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BCR/ABL induces multiple abnormalities of cytoskeletal function.

R Salgia, … , L B Chen, J D Griffin

R Salgia, … , L B Chen, J D Griffin

Published July 1, 1997
Citation Information: J Clin Invest. 1997;100(1):46-57. https://doi.org/10.1172/JCI119520.

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Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate CML development JA Wertheim	Blood	2003
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Differential interaction and activation of Rho family GTPases by p210bcr-abl and p190bcr-abl T Harnois, B Constantin, A Rioux, E Grenioux, A Kitzis, N Bourmeyster	Oncogene	2003
Abl Family Nonreceptor Tyrosine Kinases Modulate Short-Term Synaptic Plasticity EM Moresco, AJ Scheetz, WG Bornmann, AJ Koleske, RM Fitzsimonds	Journal of neurophysiology	2003
MEK kinase 1 mediates the antiapoptotic effect of the Bcr-Abl oncogene through NF-κB activation R Nawata, T Yujiri, Y Nakamura, K Ariyoshi, T Takahashi, Y Sato, Y Oka, Y Tanizawa	Oncogene	2003
Quantitative PCR identifies a minimal deleted region of 120 kb extending from the Philadelphia chromosome ABL translocation breakpoint in chronic myeloid leukemia with poor outcome E Kolomietz, P Marrano, K Yee, B Thai, I Braude, A Kolomietz, K Chun, S Minkin, S Kamel-Reid, M Minden, JA Squire	Leukemia	2003
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p53 expression in K562 cells is associated with caspase-mediated cleavage of c-ABL and BCR-ABL protein kinases AM di Bacco, TG Cotter	British Journal of Haematology	2002
Bone marrow cyclooxygenase-2 levels are elevated in chronic-phase chronic myeloid leukaemia and are associated with reduced survival FJ Giles, HM Kantarjian, BN Bekele, JE Cortes, S Faderl, DA Thomas, T Manshouri, A Rogers, MJ Keating, M Talpaz, S O'Brien, M Albitar	British Journal of Haematology	2002
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Chronic myelogenous leukemia: mechanisms underlying disease progression AS Shet, BN Jahagirdar, CM Verfaillie	Leukemia	2002
Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells M Sattler, YB Pride, LR Quinnan, S Verma, NA Malouf, H Husson, R Salgia, S Lipkowitz, JD Griffin	Oncogene	2002
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BCR-ABL–induced adhesion defects are tyrosine kinase–independent JA Wertheim, K Forsythe, BJ Druker, D Hammer, D Boettiger, WS Pear	Blood	2002
A comparison of normal and leukemic stem cell biology in Chronic Myeloid Leukemia HG J�rgensen, TL Holyoake	Hematological Oncology	2001
Recent advances in the molecular and cellular biology of chronic myeloid leukaemia: lessons to be learned from the laboratory DT Holyoake	British Journal of Haematology	2001
Abnormal growth factor modulation of beta1-integrin-mediated adhesion in chronic myelogenous leukaemia haematopoietic progenitors R Bhatia, HA Munthe, SJ Forman	British Journal of Haematology	2001
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells AY Ting, KH Kain, RL Klemke, RY Tsien	Proceedings of the National Academy of Sciences	2001
The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin Y Wang, AL Miller, MS Mooseker, AJ Koleske	Proceedings of the National Academy of Sciences	2001
HSH2: A Novel SH2 Domain-Containing Adapter Protein Involved in Tyrosine Kinase Signaling in Hematopoietic Cells T Oda, M Muramatsu, T Isogai, Y Masuho, S Asano, T Yamashita	Biochemical and Biophysical Research Communications	2001
Tyrosine kinase inhibitors in the treatment of chronic myeloid leukaemia: so far so good? MW Drummond, TL Holyoake	Blood Reviews	2001
Association of Tyrosine Phosphatase SHP-2 with F-actin at Low Cell Densities F Xu, R Zhao, Y Peng, A Guerrah, ZJ Zhao	The Journal of biological chemistry	2001
Deletion of the Src Homology 3 Domain and C-terminal Proline-rich Sequences in Bcr-Abl Prevents Abl Interactor 2 Degradation and Spontaneous Cell Migration and Impairs Leukemogenesis Z Dai, P Kerzic, WG Schroeder, IK McNiece	The Journal of biological chemistry	2001
Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor HH Yu, AH Zisch, VC Dodelet, EB Pasquale	Oncogene	2001
Growth advantage of chronic myeloid leukemia CFU-GM in vitro: survival to growth factor deprivation, possibly related to autocrine stimulation, is a more common feature than hypersensitivity to GM-CSF/IL3 and is efficiently counteracted by retinoids ± α-interferon D Ferrero, C Foli, F Giaretta, C Argentino, C Rus, A Pileri	Leukemia	2001
Abl kinase but not PI3-kinase links to the cytoskeletal defects in Bcr-Abl transformed cells I Gaston, PE Stenberg, A Bhat, BJ Druker	Experimental Hematology	2000
