Research Article
D G Karounos, J S Bryson, D A Cohen
Title and authors | Publication | Year |
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Evaluation of proinsulin(F25D) as a targeting ligand for insulin-binding B cells in autoimmune diabetes.
Apley KD, Bass LE, King J, Downes G, Wang K, Forchetti MV, Moore DJ, Kendall P, Bonami RH, Berkland CJ |
Drug delivery and translational research | 2025 |
An antigen-specific immunotherapeutic, AKS-107, deletes insulin-specific B cells and prevents murine autoimmune diabetes
Alleva DG, Delpero AR, Sathiyaseelan T, Murikipudi S, Lancaster TM, Atkinson MA, Wasserfall CH, Yu L, Ragupathy R, Bonami RH, Zion TC |
Frontiers in immunology | 2024 |
CX3CL1 Worsens Cardiorenal Dysfunction and Serves as a Therapeutic Target of Canagliflozin for Cardiorenal Syndrome
C Zheng, W Xuan, Z Chen, R Zhang, X Huang, Y Zhu, S Ma, K Chen, L Chen, M He, H Lin, W Liao, J Bin, Y Liao |
Frontiers in pharmacology | 2022 |
B Quiet: Autoantigen-Specific Strategies to Silence Raucous B Lymphocytes and Halt Cross-Talk with T Cells in Type 1 Diabetes
JL Felton, H Conway, RH Bonami |
Biomedicines | 2021 |
100 Years of insulin: Lifesaver, immune target, and potential remedy for prevention
A Ziegler, T Danne, C Daniel, E Bonifacio |
The American Journal of Medicine | 2021 |
Altered islet prohormone processing: A cause or consequence of diabetes?
A Ramzy, TJ Kieffer |
Physiological reviews | 2021 |
Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes
M von Herrath, PP Pagni, K Grove, G Christoffersson, M Tang-Christensen, AE Karlsen, JS Petersen |
Cell Metabolism | 2019 |
The Development of Immunotherapy Strategies for the Treatment of Type 1 Diabetes
K Coppieters, M von Herrath |
Frontiers in Medicine | 2018 |
Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice
J Grönholm, PP Pagni, MN Pham, CB Gibson, PF Macomber, JL Vela, M Herrath, MJ Lenardo |
Diabetologia | 2017 |
Metabolically inactive insulin: friend or foe in the prevention of autoimmune diabetes?
M Knip |
Diabetologia | 2017 |
Oral insulin (human, murine, or porcine) does not prevent diabetes in the non-obese diabetic mouse
MN Pham, C Gibson, AK Rydén, N Perdue, TE Boursalian, PP Pagni, K Coppieters, C Skonberg, T Porsgaard, M Herrath, JL Vela |
Clinical Immunology | 2016 |
Analysis of antigen specific T cells in diabetes – Lessons from pre-clinical studies and early clinical trials
B Krishnamurthy, C Selck, J Chee, G Jhala, TW Kay |
Journal of Autoimmunity | 2016 |
Progress in Molecular Biology and Translational Science
V Ovcinnikovs, LS Walker |
Progress in molecular biology and translational science | 2015 |
A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice
JS Lewis, NV Dolgova, Y Zhang, CQ Xia, CH Wasserfall, MA Atkinson, MJ Clare-Salzler, BG Keselowsky |
Clinical Immunology | 2015 |
Novel diagnostic and therapeutic approaches for autoimmune diabetes — A prime time to treat insulitis as a disease
J Grönholm, MJ Lenardo |
Clinical Immunology | 2015 |
The Effect of DPT-1 Intravenous Insulin Infusion and Daily Subcutaneous Insulin on Endogenous Insulin Secretion and Postprandial Glucose Tolerance
W Hao, CJ Greenbaum, JP Krischer, D Cuthbertson, JB Marks, JP Palmer |
Diabetes care | 2015 |
Short-term subcutaneous insulin treatment delays but does not prevent diabetes in NOD mice: Immunomodulation
V Brezar, S Culina, MC Gagnerault, R Mallone |
European Journal of Immunology | 2012 |
MECHANISMS IN ENDOCRINOLOGY: Insulin and type 1 diabetes: immune connections
S Culina, V Brezar, R Mallone |
European Journal of Endocrinology | 2012 |
The Immunological Barriers to Regenerative Medicine
PJ Fairchild |
2012 | |
Antigen-Based Immune Therapeutics for Type 1 Diabetes: Magic Bullets or Ordinary Blanks?
