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Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes.

F Ahmad, … , G L Dohm, B J Goldstein

F Ahmad, … , G L Dohm, B J Goldstein

Published July 15, 1997
Citation Information: J Clin Invest. 1997;100(2):449-458. https://doi.org/10.1172/JCI119552.

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Approaches to Decrease Hyperglycemia by Targeting Impaired Hepatic Glucose Homeostasis Using Medicinal Plants. Mata-Torres G, Andrade-Cetto A, Espinoza-Hernández F	Frontiers in pharmacology	2021
Mitochondrial ATP synthase regulates corpus cavernosum smooth muscle cell function in�vivo and in�vitro Z Xu, J Chen, J Cai, Y Xiao, Q Wang, S Chen, L Zhang, Z Wu	Experimental and therapeutic medicine	2020
Modified diterpenoids from the tuber of Icacina oliviformis as protein tyrosine phosphatase 1B inhibitors J Zhou, Z Wu, B Guo, M Sun, MM Onakpa, G Yao, M Zhao, CT Che	Organic Chemistry Frontiers	2020
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Antihyperglycemic activity of Selaginella tamariscina (Beauv.) Spring X Zheng, Y Li, L Zhang, W Feng, X Zhang	Journal of Ethnopharmacology	2011
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Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene RV Rajala, M Tanito, BG Neel, A Rajala	The Journal of biological chemistry	2010
Hepatic PTP1B Deficiency: The Promise of a Treatment for Metabolic Syndrome? KK Bence	Journal of clinical metabolism & diabetes	2010
Palmitate and inflammatory state additively induce the expression of PTP1B in muscle cells L Parvaneh, R Meshkani, S Bakhtiyari, N MohammadTaghvaie, S GorganiFiruzjaee, GR TaheriPak, A Golestani, M Foruzandeh, B Larijani, M Taghikhani	Biochemical and Biophysical Research Communications	2010
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Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys MM Swarbrick, PJ Havel, AA Levin, AA Bremer, KL Stanhope, M Butler, SL Booten, JL Graham, RA McKay, SF Murray, LM Watts, BP Monia, S Bhanot	Endocrinology	2009
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Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance: Leptin receptors in obese humans T Fuentes, I Ara, A Guadalupe-Grau, S Larsen, B Stallknecht, H Olmedillas, A Santana, JW Helge, JA Calbet, B Guerra	Experimental Physiology	2009
PTP1B inhibitory effects of tridepside and related metabolites isolated from the Antarctic lichen Umbilicaria antarctica C Seo, YH Choi, JS Ahn, JH Yim, HK Lee, H Oh	Journal of Enzyme Inhibition and Medicinal Chemistry	2009
Phosphoinositide 3-kinase signaling in the vertebrate retina RV Rajala	Journal of lipid research	2009
Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle I Nieto-Vazquez, S Fernandez-Veledo, C Alvaro, M Lorenzo	Diabetes	2008
Insulin resistance induced by tumor necrosis factor-α in myocytes and brown adipocytes12 M Lorenzo, S Fernández-Veledo, R Vila-Bedmar, L Garcia-Guerra, CD Alvaro, I Nieto-Vazquez	Journal of animal science	2008
Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture ZQ Wang, D Ribnicky, XH Zhang, I Raskin, Y Yu, WT Cefalu	Metabolism: clinical and experimental	2008
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo JM Zabolotny, YB Kim, LA Welsh, EE Kershaw, BG Neel, BB Kahn	The Journal of biological chemistry	2008
Insulin resistance associated to obesity: the link TNF-alpha I Nieto-Vazquez, S Fernández-Veledo, DK Krämer, R Vila-Bedmar, L Garcia-Guerra, M Lorenzo	Archives Of Physiology And Biochemistry	2008
Long-term effects of corticosterone on behavior, oxidative and energy metabolism of parietotemporal cerebral cortex and hippocampus of rats: comparison to intracerebroventricular streptozotocin S Hoyer, H Lannert	Journal of Neural Transmission	2008
