimer’s Disease and Blood–Brain Barrier Drug Delivery
WM Pardridge |
Pharmaceuticals (Basel, Switzerland) | 2020 |
Novel cyclic peptides facilitating transcellular blood-brain barrier transport of macromolecules in vitro and in vivo
S Yamaguchi, S Ito, T Masuda, PO Couraud, S Ohtsuki |
Journal of Controlled Release | 2020 |
Smart Strategies for Therapeutic Agent Delivery into Brain across the Blood–Brain Barrier Using Receptor-Mediated Transcytosis
T Tashima |
CHEMICAL & PHARMACEUTICAL BULLETIN | 2020 |
Strategies for Enhancing the Permeation of CNS-Active Drugs through the Blood-Brain Barrier: A Review
I Zeiadeh, A Najjar, R Karaman |
Molecules (Basel, Switzerland) | 2018 |
Use of Polyamidoamine Dendrimers in Brain Diseases
M Florendo, A Figacz, B Srinageshwar, A Sharma, D Swanson, G Dunbar, J Rossignol |
Molecules (Basel, Switzerland) | 2018 |
Recent progress of drug nanoformulations targeting to brain
AR Khan, X Yang, M Fu, G Zhai |
Journal of Controlled Release | 2018 |
Drug targeting strategies into the brain for treating neurological diseases
W Barnabas |
Journal of Neuroscience Methods | 2018 |
Neurotoxicity of Nanomaterials and Nanomedicine
Y Liu, Q He |
Neurotoxicity of Nanomaterials and Nanomedicine | 2017 |
Delivery of Biologics Across the Blood–Brain Barrier with Molecular Trojan Horse Technology
WM Pardridge |
BioDrugs | 2017 |
Self-assembled amphiphilic core-shell nanocarriers in line with the modern strategies for brain delivery
RS Elezaby, HA Gad, AA Metwally, AS Geneidi, GA Awad |
Journal of Controlled Release | 2017 |
Nanocarriers for brain specific delivery of anti-retro viral drugs: challenges and achievements
NM Varghese, V Senthil, SK Saxena |
Journal of Drug Targeting | 2017 |
Antibody therapies in CNS diseases
PO Freskgård, E Urich |
Neuropharmacology | 2016 |
Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
YJ Zuchero, X Chen, N Bien-Ly, D Bumbaca, RK Tong, X Gao, S Zhang, K Hoyte, W Luk, MA Huntley, L Phu, C Tan, D Kallop, RM Weimer, Y Lu, DS Kirkpatrick, JA Ernst, B Chih, MS Dennis, RJ Watts |
Neuron | 2016 |
Progress and perspectives on targeting nanoparticles for brain drug delivery
H Gao |
Acta Pharmaceutica Sinica B | 2016 |
Role of scavenger receptors in peptide-based delivery of plasmid DNA across a blood–brain barrier model
A Srimanee, J Regberg, M Hällbrink, O Vajragupta, Ü Langel |
International Journal of Pharmaceutics | 2016 |
Functionalized Solid-Sphere PEG- b -PCL Nanoparticles to Target Brain Capillary Endothelial Cells In Vitro
P Grossen, G Québatte, D Witzigmann, C Prescianotto-Baschong, LH Dieu, J Huwyler |
Journal of Nanomaterials | 2016 |
Can dendrimer-based nanoparticles fight neurodegenerative diseases? Current situation versus other established approaches
S Mignani, M Bryszewska, M Zablocka, B Klajnert-Maculewicz, J Cladera, D Shcharbin, JP Majoral |
Progress in Polymer Science | 2016 |
Gb3-binding lectins as potential carriers for transcellular drug delivery
SK Müller, I Wilhelm, T Schubert, K Zittlau, A Imberty, J Madl, T Eierhoff, R Thuenauer, W Römer |
Expert Opinion on Drug Delivery | 2016 |
RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies
M Malhotra, A Toulouse, BM Godinho, DJ Carthy, JF Cryan, CM O'Driscoll |
Molecular BioSystems | 2015 |
Biobetters
A Rosenberg, B Demeule |
2015 | |
Dendrimer Advances for the Central Nervous System Delivery of Therapeutics
L Xu, H Zhang, Y Wu |
ACS Chemical Neuroscience | 2014 |
Insulin Receptor Antibody-Sulfamidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type A Cells
RJ Boado, JZ Lu, EK Hui, WM Pardridge |
Molecular Pharmaceutics | 2014 |
Solid lipid nanoparticles with surface antibody for targeting the brain and inhibiting lymphatic phagocytosis
YC Kuo, CY Shih-Huang |
Journal of the Taiwan Institute of Chemical Engineers | 2014 |
Polymersomes conjugated to 83-14 monoclonal antibodies: Invitro targeting of brain capillary endothelial cells
LH Dieu, D Wu, CG Palivan, V Balasubramanian, J Huwyler |
European Journal of Pharmaceutics and Biopharmaceutics | 2014 |
Targeted delivery of protein and gene medicines through the blood-brain barrier
WM Pardridge |
Clinical Pharmacology & Therapeutics | 2014 |
Innovative Brain Tumor Therapy
G Caruso, L Merlo, M Caffo |
Innovative Brain Tumor Therapy | 2014 |
Which drug or drug delivery system can change clinical practice for brain tumor therapy?