S Culina, C Boitard, R Mallone |
Clinical and Developmental Immunology | 2011 |
Beyond the Hormone: Insulin as an Autoimmune Target in Type 1 Diabetes
V Brezar, JC Carel, C Boitard, R Mallone |
Endocrine reviews | 2011 |
Impact of Intranasal Insulin on Insulin Antibody Affinity and Isotypes in Young Children With HLA-Conferred Susceptibility to Type 1 Diabetes
SJ Ryhanen, T Harkonen, H Siljander, K Nanto-Salonen, T Simell, H Hyoty, J Ilonen, R Veijola, O Simell, M Knip |
Diabetes care | 2011 |
Otelixizumab: a novel agent for the prevention of type 1 diabetes mellitus
SA Miller, ES Onge |
Expert Opinion on Biological Therapy | 2011 |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
The Islets of Langerhans
S Islam |
2010 | |
Immune therapy for type 1 diabetes mellitus—what is unique about anti-CD3 antibodies?
L Chatenoud |
Nature Reviews Endocrinology | 2010 |
Immunotherapy of type 1 diabetes — How to rationally prioritize combination therapies in T1D
T Boettler, M Herrath |
International Immunopharmacology | 2010 |
Immunotherapy for the Prevention and Treatment of Type 1 Diabetes: Optimizing the path from bench to bedside
D Bresson, M Herrath |
Diabetes care | 2009 |
Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial
K Näntö-Salonen, A Kupila, S Simell, H Siljander, T Salonsaari, A Hekkala, S Korhonen, R Erkkola, JI Sipilä, L Haavisto, M Siltala, J Tuominen, J Hakalax, H Hyöty, J Ilonen, R Veijola, T Simell, M Knip, O Simell |
The Lancet | 2008 |
CD3-specific antibodies: a portal to the treatment of autoimmunity
L Chatenoud, JA Bluestone |
Nature Reviews Immunology | 2007 |
Preventive Interventions for Type 1 Diabetes: History, Appraisal and Prospects
John Dupre, L. Jeffrey, Mahon |
Canadian Journal of Diabetes | 2007 |
Immunological Responses to Exogenous Insulin
SE Fineberg, TT Kawabata, D Finco-Kent, RJ Fountaine, GL Finch, AS Krasner |
Endocrine reviews | 2007 |
Immune Regulation and Immunotherapy in Autoimmune Disease
J Zhang |
2007 | |
TGF-beta Signaling is Required for the Function of Insulin Reactive T Regulatory Cells
Wei Du, F. Susan Wong, Ming O. Li, Jian Peng, Hao Qi, Richard A. Flavell, Robert Sherwin and Li Wen |
Journal of Clinical Investigation | 2006 |
A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation
LK Shoda, DL Young, S Ramanujan, CC Whiting, MA Atkinson, JA Bluestone, GS Eisenbarth, D Mathis, AA Rossini, SE Campbell, R Kahn, HT Kreuwel |
Immunity | 2005 |
Animal models of diabetes mellitus
DA Rees, JC Alcolado |
Diabetic Medicine | 2005 |
Expression of cholera toxin B subunit and the B chain of human insulin as a fusion protein in transgenic tobacco plants
D Li, J OLeary, Y Huang, NP Huner, AM Jevnikar, S Ma |
Plant Cell Reports | 2005 |
Molecular Pathways Altered by Insulin B9-23 Immunization
SE Eckenrode, QG Ruan, CD Collins, P Yang, RA Mcindoe, A Muir, JX She |
Annals of the New York Academy of Sciences | 2004 |
Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus - a new surrogate measure of non-progression?