The possible influences of B2A2 and B3A2 BCR/ABL protein structure on thrombopoiesis in chronic myeloid leukaemia R Perego	European Journal of Cancer	2000
Cytoskeletal Protein PSTPIP1 Directs the PEST-Type Protein Tyrosine Phosphatase to the c-Abl Kinase to Mediate Abl Dephosphorylation F Cong, S Spencer, JF Côté, Y Wu, ML Tremblay, LA Lasky, SP Goff	Molecular Cell	2000
SHIP1, an SH2 Domain Containing Polyinositol-5-phosphatase, Regulates Migration through Two Critical Tyrosine Residues and Forms a Novel Signaling Complex with DOK1 and CRKL M Sattler, S Verma, YB Pride, R Salgia, LR Rohrschneider, JD Griffin	The Journal of biological chemistry	2000
Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571 WL Wang, ME Healy, M Sattler, S Verma, J Lin, G Maulik, CD Stiles, JD Griffin, BE Johnson, R Salgia	Oncogene	2000
Leucocyte alkaline phosphatase identifies terminally differentiated normal neutrophils and its lack in chronic myelogenous leukaemia is not dependent on p210 tyrosine kinase activity G Dotti, E Garattini, G Borleri, K Masuhara, O Spinelli, T Barbui, A Rambaldi	British Journal of Haematology	1999
Chronic Myelogenous Leukemia: From Pathogenesis to Therapy CM Verfaillie	Journal of Hematotherapy	1999
BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis M Sattler, S Verma, CH Byrne, G Shrikhande, T Winkler, PA Algate, LR Rohrschneider, JD Griffin	Molecular and cellular biology	1999
c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF R Plattner, L Kadlec, KA DeMali, A Kazlauskas, AM Pendergast	Genes & development	1999
Ex Vivo Cell Therapy RE Nordon, K Schindhelm	Ex Vivo Cell Therapy	1999
Polarized distribution of Bcr-Abl in migrating myeloid cells and co-localization of Bcr-Abl and its target proteins PA Skourides, SA Perera, R Ren	Oncogene	1999
Functional Analysis of a Single Chain Chimeric α/β-Granulocyte-Macrophage Colony-stimulating Factor Receptor: IMPORTANCE OF A GLUTAMATE RESIDUE IN THE TRANSMEMBRANE REGION S Kafert, S Luther, I Böll, K Wagner, A Ganser, M Eder	The Journal of biological chemistry	1999
Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility R Salgia, JL Li, DS Ewaniuk, YB Wang, M Sattler, WC Chen, W Richards, E Pisick, GI Shapiro, BJ Rollins, LB Chen, JD Griffin, DJ Sugarbaker	Oncogene	1999
Dominant effects of the bcr-abl oncogene on Drosophila morphogenesis FJ Fogerty, JL Juang, J Petersen, MJ Clark, FM Hoffmann, DF Mosher	Oncogene	1999
Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway Z Dai, RC Quackenbush, KD Courtney, M Grove, D Cortez, GW Reuther, AM Pendergast	Genes & development	1998
Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation AJ Koleske, AM Gifford, ML Scott, M Nee, RT Bronson, KA Miczek, D Baltimore	Neuron	1998
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A chimeric receptor/oncogene that can be regulated by a ligand in vitro and in vivo K Okuda, A D'Andrea, RA Etten, JD Griffin	Journal of Clinical Investigation	1997
Enlightening intracellular complexity of living cells with quantitative phase microscopy G Popescu, YK Park, CM Torres, B Laperrousaz, L Berguiga, EB Provera, J Elezgaray, FE Nicolini, V Maguer-Satta, A Arneodo, F Argoul	SPIE BiOS
Molekularmedizinische Grundlagen von hämatologischen Neoplasien D Ganten, K Ruckpaul, B Schlegelberger, C Fonatsch		2003
A model of human p210bcr/ABL-mediated chronic myelogenous leukemia by transduction of primary normal human CD34+ cells with a BCR/ABL-containing retroviral vector RC Zhao, Y Jiang, CM Verfaillie	Blood	2001
Adhesion to fibronectin selectively protects Bcr-Abl+cells from DNA damage–induced apoptosis H van der Kuip, AW Goetz, C Miething, J Duyster, WE Aulitzky	Blood	2001
Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis E Kolomietz, J Al-Maghrabi, S Brennan, J Karaskova, S Minkin, J Lipton, JA Squire	Blood	2001
STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells C Sillaber, F Gesbert, DA Frank, M Sattler, JD Griffin	Blood	2000
Reduced oncogenicity of p190 Bcr/Abl F-actin–binding domain mutants N Heisterkamp, JW Voncken, D Senadheera, I Gonzalez-Gomez, A Reichert, L Haataja, A Reinikainen, PK Pattengale, J Groffen	Blood	2000
Effects of the Tyrosine Kinase Inhibitor AG957 and an Anti-Fas Receptor Antibody on CD34+ Chronic Myelogenous Leukemia Progenitor Cells C Carlo-Stella, E Regazzi, G Sammarelli, S Colla, D Garau, A Gazit, B Savoldo, D Cilloni, A Tabilio, A Levitzki, V Rizzoli	Blood	1999
The C-Terminus of c-Abl Is Required for Proliferation and Viability Signaling in a c-Abl/Erythropoietin Receptor Fusion Protein K Okuda, A DAndrea, RA Etten, JD Griffin	Blood	1998

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