T Siegal |
Neuro-Oncology | 2013 |
Developing Therapeutic Antibodies for Neurodegenerative Disease
YJ Yu, RJ Watts |
Neurotherapeutics | 2013 |
Brain-targeted polymeric nanoparticles: in vivo evidences of different routes of administration in rodents
G Tosi, B Ruozi, D Belletti, A Vilella, M Zoli, MA Vandelli, F Forni |
Nanomedicine | 2013 |
Microspheres and Microcapsules in Biotechnology: Design, Preparation and Applications
C Jiang, X Jiang, Y Liu, K Shao, R Huang |
Microspheres and Microcapsules in Biotechnology: Design, Preparation and Applications | 2013 |
Design of brain imaging agents for positron emission tomography: do large bioconjugates provide an opportunity for in vivo brain imaging?
R Schirrmacher, V Bernard-Gauthier, A Reader, JP Soucy, E Schirrmacher, B Wängler, C Wängler |
Future Medicinal Chemistry | 2013 |
Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
JR Kanwar, B Sriramoju, RK Kanwar |
International Journal of Nanomedicine | 2012 |
CHEMICAL OPTIMIZATION OF NEW LIGANDS OF THE LOW-DENSITY LIPOPROTEIN RECEPTOR AS POTENTIAL VECTORS FOR CENTRAL NERVOUS SYSTEM TARGETING
malcor, payrot, david, faucon, abouzid, jacquot, N Floquet, debarbieux, rougon, martinez, khrestchatisky, vlieghe, V Lisowski |
Journal of Medicinal Chemistry | 2012 |
Liposomes and their applications in molecular imaging
M Silindir, S Erdoğan, AY Özer, S Maia |
Journal of Drug Targeting | 2012 |
In Vivo Biodistribution of Prion- and GM1-Targeted Polymersomes following Intravenous Administration in Mice
K Stojanov, JV Georgieva, RP Brinkhuis, JC van Hest, FP Rutjes, RA Dierckx, EF de Vries, IS Zuhorn |
Molecular Pharmaceutics | 2012 |
Imaging Amyloid Plaque in Alzheimer’s Disease Brain with a Biotinylated Aβ Peptide Radiopharmaceutical Conjugated to an IgG-Avidin Fusion Protein
RK Sumbria, RJ Boado, WM Pardridge |
Bioconjugate Chemistry | 2012 |
Nanotechnology in Health Care: State of the Art
G Tosi, B Ruozi, L Badiali, L Bondioli, D Belletti, F Forni, M Vandelli |
Nanotechnology in Health Care: State of the Art | 2012 |
Drug transport across the blood-brain barrier
WM Pardridge |
Journal of Cerebral Blood Flow & Metabolism | 2012 |
Schleuservermittelter Transport von Wirkstoffen ins Gehirn
M Malakoutikhah, M Teixidó, E Giralt |
Angewandte Chemie | 2011 |
Shuttle-Mediated Drug Delivery to the Brain
M Malakoutikhah, M Teixidó, E Giralt |
Angewandte Chemie International Edition | 2011 |
Nanotechnological advances for the delivery of CNS therapeutics
HL Wong, XY Wu, R Bendayan |
Advanced Drug Delivery Reviews | 2011 |
Modern Methods for Delivery of Drugs across the Blood–brain Barrier
Y Chen, L Liu |
Advanced Drug Delivery Reviews | 2011 |
Current Topics in Developmental Biology
JE Qualls, PJ Murray |
Cancer and Development | 2011 |
Pharmaceutical Sciences Encyclopedia
D Farkas, RI Shader, LL von Moltke, DJ Greenblatt |
Pharmaceutical Sciences Encyclopedia | 2010 |
Macromolecular drug transport into the brain using targeted therapy
J Lichota, T Skjørringe, LB Thomsen, T Moos |
Journal of Neurochemistry | 2010 |
The C2-streptavidin delivery system promotes the uptake of biotinylated molecules in macrophages and T-leukemia cells
J Fahrer, J Rieger, G Zandbergen, H Barth |
Biological Chemistry | 2010 |
Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and Manufacturing
CD Davis, UM Hanumegowda |
Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and Manufacturing | 2010 |
Targeted Delivery of Protein Drugs by Nanocarriers
R Solaro, F Chiellini, A Battisti |
Materials | 2010 |
Peptide- and Aptamer-Functionalized Nanovectors for Targeted Delivery of Therapeutics
TO Pangburn, MA Petersen, B Waybrant, MM Adil, E Kokkoli |
Journal of Biomechanical Engineering | 2009 |
