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Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.

K W Wucherpfennig, … , L Steinman, K G Warren

K W Wucherpfennig, … , L Steinman, K G Warren

Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1114-1122. https://doi.org/10.1172/JCI119622.

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High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase HL Schwartz, JM Chandonia, SF Kash, J Kanaani, E Tunnell, A Domingo, FE Cohen, JP Banga, AM Madec, W Richter, S Baekkeskov	Journal of Molecular Biology	1999
B-cell responses to myelin basic protein and its epitopes in autoimmune encephalomyelitis induced by Semple rabies vaccine S Piyasirisilp, T Hemachudha, DE Griffin	Journal of Neuroimmunology	1999
Molecular mapping of the major epitopes of BP180 recognized by herpes gestationis autoantibodies MS Lin, M Gharia, CL Fu, M Olague-Marchan, M Hacker, KE Harman, BS Bhogal, MM Black, LA Diaz, GJ Giudice	Clinical Immunology	1999
Highly related immunoglobulin light chain sequences in different multiple sclerosis patients JE Blalock, SR Zhou, CC Maier, FS Galin, JN Whitaker	Journal of Neuroimmunology	1999
The Immunobiology of Multiple Sclerosis: An Autoimmune Disease of the Central Nervous System P Conlon, JR Oksenberg, J Zhang, L Steinman	Neurobiology of Disease	1999
Candidate autoantigens in multiple sclerosis S Schmidt	Multiple sclerosis (Houndmills, Basingstoke, England)	1999
Detection of an Autoantibody from Pug Dogs with Necrotizing Encephalitis (Pug Dog Encephalitis) K Uchida, T Hasegawa, M Ikeda, R Yamaguchi, S Tateyama	Veterinary pathology	1999
Design and Synthesis of a Potent Cyclic Analogue of the Myelin Basic Protein Epitope MBP 72-85 : Importance of the Ala 81 Carboxyl Group and of a Cyclic Conformation for Induction of Experimental Allergic Encephalomyelitis T Tselios, L Probert, I Daliani, E Matsoukas, A Troganis, IP Gerothanassis, T Mavromoustakos, GJ Moore, JM Matsoukas	Journal of Medicinal Chemistry	1999
Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis S Shimoda, JV de Water, A Ansari, M Nakamura, H Ishibashi, RL Coppel, J Lake, EB Keeffe, TE Roche, ME Gershwin	Journal of Clinical Investigation	1998
The specificity of the antibody response in multiple sclerosis H Garren, L Steinman, C Lock	Annals of Neurology	1998
Recent advances in immunology in multiple sclerosis RS Liblau, B Fontaine	Current Opinion in Neurology	1998
In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis RL Ufret-Vincenty, L Quigley, N Tresser, SH Pak, A Gado, S Hausmann, KW Wucherpfennig, S Brocke	Journal of Experimental Medicine	1998
In Vivo Survival of Viral Antigen-specific T Cells that Induce Experimental Autoimmune Encephalomyelitis RL Ufret-Vincenty, L Quigley, N Tresser, SH Pak, A Gado, S Hausmann, KW Wucherpfennig, S Brocke	Journal of Experimental Medicine	1998
More mayhem from molecular mimics L Steinman, MB Oldstone	Nature Medicine	1997
Viral damage and the breakdown of self-tolerance L Steinman, P Conlon	Nature Medicine	1997
Activation of autoreactive T cells by peptides from human pathogens S Hausmann	Current Opinion in Immunology	1997

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