The protein tyrosine phosphatase receptor type f (PTPRF) locus is associated with coronary artery disease in type 2 diabetes C Menzaghi, G Paroni, CD Bonis, A Coco, C Vigna, G Miscio, P Lanna, V Tassi, S Bacci, V Trischitta	Journal of Internal Medicine	2008
Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation L Shi, W Zhang, YY Zhou, YN Zhang, JY Li, LH Hu, J Li	European Journal of Pharmacology	2008
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Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity RV Rajala, B Wiskur, M Tanito, M Callegan, A Rajala	Investigative ophthalmology & visual science	2008
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Fun&Co: identification of key functional differences in transcriptomes G Gamberoni, E Lamma, G Lodo, J Marchesini, N Mascellani, S Rossi, S Storari, L Tagliavini, S Volinia	Bioinformatics	2007
Effects of bis(α-furancarboxylato)oxovanadium(IV) on glucose metabolism in fat-fed/streptozotocin-diabetic rats Y Niu, W Liu, C Tian, M Xie, L Gao, Z Chen, X Chen, L Li	European Journal of Pharmacology	2007
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Comprehensive Medicinal Chemistry II E Littler, XX Zhou	Comprehensive Medicinal Chemistry II	2007
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Polymorphisms within the Protein Tyrosine Phosphatase 1B (PTPN1) Gene Promoter: Functional Characterization and Association with Type 2 Diabetes and Related Metabolic Traits R Meshkani, M Taghikhani, H Al-Kateb, B Larijani, S Khatami, GK Sidiropoulos, RA Hegele, K Adeli	Clinical chemistry	2007
Current Protocols in Pharmacology JP Renninger	Current Protocols in Pharmacology	2006
Pathophysiology of insulin resistance G Sesti	Best Practice & Research Clinical Endocrinology & Metabolism	2006
Inhibition of protein tyrosine phosphatase 1B by lignans fromMyristica fragrans S Yang, NM Kyun, JP Jang, KA Kim, BY Kim, NJ Sung, WK Oh, JS Ahn	Phytotherapy Research	2006
Improvement of diabetes, obesity and hypertension in type 2 diabetic KKAy mice by bis(allixinato)oxovanadium(IV) complex Y Adachi, Y Yoshikawa, J Yoshida, Y Kodera, A Katoh, J Takada, H Sakurai	Biochemical and Biophysical Research Communications	2006
Fetuin-null mice are protected against obesity and insulin resistance associated with aging ST Mathews, S Rakhade, X Zhou, GC Parker, DV Coscina, G Grunberger	Biochemical and Biophysical Research Communications	2006
Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum MK Na, WK Oh, YH Kim, XF Cai, SH Kim, BY Kim, JS Ahn	Bioorganic & Medicinal Chemistry Letters	2006
Protein tyrosine phosphatase 1B inhibitors from Morus root bark L Cui, MK Na, H Oh, EY Bae, DG Jeong, SE Ryu, S Kim, BY Kim, WK Oh, JS Ahn	Bioorganic & Medicinal Chemistry Letters	2006
Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana MK Na, L Cui, BS Min, KH Bae, JK Yoo, BY Kim, WK Oh, JS Ahn	Bioorganic & Medicinal Chemistry Letters	2006
Perspectives in bioinorganic chemistry of some metal based therapeutic agents S Ahmad, AA Isab, S Ali, AR Al-Arfaj	Polyhedron	2006
PTP1B inhibitory activity of kaurane diterpenes isolated from Siegesbeckia glabrescens S Kim, M Na, H Oh, J Jang, CB Sohn, BY Kim, WK Oh, JS Ahn	Journal of Enzyme Inhibition and Medicinal Chemistry	2006
The Role of the C-terminal Domain of Protein Tyrosine Phosphatase-1B in Phosphatase Activity and Substrate Binding KM Picha, SS Patel, S Mandiyan, J Koehn, LP Wennogle	The Journal of biological chemistry	2006
Protein Tyrosine Phosphatase-1B Inhibitory Activity of Isoprenylated Flavonoids Isolated from Erythrinamildbraedii MK Na, JP Jang, D Njamen, JT Mbafor, ZT Fomum, BY Kim, WK Oh, JS Ahn	Journal of Natural Products	2006
Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes DJ OGorman, HK Karlsson, S McQuaid, O Yousif, Y Rahman, D Gasparro, S Glund, AV Chibalin, JR Zierath, JJ Nolan	Diabetologia	2006
Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance JK Kim, HJ Kim, SY Park, A Cederberg, R Westergren, D Nilsson, T Higashimori, YR Cho, ZX Liu, J Dong, GW Cline, S Enerback, GI Shulman	Diabetes	2005
Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats Y Wu, JP Ouyang, K Wu, SS Wang, CY Wen, ZY Xia	British Journal of Pharmacology	2005
Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B1 Y WU, J OU-YANG, K WU, Y WANG, Y ZHOU, C WEN	Acta Pharmacologica Sinica	2005
The Pro387Leu variant of protein tyrosine phosphatase-1B is not associated with diabetes mellitus type 2 in a German population I Gouni-Berthold, E Giannakidou, D Muller-Wieland, M Faust, J Kotzka, HK Berthold, W Krone	Journal of Internal Medicine	2005
PTP1B Inhibitory Effect of Abietane Diterpenes Isolated from Salvia miltiorrhiza YM Han, H Oh, MK Na, BS Kim, WK Oh, BY Kim, DG Jeong, SE Ryu, DE Sok, JS Ahn	Biological & Pharmaceutical Bulletin	2005
Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle RR Almon, DC Dubois, JY Jin, WJ Jusko	The Journal of endocrinology	2005
Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization MT Fodero-Tavoletti, MP Hardy, B Cornell, F Katsis, CM Sadek, CA Mitchell, BE Kemp, T Tiganis	Biochemical Journal	2005
Discovery of novel inhibitor of human leukocyte common antigen-related phosphatase X Yang, J Li, Y Zhou, Q Shen, J Chen, J Li	Biochimica et Biophysica Acta (BBA) - General Subjects	2005
Protein Tyrosine Phosphatase 1B Variant Associated with Fat Distribution and Insulin Metabolism O Ukkola, T Rankinen, T Lakka, AS Leon, JS Skinner, JH Wilmore, DC Rao, YA Kesäniemi, C Bouchard	Obesity research	2005
Change in Vascular Adhesion Protein-1 and Metabolic Phenotypes after Vertical Banded Gastroplasty for Morbid Obesity HY Li, WJ Lee, MJ Chen, LM Chuang	Obesity research	2005
A Nonspecific Phosphotyrosine Phosphatase Inhibitor, Bis(maltolato)oxovanadium(IV), Improves Glucose Tolerance and Prevents Diabetes in Zucker Diabetic Fatty Rats CL Winter, JS Lange, MG Davis, GS Gerwe, TR Downs, KG Peters, B Kasibhatla	Experimental biology and medicine (Maywood, N.J.)	2005
Protein tyrosine phosphatases M Bernier	Cell Biochemistry and Biophysics	2004
A steady state analysis indicates that negative feedback regulation of PTP1B by Akt elicits bistability in insulin-stimulated GLUT4 translocation L Giri, VK Mutalik, KV Venkatesh	Theoretical biology & medical modelling	2004
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors CK Lau, CI Bayly, JY Gauthier, CS Li, M Therien, E Asante-Appiah, W Cromlish, Y Boie, F Forghani, S Desmarais, Q Wang, K Skorey, D Waddleton, P Payette, C Ramachandran, BP Kennedy, G Scapin	Bioorganic & Medicinal Chemistry Letters	2004
Protein tyrosine phosphatases: Potential role in β-cell insulin signal transduction M Bernier	Cell Biochemistry and Biophysics	2004
The allelic variant of LAR gene promoter –127 bp T→A is associated with reduced risk of obesity and other features related to insulin resistance G Miscio, V Tassi, A Coco, T Soccio, RD Paola, S Prudente, R Baratta, L Frittitta, O Ludovico, L Padovano, B Dallapiccola, UD Mario, SD Cosmo, V Trischitta	Journal of Molecular Medicine	2004
International Textbook of Diabetes Mellitus RA DeFronzo, L Mandarino, E Ferrannini	International Textbook of Diabetes Mellitus	2003
Sounding board: diabetes mellitus in the elderly: a truly heterogeneous entity? S Ratnakant, ME Ochs, SS Solomon	Diabetes, Obesity and Metabolism	2003
Insulin Resistant States and Insulin Signaling P Vollenweider	Clinical Chemistry and Laboratory Medicine	2003
Insulin sensitisation in the treatment of Type 2 diabetes M Tadayyon, SA Smith	Expert Opinion on Investigational Drugs	2003
Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component KG Peters, MG Davis, BW Howard, M Pokross, V Rastogi, C Diven, KD Greis, E Eby-Wilkens, M Maier, A Evdokimov, S Soper, F Genbauffe	Journal of Inorganic Biochemistry	2003
Novel targets and therapeutic strategies for type 2 diabetes N Morral	Trends in Endocrinology & Metabolism	2003
Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle SM Rahman, A Dobrzyn, P Dobrzyn, SH Lee, M Miyazaki, JM Ntambi	Proceedings of the National Academy of Sciences	2003
Protein-tyrosine phosphatase activity in human adipocytes is strongly correlated with insulin-stimulated glucose uptake and is a target of insulin-induced oxidative inhibition X Wu, VE Hardy, JI Joseph, S Jabbour, K Mahadev, L Zhu, BJ Goldstein	Metabolism	2003
Genetic variants of modulators of insulin action V Tassi, RD Paola, A Pizzuti, L Frittitta, V Trischitta	International Congress Series	2003
Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats A Abella, L Marti, M Camps, M Claret, J Fernández-Alvarez, R Gomis, A Gumà, N Viguerie, C Carpéné, M Palacín, X Testar, A Zorzano	Diabetes	2003
Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice RJ Gum, LL Gaede, SL Koterski, M Heindel, JE Clampit, BA Zinker, JM Trevillyan, RG Ulrich, MR Jirousek, CM Rondinone	Diabetes	2003
Protein-tyrosine-phosphatase 1B activation is regulated developmentally in muscle of neonatal pigs A Suryawan, TA Davis	American journal of physiology. Endocrinology and metabolism	2003
Antisense Protein Tyrosine Phosphatase 1B Reverses Activation of p38 Mitogen-Activated Protein Kinase in Liver of ob/ob Mice RJ Gum, LL Gaede, MA Heindel, JF Waring, JM Trevillyan, BA Zinker, ME Stark, D Wilcox, MR Jirousek, CM Rondinone, RG Ulrich	Molecular Endocrinology	2003
Structure-based prediction of free energy changes of binding of PTP1B inhibitors J Wang, SL Chan, K Ramnarayan	Journal of Computer-Aided Molecular Design	2003
Troglitazone Ameliorates Abnormal Activity of Protein Tyrosine Phosphatase in Adipose Tissues of Otsuka Long-Evans Tokushima Fatty Rats S Tagami, T Honda, H Yoshimura, H Homma, K Ohno, H Ide, S Sakaue, Y Kawakami	The Tohoku Journal of Experimental Medicine	2002
Elevated fasting insulin concentrations associate with impaired insulin signaling in skeletal muscle of healthy subjects independent of obesity E Korsheninnikova, A Sepp�l�-Lindroos, S Vehkavaara, T Goto, A Virkam�ki	Diabetes/Metabolism Research and Reviews	2002
Coordinated action of protein tyrosine phosphatases in insulin signal transduction A Cheng, N Dube, F Gu, ML Tremblay	European Journal of Biochemistry	2002
Obesity and cardiovascular disease P Poirier, RH Eckel	Current Atherosclerosis Reports	2002
Development of a time-resolved fluorescent assay for measuring tyrosine-phosphorylated proteins in cells D Waddleton, C Ramachandran, Q Wang	Analytical Biochemistry	2002
Signal Transduction BD Gomperts, IM Kramer, PE Tatham	Signal Transduction	2002
Insulin Resistance and Insulin Resistance Syndrome A Cincotta	Insulin Resistance and Insulin Resistance Syndrome	2002
Insulin Resistance and Insulin Resistance Syndrome: Recent Insights from Cellular and Animal Studies B Goldstein	Insulin Resistance and Insulin Resistance Syndrome	2002
Effects of troglitazone on skeletal muscle and liver protein tyrosine phosphatase activity in insulin-resistant otsuka long-evans tokushima fatty rats T Seiichi, S Shinji, H Toshiro, Y Haruhiko, H Hideaki, O Kosei, N Masaharu, I Hajime	Current Therapeutic Research	2002
Insulin Resistance, Defective Insulin Receptor Substrate 2--Associated Phosphatidylinositol-3' Kinase Activation, and Impaired Atypical Protein Kinase C ( / ) Activation in Myotubes From Obese Patients With Impaired Glucose Tolerance P Vollenweider, B Menard, P Nicod	Diabetes	2002