Receptor-mediated therapeutic transport across the blood–brain barrier
YY Wang, PC Lui, JY Li |
Immunotherapy | 2009 |
Single amino acid chelates (SAAC): a strategy for the design of technetium and rhenium radiopharmaceuticals
M Bartholomä, J Valliant, KP Maresca, J Babich, J Zubieta |
Chemical Communications | 2009 |
Production of human -hexosaminidase A with highly phosphorylated N-glycans by the overexpression of the Ogataea minuta MNN4 gene
H Akeboshi, Y Kasahara, D Tsuji, K Itoh, H Sakuraba, Y Chiba, Y Jigami |
Glycobiology | 2009 |
Uptake of apolipoprotein E fragment coupled liposomes by cultured brain microvessel endothelial cells and intact brain capillaries
U Hülsermann, MM Hoffmann, U Massing, G Fricker |
Journal of Drug Targeting | 2009 |
Supramolecularassemblies for the active drug targeting to the brain
A Béduneau, Y Pellequer, A Lamprecht |
Journal of drug delivery science and technology | 2009 |
Drug Delivery to the Central Nervous System
KK Jain |
2009 | |
Genetically Engineered Clostridial C2 Toxin as a Novel Delivery System for Living Mammalian Cells
J Fahrer, R Plunien, U Binder, T Langer, H Seliger, H Barth |
Bioconjugate Chemistry | 2009 |
Getting into the Brain: Approaches to Enhance Brain Drug Delivery
MM Patel, BR Goyal, SV Bhadada, JS Bhatt, AF Amin |
CNS Drugs | 2009 |
Psychoneuroimmunology
F Tausk, I Elenkov, J Moynihan |
Dermatologic Therapy | 2008 |
Strategies to advance translational research into brain barriers
E Neuwelt, NJ Abbott, L Abrey, WA Banks, B Blakley, T Davis, B Engelhardt, P Grammas, M Nedergaard, J Nutt, W Pardridge, GA Rosenberg, Q Smith, LR Drewes |
The Lancet Neurology | 2008 |
Antibody-Mediated Targeting of siRNA via the Human Insulin Receptor Using Avidin−Biotin Technology
CF Xia, RJ Boado, WM Pardridge |
Molecular Pharmaceutics | 2008 |
Synthesis and Screening of a Library of Re/Tc-Based Amyloid Probes Derived from β-Breaker Peptides
KA Stephenson, LC Reid, J Zubieta, JW Babich, MP Kung, HF Kung, JF Valliant |
Bioconjugate Chemistry | 2008 |
Strategies to Improve Drug Delivery Across the Blood-Brain Barrier:
AG de Boer, PJ Gaillard |
Clinical Pharmacokinetics | 2007 |
Blood–Brain Barrier Transport of Therapeutics via Receptor-Mediation
AR Jones, EV Shusta |
Pharmaceutical Research | 2007 |
Drug Targeting to the Brain
WM Pardridge |
Pharmaceutical Research | 2007 |
Nanotechnologies for the Life Sciences
C Leuschner |
Nanotechnologies for the Life Sciences | 2007 |
Strategies to Improve Drug Delivery Across the Blood-Brain Barrier
AG de Boer, PJ Gaillard |
Clinical Pharmacokinetics | 2007 |
Drug Targeting to the Brain
AG Boer, PJ Gaillard |
Annual Review of Pharmacology and Toxicology | 2007 |
Appetite and Body Weight
B Beck |
Appetite and Body Weight | 2007 |
Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology
CF Xia, Y Zhang, Y Zhang, RJ Boado, WM Pardridge |
Pharmaceutical Research | 2007 |
Humanization of anti-human insulin receptor antibody for drug targeting across the human blood–brain barrier
RJ Boado, Y Zhang, Y Zhang, WM Pardridge |
Biotechnology and Bioengineering | 2006 |
Pharmacokinetics and brain uptake of lactoferrin in rats
B Ji, J Maeda, M Higuchi, K Inoue, H Akita, H Harashima, T Suhara |
Life Sciences | 2006 |
Blood-Brain Barriers: From Ontogeny to Artificial Interfaces
R Dermietzel, DC Spray, M Nedergaard |
2006 | |
Neuroprotection in experimental stroke with targeted neurotrophins
D Wu |
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics | 2005 |
Drug transport to brain with targeted liposomes
A Schnyder, J Huwyler |
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics | 2005 |
Targeted delivery across the blood–brain barrier
PJ Gaillard, CC Visser, AG de Boer |
