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Tyrosine kinase inhibition ameliorates the hyperdynamic state and decreases nitric oxide production in cirrhotic rats with portal hypertension and ascites.

J C López-Talavera, … , R Esteban, J Guardia

J C López-Talavera, … , R Esteban, J Guardia

Published August 1, 1997
Citation Information: J Clin Invest. 1997;100(3):664-670. https://doi.org/10.1172/JCI119578.

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Citations to this article (40)

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Xiaozhang Tie Improves Intestinal Motility in Rats With Cirrhotic Ascites by Regulating the Stem Cell Factor/c-kit Pathway in Interstitial Cells of Cajal Q Zhao, F Xing, Y Tao, H Liu, K Huang, Y Peng, N Feng, C Liu	Frontiers in pharmacology	2020
Vascular syndromes in liver cirrhosis B Shenoda, J Boselli	Clinical Journal of Gastroenterology	2019
Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis X Ariza, I Graupera, M Coll, E Solà, R Barreto, E García, R Moreira, C Elia, M Morales-Ruiz, M Llopis, P Huelin, C Solé, N Fabrellas, E Weiss, F Nevens, A Gerbes, J Trebicka, F Saliba, C Fondevila, V Hernández-Gea, J Fernández, M Bernardi, V Arroyo, W Jiménez, C Deulofeu, M Pavesi, P Angeli, R Jalan, R Moreau, P Sancho-Bru, P Ginès	Journal of Hepatology	2016
Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism: AG126 in Autoimmunity and Inflammation C Menzfeld, M John, D Rossum, T Regen, J Scheffel, H Janova, A Götz, S Ribes, R Nau, A Borisch, P Boutin, K Neumann, V Bremes, J Wienands, HM Reichardt, F Lühder, D Tischner, V Waetzig, T Herdegen, P Teismann, I Greig, M Müller, T Pukrop, A Mildner, H Kettenmann, W Brück, M Prinz, S Rotshenker, MS Weber, UK Hanisch	Glia	2015
Mechanisms of Decompensation and Organ Failure in Cirrhosis: From Peripheral arterial Vasodilation to Systemic Inflammation Hypothesis M Bernardi, R Moreau, P Angeli, B Schnabl, V Arroyo	Journal of Hepatology	2015
Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance A Albillos, M Lario, M Álvarez-Mon	Journal of Hepatology	2014
Seldin and Giebisch's The Kidney CJ Cooper, LD Dworkin, WL Henrich	Seldin and Giebisch's The Kidney	2013
Fenofibrate A peroxisome proliferator activated receptor-α agonist treatment ameliorates Concanavalin A-induced hepatitis in rats DI Mohamed, AA Elmelegy, LF El-Aziz, HS kawy, AA El-Samad, OA El-Kharashi	European Journal of Pharmacology	2013
Intestinal decontamination improves liver haemodynamics in patients with alcohol-related decompensated cirrhosis J Vlachogiannakos, AS Saveriadis, N Viazis, I Theodoropoulos, K Foudoulis, S Manolakopoulos, S Raptis, DG Karamanolis	Alimentary Pharmacology & Therapeutics	2009
Hypertension portale : avancées et perspectives D Lebrec, R Moreau	Gastroentérologie Clinique et Biologique	2009
A novel model of CCl4-induced cirrhosis with ascites in the mouse M Domenicali, P Caraceni, F Giannone, M Baldassarre, G Lucchetti, C Quarta, C Patti, L Catani, C Nanni, RM Lemoli, M Bernardi	Journal of Hepatology	2009
Chronic Inflammation of Liver and Gut G Adler, JD Jia, DM Fan, NF LaRusso, C Owyang		2009
Liver–kidney pathophysiological interrelationships in liver diseases P Gentilini, GL Villa	Digestive and Liver Disease	2008
The future treatment of portal hypertension J Reichen, D Lebrec	Best Practice & Research Clinical Gastroenterology	2007
Effect of hyperleptinaemia on chronic ethanol-induced hepatotoxicity in mice V Balasubramaniyan, N Nalini	Fundamental and Clinical Pharmacology	2006