Improved Insulin Sensitivity and Resistance to Weight Gain in Mice Null for the Ahsg Gene ST Mathews, GP Singh, M Ranalletta, VJ Cintron, X Qiang, AS Goustin, KL Jen, MJ Charron, W Jahnen-Dechent, G Grunberger	Diabetes	2002
A Variation in 3′ UTR of hPTP1B Increases Specific Gene Expression and Associates with Insulin Resistance RD Paola, L Frittitta, G Miscio, M Bozzali, R Baratta, M Centra, D Spampinato, MG Santagati, T Ercolino, C Cisternino, T Soccio, S Mastroianno, V Tassi, P Almgren, A Pizzuti, R Vigneri, V Trischitta	The American Journal of Human Genetics	2002
Protein tyrosine phosphatase 1B: a new target for the treatment of obesity and associated co-morbidities O Ukkola, M Santaniemi	Journal of Internal Medicine	2002
Investigation of Potential Bioisosteric Replacements for the Carboxyl Groups of Peptidomimetic Inhibitors of Protein Tyrosine Phosphatase 1B: Identification of a Tetrazole-Containing Inhibitor with Cellular Activity C Liljebris, SD Larsen, D Ogg, BJ Palazuk, JE Bleasdale	Journal of Medicinal Chemistry	2002
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance JM Zabolotny, YB Kim, OD Peroni, JK Kim, MA Pani, O Boss, LD Klaman, S Kamatkar, GI Shulman, BB Kahn, BG Neel	Proceedings of the National Academy of Sciences	2001
Effects of adenovirus-mediated liver-selective overexpression of protein tyrosine phosphatase-1b on insulin sensitivityin vivo J Wang, AT Cheung, JK Kolls, WW Starks, A Martinez-Hernandez, D Dietzen, M Bryer-Ash	Diabetes, Obesity and Metabolism	2001
Modulation of insulin-stimulated glycogen synthesis by Src Homology Phosphatase 2 DM Ouwens, GC van der Zon, JA Maassen	Molecular and Cellular Endocrinology	2001
A P387L Variant in Protein Tyrosine Phosphatase-1B (PTP-1B) Is Associated With Type 2 Diabetes and Impaired Serine Phosphorylation of PTP-1B In Vitro SM Echwald, H Bach, H Vestergaard, B Richelsen, K Kristensen, T Drivsholm, K Borch-Johnsen, T Hansen, O Pedersen	Diabetes	2001
Decreased In Situ Insulin Receptor Dephosphorylation in Hyperglycemia-Induced Insulin Resistance in Rat Adipocytes S Tang, H Le-Tien, BJ Goldstein, P Shin, R Lai, IG Fantus	Diabetes	2001
Synthesis and Biological Activity of a Novel Class of Small Molecular Weight Peptidomimetic Competitive Inhibitors of Protein Tyrosine Phosphatase 1B SD Larsen, T Barf, C Liljebris, PD May, D Ogg, TJ O'Sullivan, BJ Palazuk, HJ Schostarez, FC Stevens, JE Bleasdale	Journal of Medicinal Chemistry	2001
Small Molecule Peptidomimetics Containing a Novel Phosphotyrosine Bioisostere Inhibit Protein Tyrosine Phosphatase 1B and Augment Insulin Action JE Bleasdale, D Ogg, BJ Palazuk, CS Jacob, ML Swanson, XY Wang, DP Thompson, RA Conradi, WR Mathews, AL Laborde, CW Stuchly, A Heijbel, K Bergdahl, CA Bannow, CW Smith, C Svensson, C Liljebris, HJ Schostarez, PD May, FC Stevens, SD Larsen	Biochemistry	2001
Protein tyrosine phosphatase-1B in diabetes B Kennedy	Biochemical Pharmacology	2000
Molecular Basis for the Dephosphorylation of the Activation Segment of the Insulin Receptor by Protein Tyrosine Phosphatase 1B A Salmeen, JN Andersen, MP Myers, NK Tonks, D Barford	Molecular Cell	2000
Insulin and high glucose modulation of phosphatase and reductase enzymes in the human erythrocytes: a comparative analysis in normal and diabetic states F Marques	Diabetes Research and Clinical Practice	2000
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice LD Klaman, O Boss, OD Peroni, JK Kim, JL Martino, JM Zabolotny, N Moghal, M Lubkin, YB Kim, AH Sharpe, A Stricker-Krongrad, GI Shulman, BG Neel, BB Kahn	Molecular and cellular biology	2000
Bradykinin enhances insulin receptor tyrosine kinase in 32D cells reconstituted with bradykinin and insulin signaling pathways H Motoshima, E Araki, T Nishiyama, T Taguchi, K Kaneko, Y Hirashima, K Yoshizato, A Shirakami, K Sakai, J Kawashima, T Shirotani, H Kishikawa, M Shichiri	Diabetes Research and Clinical Practice	2000