Expert Opinion on Drug Delivery | 2005 |
99mTc complex conjugated to insulin: CNS radio-pharmaceuticals design based on principles of blood-brain barrier transport vector
F Liu, C Fan, J Zhang, W Wang, B Liu |
Chinese Science Bulletin | 2005 |
Blood-Spinal Cord and Brain Barriers in Health and Disease
E Anderson, L Ryan, H Xiong, S Swindells, J Zheng, HE Gendelman |
Blood-Spinal Cord and Brain Barriers in Health and Disease | 2004 |
Aspartic Proteases Involved in Alzheimer's Disease
B Schmidt |
ChemBioChem | 2003 |
Peptide Transport and Delivery into the Central Nervous System
L Prokai, K Prokai-Tatrai |
2003 | |
Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical
HJ Lee, Y Zhang, C Zhu, K Duff, WM Pardridge |
Journal of Cerebral Blood Flow & Metabolism | 2002 |
IMPY: an improved thioflavin-T derivative for in vivo labeling of β-amyloid plaques
MP Kung, C Hou, ZP Zhuang, B Zhang, D Skovronsky, JQ Trojanowski, VM Lee, HF Kung |
Brain Research | 2002 |
Membrane Transporters as Drug Targets
GL Amidon, W Sadée |
2002 | |
Vector-mediated drug delivery to the brain
J Temsamani, C Rousselle, AR Rees, JM Scherrmann |
Expert Opinion on Biological Therapy | 2001 |
Prodrug based optimal drug delivery via membrane transporter/receptor
C Yang, GS Tirucherai, AK Mitra |
Expert Opinion on Biological Therapy | 2001 |
Pharmacological in vitro evaluation of new substance P-cyclodextrin derivatives designed to drug targeting towards NK1-receptor bearing cells
C Péan, A Wijkhuisen, F Djedaïni-Pilard, J Fischer, S Doly, M Conrath, J Y Couraud, J Grassi, B Perly, C Créminon |
Biochimica et Biophysica Acta | 2001 |
Endogenous carriers and ligands in non-immunogenic site-specific drug delivery
SP Vyas, V Sihorkar |
Advanced Drug Delivery Reviews | 2000 |
The Blood-Brain Barrier and Drug Delivery to the CNS
A Tsuji |
The Blood-Brain Barrier and Drug Delivery to the CNS | 2000 |
Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor
MJ Coloma, HJ Lee, A Kurihara, EM Landaw, RJ Boado, SL Morrison, WM Pardridge |
Pharmaceutical Research | 2000 |
Drug Targeting to the Brain Using Avidin-Biotin Technology in the Mouse (Blood-Brain Barrier, Monoclonal Antibody, Transferrin Receptor, Alzheimer's Disease)
H Lee, W Pardridge |
Journal of Drug Targeting | 2000 |
Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders
MM Verbeek, RM de Waal, HV Vinters |
2000 | |
Blood–brain barrier permeability to small and large molecules
EM Cornford, S Hyman |
Advanced Drug Delivery Reviews | 1999 |
BARRIER MECHANISMS IN THE BRAIN, I. ADULT BRAIN
N Saunders, M Habgood, KM Dziegielewska |
Clinical and Experimental Pharmacology and Physiology | 1999 |
Potential applications of polymers in the delivery of drugs to the central nervous system
DW Miller, AV Kabanov |
Colloids and Surfaces B: Biointerfaces | 1999 |
Non-invasive drug delivery to the human brain using endogenous blood–brain barrier transport systems
WM Pardridge |
Pharmaceutical Science & Technology Today | 1999 |
Transfer of Some Carboxylic Acids in the Olfactory System Following Intranasal Administration
C Eriksson, U Bergman, A Franzén, M Sjöblom, EB Brittebo |
Journal of Drug Targeting | 1999 |
Model for the regulation of energy balance and adiposity by the central nervous system
MW Schwartz, DG Baskin, KJ Kaiyala, SC Woods |
The American journal of clinical nutrition | 1999 |
Cytokines, Stress, and Depression
R Dantzer, EE Wollman, R Yirmiya |
1999 | |
Signals That Regulate Food Intake and Energy Homeostasis
SC Woods, RJ Seeley, D Porte, MW Schwartz |
Science | 1998 |
Drug Delivery to the Brain
WM Pardridge |
Journal of Cerebral Blood Flow & Metabolism | 1997 |
Advances in Pharmacology
B Drenger, Y Ginosar, Y Gozal |
Advances in Pharmacology | 1994 |