Hepatorenal syndrome / Hepatorenales Syndrom S Demırtaş, M Can, A Yarpuzlu	LaboratoriumsMedizin	2006
Molecular and Structural Basis of Portal Hypertension R Moreau, D Lebrec	Clinics in Liver Disease	2006
Mesenteric Th1 polarization and monocyte TNF-alpha production: first steps to systemic inflammation in rats with cirrhosis L Muñoz, A Albillos, M Nieto, E Reyes, L Lledó, J Monserrat, E Sanz, A la Hera, M Alvarez-Mon	Hepatology	2005
Portal Hypertension RJ Groszmann, JG Abraldes	Journal of Clinical Gastroenterology	2005
Infection, coagulation, and variceal bleeding in cirrhosis U Thalheimer, CK Triantos, DN Samonakis, D Patch, AK Burroughs	Gut	2005
Tyrphostin AG 126 inhibits development of postoperative ileus induced by surgical manipulation of murine colon BA Moore, A Türler, MA Pezzone, K Dyer, J Grandis, AJ Bauer	AJP Gastrointestinal and Liver Physiology	2004
Nitric oxide in ascitic fluid is an independent predictor of the development of renal impairment in patients with cirrhosis and spontaneous bacterial peritonitis: J Such, DJ Hillebrand, C Guarner, L Berk, P Zapater, J Westengard, C Peralta, G Soriano, J Pappas, R Francs, C Muoz, BA Runyon	European Journal of Gastroenterology & Hepatology	2004
Portal Hypertension in the 21st Century RJ Groszmann, J Bosch		2004
Increased tumour necrosis factor alpha production in mesenteric lymph nodes of cirrhotic patients with ascites J Genescà, R Martí, F Rojo, F Campos, V Peribáñez, A Gónzalez, L Castells, C Ruiz-Marcellán, C Margarit, R Esteban, J Guardia, R Segura	Gut	2003
Handbook of Cell Signaling MF White	Handbook of Cell Signaling	2003
Oral administration of lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance JI Togawa, H Nagase, K Tanaka, M Inamori, A Nakajima, N Ueno, T Saito, H Sekihara	Journal of Gastroenterology and Hepatology	2002
Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-α via the PI 3-kinase–Akt signaling pathway H Kawanaka	Hepatology	2002
Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance JI Togawa, H Nagase, K Tanaka, M Inamori, T Umezawa, A Nakajima, M Naito, S Sato, T Saito, H Sekihara	AJP Gastrointestinal and Liver Physiology	2002
Regulation of matrix metalloproteinases and effect of MMP-inhibition in heart transplant related reperfusion injury V Falk, PM Soccal, J GrunenfelderGrünenfelder, G Hoyt, T Walther, RC Robbins	European Journal of Cardio-Thoracic Surgery	2002
The hepatorenal syndrome L Dagher, K Moore	Gut	2001
Data Mining in Structural Biology I Schlichting, U Egner		2001
Bioorganic Chemistry of Biological Signal Transduction H Waldmann		2000
Protein Tyrosine Kinase Inhibitors as Novel Therapeutic Agents A Levitzki	Pharmacology & Therapeutics	1999
Endotoxemia: an unnecessary but aggravating condition in portal hypertension? P Sogni, R Moreau, D Lebrec	Journal of Hepatology	1999
NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats R Wiest, V Shah, WC Sessa, RJ Groszmann	AJP Gastrointestinal and Liver Physiology	1999
Adrenomedullin, a vasodilator peptide implicated in hemodynamic alterations of liver cirrhosis: relationship to nitric oxide J Genesca, A Gonzalez, R Catalan, R Segura, M Martinez, R Esteban, R J Groszmann, J Guardia	Digestive Diseases and Sciences	1999
Suppression of Experimental Autoimmune Encephalomyelitis by Tyrphostin AG-556 T Brenner, E Poradosu, D Soffer, C Sicsic, A Gazit, A Levitzki	Experimental Neurology	1998
Physiopathologie de l’hypertension portale R Moreau, D Lebrec	Acta Endoscopica	1995
Hepatorenal syndrome M Levy	Kidney International	1993

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