Structure–Activity Relationship and Rational Design of 3,4-Dephostatin Derivatives as Protein Tyrosine Phosphatase Inhibitors T Watanabe, T Suzuki, Y Umezawa, T Takeuchi, M Otsuka, K Umezawa	Tetrahedron	2000
Vanadate enhances but does not normalize glucose transport and insulin receptor phosphorylation in skeletal muscle from obese women with gestational diabetes mellitus J Shao, PM Catalano, H Yamashita, T Ishizuka, JE Friedman	American Journal of Obstetrics and Gynecology	2000
Overexpression of Protein-tyrosine Phosphatase-1B in Adipocytes Inhibits Insulin-stimulated Phosphoinositide 3-Kinase Activity without Altering Glucose Transport or Akt/Protein Kinase B Activation CL Venable, EU Frevert, YB Kim, BM Fischer, S Kamatkar, BG Neel, BB Kahn	The Journal of biological chemistry	2000
Obesity: Pathology and Therapy DH Lockwood, TC Heffner		2000
Gene Engineering in Endocrinology MA Shupnik		2000
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats ZY Jiang, YW Lin, A Clemont, EP Feener, KD Hein, M Igarashi, T Yamauchi, MF White, GL King	Journal of Clinical Investigation	1999
Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance A Virkamäki, K Ueki, CR Kahn	Journal of Clinical Investigation	1999
Overexpression of Protein Tyrosine Phosphatase-α (PTP-α) but not PTP-κ Inhibits Translocation of GLUT4 in Rat Adipose Cells LN Cong, H Chen, Y Li, CH Lin, J Sap, MJ Quon	Biochemical and Biophysical Research Communications	1999
Role of protein tyrosine phosphatase-1B in diabetes and obesity BP Kennedy	Biomedicine & Pharmacotherapy	1999
G-protein-coupled, extracellular Ca(2+)-sensing receptor: a versatile regulator of diverse cellular functions J Fox, MA Miller, GB Stroup, EF Nemeth, SC Miller	Vitamins and hormones	1999
Insulin Signalling FH Nystrom, MJ Quon	Cellular Signalling	1999
A Soluble PC-1 Circulates in Human Plasma: Relationship with Insulin Resistance and Associated Abnormalities* L Frittitta, S Camastra, R Baratta, BV Costanzo, M DAdamo, S Graci, D Spampinato, BA Maddux, R Vigneri, E Ferrannini, V Trischitta	The Journal of clinical endocrinology and metabolism	1999
Potent and Highly Selective Inhibitors of the Protein Tyrosine Phosphatase 1B M Taing, YF Keng, K Shen, L Wu, DS Lawrence, ZY Zhang	Biochemistry	1999
Structure-Based Discovery of Small Molecule Inhibitors Targeted to Protein Tyrosine Phosphatase 1B M Sarmiento, L Wu, YF Keng, L Song, Z Luo, Z Huang, GZ Wu, AK Yuan, ZY Zhang	Journal of Medicinal Chemistry	1999
Inhibition of the Transmembrane Protein Tyrosine Phosphatase LAR by 3S-Peptide-I Enhances Insulin Receptor Phosphorylation in Intact Cells HK Kole, S Kole, BP Mallory, PM Li, BJ Goldstein, M Bernier	Journal of Basic and Clinical Physiology and Pharmacology	1998
Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas (Crk-associated substrate), promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1 A Sorokin, E Reed	Biochemical Journal	1998
The insulin receptor--a critical link in glucose homeostasis and insulin action ME Patti, CR Kahn	Journal of Basic and Clinical Physiology and Pharmacology	1998
An in Vivo Model for Elucidation of the Mechanism of Tumor Necrosis Factor-α (TNF-α)-Induced Insulin Resistance: Evidence for Differential Regulation of Insulin Signaling by TNF-α AT Cheung, D Ree, JK Kolls, J Fuselier, DH Coy, M Bryer-Ash	Endocrinology	1998
A Phosphotyrosyl Mimetic Peptide Reverses Impairment of Insulin-Stimulated Translocation of GLUT4 Caused by Overexpression of PTP1B in Rat Adipose Cells H Chen, LN Cong, Y Li, ZJ Yao, L Wu, ZY Zhang, TR Burke, MJ Quon	Biochemistry	1998
Advances in Structural Biology A Ghahary, P Rajeet, EE Tredget	Advances in Structural Biology	1996

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