D Schatz, D Cuthbertson, M Atkinson, MC Salzler, W Winter, A Muir, J Silverstein, R Cook, N Maclaren, JX She, C Greenbaum, J Krischer |
Pediatric Diabetes | 2004 |
Neuroendocrine Immuno-ontogeny of the Pathogenesis of Autoimmune Diabetes in the Nonobese Diabetic (NOD) Mouse
F Homo-Delarche |
ILAR journal / National Research Council, Institute of Laboratory Animal Resources | 2004 |
Gene expression profiles define a key checkpoint for type 1 diabetes in NOD mice
Sarah E Eckenrode, Qingguo Ruan, Ping Yang, Weipeng Zheng, Richard A McIndoe, Jin-Xiong She |
Diabetes | 2004 |
Characterization of antibody responses to endogenous and exogenous antigen in the nonobese diabetic mouse
K Koczwara, M Schenker, S Schmid, K Kredel, AG Ziegler, E Bonifacio |
Clinical Immunology | 2003 |
Immunomodulatory vaccination in autoimmune disease
I Urbanek-Ruiz, PJ Ruiz, L Steinman, CG Fathman |
Endocrinology & Metabolism Clinics of North America | 2002 |
Islet abnormalities in the pathogenesis of autoimmune diabetes
JG Rosmalen, PJ Leenen, C Pelegri, HA Drexhage, F Homo-Delarche |
Trends in Endocrinology & Metabolism | 2002 |
Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice
FJ Baker, M Lee, Y Chien, MM Davis |
Proceedings of the National Academy of Sciences | 2002 |
Inhaled Insulin and Insulin Antibodies: A New Twist to an Old Debate
JA Stoever, JP Palmer |
Diabetes Technology & Therapeutics | 2002 |
Immunotherapy of type 1 diabetes: lessons for other autoimmune diseases
JF Bach |
Arthritis research | 2002 |
TOLERANCE TOISLETAUTOANTIGENS INTYPE1 DIABETES
JF Bach, L Chatenoud |
Annual Review of Immunology | 2001 |
New therapeutic approaches to type 1 diabetes: from prevention to cellular or gene therapies
C Thivolet |
Clinical Endocrinology | 2001 |
Pathophysiology of Immune-Mediated (Type 1) Diabetes Mellitus
M Abel, M Krokowski |
BioDrugs | 2001 |
Recombinant DNA Technology in the Treatment of Diabetes: Insulin Analogs
Z Vajo, J Fawcett, WC Duckworth |
Endocrine reviews | 2001 |
Does GAD Have a Unique Role in Triggering IDDM?
S Baekkeskov, J Kanaani, JC Jaume, S Kash |
Journal of Autoimmunity | 2000 |
The molecular specificity of insulin autoantibodies
KN Potter, TJ Wilkin |
Diabetes/Metabolism Research and Reviews | 2000 |
Islet Abnormalities Associated with an Early Influx of Dendritic Cells and Macrophages in NOD and NODscid Mice
JG Rosmalen, F Homo-Delarche, S Durant, M Kap, PJ Leenen, HA Drexhage |
Laboratory Investigation | 2000 |
Prevention of Type 1 Diabetes: Is Now the Time?1
DJ Becker, RE LaPorte, I Libman, M Pietropaolo, HM Dosch |
The Journal of clinical endocrinology and metabolism | 2000 |
Multiple Genes/Multiple Autoantigens Role in Type 1 Diabetes
N Abiru, GS Eisenbarth |
Clinical Reviews in Allergy & Immunology | 2000 |
Pathogenesis, prediction and trials for the prevention of insulin-dependent (type 1) diabetes mellitus1Abbreviations: s.c., subcutaneous; i.p., intraperitoneal; i.v., intravenous; IFA, incomplete Freund's adjuvant; DTP, diphtheria-tetanus-pertussis; LCMV, lymphocytic choriomeningitis virus; GAD, glutamic acid decarboxylase; ICA, islet cell autoantibody; JDF, juvenile diabetes foundation; IAA, insulin autoantibody; GAA, glutamic acid decarboxylase autoantibody; DM, diabetes mellitus; RIA, radioimmunoassay; AA, autoantibody; kD, kilodalton; FPIR, first phase insulin release; IIF, indirect immunofluoresence; IGT, impaired glucose tolerance; OGT, oral glucose tolerance.1
PM Graves, GS Eisenbarth |
Advanced Drug Delivery Reviews | 1999 |
Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis
FS Wong, BN Dittel, CA Janeway |
Immunological Reviews | 1999 |
Insulin-dependent diabetes mellitus and its animal models
FS Wong, CA Janeway |
Current Opinion in Immunology | 1999 |
Effects of insulin administration in a group of high-risk, non-diabetic, first-degree relatives of Type 1 diabetic patients: an open pilot trial
C Rodriguez-Villar, I Conget, R Casamitjana, G Ercilla, R Gomis |
Diabetic Medicine | 1999 |
Antigen-based immunotherapy for autoimmune disease: from animal models to humans?
J Tian, A Olcott, L Hanssen, D Zekzer, DL Kaufman |
Immunology Today | 1999 |